Cocaine-induced Psychosis and Brain-derived Neurothrophic Factor in Patients with Cocaine Dependence: Report of Two Cases
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Brain-derived neurotrophic factor (BDNF) is linked to numerous brain functions. In addition, BDNF alterations contribute to neurological, mental, and addictive disorders. Cocaine dependence has received much attention recently due to its prevalence and psychological effects. Symptoms of psychosis are one of the most serious adverse events precipitated by cocaine use. It is particularly important to identify patients at risk of developing cocaine-induced psychosis (CIP). We described two cases of patients with cocaine dependence who presented with CIP and had changes in their BDNF levels during the psychotic episode. BDNF levels were initially low in both patients, and then decreased by more than 50% in association with CIP. The relationship between BDNF and psychosis is described in the literature. These cases revealed that BDNF levels decreased during a CIP episode and, thus, it is necessary to investigate BDNF and its relationship with CIP further.
Abstract
Brain-derived neurotrophic factor (BDNF) is linked to numerous brain functions. In addition, BDNF alterations contribute to neurological, mental, and addictive disorders. Cocaine dependence has received much attention recently due to its prevalence and psychological effects. Symptoms of psychosis are one of the most serious adverse events precipitated by cocaine use. It is particularly important to identify patients at risk of developing cocaine-induced psychosis (CIP). We described two cases of patients with cocaine dependence who presented with CIP and had changes in their BDNF levels during the psychotic episode. BDNF levels were initially low in both patients, and then decreased by more than 50% in association with CIP. The relationship between BDNF and psychosis is described in the literature. These cases revealed that BDNF levels decreased during a CIP episode and, thus, it is necessary to investigate BDNF and its relationship with CIP further.
참고문헌 (25)
- Milawaty Nurjono, "A Review of Brain-derived Neurotrophic Factor as a Candidate Biomarker in Schizophrenia", Clinical Psychopharmacology and Neuroscience, 10(2), pp.61~70 (2012), 대한정신약물학회[DOI]
- Nieto R, "BDNF and schizophrenia:from neurodevelopment to neuronal plasticity, learning, and memory", Front Psychiatry, 4, pp.45~ (2013)
- Corominas-Roso M, "Brain-derived neurotrophic factor serum levels in cocaine-dependent patients during early abstinence", Eur Neuropsychopharmacol, 23, pp.1078~1084 (2013)
- Corominas M, "Brain-derived neurotrophic factor and its intracellular signaling pathways in cocaine addiction", Neuropsychobiology, 55, pp.2~13 (2007)
- Corominas-Roso M, "Serum brain-derived neurotrophic factor levels and cocaine-induced transient psychotic symptoms", Neuropsychobiology, 68, pp.146~155 (2013)
- Autry AE, "Brain-derived neurotrophic factor and neuropsychiatric disorders", Pharmacol Rev, 64, pp.238~258 (2012)
- Zhang H, "Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependence", Am J Med Genet B Neuropsychiatr Genet, 141B, pp.387~393 (2006)
- Fernandes BS, "Peripheral brain-derived neurotrophic factor in schizophrenia and the role of antipsychotics:meta-analysis and implications", Mol Psychiatry, 20, pp.1108~1119 (2015)
- Green MJ, "Brain-derived neurotrophic factor levels in schizophrenia:a systematic review with meta-analysis", Mol Psychiatry, 16, pp.960~972 (2011)
- Toll A, "Brain-derived neurotrophic factor levels in first episode of psychosis: A systematic review", World J Psychiatry, 5, pp.154~159 (2015)
- Rizos EN, "Association of serum brainderived neurotrophic factor and duration of untreated psychosis in first-episode patients with schizophrenia", Neuropsychobiology, 62, pp.87~90 (2010)
- Roncero C, "Risk factors for cocaine-induced psychosis in cocaine-dependent patients", Eur Psychiatry, 28, pp.141~146 (2013)
- Roncero C, "Prevalence and risk factors of psychotic symptoms in cocaine-dependent patients", Actas Esp Psiquiatr, 40, pp.187~197 (2012)
- D'Sa C, "Increased serum brain-derived neurotrophic factor is predictive of cocaine relapse outcomes: a prospective study", Biol Psychiatry, 70, pp.706~711 (2011)
- Godar R, "Reduction of high-fat diet-induced obesity after chronic administration of brain-derived neurotrophic factor in the hypothalamic ventromedial nucleus", Neuroscience, 194, pp.36~52 (2011)
- Zoladz JA, "The effect of physical activity on the brain derived neurotrophic factor: from animal to human studies", J Physiol Pharmacol, 61, pp.533~541 (2010)
- Ardais AP, "Caffeine triggers behavioral and neurochemical alterations in adolescent rats", Neuroscience, 270, pp.27~39 (2014)
- Capiotti KM, "Early exposure to caffeine affects gene expression of adenosine receptors, DARPP-32and BDNF without affecting sensibility and morphology of developing zebrafish (Danio rerio)", Neurotoxicol Teratol, 33, pp.680~685 (2011)
- Zhang XY, "Nicotine dependence and serum BDNF levels in male patients with schizophrenia", Psychopharmacology (Berl), 212, pp.301~307 (2010)
- Molendijk ML, "Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N=9484)", Mol Psychiatry, 19, pp.791~800 (2014)
- Schultze-Lutter F, "Personality disorders and accentuations in at-risk persons with and without conversion to first-episode psychosis", Early Interv Psychiatry, 6, pp.389~398 (2012)
- Perroud N, "Response to psychotherapy in borderline personality disorder and methylation status of the BDNF gene", Transl Psychiatry, 3, pp.e207~ (2013)
- Koenigsberg HW, "Platelet protein kinase C and brainderived neurotrophic factor levels in borderline personality disorder patients", Psychiatry Res, 199, pp.92~97 (2012)
- Balaratnasingam S, "Brain derived neurotrophic factor: a novel neurotrophin involved in psychiatric and neurological disorders", Pharmacol Ther, 134, pp.116~124 (2012)
- von Diemen L, "Increase in brain-derived neurotrophic factor expression in early crack cocaine withdrawal", Int J Neuropsychopharmacol, 17, pp.33~40 (2014)