Neutrophil Gelatinase-Associated Lipocalin as a Promising Novel Biomarker for Early Detection of Kidney Injury
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Acute kidney injury (AKI) is a common complication of various critical illnesses and shows independent associations with mortality, morbidity, and prolonged hospitalization [1-5]. The current standard of the diagnostic criteria for AKI is based on consensus from consortiums such as the AKI Network or Kidney Disease: Improving Global Outcomes (KDIGO) [6]. Their AKI definitions involve increased serum creatinine (SCr) and/or decreased urine output [5, 6]. This SCr-based standardization provides several merits from both research and clinical aspects by permitting comparative analysis among patients or studies [1]. However, there are some recognized limitations of these SCr-based AKI definitions as outlined below [2, 3].
Abstract
Acute kidney injury (AKI) is a common complication of various critical illnesses and shows independent associations with mortality, morbidity, and prolonged hospitalization [1-5]. The current standard of the diagnostic criteria for AKI is based on consensus from consortiums such as the AKI Network or Kidney Disease: Improving Global Outcomes (KDIGO) [6]. Their AKI definitions involve increased serum creatinine (SCr) and/or decreased urine output [5, 6]. This SCr-based standardization provides several merits from both research and clinical aspects by permitting comparative analysis among patients or studies [1]. However, there are some recognized limitations of these SCr-based AKI definitions as outlined below [2, 3].
참고문헌 (14)
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