Seropositivity of Toxoplasma gondii and Toxocara spp. in Children with Cryptogenic Epilepsy, Benha, Egypt
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The present study aimed to investigate the possible association of Toxoplasma gondii and Toxocara spp. infections with cryptogenic epilepsy in children. The study was carried out between June 2014 and March 2015. Total 90 children (40 with cryptogenic epilepsy, 30 with non-cryptogenic epilepsy, and 20 healthy control children) were evaluated to determine the anti-Toxocara and anti-T. gondii IgG seropositivity using ELISA kits. Epileptic cases were selected from those attending the pediatrics outpatient clinic of Benha University Hospital, Pediatrics Neurology Unit, and from Benha Specialized Hospital of children. The results showed that the level of anti-T. gondii IgG seropositivity was significantly higher among children with cryptogenic epilepsy (20%) than among children with non-cryptogenic children (0%). In healthy controls (10%), there was no association between toxocariasis seropositivity and cryptogenic epilepsy (only 5.7%; 4 out of 70 cases) among cases and 10% (2 out of 20) among controls. Among toxocariasis IgG positive cases, 3 (7.5%) were cryptogenic, and only 1 (3.3%) was non-cryptogenic. These statistically significant results support the association between T. gondii infection and cryptogenic epilepsy while deny this association with toxocariasis.
Abstract
The present study aimed to investigate the possible association of Toxoplasma gondii and Toxocara spp. infections with cryptogenic epilepsy in children. The study was carried out between June 2014 and March 2015. Total 90 children (40 with cryptogenic epilepsy, 30 with non-cryptogenic epilepsy, and 20 healthy control children) were evaluated to determine the anti-Toxocara and anti-T. gondii IgG seropositivity using ELISA kits. Epileptic cases were selected from those attending the pediatrics outpatient clinic of Benha University Hospital, Pediatrics Neurology Unit, and from Benha Specialized Hospital of children. The results showed that the level of anti-T. gondii IgG seropositivity was significantly higher among children with cryptogenic epilepsy (20%) than among children with non-cryptogenic children (0%). In healthy controls (10%), there was no association between toxocariasis seropositivity and cryptogenic epilepsy (only 5.7%; 4 out of 70 cases) among cases and 10% (2 out of 20) among controls. Among toxocariasis IgG positive cases, 3 (7.5%) were cryptogenic, and only 1 (3.3%) was non-cryptogenic. These statistically significant results support the association between T. gondii infection and cryptogenic epilepsy while deny this association with toxocariasis.
참고문헌 (26)
- Chang BS, "Epilepsy", N Engl J Med, 349, pp.1257~1266 (2003)
- Fisher RS, "ILAE official report: a practical clinical definition of epilepsy", Epilepsia, 55, pp.475~482 (2014)
- Hauser WA, "The epidemiology of epilepsy in Rochester, Minnesota, 1935 through 1967", Epilepsia, 16, pp.1~66 (1975)
- Fisher RS, "Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE)", Epilepsia, 46, pp.470~472 (2005)
- National Clinical Guideline Centre, , 21~28 (2012)
- Thurman DJ, "ILAE Epidemiology Commission Report. Standards for epidemiologic studies and surveillance of epilepsy", Epilepsia, 52(suppl 7), pp.2~26 (2011)
- Forsgren L, "Estimations of the prevalence of epilepsy in sub-Saharan Africa", Lancet Neurol, 7, pp.21~22 (2008)
- Forsgren L, "The epidemiology of epilepsy in Europe-a systematic review", Eur J Neurol, 12, pp.245~253 (2005)
- Garcia-Martin G, "Prevalence and clinical characteristics of epilepsy in the South of Spain", Epilepsy Res, 102, pp.100~108 (2012)
- Rai D, "Epilepsy and psychiatric comorbidity: a nationally representative population-based study", Epilepsia, 53, pp.1095~1103 (2012)
- El-Tantawy NL, "Hasaneen BM. Seroprevalence of Toxoplasma gondii and Toxocara spp. in children with cryptogenic epilepsy", Am J Infect Dis Microbiol, 1, pp.92~95 (2013)
- Stommel EW, "Cryptogenic epilepsy: an infectious etiology?", Epilepsia, 42, pp.436~438 (2001)
- Nicoletti A, "Epilepsy, cysticercosis, and toxocariasis: a population-based case-control study in rural Bolivia", Neurology, 58, pp.1256~1261 (2002)
- Nicoletti A, "Epilepsy and toxocariasis: a case-control study in Burundi", Epilepsia, 48, pp.894~899 (2007)
- Senanayake N, "Aetiologic factors of epilepsy in the tropics", Trop Geogr Neurol, 1, pp.69~80 (1991)
- Neto MC, "Epilepsy in Children", pp.79~86 (1996), Chapman & Hall
- Zibaei M, "Toxoplasma infection and epilepsy: a case-control study in Iran", Neurology Asia, 16, pp.299~302 (2011)
- Frenkel JK, "Cyst rupture as a pathogenic mechanism of toxoplasmic encephalitis", Am J Trop Med Hyg, 36, pp.517~522 (1987)
- Woodruff AW, "Infection with animal helminths as a factor in causing poliomyelitis and epilepsy", Br Med J, 1, pp.1576~1579 (1966)
- Akyol A, "Epilepsy and seropositivity rates of Toxocara canis and Toxoplasma gondii", Seizure, 16, pp.233~237 (2007)
- Kaiser C, "Case-control studies on the relationship between onchocerciasis and epilepsy: systematic review and meta-analysis", PLoS Negl Trop Dis, 7, pp.e2147~ (2013)
- Arpino C, "Toxocara infection and epilepsy in children: a case-control study", Epilepsia, 31, pp.33~36 (1990)
- Nicoletti A, "Epilepsy and toxocariasis: a case-control study in Italy", Epilepsia, 49, pp.594~599 (2008)
- Glickman LT, "Toxocara infection and epilepsy in children", J Pediatr, 94, pp.75~78 (1979)
- Yemadje LP, "Understanding the differences in prevalence of epilepsy in tropical regions", Epilepsia, 52, pp.1376~1381 (2011)