Are Mannan-binding Lectine Serin Protease-2 and Alpha-1-microglobulin and Bukinin Precursor the Potential Biomarkers of Manic Episode? A Study via Urinary Proetomic Analysis
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Objective: Investigating the molecular basis of bipolar disorder (BD) is crucial in terms of developing effective treatment strategies as well as objective laboratory-based diagnostic tools for the disease. Methods: We examined the urine samples of BD patients both in manic episode and after remission and compared their urinary protein profiles with the controls. Twelve patients and twelve controls (C group) included to the study. Urinary samples of patients were first collected during manic episode (M group) and then after remission (R group). Two-dimensional gel electrophoresis (2-DE) coupled to MALDI-TOF/TOF massspectrometry approach and Western blot analysis were used. Results: Alpha-1-microglobulin and bukinin precursor (AMBP), Mannan-binding lectine serin protease-2 (MASP-2), and Ig gamma-1-chain displayed significant increases in their abundance in the urine protein pool of M group in comparison to the C and R groups. Alpha-1B glycoprotein and prostaglandin-H2 D-isomerase (PGD2) levels were significantly higher in the urine protein pool of the M and R groups in comparison to the C group. Annexin A1 was downregulated significantly in the urine protein pool of the M group in comparison to the C group. Conclusion: Intensities of MASP-2 and AMBP proteins discriminated manic episode from remission period and healthy controls indicating that these proteins may be candidate biomarkers for manic episode. The decrease in Annexin A1 and increase in Ig gamma-1 chain levels appeared to be associated with “Manic Episode” while the increase in PGD2 and alpha-1B glycoprotein levels appeared to be associated with “Bipolar Disorder”.
Abstract
Objective: Investigating the molecular basis of bipolar disorder (BD) is crucial in terms of developing effective treatment strategies as well as objective laboratory-based diagnostic tools for the disease. Methods: We examined the urine samples of BD patients both in manic episode and after remission and compared their urinary protein profiles with the controls. Twelve patients and twelve controls (C group) included to the study. Urinary samples of patients were first collected during manic episode (M group) and then after remission (R group). Two-dimensional gel electrophoresis (2-DE) coupled to MALDI-TOF/TOF massspectrometry approach and Western blot analysis were used. Results: Alpha-1-microglobulin and bukinin precursor (AMBP), Mannan-binding lectine serin protease-2 (MASP-2), and Ig gamma-1-chain displayed significant increases in their abundance in the urine protein pool of M group in comparison to the C and R groups. Alpha-1B glycoprotein and prostaglandin-H2 D-isomerase (PGD2) levels were significantly higher in the urine protein pool of the M and R groups in comparison to the C group. Annexin A1 was downregulated significantly in the urine protein pool of the M group in comparison to the C group. Conclusion: Intensities of MASP-2 and AMBP proteins discriminated manic episode from remission period and healthy controls indicating that these proteins may be candidate biomarkers for manic episode. The decrease in Annexin A1 and increase in Ig gamma-1 chain levels appeared to be associated with “Manic Episode” while the increase in PGD2 and alpha-1B glycoprotein levels appeared to be associated with “Bipolar Disorder”.
참고문헌 (45)
- Kupfer DJ, "The increasing medical burden in bipolar disorder", JAMA, 293, pp.2528~2530 (2005)
- Teixeira AL, "Update on bipolar disorder biomarker candidates", Expert Rev Mol Diagn, 16, pp.1209~1220 (2016)
- Bartoli F, "Update on bipolar disorder biomarker candidates: what about uric acid", adenosine hypothesis?, 2017, pp.17, 105~106
- de Oliveira GS, "Decreased brain-derived neurotrophic factor in medicated and drug-free bipolar patients", J Psychiatr Res, 43, pp.1171~1174 (2009)
- Iria Grande, "The Role of BDNF as a Mediator of Neuroplasticity in Bipolar Disorder", PSYCHIATRY INVESTIGATION, 7(4), pp.243~250 (2010), 대한신경정신의학회
- Jacoby AS, "Cytokines, brain-derived neurotrophic factor and C-reactive protein in bipolar I disorder-Results from a prospective study", J Affect Disord, 197, pp.167~174 (2016)
- Rolstad S, "CSF neuroinflammatory biomarkers in bipolar disorder are associated with cognitive impairment", Eur Neuropsychopharmacol, 25, pp.1091~1098 (2015)
- Johnston-Wilson NL, "Disease-specific alterations in frontal cortex brain proteins in schizophrenia, bipolar disorder, and major depressive disorder. The Stanley Neuropathology Consortium", Mol Psychiatry, 5, pp.142~149 (2000)
- Maffioletti E, "Micro spies from the brain to the periphery : new clues from studies on microRNAs in neuropsychiatric disorders", Front Cell Neurosci, 8, pp.75~ (2014)
- Monfrim X, "Immune dysfunction in bipolar disorder and suicide risk: is there an association between peripheral corticotropin-releasing hormone and interleukin-1β?", Bipolar Disord, 16, pp.741~747 (2014)
- Sandberg JV, "Low neuropeptide Y in cerebrospinal fluid in bipolar patients is associated with previous and prospective suicide attempts", Eur Neuropsychopharmacol, 24, pp.1907~1915 (2014)
- An M, "Urinary biomarkers of brain diseases", Genomics Proteomics Bioinformatics, 13, pp.345~354 (2015)
- Chengappa KN, "Rates of response, euthymia and remission in two placebo-controlled olanzapine trials for bipolar mania", Bipolar Disord, 5, pp.1~5 (2003)
- Pieper R, "Preparation of urine samples for proteomic analysis", Methods Mol Biol, 425, pp.89~99 (2008)
- Kanli A, "Identification of differentially regulated deceitful proteins in SH-SY5Y cells engineered with Tet-regulated protein expression system", J Cell Biochem, 119, pp.6065~6071 (2018)
- Butler TAJ, "Misleading westerns : common quantification mistakes in Western blot densitometry and proposed corrective measures", Biomed Res Int, 2019, pp.5214821~ (2019)
- Bayes A, "Differential diagnosis of bipolar II disorder and borderline personality disorder", Curr Psychiatry Rep, 21, pp.125~ (2019)
- McIntyre RS, "Differential diagnosis of major depressive disorder versus bipolar disorder:current status and best clinical practices", J Clin Psychiatry, 80, pp.ot18043ah2~ (2019)
- Menezes IC, "Genetic biomarkers for differential diagnosis of major depressive disorder and bipolar disorder : a systematic and critical review", Behav Brain Res, 357-358, pp.29~38 (2019)
- Munkholm K, "Cytokines in bipolar disorder : a systematic review and meta-analysis", J Affect Disord, 144, pp.16~27 (2013)
- Frye MA, "Feasibility of investigating differential proteomic expression in depression : implications for biomarker development in mood disorders", Transl Psychiatry, 5, pp.e689~ (2015)
- Yoshimi N, "Cerebrospinal fluid metabolomics identifies a key role of isocitrate dehydrogenase in bipolar disorder : evidence in support of mitochondrial dysfunction hypothesis", Mol Psychiatry, 21, pp.1504~1510 (2016)
- Zhang R, "Metabolomic profiling of post-mortem brain reveals changes in amino acid and glucose metabolism in mental illness compared with controls", Comput Struct Biotechnol J, 14, pp.106~116 (2016)
- Szklarczyk D, "STRING v11 : protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets", Nucleic Acids Res, 47, pp.D607~ (2019)
- Kidmose RT, "Structural basis for activation of the complement system by component C4 cleavage", Proc Natl Acad Sci U S A, 109, pp.15425~15430 (2012)
- Foldager L, "Bipolar and panic disorders may be associated with hereditary defects in the innate immune system", J Affect Disord, 164, pp.148~154 (2014)
- Foldager L, "MBL and MASP-2 concentrations in serum and MBL2promoter polymorphisms are associated to schizophrenia", Acta Neuropsychiatr, 24, pp.199~207 (2012)
- Woo JJ, "The complement system in schizophrenia: where are we now and what's next?", Mol Psychiatry, 25, pp.114~130 (2020)
- Wang Y, "Urinary peptidomics identifies potential biomarkers for major depressive disorder", Psychiatry Res, 217, pp.25~33 (2014)
- Gertow J, "Altered protein composition of subcutaneous adipose tissue in chronic kidney disease", Kidney Int Rep, 2, pp.1208~1218 (2017)
- Zager RA, "Alpha 1 microglobulin : a potentially paradoxical anti-oxidant agent", Adv Tech Biol Med, 5, pp.238~ (2017)
- Marín-Méndez JJ, "Differential expression of prostaglandin D2synthase(PTGDS)in patients with attention deficit-hyperactivity disorder and bipolar disorder", J Affect Disord, 138, pp.479~484 (2012)
- Duncan RE, "Brain arachidonic acid uptake and turnover : implications for signaling and bipolar disorder", Curr Opin Clin Nutr Metab Care, 13, pp.130~138 (2010)
- Gurvich A, "A role for prostaglandins in rapid cycling suggested by episode-specific gene expression shifts in peripheral blood mononuclear cells : a preliminary report", Bipolar Disord, 16, pp.881~888 (2014)
- Bellei E, "Discovery of restless legs syndrome plasmatic biomarkers by proteomic analysis", Brain Behav, 8, pp.e01062~ (2018)
- Biswas S, "Identification of novel autoantigen in the synovial fluid of rheumatoid arthritis patients using an immunoproteomics approach", PLoS One, 8, pp.e56246~ (2013)
- Ditzen C, "Cerebrospinal fluid biomarkers for major depression confirm relevance of associated pathophysiology", Neuropsychopharmacology, 37, pp.1013~1025 (2012)
- Perretti M, "Annexin A1 and glucocorticoids as effectors of the resolution of inflammation", Nat Rev Immunol, 9, pp.62~70 (2009)
- Bruschi M, "Annexin A1 and autoimmunity : from basic science to clinical applications", Int J Mol Sci, 19, pp.1348~ (2018)
- Leoni G, "Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair", J Clin Invest, 125, pp.1215~1227 (2015)
- Gussenhoven R, "Annexin A1 as neuroprotective determinant for blood-brain barrier integrity in neonatal hypoxic-ischemic encephalopathy", J Clin Med, 8, pp.137~ (2019)
- Patel JP, "Disruption in the blood-brain barrier: the missing link between brain and body inflammation in bipolar disorder?", Neural Plast, 2015, pp.708306~ (2015)
- Beck A, "8th Annual european antibody congress 2012- Nov 27-28, 2012, Geneva, Switzerland", MAbs, 5, pp.339~357 (2013)
- Moore GL, "Engineered Fc variant antibodies with enhanced ability to recruit complement and mediate effector functions", MAbs, 2, pp.181~189 (2010)
- Berk M, "From neuroprogression to neuroprotection : implications for clinical care", Med J Aust, 193(S4), pp.S36~S40 (2010)
