A Comparison of Developmental Trajectories of Prepulse Inhibition between Male and Female Rats
0
조회
0
다운로드
1
인용
0
참고문헌
초록
Objective: Various studies have demonstrated that childhood and adolescence are critical periods of brain development characterized by both dramatic changes and sexual dimorphism in anatomy, physiology and cognition. Prepulse inhibition (PPI) is an operational model of sensorimotor gating process, but data concerning the interactions of sex and normal ontogeny of PPI is of a particular paucity. Methods: We led a longitudinal study to compare the PPI between male and female Sprague-Dawley rats during postnatal day 23 to 43. Results: We found that the PPI of both male and female rats increased during this period. We also found that the PPI of male and female rats had different developmental trajectories when the prepulse intensity was 20 dB [A] above background, a result similar with a previous study done in humans. Conclusion: The finding confirms the face validity of PPI as a model of information processing across species and supports its utilization for investigation of potential aetiological factors implicated in mental disorders.
Abstract
Objective: Various studies have demonstrated that childhood and adolescence are critical periods of brain development characterized by both dramatic changes and sexual dimorphism in anatomy, physiology and cognition. Prepulse inhibition (PPI) is an operational model of sensorimotor gating process, but data concerning the interactions of sex and normal ontogeny of PPI is of a particular paucity. Methods: We led a longitudinal study to compare the PPI between male and female Sprague-Dawley rats during postnatal day 23 to 43. Results: We found that the PPI of both male and female rats increased during this period. We also found that the PPI of male and female rats had different developmental trajectories when the prepulse intensity was 20 dB [A] above background, a result similar with a previous study done in humans. Conclusion: The finding confirms the face validity of PPI as a model of information processing across species and supports its utilization for investigation of potential aetiological factors implicated in mental disorders.
참고문헌 (36)
- De Bellis MD, "Sex differences in brain maturation during childhood and adolescence", Cereb Cortex, 11, pp.552~557 (2001)
- Lenroot RK, "GL, Clasen LS, et al. Sexual dimorphism of brain developmental trajectories during childhood and adolescence", Neuroimage, 36, pp.1065~1073 (2007)
- Sowell ER, "Development of cortical and subcortical brain structures in childhood and adolescence: a structural MRI study", Dev Med Child Neurol, 44, pp.4~16 (2002)
- Yurgelun-Todd DA, "Sex differences in cerebral tissue volume and cognitive performance during adolescence", Psychol Rep, 91, pp.743~757 (2002)
- Casey BJ, "Structural and functional brain development and its relation to cognitive development", Biol Psychol, 54, pp.241~257 (2000)
- Luna B, "Maturation of cognitive processes from late childhood to adulthood", Child Dev, 75, pp.1357~1372 (2004)
- Braff DL, "Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies", Psychopharmacology (Berl), 156, pp.234~258 (2001)
- Fendt M, "Brain stem circuits mediating prepulse inhibition of the startle reflex", Psychopharmacology (Berl), 156, pp.216~224 (2001)
- Ornitz EM, "Maturation of startle modulation", Psychophysiology, 23, pp.624~634 (1986)
- Ellwanger J, "The relationship of age to prepulse inhibition and habituation of the acoustic startle response", Biol Psychol, 62, pp.175~195 (2003)
- Parisi T, "Ontogeny of control over the acoustic startle reflex by visual prestimulation in the rat", Dev Psychobiol, 14, pp.311~316 (1981)
- Romero E, "Ontogeny of sensorimotor gating and immune impairment induced by prenatal immune challenge in rats: implications for the etiopathology of schizophrenia", Mol Psychiatry, 15, pp.372~383 (2010)
- Lehmann J, "Sex differences in the acoustic startle response and prepulse inhibition in Wistar rats", Behav Brain Res, 104, pp.113~117 (1999)
- Swerdlow NR, "Men are more inhibited than women by weak prepulses", Biol Psychiatry, 34, pp.253~260 (1993)
- Koch M, "Sensorimotor gating changes across the estrous cycle in female rats", Physiol Behav, 64, pp.624~628 (1998)
- Andersen SL, "Trajectories of brain development: point of vulnerability or window of opportunity?", Neurosci Biobehav Rev, 27, pp.3~18 (2003)
- Spear LP, "The adolescent brain and age-related behavioral manifestations", Neurosci Biobehav Rev, 24, pp.417~463 (2000)
- Blumenthal TD, "Prepulse inhibition decreases as startle reactivity habituates", Psychophysiology, 34, pp.446~450 (1997)
- Brody SA, "A developmental influence of the N-methyl-D-aspartate receptor NR3A subunit on prepulse inhibition of startle", Biol Psychiatry, 57, pp.1147~1152 (2005)
- Swerdlow NR, "Startle gating deficits in a large cohort of patients with schizophrenia: relationship to medications, symptoms, neurocognition, and level of function", Arch Gen Psychiatry, 63, pp.1325~1335 (2006)
- Gouchie C, "The relationship between testosterone levels and cognitive ability patterns", Psychoneuroendocrinology, 16, pp.323~334 (1991)
- Johnson ES, "Developmental patterns of spatial ability: an early sex difference", Child Dev, 58, pp.725~740 (1987)
- Ornitz EM, "Maturation of prestimulation-induced startle modulation in girls", Psychophysiology, 28, pp.11~20 (1991)
- Corpé9chot C, "Testosterone, dihydrotestosterone and androstanediols in plasma, testes and prostates of rats during development", Acta Endocrinol (Copenh), 96, pp.127~135 (1981)
- Swerdlow NR, "Changes in sensorimotor inhibition across the menstrual cycle: implications for neuropsychiatric disorders", Biol Psychiatry, 41, pp.452~460 (1997)
- Andersen SL, "Pubertal changes in gonadal hormones do not underlie adolescent dopamine receptor overproduction", Psychoneuroendocrinology, 27, pp.683~691 (2002)
- Andersen SL, "Sex differences in dopamine receptor overproduction and elimination", Neuroreport, 8, pp.1495~1498 (1997)
- Swerdlow NR, "Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges", Psychopharmacology (Berl), 156, pp.194~215 (2001)
- Rivest RW, "Sexual maturation in female rats: hereditary, developmental and environmental aspects", Experientia, 47, pp.1027~1038 (1991)
- Davis M, "Apomorphine disrupts the inhibition of acoustic startle induced by weak prepulses in rats", Psychopharmacology (Berl), 102, pp.1~4 (1990)
- Gewirtz JC, "Habituation of prepulse inhibition of the startle reflex using an auditory prepulse close to background noise", Behav Neurosci, 109, pp.388~395 (1995)
- Blumenthal TD, "Inhibition of the human startle response is affected by both prepulse intensity and eliciting stimulus intensity", Biol Psychol, 44, pp.85~104 (1996)
- Csomor PA, "On the influence of baseline startle reactivity on the indexation of prepulse inhibition", Behav Neurosci, 122, pp.885~900 (2008)
- Graham FK, "Presidential Address, 1974. The more or less startling effects of weak prestimulation", Psychophysiology, 12, pp.238~248 (1975)
- Perlstein WM, "Lead stimulation effects on reflex blink, exogenous brain potentials, and loudness judgments", Psychophysiology, 30, pp.347~358 (1993)
- Bradley MM, "A multi-process account of startle modulation during affective perception", Psychophysiology, 43, pp.486~497 (2006)