Molecular and Cytogenetic Studies in a Child with Burkitt Lymphoma and Ataxia-Telangiectasia Syndrome Harboring MYC Overexpression and Partial Trisomy 8
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Dear Editor, Burkitt lymphoma/leukemia (BL/L) was the first neoplasia associated with rearrangement in MYC that is the molecular hallmark of this disease. Particularly, immunoglobulin genes are associated with MYC in BL/L, where the juxtaposition with heavy chain locus (14q32) or light chain loci (2p12 and 22q11) leads to MYC overexpression, which is believed to play a central role in BL/L pathogenesis
Abstract
Dear Editor, Burkitt lymphoma/leukemia (BL/L) was the first neoplasia associated with rearrangement in MYC that is the molecular hallmark of this disease. Particularly, immunoglobulin genes are associated with MYC in BL/L, where the juxtaposition with heavy chain locus (14q32) or light chain loci (2p12 and 22q11) leads to MYC overexpression, which is believed to play a central role in BL/L pathogenesis
참고문헌 (10)
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