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Maladaptive Alterations of Defensive Response Following Developmental Complex Stress in Rats

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Objective: Despite the etiological significance of complex developmental trauma in adult personality disorders and treatment-resistant depression, neurobiological studies have been rare due to the lack of useful animal models. As a first step, we devised an animal model to investigate the effects of multiple trauma-like stress during different developmental periods. Methods: Twenty-one male Sprague-Dawley rats were classified into 3 groups based on the stress protocol: fear conditioning control (FCC, n = 6), complex stress (ComS, n = 9), and control (n = 6). While the ComS experienced three types of stress (maternal separation, juvenile isolation, electric foot shock), the FCC only experienced an electric foot shock stress and the control never experienced any. We compared fear responses at postnatal day (PND) 29 and PND 56 through freezing time per episode (FTpE), total freezing time (TFT), total freezing episodes (TFE), and ultrasonic vocalization (USV). Results: ComS showed the longest FTpE in the conditioned fear response test. ComS and FCC exhibited the longer TFT and these two groups only displayed USV. ComS show difference TFE between PND 29 and PND 56. Conclusion: The results of this investigation show that complex stress may affect not quantity of fear response but characteristics of fear response. Longer FTpE may be associated with tonic immobility which could be considered as a failed self-protective reaction and might be analogous to a sign of inappropriate coping strategy and self-dysregulation in complex trauma patients.

Abstract

Objective: Despite the etiological significance of complex developmental trauma in adult personality disorders and treatment-resistant depression, neurobiological studies have been rare due to the lack of useful animal models. As a first step, we devised an animal model to investigate the effects of multiple trauma-like stress during different developmental periods. Methods: Twenty-one male Sprague-Dawley rats were classified into 3 groups based on the stress protocol: fear conditioning control (FCC, n = 6), complex stress (ComS, n = 9), and control (n = 6). While the ComS experienced three types of stress (maternal separation, juvenile isolation, electric foot shock), the FCC only experienced an electric foot shock stress and the control never experienced any. We compared fear responses at postnatal day (PND) 29 and PND 56 through freezing time per episode (FTpE), total freezing time (TFT), total freezing episodes (TFE), and ultrasonic vocalization (USV). Results: ComS showed the longest FTpE in the conditioned fear response test. ComS and FCC exhibited the longer TFT and these two groups only displayed USV. ComS show difference TFE between PND 29 and PND 56. Conclusion: The results of this investigation show that complex stress may affect not quantity of fear response but characteristics of fear response. Longer FTpE may be associated with tonic immobility which could be considered as a failed self-protective reaction and might be analogous to a sign of inappropriate coping strategy and self-dysregulation in complex trauma patients.

참고문헌 (64)

  1. Joelle LeMoult, "Meta-analysis: Exposure to Early Life Stress and Risk for Depression in Childhood and Adolescence", Journal of the American Academy of Child & Adolescent Psychiatry, 59(7), pp.842~855 (2020), Elsevier BV[DOI]
  2. Martins-Monteverde CMS, "Relationship between depression and subtypes of early life stress in adult psychiatric patients", Front Psychiatry, 10, pp.19~ (2019)
  3. Dallé E, "Early life stress, depression and Parkinson’s disease : a new approach", Mol Brain, 11, pp.18~ (2018)
  4. Young EA, "Childhood adversity and vulnerability to mood and anxiety disorders", Depress Anxiety, 5, pp.66~72 (1997)
  5. Cook A, "Complex trauma in children and adolescents", Psychiatr Ann, 35, pp.390~398 (2005)
  6. The third national incidence study of child abuse and neglect (NIS-3): public use file manual, "Sedlak AJ", US Department of Health and Human Services, ~ (1997)
  7. van der Kolk BA, "Developmental trauma disorder : toward a rational diagnosis for children with complex trauma histories", Psychiatr Ann, 35, pp.401~408 (2005)
  8. Jumper SA, "A meta-analysis of the relationship of child sexual abuse to adult psychological adjustment", Child Abuse Negl, 19, pp.715~728 (1995)
  9. Spinazzola J, "Survey evaluates : complex trauma exposure, outcome, and intervention among children and adolescents", Psychiatr Ann, 35, pp.433~439 (2005)
  10. Jongho Do, "From Gut to Brain: Alteration in Inflammation Markers in the Brain of Dextran Sodium Sulfate-induced Colitis Model Mice", Clinical Psychopharmacology and Neuroscience, 16(4), pp.422~433 (2018), 대한정신약물학회[DOI]
  11. Ather Muneer, "Telomere Biology in Mood Disorders: An Updated, Comprehensive Review of the Literature", Clinical Psychopharmacology and Neuroscience, 17(3), pp.343~363 (2019), 대한정신약물학회[DOI]
  12. Gekker M, "Early scars are forever : childhood abuse in patients with adult-onset PTSD is associated with increased prevalence and severity of psychiatric comorbidity", Psychiatry Res, 267, pp.1~6 (2018)
  13. Scheering MS, "A relational perspective on PTSD in early childhood", J Trauma Stress, 14, pp.799~815 (2001)
  14. Kinniburgh KJ, "Attachment, self-regulation, and competency : a comprehensive intervention framework for children with complex trauma", Psychiatr Ann, 35, pp.424~430 (2005)
  15. Campbell A, "Alarming increase of suicide in a remote Indigenous Australian population : an audit of data from 2005 to 2014", World Psychiatry, 15, pp.296~297 (2016)
  16. Baumeister RF, "Self‐regulation, ego depletion, and motivation", Soc Personal Psychol Compass, 1, pp.115~128 (2007)
  17. Ryan K, "A multidisciplinary model for treating complex trauma in early childhood", Int J Play Ther, 26, pp.111~123 (2017)
  18. "ICD-11 for mortality and morbidity statistics" (2018)[URL]
  19. Herzog JI, "Increased recruitment of cognitive control in the presence of traumatic stimuli in complex PTSD", Eur Arch Psychiatry Clin Neurosci, 269, pp.147~159 (2019)
  20. Boccia M, "Different neural modifications underpin PTSD after different traumatic events : an fMRI meta-analytic study", Brain Imaging Behav, 10, pp.226~237 (2016)
  21. Schlumpf YR, "Functional reorganization of neural networks involved in emotion regulation following trauma therapy for complex trauma disorders", Neuroimage Clin, 23, pp.101807~ (2019)
  22. Teicher MH, "The neurobiological consequences of early stress and childhood maltreatment", Neurosci Biobehav Rev, 27, pp.33~44 (2003)
  23. Schmidt MV, "Early life stress paradigms in rodents: potential animal models of depression?", Psychopharmacology (Berl), 214, pp.131~140 (2011)
  24. Goodwill HL, "Early life stress leads to sex differences in development of depressive-like outcomes in a mouse model", Neuropsychopharmacology, 44, pp.711~720 (2019)
  25. 김민지, "생애초기스트레스가 중추신경계 구조 및기능 발달에 미치는 영향 : 동물모델 연구문헌 리뷰", 신경정신의학, 55(2), pp.75~88 (2016), 대한신경정신의학회[DOI]
  26. Millstein RA, "Effects of repeated maternal separation on anxiety-and depression-related phenotypes in different mouse strains", Neurosci Biobehav Rev, 31, pp.3~17 (2007)
  27. Banqueri M, "Behavioral effects in adolescence and early adulthood in two length models of maternal separation in male rats", Behav Brain Res, 324, pp.77~86 (2017)
  28. de Kloet ER, "Stress, genes and the mechanism of programming the brain for later life", Neurosci Biobehav Rev, 29, pp.271~281 (2005)
  29. Klein ZA, "Changes in hypothalamic-pituitaryadrenal stress responsiveness before and after puberty in rats", Horm Behav, 64, pp.357~363 (2013)
  30. Arakawa H, "Ethological approach to social isolation effects in behavioral studies of laboratory rodents", Behav Brain Res, 341, pp.98~108 (2018)
  31. Karelina K, "Modeling social influences on human health", Psychosom Med, 73, pp.67~74 (2011)
  32. Cacioppo JT, "The neuroendocrinology of social isolation", Annu Rev Psychol, 66, pp.733~767 (2015)
  33. Campeau S, "Involvement of subcortical and cortical afferents to the lateral nucleus of the amygdala in fear conditioning measured with fear-potentiated startle in rats trained concurrently with auditory and visual conditioned stimuli", J Neurosci, 15(3 Pt 2), pp.2312~2327 (1995)
  34. Bauer EP, "Serotonin in fear conditioning processes", Behav Brain Res, 277, pp.68~77 (2015)
  35. Willner P, "Validation of chronic mild stress in the Wistar-Kyoto rat as an animal model of treatment-resistant depression", Behav Pharmacol, 30(2 and 3-Spec Issue), pp.239~250 (2019)
  36. Arp JM, "Blocking glucocorticoid receptors at adolescent age prevents enhanced freezing between repeated cue-exposures after conditioned fear in adult mice raised under chronic early life stress", Neurobiol Learn Mem, 133, pp.30~38 (2016)
  37. Nylander I, "Is the rodent maternal separation model a valid and effective model for studies on the early-life impact on ethanol consumption?", Psychopharmacology (Berl), 229, pp.555~569 (2013)
  38. Czéh B, "Animal models of major depression and their clinical implications", Prog Neuropsychopharmacol Biol Psychiatry, 64, pp.293~310 (2016)
  39. Belovicova K, "Animal tests for anxiety-like and depression-like behavior in rats", Interdiscip Toxicol, 10, pp.40~43 (2017)
  40. Pawlak CR, "The elevated plus-maze test : differential psychopharmacology of anxiety-related behavior", Emot Rev, 4, pp.98~115 (2012)
  41. Hu C, "Re-evaluation of the interrelationships among the behavioral tests in rats exposed to chronic unpredictable mild stress", PLoS One, 12, pp.e0185129~ (2017)
  42. Bali A, "Electric foot shock stress : a useful tool in neuropsychiatric studies", Rev Neurosci, 26, pp.655~677 (2015)
  43. Lee JH, "Chasing as a model of psychogenic stress : characterization of physiological and behavioral responses", Stress, 21, pp.323~332 (2018)
  44. Huot RL, "Foster litters prevent hypothalamic-pituitary-adrenal axis sensitization mediated by neonatal maternal separation", Psychoneuroendocrinology, 29, pp.279~289 (2004)
  45. Own LS, "Maternal behavior and offspring resiliency to maternal separation in C57Bl", 6 mice, 2013, pp.63, 411~417
  46. Weiss IC, "Effect of social isolation on stress-related behavioural and neuroendocrine state in the rat", Behav Brain Res, 152, pp.279~295 (2004)
  47. Flandreau EI, "Behavioral neurobiology of PTSD", pp.47~68 (2018), Springer International Publishing
  48. Gallup Jr GG, "Tonic immobility as a measure of fear in domestic fowl", Anim Behav, 27, pp.316~317 (1979)
  49. Northoff G, "What catatonia can tell us about"top-down modulation" : a neuropsychiatric hypothesis", Behav Brain Sci, 25, pp.555~577 (2002)
  50. Jelen P, "22-kHz ultrasonic vocalization in rats as an index of anxiety but not fear : behavioral and pharmacological modulation of affective state", Behav Brain Res, 141, pp.63~72 (2003)
  51. Budylin T, "Ultrasonic vocalization sex differences in 5-HT1A-R deficient mouse pups : predictive phenotypes associated with later-life anxiety-like behaviors", Behav Brain Res, 373, pp.112062~ (2019)
  52. Graham LK, "Strain and sex differences in fear conditioning : 22 kHz ultrasonic vocalizations and freezing in rats", Psychol Neurosci, 2, pp.219~225 (2009)
  53. Zhang L, "Psychiatric disorders: methods and protocols", pp.331~344 (2019), Springer
  54. Gallup Jr GG, "Motor activity and movement disorders", pp.57~80 (1996), Springer
  55. Marx BP, "Tonic immobility as an evolved predator defense : implications for sexual assault survivors", Clin Psychol Sci Pract, 15, pp.74~90 (2008)
  56. Kalaf J, "Sexual trauma is more strongly associated with tonic immobility than other types of trauma-a population based study", J Affect Disord, 215, pp.71~76 (2017)
  57. Putnam FW, "Dissociation in children and adolescents : a developmental perspective" (1997), Guilford Press
  58. Lloyd CS, "Assessing post-traumatic tonic immobility responses : the scale for tonic immobility occurring post-trauma", Chronic Stress, 3, pp.247~292 (2019)
  59. Volchan E, "Immobility reactions under threat : a contribution to human defensive cascade and PTSD", Neurosci Biobehav Rev, 76(Pt A), pp.29~38 (2017)
  60. Yee N, "Juvenile stress potentiates aversive 22-kHz ultrasonic vocalizations and freezing during auditory fear conditioning in adult male rats", Stress, 15, pp.533~544 (2012)
  61. Foilb AR, "The transformation of hormonal stress responses throughout puberty and adolescence", J Endocrinol, 210, pp.391~398 (2011)
  62. de Kleine RA, "Tonic immobility during re-experiencing the traumatic event in posttraumatic stress disorder", Psychiatry Res, 270, pp.1105~1109 (2018)
  63. Meaney MJ, "Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations", Annu Rev Neurosci, 24, pp.1161~1192 (2001)
  64. Kuiling JME, "The role of tonic immobility and control in the development of intrusive memories after experimental trauma", Memory, 27, pp.772~779 (2019)

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