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Multicenter, Open-Label Study to Evaluate the Effects of Methylphenidate-OROS(Concerta) on Cognitive Functions in Children with Attention Deficit Hyperactivity Disorder

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초록

Current models of ADHD are based on neuropsychological theories of impaired functioning of the frontal lobes, particularly the prefrontal cortex (PFC). Children with ADHD show improvements in performance on tests of executive function, attention, and vigilance following stimulant treatment. The aim of this study was to evaluate the effects of methylphenidate-OROS (MPH-OROS) on cognitive function and intellectual performance in Korean children with ADHD. Ninety-one elementary school children with ADHD (combined type), 6-12 years old, participated in the multicenter, 4-week open trial of MPH-OROS. Function was assessed using behavioral checklists, the KWISC-III, Continuous Performance Test (CPT), Trail-Making Test (TMT), and Wisconsin Card Sorting Test (WCST). In total, 83 subjects were analyzed using paired t-tests (repeated measures). After MPH-OROS treatment, significant improvements (p<0.01) were observed in the WISC-III, with reduced auditory omission errors, commission errors, and visual omission errors on the CPT. TMT and perseverative response times improved and perseverative errors decreased significantly (p<0.01); perseverative errors and categories completed on the WCST improved significantly. The majority of patients (79.5%) showed at least one adverse effect, with most being mild. Common adverse effects were appetite loss (19.2%), insomnia (19.2%), and headache (9.6%). Although our findings suggest that MPH-OROS has beneficial effects on cognitive and intellectual function, especially on executive function, in children with ADHD, a further long-term follow-up study of these effects is warranted.

Abstract

Current models of ADHD are based on neuropsychological theories of impaired functioning of the frontal lobes, particularly the prefrontal cortex (PFC). Children with ADHD show improvements in performance on tests of executive function, attention, and vigilance following stimulant treatment. The aim of this study was to evaluate the effects of methylphenidate-OROS (MPH-OROS) on cognitive function and intellectual performance in Korean children with ADHD. Ninety-one elementary school children with ADHD (combined type), 6-12 years old, participated in the multicenter, 4-week open trial of MPH-OROS. Function was assessed using behavioral checklists, the KWISC-III, Continuous Performance Test (CPT), Trail-Making Test (TMT), and Wisconsin Card Sorting Test (WCST). In total, 83 subjects were analyzed using paired t-tests (repeated measures). After MPH-OROS treatment, significant improvements (p<0.01) were observed in the WISC-III, with reduced auditory omission errors, commission errors, and visual omission errors on the CPT. TMT and perseverative response times improved and perseverative errors decreased significantly (p<0.01); perseverative errors and categories completed on the WCST improved significantly. The majority of patients (79.5%) showed at least one adverse effect, with most being mild. Common adverse effects were appetite loss (19.2%), insomnia (19.2%), and headache (9.6%). Although our findings suggest that MPH-OROS has beneficial effects on cognitive and intellectual function, especially on executive function, in children with ADHD, a further long-term follow-up study of these effects is warranted.

참고문헌 (48)

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관련 논문AI추천

Switching from Methylphenidate-Immediate Release (MPH-IR) to Methylphenidate- OROS (OROS-MPH): A Multi-center, Open-label Study in Korea김붕년, 김예니, 김재원, 신민섭, 정운선, 조수철, Jun-Won Hwang대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2011 · 제9권 제1호Differences in the Clinical Characteristics of Remission and Non-Remission Groups with Once-Daily OROS-Methylphenidate Treatment of Attention-Deficit/Hyperactivity Disorder육기환, 윤형준, 이상혁, 최태규, 홍나래, 홍현주대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2008 · 제6권 제1호한국의 주의력결핍/과잉행동장애 아동에서 Oros-Methylphenidate의 임상적 효능과 부작용에 대한 단기간의 다기관 개방연구서완석, 이종훈대한생물치료정신의학회 · 생물치료정신의학2007 · 제13권 제2호ADHD 아동에서 나이, 지능, 용량 및 불안 증상에 따른 Oros-methylphenidate 임상효과의 차이배대석, 서완석, 송창진, 이종훈, 정성훈, 정운선, 정철호, 최상용대한생물치료정신의학회 · 생물치료정신의학2006 · 제12권 제2호주의력결핍 과잉행동장애 환자의 약물치료에 따른 지적효율성의 변화박형배, 배대석, 서완석, 송창진, 하정상영남대학교 의과대학 · Journal of Yeungnam Medical Science2001 · 제18권 제2호Effect of Methylphenidate on Sleep Parameters in Children with ADHD구본훈, 서완석, 성형모, 최태영, Jong Hun Lee, Sang Heon Lee, So-Jeong Choi, So Yeun Kim대한신경정신의학회 · PSYCHIATRY INVESTIGATION2012 · 제9권 제4호

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