Mac-2 Binding Protein Glycosylation Isomer: Emerging Non-Invasive Serum Marker for Liver Fibrosis
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초록
Glycoprotein, which has glycan branches on its protein surface, is one of major forms of proteins existing in human body [1]. Its sugar composition and branched structure are known to be very specific to differentiation stages or pathologic changes of cell [1]. Therefore, as a glycoprotein-based biomarkers (glyco-biomarkers), it has been already used as laboratory tests like hemoglobin A1c for blood glucose monitoring or carbohydrate-deficient transferrin for chronic alcohol consumption [1, 2]. A new glycobiomarker named Mac-2 binding protein glycosylation isomer (M2BPGi, Wisteria floribunda agglutinin-positive Mac-2 binding protein) is emerging as a serum marker for liver fibrosis.
Abstract
Glycoprotein, which has glycan branches on its protein surface, is one of major forms of proteins existing in human body [1]. Its sugar composition and branched structure are known to be very specific to differentiation stages or pathologic changes of cell [1]. Therefore, as a glycoprotein-based biomarkers (glyco-biomarkers), it has been already used as laboratory tests like hemoglobin A1c for blood glucose monitoring or carbohydrate-deficient transferrin for chronic alcohol consumption [1, 2]. A new glycobiomarker named Mac-2 binding protein glycosylation isomer (M2BPGi, Wisteria floribunda agglutinin-positive Mac-2 binding protein) is emerging as a serum marker for liver fibrosis.
참고문헌 (7)
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- Cho SY, "Mean platelet volume and mean platelet volume", platelet count ratio in patients with chronic alcohol consumption, 2015, pp.26, 371~372
- 문희원, "Usefulness of Enhanced Liver Fibrosis, Glycosylation Isomer of Mac-2 Binding Protein, Galectin-3, and Soluble Suppression of Tumorigenicity 2 for Assessing Liver Fibrosis in Chronic Liver Diseases", Annals of Laboratory Medicine, 38(4), pp.331~337 (2018), 대한진단검사의학회
- Lambrecht J, "Prospects in non-invasive assessment of liver fibrosis: liquid biopsy as the future gold standard?", Biochim Biophys Acta, 1864, pp.1024~1036 (2018)[DOI]
- Shirabe K, "Mac-2 binding protein glycan isomer (M2BPGi) is a new serum biomarker for assessing liver fibrosis: more than a biomarker of liver fibrosis", J Gastroenterol (2018)
- Atsukawa M, "Serum Wisteria floribunda agglutinin-positive Mac-2 binding protein more reliably distinguishes liver fibrosis stages in non-alcoholic fatty liver disease than serum Mac-2 binding protein", Hepatol Res (2017)
- Dong Wook Jekarl, "Diagnosis of Liver Fibrosis With Wisteria floribunda Agglutinin-Positive Mac-2 Binding Protein (WFAM2BP) Among Chronic Hepatitis B Patients", Annals of Laboratory Medicine, 38(4), pp.348~354 (2018), 대한진단검사의학회