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Treatment Response in First-episode Schizophrenia

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First episode schizophrenia (FES) patients tend to be more responsive to treatment. An adequate response has been associated with a favourable long-term course in FES patients. Yet, despite the generally very favourable response profile around one quarter of the patients shows persisting symptoms of psychosis. To improve the outcome and course of psychosis great effort has emerged in identifying biological and clinical variables associated with non-response in order to identify non-responders as early as possible and adopt specific treatment strategies improving illness outcome. Different antipsychotic treatment regimens have been evaluated in terms of their efficacy in reducing symptoms of FES with psychological interventions gaining increasing importance in the treatment concept of patients suffering from their first illness episode. Therefore, aim of this review is to summarize current evidence on the response patterns, the most important predictors of response/non-response as well as on effective treatment interventions in FES patients.

Abstract

First episode schizophrenia (FES) patients tend to be more responsive to treatment. An adequate response has been associated with a favourable long-term course in FES patients. Yet, despite the generally very favourable response profile around one quarter of the patients shows persisting symptoms of psychosis. To improve the outcome and course of psychosis great effort has emerged in identifying biological and clinical variables associated with non-response in order to identify non-responders as early as possible and adopt specific treatment strategies improving illness outcome. Different antipsychotic treatment regimens have been evaluated in terms of their efficacy in reducing symptoms of FES with psychological interventions gaining increasing importance in the treatment concept of patients suffering from their first illness episode. Therefore, aim of this review is to summarize current evidence on the response patterns, the most important predictors of response/non-response as well as on effective treatment interventions in FES patients.

참고문헌 (80)

  1. Frangou S, "How to manage the first episode of schizophrenia", BMJ, 321, pp.522~523 (2000)
  2. Redmond C, "The personal meaning of romantic relationships for young people with psychosis", Clin Child Psychol Psychiatry, 15, pp.151~170 (2010)
  3. Schnabel R, "Predisposing factors for early retirement in patients with schizophrenia in Germany", Eur J Health Econ, 9, pp.265~274 (2008)
  4. Harrison G, "Recovery from psychotic illness: a 15- and 25-year international follow-up study", Br J Psychiatry, 178, pp.506~517 (2001)
  5. Loebel AD, "Duration of psychosis and outcome in first-episode schizophrenia", Am J Psychiatry, 149, pp.1183~1188 (1992)
  6. International Early Psychosis Association Writing Group, "International clinical practice guidelines for early psychosis", Br J Psychiatry Suppl, 48, pp.s120~s124 (2005)
  7. Lambert M, "Management of incomplete remission and treatment resistance in first-episode psychosis", Expert Opin Pharmacother, 9, pp.2039~2051 (2008)
  8. Jäger M, "Psychopathological characteristics and treatment response of first episode compared with multiple episode schizophrenic disorders", Eur Arch Psychiatry Clin Neurosci, 257, pp.47~53 (2007)
  9. Falkai P, "WFSBP Task Force on Treatment Guidelines for Schizophrenia. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia, Part 1: acute treatment of schizophrenia", World J Biol Psychiatry, 6, pp.132~191 (2005)
  10. Robinson DG, "Predictors of treatment response from a first episode of schizophrenia or schizoaffective disorder", Am J Psychiatry, 156, pp.544~549 (1999)
  11. Emsley R, "Time course for antipsychotic treatment response in first-episode schizophrenia", Am J Psychiatry, 163, pp.743~745 (2006)
  12. Birchwood M, "Early intervention in psychosis. The critical period hypothesis", Br J Psychiatry Suppl, 172, pp.53~59 (1998)
  13. McGlashan TH, "A selective review of recent North American long-term followup studies of schizophrenia", Schizophr Bull, 14, pp.515~542 (1988)
  14. Leucht S, "Measurement-based psychiatry: definitions of response, remission, stability, and relapse in schizophrenia", J Clin Psychiatry, 67, pp.1813~1814 (2006)
  15. Leucht S, "Defining ‘response’ in antipsychotic drug trials: recommendations for the use of scale-derived cutoffs", Neuropsychopharmacology, 32, pp.1903~1910 (2007)
  16. Lieberman J, "Time course and biologic correlates of treatment response in first-episode schizophrenia", Arch Gen Psychiatry, 50, pp.369~376 (1993)
  17. Emsley RA, "Risperidone in the treatment of first-episode psychotic patients: a double-blind multicenter study", Schizophr Bull, 25, pp.721~729 (1999), Risperidone Working Group
  18. Sanger TM, "Olanzapine versus haloperidol treatment in first-episode psychosis", Am J Psychiatry, 156, pp.79~87 (1999)
  19. Agid O, "Delayed-onset hypothesis of antipsychotic action: a hypothesis tested and rejected", Arch Gen Psychiatry, 60, pp.1228~1235 (2003)
  20. Leucht S, "Early-onset hypothesis of antipsychotic drug action: a hypothesis tested, confirmed and extended", Biol Psychiatry, 57, pp.1543~1549 (2005)
  21. Kinon BJ, "Predicting response to atypical antipsychotics based on early response in the treatment of schizophrenia", Schizophr Res, 102, pp.230~240 (2008)
  22. Kinon BJ, "Early response to antipsychotic drug therapy as a clinical marker of subsequent response in the treatment of schizophrenia", Neuropsychopharmacology, 35, pp.581~590 (2010)
  23. Derks EM, "Antipsychotic drug treatment in first-episode psychosis: should patients be switched to a different antipsychotic drug after 2, 4, or 6 weeks of nonresponse?", J Clin Psychopharmacol, 30, pp.176~180 (2010), EUFEST Study Group
  24. Gallego JA, "Time to treatment response in first-episode schizophrenia: should acute treatment trials last several months?", J Clin Psychiatry, 72, pp.1691~1696 (2011)
  25. Schennach-Wolff R, "An early improvement threshold to predict response and remission in first-episode schizophrenia", Br J Psychiatry, 196, pp.460~466 (2010)
  26. Schennach R, "Should early improvement be re-defined to better predict the maintenance of response in FES patients?", Acta Psychiatrica Scandinavic (2012)
  27. Silvestri S, "Increased dopamine D2 receptor binding after long-term treatment with antipsychotics in humans: a clinical PET study", Psychopharmacology, 152, pp.174~180 (2000)
  28. Deng MY, "A naturalistic study of grey matter volume increase after early treatment in anti-psychotic naïve, newly diagnosed schizophrenia", Psychopharmacology, 206, pp.437~446 (2009)
  29. Dolzan V, "Acute antipyschotic efficacy and side effects in schizophrenia: association with serotonin transporter promoter genotypes", Prog Neuropsychopharmacol Biol Psychiatry, 32, pp.1562~1566 (2008)
  30. Rasmussen H, "Serotonin2A receptor blockade and clinical effect in first-episode schizophrenia patients treated with quetiapine", Psychopharmacology, 213, pp.583~592 (2011)
  31. Ikeda M, "Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia", Pharmacogenomics, 9, pp.1437~1443 (2008)
  32. Lencz T, "DRD2 promoter region variation as a predictor of sustained response to antipsychotic medication in first-episode schizophrenia patients", Am J Psychiatry, 163, pp.529~531 (2006)
  33. Pelayo-Terán JM, "Catechol-O-methyltransferase Val158Met polymorphism and negative symptoms after acute antipsychotic treatment in first-episode non-affective psychosis", Psychiatry Res, 185, pp.286~289 (2011)
  34. Kapur S, "Relationship between dopamine D(2) occupancy, clinical response, and side effects: a double-blind PET study of first-episode schizophrenia", Am J Psychiatry, 157, pp.514~520 (2000)
  35. Szeszko PR, "Magnetic resonance imaging predictors of treatment response in first-episode schizophrenia", Schizophr Bull, 38, pp.569~578 (2012)
  36. Garner B, "Pituitary volume and early treatment response in drug-naïve first-episode psychosis patients", Schizophr Res, 113, pp.65~71 (2009)
  37. Belvederi Murri M, "Hypothalamic-pituitaryadrenal axis and clinical symptoms in first-episode psychosis", Psychoneuroendocrinology, 37, pp.629~644 (2012)
  38. van Venrooij JA, "Impaired neuroendocrine and immune response to acute stress in medication-naive patients with a first episode of psychosis", Schizophr Bull, 38, pp.272~279 (2012)
  39. Merlo MC, "Differences in the EEG profiles of early and late responders to antipsychotic treatment in first-episode, drug-naive psychotic patients", Schizophr Res, 30, pp.221~228 (1998)
  40. McGlashan TH, "Duration of untreated psychosis in firstepisode schizophrenia: marker or determinant of course?", Biol Psychiatry, 46, pp.899~907 (1999)
  41. Norman RM, "Duration of untreated psychosis: a critical examination of the concept and its importance", Psychol Med, 31, pp.381~400 (2001)
  42. Addington J, "Duration of untreated psychosis: impact on 2-year outcome", Psychol Med, 34, pp.277~284 (2004)
  43. de Haan L, "Duration of untreated psychosis and outcome of schizophrenia: delay in intensive psychosocial treatment versus delay in treatment with antipsychotic medication", Schizophr Bull, 29, pp.341~348 (2003)
  44. Bottlender R, "The impact of the duration of untreated psychosis prior to first psychiatric admission on the 15-year outcome in schizophrenia", Schizophr Res, 62, pp.37~44 (2003)
  45. Larsen TK, "Premorbid functioning versus duration of untreated psychosis in 1 year outcome in first-episode psychosis", Schizophr Res, 45, pp.1~9 (2000)
  46. Crespo-Facorro B, "Predictors of acute treatment response in patients with a first episode of non-affective psychosis: sociodemographics, premorbid and clinical variables", J Psychiatr Res, 41, pp.659~666 (2007)
  47. Verdoux H, "Is the association between duration of untreated psychosis and outcome confounded? A two year follow-up study of first-admitted patients", Schizophr Res, 49, pp.231~241 (2001)
  48. Perkins D, "Predictors of antipsychotic treatment response in patients with first-episode schizophrenia, schizoaffective and schizophreniform disorders", Br J Psychiatry, 185, pp.18~24 (2004), HGDH Research Group.
  49. Schimmelmann BG, "Impact of duration of untreated psychosis on pre-treatment, baseline, and outcome characteristics in an epidemiological first-episode psychosis cohort", J Psychiatr Res, 42, pp.982~990 (2008)
  50. CeskováE, "Psychopathology and treatment responsiveness of patients with first-episode schizophrenia", Neuropsychiatr Dis Treat, 1, pp.179~185 (2005)
  51. Addington J, "Symptom outcome 1 year after admission to an early psychosis program", Can J Psychiatry, 48, pp.204~207 (2003)
  52. Schennach-Wolff R, "Predictors of response and remission in the acute treatment of first-episode schizophrenia patients--is it all about early response?", Eur Neuropsychopharmacol, 21, pp.370~378 (2011)
  53. Drake RJ, "Insight as a predictor of the outcome of firstepisode nonaffective psychosis in a prospective cohort study in England", J Clin Psychiatry, 68, pp.81~86 (2007)
  54. Prikryl R, "Neurological soft signs and their relationship to 1-year outcome in first-episode schizophrenia", Eur Psychiatry, 22, pp.499~504 (2007)
  55. Oosthuizen P, "A randomized, controlled comparison of the efficacy and tolerability of low and high doses of haloperidol in the treatment of first-episode psychosis", Int J Neuropsychopharmacol, 7, pp.125~131 (2004)
  56. Robinson DG, "Pharmacological treatments for first-episode schizophrenia", Schizophr Bull, 31, pp.705~722 (2005)
  57. Kinon BJ, "Mechanisms of action of atypical antipsychotic drugs: a critical analysis", Psychopharmacology, 124, pp.2~34 (1996)
  58. Mö€ller HJ, "Management of the negative symptoms of schizophrenia: new treatment options", CNS Drugs, 17, pp.793~823 (2003)
  59. Mö~ller HJ, "State of the art of drug treatment of schizophrenia and the future position of the novel", atypical antipsychotics, 2000, pp.1, 204~214
  60. Lieberman JA, "Comparative efficacy and safety of atypical and conventional antipsychotic drugs in first-episode psychosis: a randomized, double-blind trial of olanzapine versus haloperidol", Am J Psychiatry, 160, pp.1396~1404 (2003), HGDH Study Group
  61. Schooler N, "Early Psychosis Global Working Group. Risperidone and haloperidol in first-episode psychosis: a long-term randomized trial", Am J Psychiatry, 162, pp.947~953 (2005)
  62. Mö~ller HJ, "Short-term treatment with risperidone or haloperidol in first-episode schizophrenia: 8-week results of a randomized controlled trial within the German Research Network on Schizophrenia", Int J Neuropsychopharmacol, 11, pp.985~997 (2008)
  63. Kahn RS, "Effectiveness of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: an open randomised clinical trial", Lancet, 371, pp.1085~1097 (2008), EUFEST study group
  64. Boter H, "Effectiveness of antipsychotics in first-episode schizophrenia and schizophreniform disorder on response and remission: an open randomized clinical trial (EUFEST)", Schizophr Res, 115, pp.97~103 (2009), EUFEST study group
  65. Crossley NA, "Efficacy of atypical v. typical antipsychotics in the treatment of early psychosis: meta-analysis", Br J Psychiatry, 196, pp.434~439 (2010)
  66. Rummel C, "New generation antipsychotics for first episode schizophrenia", Cochrane Database Syst Rev, 4, pp.CD004410~ (2003)
  67. Lieberman JA, "Antipsychotic drug effects on brain morphology in first-episode psychosis", Arch Gen Psychiatry, 62, pp.361~370 (2005), HGDH Study Group
  68. Crespo-Facorro B, "Effect of antipsychotic drugs on brain morphometry. A randomized controlled one-year follow-up study of haloperidol, risperidone and olanzapine", Prog Neuropsychopharmacol Biol Psychiatry, 32, pp.1936~1943 (2008)
  69. National Institute for Clinical Excellence., "Schizophrenia, In NICE Clinical Guideline 82" (2009), NICE
  70. Manchanda R, "Persistent psychoses in first episode patients", Schizophr Res, 80, pp.113~116 (2005)
  71. Lieberman JA, "Atypical and conventional antipsychotic drugs in treatment-naive first-episode schizophrenia: a 52-week randomized trial of clozapine vs chlorpromazine", Neuropsychopharmacology, 28, pp.995~1003 (2003)
  72. Woerner MG, "Clozapine as a first treatment for schizophrenia", Am J Psychiatry, 160, pp.1514~1516 (2003)
  73. Agid O, "An algorithm-based approach to firstepisode schizophrenia: response rates over 3 prospective antipsychotic trials with a retrospective data analysis", J Clin Psychiatry, 72, pp.1439~1444 (2011)
  74. Agid O, "Early use of clozapine for poorly responding first-episode psychosis", J Clin Psychopharmacol, 27, pp.369~373 (2007)
  75. Zhang ZJ, "Electroconvulsive therapy improves antipsychotic and somnographic responses in adolescents with first-episode psychosis - A case-control study", Schizophr Res, 137, pp.97~103 (2012)
  76. Suzuki K, "Improvement of psychiatric symptoms after electroconvulsive therapy in young adults with intractable first-episode schizophrenia and schizophreniform disorder", Tohoku J Exp Med, 210, pp.213~220 (2006)
  77. Ohlsen RI, "Clinical effectiveness in first-episode patients", Eur Neuropsychopharmacol, 14(Suppl 4), pp.S445~S451 (2004)
  78. Penn DL, "Psychosocial treatment for first-episode psychosis: a research update", Am J Psychiatry, 162, pp.2220~2232 (2005)
  79. Crespo-Facorro B, "Treatment of the first episode of schizophrenia: an update on pharmacologic and psychological interventions", Curr Psychiatry Rep, 10, pp.202~209 (2008)
  80. Askey R, "Family work in first-onset psychosis: a literature review", J Psychiatr Ment Health Nurs, 14, pp.356~365 (2007)

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