Relationship between Handgrip Strength and Low-grade Inflammation in Older Adults with Depression
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Objective: The relationship among physical functional decline, low-grade inflammation, and depression remains unclear. The aim of this study was to examine the association between hand grip strength (HGS) and high-sensitivity C-reactive protein (hs-CRP) in a large sample with depression. Methods: This study used data obtained from a representative Korean sample of 9,402 people who participated in the seventh Korean National Health and Nutrition Examination Survey. Physical function was assessed using a digital grip strength dynamometer. Depression was identified using a cutoff of 5 on the Patient Health Questionnaire-9 (PHQ-9), and high hs-CPR level was defined as ≥ 3.0 mg/L. Results: In older adults (≥ 60 years) with depression, 43.8% of those with high hs-CRP levels had low HGS, compared to 21.8% of those with hs-CRP levels < 3.0 mg/L (p = 0.002). Multivariate analysis revealed that, after adjustments for potentially confounding factors, high hs-CRP was independently associated with lower HGS (B = −2.25; 95% confidence interval = −4.49 to −0.02) in older adults with depression, but not in younger or middle-aged adults with depression. Conclusion: These findings suggest a significant correlation between physical functional decline and low-grade inflammation in older adults with depression.
Abstract
Objective: The relationship among physical functional decline, low-grade inflammation, and depression remains unclear. The aim of this study was to examine the association between hand grip strength (HGS) and high-sensitivity C-reactive protein (hs-CRP) in a large sample with depression. Methods: This study used data obtained from a representative Korean sample of 9,402 people who participated in the seventh Korean National Health and Nutrition Examination Survey. Physical function was assessed using a digital grip strength dynamometer. Depression was identified using a cutoff of 5 on the Patient Health Questionnaire-9 (PHQ-9), and high hs-CPR level was defined as ≥ 3.0 mg/L. Results: In older adults (≥ 60 years) with depression, 43.8% of those with high hs-CRP levels had low HGS, compared to 21.8% of those with hs-CRP levels < 3.0 mg/L (p = 0.002). Multivariate analysis revealed that, after adjustments for potentially confounding factors, high hs-CRP was independently associated with lower HGS (B = −2.25; 95% confidence interval = −4.49 to −0.02) in older adults with depression, but not in younger or middle-aged adults with depression. Conclusion: These findings suggest a significant correlation between physical functional decline and low-grade inflammation in older adults with depression.
참고문헌 (53)
- Rantanen T, "Midlife hand grip strength as a predictor of old age disability", JAMA, 281, pp.558~560 (1999)
- Giampaoli S, "Hand-grip strength predicts incident disability in nondisabled older men", Age Ageing, 28, pp.283~288 (1999)
- Wu Y, "Association of grip strength with risk of all-cause mortality, cardiovascular diseases, and cancer in community-dwelling populations : a meta-analysis of prospective cohort studies", J Am Med Dir Assoc, 18, pp.551~ (2017)[DOI]
- Celis-Morales CA, "Associations of grip strength with cardiovascular, respiratory, and cancer outcomes and all cause mortality: prospective cohort study of half a million UK Biobank participants", BMJ, 361, pp.k1651~ (2018)
- Cesari M, "Inflammatory markers and physical performance in older persons : the InCHIANTI study", J Gerontol A Biol Sci Med Sci, 59, pp.242~248 (2004)
- Penninx BW, "Inflammatory markers and incident mobility limitation in the elderly", J Am Geriatr Soc, 52, pp.1105~1113 (2004)
- Hsu FC, "Association between inflammatory components and physical function in the health, aging, and body composition study : a principal component analysis approach", J Gerontol A Biol Sci Med Sci, 64, pp.581~589 (2009)
- Schaap LA, "Higher inflammatory marker levels in older persons : associations with 5-year change in muscle mass and muscle strength", J Gerontol A Biol Sci Med Sci, 64, pp.1183~1189 (2009)
- Gale CR, "Factors associated with symptoms of anxiety and depression in five cohorts of community-based older people : the HALCyon(Healthy Ageing across the Life Course)Programme", Psychol Med, 41, pp.2057~2073 (2011)
- van Milligen BA, "Objective physical functioning in patients with depressive and", or anxiety disorders, 2011, pp.131, 193~199
- Smith L, "Depressive symptoms, handgrip strength, and weight status in US older adults", J Affect Disord, 238, pp.305~310 (2018)
- Fukumori N, "Association between hand-grip strength and depressive symptoms : Locomotive Syndrome and Health Outcomes in Aizu Cohort Study(LOHAS)", Age Ageing, 44, pp.592~598 (2015)
- Firth J, "Association between muscular strength and cognition in people with major depression or bipolar disorder and healthy controls", JAMA Psychiatry, 75, pp.740~746 (2018)
- Rijk JM, "Prognostic value of handgrip strength in people aged 60 years and older : a systematic review and meta-analysis", Geriatr Gerontol Int, 16, pp.5~20 (2016)
- Vaughan L, "Depression and frailty in later life : a systematic review", Clin Interv Aging, 10, pp.1947~1958 (2015)
- Brown PJ, "The depressed frail phenotype : the clinical manifestation of increased biological aging", Am J Geriatr Psychiatry, 24, pp.1084~1094 (2016)
- Arts MH, "Relationship between physical frailty and low-grade inflammation in late-life depression", J Am Geriatr Soc, 63, pp.1652~1657 (2015)
- Abdullah Bolu, "Serum Levels of High Sensitivity C-reactive Protein in Drug-naïve First-episode Psychosis and Acute Exacerbation of Schizophrenia", Clinical Psychopharmacology and Neuroscience, 17(2), pp.244~249 (2019), 대한정신약물학회[DOI]
- Kweon S, "Data resource profile : the Korea National Health and Nutrition Examination Survey(KNHANES)", Int J Epidemiol, 43, pp.69~77 (2014)
- Kroenke K, "The PHQ-9 : validity of a brief depression severity measure", J Gen Intern Med, 16, pp.606~613 (2001)
- Han C, "Validation of the Patient Health Questionnaire-9 Korean version in the elderly population : the Ansan Geriatric study", Compr Psychiatry, 49, pp.218~223 (2008)
- Roberts HC, "A review of the measurement of grip strength in clinical and epidemiological studies : towards a standardised approach", Age Ageing, 40, pp.423~429 (2011)
- Chen LK, "Sarcopenia in Asia : consensus report of the Asian Working Group for Sarcopenia", J Am Med Dir Assoc, 15, pp.95~101 (2014)
- Pearson TA, "Markers of inflammation and cardiovascular disease : application to clinical and public health practice : a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association", Circulation, 107, pp.499~511 (2003)
- Gordon AJ, "Three questions can detect hazardous drinkers", J Fam Pract, 50, pp.313~320 (2001)
- Kurtze N, "Reliability and validity of the international physical activity questionnaire in the Nord-Trøndelag health study(HUNT)population of men", BMC Med Res Methodol, 8, pp.63~ (2008)
- "International physical activity questionnaire"[URL]
- Rural Development Administration, "Food composition table" (2006), National Rural Resources Development Institute
- Grundy SM, "Diagnosis and management of the metabol-ic syndrome : an American Heart Association", National Heart, Lung, and Blood Institute Scientific Statement, 2005, pp.112, 2735~2752
- Veronese N, "Poor physical performance predicts future onset of depression in elderly people : Progetto Veneto Anziani longitudinal study", Phys Ther, 97, pp.659~668 (2017)
- Buigues C, "The relationship between depression and frailty syndrome : a systematic review", Aging Ment Health, 19, pp.762~772 (2015)
- Soysal P, "Relationship between depression and frailty in older adults : a systematic review and meta-analysis", Ageing Res Rev, 36, pp.78~87 (2017)
- Penninx BW, "Exploring the effect of depression on physical disability : longitudinal evidence from the established populations for epidemiologic studies of the elderly", Am J Public Health, 89, pp.1346~1352 (1999)
- Lenze EJ, "The association of late-life depression and anxiety with physical disability : a review of the literature and prospectus for future research", Am J Geriatr Psychiatry, 9, pp.113~135 (2001)
- Choi H, "Impact of social isolation on behavioral health in elderly : systematic review", World J Psychiatry, 5, pp.432~438 (2015)
- Jung YE, "Elevated hs-CRP level is associated with depression in younger adults : results from the Korean National Health and Nutrition Examination Survey(KNHANES 2016)", Psychoneuroendocrinology, 109, pp.104397~ (2019)
- Tabatabaeizadeh SA, "There is an association between serum high-sensitivity C-reactive protein(hs-CRP)concentrations and depression score in adolescent girls", Psychoneuroendocrinology, 88, pp.102~104 (2018)
- Ford DE, "Depression and C-reactive protein in US adults : data from the Third National Health and Nutrition Examination Survey", Arch Intern Med, 164, pp.1010~1014 (2004)
- Wium-Andersen MK, "Elevated C-reactive protein levels, psychological distress, and depression in 73, 131 individuals", JAMA Psychiatry, 70, pp.176~184 (2013)
- Song BM, "Association between C reactive protein level and depressive symptoms in an elderly Korean population : Korean Social Life, Health and Aging Project", BMJ Open, 5, pp.e006429~ (2015)
- Liukkonen T, "The association between C-reactive protein levels and depression : results from the Northern Finland 1966 birth cohort study", Biol Psychiatry, 60, pp.825~830 (2006)
- Chaiton M, "Depressive symptoms and C-reactive protein are not associated in a population-based sample of adolescents", Int J Behav Med, 17, pp.216~222 (2010)
- de Menezes ST, "Lack of association between depression and C-reactive protein level in the baseline of Longitudinal Study of Adult Health(ELSA-Brasil)", J Affect Disord, 208, pp.448~454 (2017)
- Almeida OP, "The association between C-reactive protein concentration and depression in later life is due to poor physical health : results from the Health in Men Study(HIMS)", Psychol Med, 37, pp.1775~1786 (2007)
- Schaap LA, "Inflammatory markers and loss of muscle mass(sarcopenia)and strength", Am J Med, 119, pp.526~ (2006)
- Bremmer MA, "Inflammatory markers in late-life depression : results from a population-based study", J Affect Disord, 106, pp.249~255 (2008)
- Schiepers OJ, "Cytokines and major depression", Prog Neuropsychopharmacol Biol Psychiatry, 29, pp.201~217 (2005)
- Visser M, "Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women : the Health ABC Study", J Gerontol A Biol Sci Med Sci, 57, pp.M326~ (2002)
- Alexopoulos GS, "The inflammation hypothesis in geriatric depression", Int J Geriatr Psychiatry, 26, pp.1109~1118 (2011)
- Fried LP, "Nonlinear multisystem physiological dysregulation associated with frailty in older women : implications for etiology and treatment", J Gerontol A Biol Sci Med Sci, 64, pp.1049~1057 (2009)
- Wilson D, "Frailty and sarcopenia : the potential role of an aged immune system", Ageing Res Rev, 36, pp.1~10 (2017)
- Castanon N, "Effects of antidepressants on cytokine production and actions", Brain Behav Immun, 16, pp.569~574 (2002)
- Sproston NR, "Role of C-reactive protein at sites of inflammation and infection", Front Immunol, 9, pp.754~ (2018)
