Medication Adherence Using Electronic Monitoring in Severe Psychiatric Illness: 4 and 24 Weeks after Discharge
0
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
Objective: The purpose of this study was to examine post-hospitalization outpatient drug adherence in patients with severe psychiatric illness, including bipolar disorder and schizophrenia, and to investigate factors associated with drug adherence. Methods: Eighty-one patients diagnosed with schizophrenia or bipolar disorder who were hospitalized due to aggravation of psychiatric symptoms were monitored. At hospitalization, we conducted clinical assessments such as the Clinical Global Impression-Severity, Drug Attitude Inventory, Contour Drawing Rating Scale, Multidimensional Scale of Perceived Social Support scale, and patients’ demographic factors. We measured drug adherence using the Medication Event Monitoring System (MEMS), pill count, and patients’ self-report upon out-patients visits, 4 and 24 weeks after discharge. Results: The mean values of the various measures of adherence were as follows: MEMS (4 weeks) 84.8%, pill count (4 weeks) 94.6%, self-report (4 weeks) 92.6%, MEMS (24 weeks) 81.6%, pill count (24 weeks) 90.6%, and self-report (24 weeks) 93.6%. The adherence agreement between MEMS, pill count, and self-report was moderate (4 weeks intraclass correlation [ICC]=0.54, 24 weeks ICC=0.52). Non-adherence (MEMS ≤0.08) was observed in 26.4% of the patients at 4 weeks and 37.7% at 24 weeks. There was a negative correlation between drug adherence assessed 4 weeks after discharge and Contour Drawing Rating Scale difference score (r=−0.282, p＜0.05). A positive correlation was found between drug adherence assessed 24 weeks after discharge and Drug Attitude Inventory (r=0.383, p＜0.01). Conclusion: Patients’ attitude towards their medication and their degree of physical dissatisfaction influenced post-hospitalization drug adherence in severe psychiatric patients.
Abstract
Objective: The purpose of this study was to examine post-hospitalization outpatient drug adherence in patients with severe psychiatric illness, including bipolar disorder and schizophrenia, and to investigate factors associated with drug adherence. Methods: Eighty-one patients diagnosed with schizophrenia or bipolar disorder who were hospitalized due to aggravation of psychiatric symptoms were monitored. At hospitalization, we conducted clinical assessments such as the Clinical Global Impression-Severity, Drug Attitude Inventory, Contour Drawing Rating Scale, Multidimensional Scale of Perceived Social Support scale, and patients’ demographic factors. We measured drug adherence using the Medication Event Monitoring System (MEMS), pill count, and patients’ self-report upon out-patients visits, 4 and 24 weeks after discharge. Results: The mean values of the various measures of adherence were as follows: MEMS (4 weeks) 84.8%, pill count (4 weeks) 94.6%, self-report (4 weeks) 92.6%, MEMS (24 weeks) 81.6%, pill count (24 weeks) 90.6%, and self-report (24 weeks) 93.6%. The adherence agreement between MEMS, pill count, and self-report was moderate (4 weeks intraclass correlation [ICC]=0.54, 24 weeks ICC=0.52). Non-adherence (MEMS ≤0.08) was observed in 26.4% of the patients at 4 weeks and 37.7% at 24 weeks. There was a negative correlation between drug adherence assessed 4 weeks after discharge and Contour Drawing Rating Scale difference score (r=−0.282, p＜0.05). A positive correlation was found between drug adherence assessed 24 weeks after discharge and Drug Attitude Inventory (r=0.383, p＜0.01). Conclusion: Patients’ attitude towards their medication and their degree of physical dissatisfaction influenced post-hospitalization drug adherence in severe psychiatric patients.
참고문헌 (52)
- Haynes RB, "Interventions for helping patients to follow prescriptions for medications", Cochrane Database Syst Rev, (2), pp.CD000011~ (2002)
- Velligan DI, "Psychopharmacology : perspectives on medication adherence and atypical antipsychotic medications", Psychiatr Serv, 54, pp.665~667 (2003)
- Blackwell B, "Patient compliance", N Engl J Med, 289, pp.249~252 (1973)
- Murray RM, "A developmental model for similarities and dissimilarities between schizophrenia and bipolar disorder", Schizophr Res, 71, pp.405~416 (2004)
- Lieberman JA, "Comprehensive care of schizophrenia: a textbook of clinical management" (2012), Oxford University Press
- Altman S, "Predictors of relapse in bipolar disorder : a review", J Psychiatr Pract, 12, pp.269~282 (2006)
- Gonzalez‐Pinto A, "Suicidal risk in bipolar I disorder patients and adherence to long‐term lithium treatment", Bipolar Disord, 8, pp.618~624 (2006)
- Jónsdóttir H, "Predictors of medication adherence in patients with schizophrenia and bipolar disorder", Acta Psychiatr Scand, 127, pp.23~33 (2013)
- Svarstad BL, "Using drug claims data to assess the relationship of medication adherence with hospitalization and costs", Psychiatr Serv, 52, pp.805~811 (2001)
- Scott J, "Nonadherence with mood stabilizers : prevalence and predictors", J Clin Psychiatry, 63, pp.384~390 (2002)
- Jeste SD, "Cognitive predictors of medication adherence among middle-aged and older outpatients with schizophrenia", Schizophr Res, 63, pp.49~58 (2003)
- Lindenmayer JP, "Medication nonadherence and treatment outcome in patients with schizophrenia or schizoaffective disorder with suboptimal prior response", J Clin Psychiatry, 70, pp.990~996 (2009)
- Higashi K, "Medication adherence in schizophrenia : factors influencing adherence and consequences of nonadherence, a systematic literature review", Ther adv psychopharmacol, 3, pp.200~218 (2013)
- Robinson D, "Predictors of relapse following response from a first episode of schizophrenia or schizoaffective disorder", Arch Gen Psychiatry, 56, pp.241~247 (1999)
- Haywood TW, "Predicting the"revolving door"phenomenon among patients with schizophrenic, schizoaffective, and affective disorders", Am J Psychiatry, 152, pp.856~861 (1995)
- Yang J, "Symptom severity and attitudes toward medication : impacts on adherence in outpatients with schizophrenia", Schizophr Res, 134, pp.226~231 (2012)
- Geddes JR, "Treatment of bipolar disorder", Lancet, 381, pp.1672~1682 (2013)
- Bellack AS, "The expert consensus guideline series : adherence problems in patients with serious and persistent mental illness", J Clin Psychiatry, 70, pp.1~48 (2009)
- Cramer JA, "How often is medication taken as prescribed? A novel assessment technique", JAMA, 261, pp.3273~3277 (1989)
- Saini SD, "Effect of medication dosing frequency on adherence in chronic diseases", Am J Manag Care, 15, pp.e22~e33 (2009)
- Diaz E, "Use of the Medication Event Monitoring System to estimate medication compliance in patients with schizophrenia", J Psychiatry Neurosci, 26, pp.325~329 (2001)
- George CF, "Compliance with tricyclic antidepressants : the value of four different methods of assessment", Br J Clin Pharmacol, 50, pp.166~171 (2000)
- Remington G, "Examining levels of antipsychotic adherence to better understand nonadherence", J Clin Psychopharmacol, 33, pp.261~263 (2013)
- García S, "Adherence to antipsychotic medication in bipolar disorder and schizophrenic patients : a systematic review", J Clin Psychopharmacol, 36, pp.355~371 (2016)
- Sendt KV, "A systematic review of factors influencing adherence to antipsychotic medication in schizophrenia-spectrum disorders", Psychiatry Res, 225, pp.14~30 (2015)
- Weiden PJ, "Obesity as a risk factor for antipsychotic noncompliance", Schizophr Res, 66, pp.51~57 (2004)
- Lingam R, "Treatment non‐adherence in affective disorders", Acta Psychiatr Scand, 105, pp.164~172 (2002)
- Vieta E, "Improving treatment adherence in bipolar disorder through psychoeducation", J Clin Psychiatry, 66(Suppl 1), pp.24~29 (2005)
- Colom F, "Identifying and improving non‐adherence in bipolar disorders", Bipolar Disord 2005;7 Suppl, 7(Suppl 5), pp.24~31 (2005)
- Guy W, "ECDEU assessment manual for psychopharmacology: 1976", National Institute of Mental Health, 217~222 (1976)
- 윤보현, "한국판 약물태도 척도의 심리측정적 특성", 대한정신약물학회지, 16(6), pp.480~487 (2005), 대한정신약물학회
- Freudenreich O, "Attitudes of schizophrenia outpatients toward psychiatric medications : relationship to clinical variables and insight", J Clin Psychiatry, 65, pp.1372~1376 (2004)
- Thompson MA, "Development and validation of a new body-image assessment scale", J Pers Assess, 64, pp.258~269 (1995)
- Shin JS, "The effects of social supports on psychosocial well-being of the unemployed", Korean J Soc Welf, 37, pp.241~269 (1999)
- Colom F, "Clinical factors associated with treatment noncompliance in euthymic bipolar patients", J Clin Psychiatry, 61, pp.549~555 (2000)
- Sajatovic M, "Treatment adherence with antipsychotic medications in bipolar disorder", Bipolar Disord, 8, pp.232~241 (2006)
- Licht RW, "A lithium clinic for bipolar patients : 2‐year outcome of the first 148 patients", Acta Psychiatr Scand, 104, pp.387~390 (2001)
- Martinez-Aran A, "Treatment nonadherence and neurocognitive impairment in bipolar disorder", J Clin Psychiatry, 70, pp.1017~1023 (2009)
- Miller R, "A prospective study of cannabis use as a risk factor for non-adherence and treatment dropout in first-episode schizophrenia", Schizophr Res, 113, pp.138~144 (2009)
- Karow A, "Association of subjective well-being, symptoms, and side effects with compliance after 12 months of treatment in schizophrenia", J Clin Psychiatry, 68, pp.75~80 (2007)
- Lacro JP, "Prevalence of and risk factors for medication nonadherence in patients with schizophrenia : a comprehensive review of recent literature", J Clin Psychiatry, 63, pp.892~909 (2002)
- van Nimwegen-Campailla L, "Effect of early dysphoric response and cannabis use on discontinuation of olanzapine or risperidone in patients with early psychosis", Pharmacopsychiatry, 43, pp.281~ (2010)
- Brain C, "Drug attitude and other predictors of medication adherence in schizophrenia : 12 months of electronic monitoring(MEMS(Ⓡ))in the Swedish COAST-study", Eur Neuropsychopharmacol, 23, pp.1754~1762 (2013)
- Nakonezny PA, "Electronically monitored adherence in outpatients with schizophrenia or schizoaffective disorder: a comparison of first- vs. second-generation antipsychotics", Schizophr Res, 82, pp.107~114 (2006)
- Sajatovic M, "Psychoeducational approaches to medication adherence in patients with bipolar disorder", Dis Manag Health Outcomes, 15, pp.181~192 (2007)
- Busby KK, "Review : patient, treatment, and systems‐ level factors in bipolar disorder nonadherence : a summary of the literature", CNS Neurosci Ther, 16, pp.308~315 (2010)
- Cramer JA, "Enhancing medication compliance for people with serious mental illness", J Nerv Ment Dis, 187, pp.53~55 (1999)
- Velligan DI, "Relationships among subjective and objective measures of adherence to oral antipsychotic medications", Psychiatr Serv, 58, pp.1187~1192 (2007)
- 유지희, "일 대학병원 정신과 외래 환자의 약물 순응도에 영향을 미치는 요인", 대한정신약물학회지, 21(1), pp.29~34 (2010), 대한정신약물학회
- Nivedhitha Selvakumar, "A Cross-sectional Analysis of Patterns and Predictors of Medication Adherence in Bipolar Disorder: Single Center Experience from South India", Clinical Psychopharmacology and Neuroscience, 16(2), pp.168~175 (2018), 대한정신약물학회[DOI]
- Krueger KP, "Improving adherence and persistence: a review and assessment of interventions and description of steps toward a national adherence initiative", J Am Pharm Assoc, 43, pp.668~678 (2003)
- Fleischhacker WW, "Factors influencing compliance in schizophrenia patients", J Clin Psychiatry, 64(Suppl 16), pp.10~13 (2003)