본문 바로가기
KERD
논문KCI 등재

Effectiveness of Platelet Function Analyzer-100 for Laboratory Detection of Anti-Platelet Drug-Induced Platelet Dysfunction

1

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류병리학

초록

Background: High on-treatment platelet reactivity (HTPR) is the phenomenon wherein patients exhibit normal platelet activity in laboratory testing despite adequate adherence to anti-platelet treatment. We investigated the detection rates of Platelet Function Analyzer (PFA)-100 (Dade Behring AG, Düdingen, Switzerland) for drug-induced platelet dysfunction and analyzed potential contributors to HTPR with practical PFA-100 data over six years. Methods: We used data from 6,957 patients who underwent PFA-100 testing after receiving aspirin, clopidogrel, or non-steroidal anti-inflammatory drugs (NSAIDs). Of these, 6,163 patients were tested with only the collagen/epinephrine cartridge (Col/EPI) of PFA-100; 794 were tested with both Col/EPI and the collagen/ADP cartridge (Col/ADP). We calculated PFA-100 closure time (CT) for each drug and compared the clinical and laboratory characteristics of the patients with prolonged CTs and normal CTs (i.e., HTPR). Results: In Col/EPI, 73.2% (365/499), 72.6% (390/537), and 55.3% (3,442/6,228) patients showed prolonged CTs for aspirin, clopidogrel, and NSAIDs, respectively. In Col/ADP, prolonged CTs were observed in 37.4% (34/91), 43.2% (35/81), and 29.6% (200/676) of patients receiving aspirin, clopidogrel, and NSAIDs, respectively. Of the patients tested with both cartridges, 88.9% (48/54), 95.3% (41/43), and 89.0% (577/648) of the patients receiving aspirin, clopidogrel, and NSAIDs had prolonged CTs, and 10.0% (79/794) showed normal CTs regardless of drugs. For clopidogrel users (both cartridges), there were more patients with malignancies in the normal CT than prolonged CT group. Conclusions: PFA-100 is not sufficiently effective for laboratory screening of drug-induced platelet dysfunction. Malignancy may contribute to clopidogrel-related HTPR in PFA-100.

Abstract

Background: High on-treatment platelet reactivity (HTPR) is the phenomenon wherein patients exhibit normal platelet activity in laboratory testing despite adequate adherence to anti-platelet treatment. We investigated the detection rates of Platelet Function Analyzer (PFA)-100 (Dade Behring AG, Düdingen, Switzerland) for drug-induced platelet dysfunction and analyzed potential contributors to HTPR with practical PFA-100 data over six years. Methods: We used data from 6,957 patients who underwent PFA-100 testing after receiving aspirin, clopidogrel, or non-steroidal anti-inflammatory drugs (NSAIDs). Of these, 6,163 patients were tested with only the collagen/epinephrine cartridge (Col/EPI) of PFA-100; 794 were tested with both Col/EPI and the collagen/ADP cartridge (Col/ADP). We calculated PFA-100 closure time (CT) for each drug and compared the clinical and laboratory characteristics of the patients with prolonged CTs and normal CTs (i.e., HTPR). Results: In Col/EPI, 73.2% (365/499), 72.6% (390/537), and 55.3% (3,442/6,228) patients showed prolonged CTs for aspirin, clopidogrel, and NSAIDs, respectively. In Col/ADP, prolonged CTs were observed in 37.4% (34/91), 43.2% (35/81), and 29.6% (200/676) of patients receiving aspirin, clopidogrel, and NSAIDs, respectively. Of the patients tested with both cartridges, 88.9% (48/54), 95.3% (41/43), and 89.0% (577/648) of the patients receiving aspirin, clopidogrel, and NSAIDs had prolonged CTs, and 10.0% (79/794) showed normal CTs regardless of drugs. For clopidogrel users (both cartridges), there were more patients with malignancies in the normal CT than prolonged CT group. Conclusions: PFA-100 is not sufficiently effective for laboratory screening of drug-induced platelet dysfunction. Malignancy may contribute to clopidogrel-related HTPR in PFA-100.

참고문헌 (40)

  1. Mammen EF, "PFA-100 system : a new method for assessment of platelet dysfunction", Semin Thromb Hemost, 24, pp.195~202 (1998)
  2. Fintel DJ, "Oral antiplatelet therapy for atherothrombotic disease : overview of current and emerging treatment options", Vasc Health Risk Manag, 8, pp.77~89 (2012)
  3. Stegnar M, "Platelet function tests and resistance to antiplatelet therapy", Srp Arh Celok Lek, 138, pp.59~63 (2010)
  4. Lordkipanidzé M, "Comparison of four tests to assess inhibition of platelet function by clopidogrel in stable coronary artery disease patients", Eur Heart J, 29, pp.2877~2885 (2008)
  5. Cattaneo M, "Resistance to antiplatelet drugs : molecular mechanisms and laboratory detection", J Thromb Haemost, 5, pp.230~237 (2007)
  6. Agarwal S, "Quantifying the effect of antiplatelet therapy : a comparison of the Platelet Function Analyzer(PFA-100®)and modified thromboelastography(mTEG®)with light transmission platelet aggregometry", Anesthesiology, 105, pp.676~683 (2006)
  7. Bartels A, "Failure of the platelet function assay(PFA)-100 to detect antiplatelet agents", Surgery, 158, pp.1012~1018 (2015)[DOI]
  8. Baigent C, "Selective cyclooxygenase 2 inhibitors, aspirin, and cardiovascular disease : a reappraisal", Arthritis Rheum, 48, pp.12~20 (2003)
  9. Bozimowski G, "A review of nonsteroidal anti-inflammatory drugs", AANA J, 83, pp.425~433 (2015)
  10. Goldenberg NA, "Brief communication : duration of platelet dysfunction after a 7-day course of ibuprofen", Ann Intern Med, 142, pp.506~509 (2005)
  11. van Kraaij DJ, "A comparison of the effects of nabumetone vs meloxicam on serum thromboxane B2 and platelet function in healthy volunteers", Br J Clin Pharmacol, 53, pp.644~647 (2002)
  12. Kearney PM, "Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials", BMJ, 332, pp.1302~1308 (2006)
  13. 김정아, "Influence of Blood Lipids on Global Coagulation Test Results", Annals of Laboratory Medicine, 35(1), pp.15~21 (2015), 대한진단검사의학회
  14. Catena C, "Abnormalities of coagulation in hypertensive patients with reduced creatinine clearance", Am J Med, 109, pp.556~561 (2000)
  15. Jakl M, "High on-treatment platelet reactivity : risk factors and 5-year outcomes in patients with acute myocardial infarction", Anatol J Cardiol, 17, pp.113~118 (2017)
  16. Park KW, "Clinical predictors of high posttreatment platelet reactivity to clopidogrel in Koreans", Cardiovasc Ther, 30, pp.5~11 (2012)
  17. Maree AO, "Platelet response to low-dose enteric-coated aspirin in patients with stable cardiovascular disease", J Am Coll Cardiol, 46, pp.1258~1263 (2005)
  18. Kundu SK, "Description of an in vitro platelet function analyzer--PFA-100", Semin Thromb Hemost, 21(S2), pp.106~112 (1995)
  19. Harrison P, "Performance of the platelet function analyser PFA-100 in testing abnormalities of primary haemostasis", Blood Coagul Fibrinolysis, 10, pp.25~31 (1999)
  20. Warner TD, "Anti-platelet therapy : cyclo-oxygenase inhibition and the use of aspirin with particular regard to dual anti-platelet therapy", Br J Clin Pharmacol, 72, pp.619~633 (2011)
  21. 조영욱, "한국인 성인에서 Platelet Function Analyzer-100 폐색시간의분석 전 변수 확인 및 참고범위 설정", Annals of Laboratory Medicine, 27(5), pp.318~323 (2007), 대한진단검사의학회
  22. Paniccia R, "Different methodologies for evaluating the effect of clopidogrel on platelet function in high-risk coronary artery disease patients", J Thromb Haemost, 5, pp.1839~1847 (2007)
  23. Patrono C, "Drug insight : aspirin resistance--fact or fashion", Nat Clin Pract Cardiovasc Med, 4, pp.42~50 (2007)
  24. Harrison P, "Screening for aspirin responsiveness after transient ischemic attack and stroke : comparison of 2 point-of-care platelet function tests with optical aggregometry", Stroke, 36, pp.1001~1005 (2005)
  25. Cattaneo M, "Aspirin and clopidogrel : efficacy, safety, and the issue of drug resistance", Arterioscler Thromb Vasc Biol, 24, pp.1980~1987 (2004)
  26. Peters BJ, "CYP2C19 and ABCB1 genes and individualized treatment with clopidogrel", Pharmacogenomics, 12, pp.141~144 (2011)
  27. Xie HG, "Individual variability in the disposition of and response to clopidogrel : pharmacogenomics and beyond", Pharm Ther, 129, pp.267~289 (2011)
  28. Bouman HJ, "Paraoxonase-1 is a major determinant of clopidogrel efficacy", Nat Med, 17, pp.110~116 (2011)
  29. Arméro S, "Intra-individual variability in clopidogrel responsiveness in coronary artery disease patients under long term therapy", Platelets, 21, pp.503~507 (2010)
  30. Wijeyeratne YD, "Anti-platelet therapy : ADP receptor antagonists", Br J Clin Pharmacol, 72, pp.647~657 (2011)
  31. Blaicher AM, "Effect of non-selective, non-steroidal anti-inflammatory drugs and cyclo-oxygenase-2 selective inhibitors on the PFA-100 closure time", Anaesthesia, 59, pp.1100~1103 (2004)
  32. Favaloro EJ, "Clinical utility of the PFA-100", Semin Thromb Hemost, 34, pp.709~733 (2008)
  33. Angchaisuksiri P, "Cancer-associated thrombosis in Asia", Thromb J, 14(S1), pp.26~ (2016)
  34. Mahé I, "Factors influencing adherence to clinical guidelines in the management of cancer-associated thrombosis", J Thromb Haemost, 14, pp.2107~2113 (2016)
  35. Caine GJ, "The hypercoagulable state of malignancy : pathogenesis and current debate", Neoplasia, 4, pp.465~473 (2002)
  36. Falanga A, "Coagulation and cancer : biological and clinical aspects", J Thromb Haemost, 11, pp.223~233 (2013)
  37. Nierodzik ML, "Role of platelets, thrombin, integrin IIb-IIIa, fibronectin and von Willebrand factor on tumor adhesion in vitro and metastasis in vivo", Thromb Haemost, 74, pp.282~290 (1995)
  38. Lima LG, "Activation of blood coagulation in cancer : implications for tumour progression", Biosci Rep, 33, pp.e00064~ (2013)
  39. Falanga A, "Procoagulant mechanisms in tumour cells", Best Pract Res Clin Haematol, 22, pp.49~60 (2009)
  40. 이명숙, "가능성 있는 폰빌레브란트병의 유병률에 대한 연구", Clinical Pediatric Hematology-Oncology, 21(1), pp.16~22 (2014), 대한소아혈액종양학회

관련 논문AI추천

Determination of the Prevalence of Aspirin and Clopidogrel Resistances in Patients with Coronary Artery Disease by using Various Platelet-function Tests고리영, 김무현, 김보람, 김지은, 우광숙, 한진영, Long-Hao Yu대한진단검사의학회 · Annals of Laboratory Medicine2010 · 제30권 제5호Platelet Function Analyzer-200 P2Y Results Are Predictive of the Risk of Major Adverse Cardiac Events in Korean Patients Receiving Clopidogrel Therapy Following Acute Coronary Syndrome김경희, 김무현, 김정만, 안규대, 우광숙, 임현호, 한진영, Shuhua Li대한진단검사의학회 · Annals of Laboratory Medicine2018 · 제38권 제5호Clinical significance of high on-treatment platelet reactivity in patients with prolonged clopidogrel therapy신동금, 조정래, 최재혁, 한동훈, Eun-Joo Park, Min-Kyung Kang, Namho Lee, Sehun Kim, Seonghoon Choi대한내과학회 · The Korean Journal of Internal Medicine2021 · 제36권 제1호Monitoring the Antiplatelet Effect of Cilostazol with Light Transmission Aggregometer: Two Cases of Possible Cilostazol Resistance박성욱, 박찬정, 심효은, 이승환, 장성수, 지현숙대한진단검사의학회 · Laboratory Medicine Online2016 · 제6권 제4호Correlation Between the CYP2C19 Phenotype Status and the Results of Three Different Platelet Function Tests in Cardiovascular Disease Patients Receiving Antiplatelet Therapy: An Emphasis on Newly Introduced Platelet Function Analyzer-200 P2Y Test김무현, 김보람, 우광숙, 최재임, 한진영, Long Zhe Guo, Ri-Young Goh, Shuhua Li대한진단검사의학회 · Annals of Laboratory Medicine2016 · 제36권 제1호혈소판 약물 반응검사를 토대로 한 항혈소판제 치료방침의 효과성 평가: 체계적 문헌고찰서재경, 이현아한국보건의료기술평가학회 · 보건의료기술평가2024 · 제12권 제1호

이 간행물의 다른 논문 (18건)