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Molecular and Cytogenetic Studies in a Child with Burkitt Lymphoma and Ataxia-Telangiectasia Syndrome Harboring MYC Overexpression and Partial Trisomy 8

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초록

Dear Editor, Burkitt lymphoma/leukemia (BL/L) was the first neoplasia associated with rearrangement in MYC that is the molecular hallmark of this disease. Particularly, immunoglobulin genes are associated with MYC in BL/L, where the juxtaposition with heavy chain locus (14q32) or light chain loci (2p12 and 22q11) leads to MYC overexpression, which is believed to play a central role in BL/L pathogenesis

Abstract

Dear Editor, Burkitt lymphoma/leukemia (BL/L) was the first neoplasia associated with rearrangement in MYC that is the molecular hallmark of this disease. Particularly, immunoglobulin genes are associated with MYC in BL/L, where the juxtaposition with heavy chain locus (14q32) or light chain loci (2p12 and 22q11) leads to MYC overexpression, which is believed to play a central role in BL/L pathogenesis

참고문헌 (10)

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  5. Onnis A, "Alteration of microRNAs regulated by c-Myc in Burkitt lymphoma", PloS One, 23, pp.909~920 (2010)
  6. Leucci E, "MYC translocation-negative classical Burkitt lymphoma cases: an alternative pathogenic mechanism involving miRNA deregulation", J Pathol, 216, pp.440~450 (2008)[DOI]
  7. Robertus JL, "miRNA profiling in B non-Hodgkin lymphoma: a MYC-related miRNA profile characterizes Burkitt lymphoma", Br J Haematol, 149, pp.896~899 (2010)[DOI]
  8. Schoenaker MHD, "Treatment of acute leukemia in children with ataxia-telangiectasia (A-T)", Eur J Med Genet, 59, pp.641~646 (2016)[DOI]
  9. Sandlund JT, "Pilot study of modified LMB-based therapy for children with ataxia-telangiectasia and advanced stage high grade mature b-cell malignancies", Pediatr Blood Cancer, 61, pp.360~362 (2014)[DOI]
  10. Vera-Lozada G, "Analysis of biological and technical variability in gene expression assays from formalin-fixed paraffin-embedded classical Hodgkin lymphomas", Exp Mol Pathol, 97, pp.433~439 (2014)[DOI]

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