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The Relief Effects of Ramelteon on Refractory Chronic Migraine: A Case Report

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초록

The selective melatonin receptor agonism effect of ramelteon is useful for insomnia. Here we wanted to present a refractory chronic migraine case, who had significant improvements in migraine after using ramelteon. The possible mechanism for the ramelteon in the migraine relief might be related to melatonin effects.

Abstract

The selective melatonin receptor agonism effect of ramelteon is useful for insomnia. Here we wanted to present a refractory chronic migraine case, who had significant improvements in migraine after using ramelteon. The possible mechanism for the ramelteon in the migraine relief might be related to melatonin effects.

참고문헌 (6)

  1. Reynoldson JN, "Ramelteon: a novel approach in the treatment of insomnia", Ann Pharmacother, 42, pp.1262~1271 (2008)
  2. Peres MF, "Potential therapeutic use of melatonin in migraine and other headache disorders", Expert Opin Investig Drugs, 15, pp.367~375 (2006)
  3. Srinivasan V, "Potential use of melatonergic drugs in analgesia: mechanisms of action", Brain Res Bull, 81, pp.362~371 (2010)
  4. Toglia JU, "Melatonin: a significant contributor to the pathogenesis of migraine", Med Hypotheses, 57, pp.432~434 (2001)
  5. Alstadhaug KB, "Prophylaxis of migraine with melatonin: a randomized controlled trial", Neurology, 75, pp.1527~1532 (2010)
  6. Lionetto L, "Emerging treatment for chronic migraine and refractory chronic migraine", Expert Opin Emerg Drugs, 17, pp.393~406 (2012)

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