본문 바로가기
KERD
논문KCI 등재

Roles of Matrix Metalloproteinases and Their Targets in Epileptogenesis and Seizures

1

조회

0

다운로드

1

인용

0

참고문헌

키워드

초록

Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) remodel the pericellular environment by regulating the cleavage of extracellular matrix proteins, cell surface components, neurotransmitter receptors, and growth factors,which together regulate cell adhesion, synaptogenesis, synaptic plasticity, and long-term potentiation. Increased MMP activity and dysregulation of the balance between MMPs and TIMPs have also been implicated in various pathological conditions. Recent studies have suggested that prolonged seizures are associated with high MMP levels in serum and neural tissues, and certain extracellular macromolecule targets may influence the pathogenesis of epilepsy and seizure. In this review, we discuss the roles of MMP activation in animal models of epilepsy

Abstract

Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) remodel the pericellular environment by regulating the cleavage of extracellular matrix proteins, cell surface components, neurotransmitter receptors, and growth factors,which together regulate cell adhesion, synaptogenesis, synaptic plasticity, and long-term potentiation. Increased MMP activity and dysregulation of the balance between MMPs and TIMPs have also been implicated in various pathological conditions. Recent studies have suggested that prolonged seizures are associated with high MMP levels in serum and neural tissues, and certain extracellular macromolecule targets may influence the pathogenesis of epilepsy and seizure. In this review, we discuss the roles of MMP activation in animal models of epilepsy

참고문헌 (65)

  1. Yong VW, "Metalloproteinases in biology and pathology of the nervous system", Nat Rev Neurosci, 2, pp.502~511 (2001)
  2. Ethell IM, "Matrix metalloproteinases in brain development and remodeling: synaptic functions and targets", J Neurosci Res, 85, pp.2813~2823 (2007)
  3. Sternlicht MD, "How matrix metalloproteinases regulate cell behavior", Annu Rev Cell Dev Biol, 17, pp.463~516 (2001)
  4. Mannello F, "Tissue inhibitors of metalloproteinases and programmed cell death: conundrums, controversies and potential implications", Apoptosis, 6, pp.479~482 (2001)
  5. Vaillant C, "Spatiotemporal expression patterns of metalloproteinases and their inhibitors in the postnatal developing rat cerebellum", J Neurosci, 19, pp.4994~5004 (1999)
  6. Dzwonek J, "Matrix metalloproteinases and their endogenous inhibitors in neuronal physiology of the adult brain", FEBS Lett, 567, pp.129~135 (2004)
  7. Clark IM, "The regulation of matrix metalloproteinases and their inhibitors", Int J Biochem Cell Biol, 40, pp.1362~1378 (2008)
  8. Rivera S, "Tissue inhibitor of metalloproteinases-1 (TIMP-1) is differentially induced in neurons and astrocytes after seizures: evidence for developmental, immediate early gene, and lesion response", J Neurosci, 17, pp.4223~4235 (1997)
  9. Nedivi E, "Numerous candidate plasticity-related genes revealed by differential cDNA cloning", Nature, 363, pp.718~722 (1993)
  10. Szklarczyk A, "Matrix metalloproteinase-9 undergoes expression and activation during dendritic remodeling in adult hippocampus", J Neurosci, 22, pp.920~930 (2002)
  11. Nagy V, "Matrix metalloproteinase-9 is required for hippocampal late-phase long-term potentiation and memory", J Neurosci, 26, pp.1923~1934 (2006)
  12. Meighan SE, "Effects of extracellular matrix-degrading proteases matrix metalloproteinases 3 and 9 on spatial learning and synaptic plasticity", J Neurochem, 96, pp.1227~1241 (2006)
  13. Mizoguchi H, "Alterations of emotional and cognitive behaviors in matrix metalloproteinase-2 and -9-deficient mice", Open Behav Sci J, 4, pp.19~25 (2010)
  14. Mizoguchi H, "Matrix metalloproteinases contribute to neuronal dysfunction in animal models of drug dependence, Alzheimer’s disease, and epilepsy", Biochem Res Int (2011)
  15. Morimoto K, "Kindling and status epilepticus models of epilepsy: rewiring the brain", Prog Neurobiol, 73, pp.1~60 (2004)
  16. Wilczynski GM, "Important role of matrix metalloproteinase 9 in epileptogenesis", J Cell Biol, 180, pp.1021~1035 (2008)
  17. Zeng LH, "Kainate seizures cause acute dendritic injury and actin depolymerization in vivo", J Neurosci, 27, pp.11604~11613 (2007)
  18. Suenaga N, "Roles of matrix metalloproteinase-9 and tissue inhibitors of metalloproteinases 1 in acute encephalopathy following prolonged febrile seizures", J Neurol Sci, 266, pp.126~130 (2008)
  19. Li S, "Increased expression of matrix metalloproteinase 9 in cortical lesions from patients with focal cortical dysplasia type IIb and tuberous sclerosis complex", Brain Res, 1453, pp.46~55 (2012)
  20. Leppert D, "Matrix metalloproteinase (MMP)-8 and MMP-9 in cerebrospinal fluid during bacterial meningitis: association with blood-brain barrier damage and neurological sequelae", Clin Infect Dis, 31, pp.80~84 (2000)
  21. Heuser K, "Temporal lobe epilepsy and matrix metalloproteinase 9: a tempting relation but negative genetic association", Seizure, 19, pp.335~338 (2010)
  22. Rylski M, "JunB is a repressor of MMP-9 transcription in depolarized rat brain neurons", Mol Cell Neurosci, 40, pp.98~110 (2009)
  23. Konopacki FA, "Synaptic localization of seizureinduced matrix metalloproteinase-9 mRNA", Neuroscience, 150, pp.31~39 (2007)
  24. Le AP, "Matrix metalloproteinase-7 regulates cleavage of pro-nerve growth factor and is neuroprotective following kainic acid-induced seizures", J Neurosci, 32, pp.703~712 (2012)
  25. Stein VM, "Seizure activity in dogs is associated with enhanced TIMP-2 expression of microglia", Vet Immunol Immunopathol, 146, pp.101~105 (2012)
  26. Wright JW, "The brain angiotensin system and extracellular matrix molecules in neural plasticity, learning, and memory", Prog Neurobiol, 72, pp.263~293 (2004)
  27. Zhang JW, "Regional and differential expression of gelatinases in rat brain after systemic kainic acid or bicuculline administration", Eur J Neurosci, 10, pp.3358~3368 (1998)
  28. Kim GW, "The role of MMP-9 in integrin-mediated hippocampal cell death after pilocarpine-induced status epilepticus", Neurobiol Dis, 36, pp.169~180 (2009)
  29. Goddard GV, "A permanent change in brain function resulting from daily electrical stimulation", Exp Neurol, 25, pp.295~330 (1969)
  30. Racine RJ, "Modification of seizure activity by electrical stimulation. II. Motor seizure", Electroencephalogr Clin Neurophysiol, 32, pp.281~294 (1972)
  31. Pinel JP, "Electrode placement and kindlinginduced experimental epilepsy", Exp Neurol, 58, pp.335~346 (1978)
  32. Sutula T, "Synaptic reorganization in the hippocampus induced by abnormal functional activity", Science, 239, pp.1147~1150 (1988)
  33. Cavazos JE, "Mossy fiber synaptic reorganization induced by kindling: time course of development, progression, and permanence", J Neurosci, 11, pp.2795~2803 (1991)
  34. Cavazos JE, "Neuronal loss induced in limbic pathways by kindling: evidence for induction of hippocampal sclerosis by repeated brief seizures", J Neurosci, 14, pp.3106~3121 (1994)
  35. Mizoguchi H, "Matrix metalloproteinase-9 contributes to kindled seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus", J Neurosci, 31, pp.12963~12971 (2011)
  36. Girgenti MJ, "Characterization of electroconvulsive seizure-induced TIMP-1 and MMP-9 in hippocampal vasculature", Int J Neuropsychopharmacol, 14, pp.535~544 (2011)
  37. Takács E, "Matrix metalloproteinase-9 activity increased by two different types of epileptic seizures that do not induce neuronal death: a possible role in homeostatic synaptic plasticity", Neurochem Int, 56, pp.799~809 (2010)
  38. Jourquin J, "Neuronal activity-dependent increase of net matrix metalloproteinase activity is associated with MMP-9 neurotoxicity after kainate", Eur J Neurosci, 18, pp.1507~1517 (2003)
  39. Hoehna Y, "Matrix metalloproteinase 9 regulates cell death following pilocarpine-induced seizures in the developing brain", Neurobiol Dis, 48, pp.339~347 (2012)
  40. Ben-Ari Y, "clinical and pathological alterations following systemic administration of kainic acid, bicuculline or pentetrazole: metabolic mapping using the deoxyglucose method with special reference to the pathology of epilepsy", Neuroscience, 6, pp.1361~1391 (1981)
  41. Parent JM, "Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus", J Neurosci, 17, pp.3727~3738 (1997)
  42. Bengzon J, "Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures", Proc Natl Acad Sci U S A, 94, pp.10432~10437 (1997)
  43. Buga AM, "Repeated PTZ treatment at 25-day intervals leads to a highly efficient accumulation of doublecortin in the dorsal hippocampus of rats", PLoS One, 7 (2012)
  44. Gray WP, "Kainic acid increases the proliferation of granule cell progenitors in the dentate gyrus of the adult rat", Brain Res, 790, pp.52~59 (1998)
  45. Yang F, "Different effects of mild and severe seizures on hippocampal neurogenesis in adult rats", Hippocampus, 18, pp.460~468 (2008)
  46. Yang DI, "The duration of sustained convulsive seizures determines the pattern of hippocampal neurogenesis and the development of spontaneous epilepsy in rats", Epilepsy Res, 98, pp.206~215 (2012)
  47. Wang L, "Matrix metalloproteinase 2 (MMP2) and MMP9 secreted by erythropoietin-activated endothelial cells promote neural progenitor cell migration", J Neurosci, 26, pp.5996~6003 (2006)
  48. Benekareddy M, "Antidepressant treatments regulate matrix metalloproteinases-2 and -9 (MMP-2", MMP-9) and tissue inhibitors of the metalloproteinases (TIMPS 1-4) in the adult rat hippocampus, 2008, pp.62, 590~600
  49. Cabelli RJ, "Inhibition of ocular dominance column formation by infusion of NT-4", 5 or BDNF, 1995, pp.267, 1662~1666
  50. Horch HW, "Destabilization of cortical dendrites and spines by BDNF", Neuron, 23, pp.353~364 (1999)
  51. Nagappan G, "Control of extracellular cleavage of ProBDNF by high frequency neuronal activity", Proc Natl Acad Sci U S A, 106, pp.1267~1272 (2009)
  52. Lee R, "Regulation of cell survival by secreted proneurotrophins", Science, 294, pp.1945~1948 (2001)
  53. Hwang JJ, "Activation of the Trk signaling pathway by extracellular zinc. Role of metalloproteinases", J Biol Chem, 280, pp.11995~12001 (2005)
  54. Koyama R, "Brain-derived neurotrophic factor induces hyperexcitable reentrant circuits in the dentate gyrus", J Neurosci, 24, pp.7215~7224 (2004)
  55. Bilousova TV, "Matrix metalloproteinase-7 disrupts dendritic spines in hippocampal neurons through NMDA receptor activation", J Neurochem, 97, pp.44~56 (2006)
  56. Gu Z, "A highly specific inhibitor of matrix metalloproteinase- 9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia", J Neurosci, 25, pp.6401~6408 (2005)
  57. Michaluk P, "Beta-dystroglycan as a target for MMP-9, in response to enhanced neuronal activity", J Biol Chem, 282, pp.16036~16041 (2007)
  58. Hübschmann MV, "Neural cell adhesion molecule function is regulated by metalloproteinase-mediated ectodomain release", J Neurosci Res, 80, pp.826~837 (2005)
  59. Oray S, "Dendritic spine dynamics are regulated by monocular deprivation and extracellular matrix degradation", Neuron, 44, pp.1021~1030 (2004)
  60. Wu YP, "The tissue plasminogen activator (tPA)", plasmin extracellular proteolytic system regulates seizure-induced hippocampal mossy fiber outgrowth through a proteoglycan substrate, 2000, pp.148, 1295~1304
  61. Dziembowska M, "Activity-dependent local translation of matrix metalloproteinase-9", J Neurosci, 32, pp.14538~14547 (2012)
  62. Bouchard V, "Fak", Src signaling in human intestinal epithelial cell survival and anoikis: differentiation statespecific uncoupling with the PI3-K, Erk pathways, pp.J Cell Physiol, 2007[DOI]
  63. Pankov R, "Specific beta1 integrin site selectively regulates Akt", protein kinase B signaling via local activation of protein phosphatase 2A, 2003, pp.278, 18671~18681
  64. Lee SR, "Induction of caspase-mediated cell death by matrix metalloproteinases in cerebral endothelial cells after hypoxia-reoxygenation", J Cereb Blood Flow Metab, 24, pp.720~727 (2004)
  65. Levkau B, "Activation of metalloproteinases and their association with integrins: an auxiliary apoptotic pathway in human endothelial cells", Cell Death Differ, 9, pp.1360~1367 (2002)

관련 논문AI추천

Extracellular matrixes and neuroinflammation박태주, Dong Gil Jang, Eun Kyung Song, Hyo Jung Sim, Taejoon Kwon생화학분자생물학회 · BMB Reports2020 · 제53권 제10호Neuropathologic and Clinical Features of Human Medial Temporal Lobe Epilepsy주건, 김만호, 김진희, 노재규, 박경일, 배은기, 이상건, 이순태, 정근화, 정기영, 정천기대한신경과학회 · Journal of Clinical Neurology2010 · 제6권 제2호Altered expression of parvalbumin immunoreactivity in rat main olfactory bulb following pilocarpine-induced status epilepticus김덕수, 박대균, 유대영, Yeon Hee Yu생화학분자생물학회 · BMB Reports2020 · 제53권 제4호간질을 동반하는 신경질환에서 염증반응의 역할이란, 최지은대한소아신경학회 · 대한소아신경학회지2008 · 제16권 제2호New Roles for Old Glue: Astrocyte Function in Synaptic Plasticity and Neurological DisordersMi Hyeon Jang, Syed M. Q. Hussaini대한배뇨장애요실금학회 · International Neurourology Journal2018 · 제22권 제1호Brain Neuroplasticity after Treatment with Antiseizure: A ReviewClaudio Lopes de Vasconcelos, Cynthia Cavalcanti de Albuquerque, Débora Lopes Silva de Souza, Fausto Pierdoná Guzen, Francisca Idalina Neta, Hosana Mirelle Goes e Silva Costa, José Rodolfo Lopes de Paiva Cavalcanti, Lucídio Clebeson de Oliveira, Luís Marcos de Medeiros Guerra, Paulo Leonardo Araujo de Gois Morais대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2023 · 제21권 제4호

이 간행물의 다른 논문 (8건)