The Relationship between the SNAP-25 Polymorphism and Omission Errors in Korean Children with Attention Deficit Hyperactivity Disorder
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초록
Objective: This study aimed to investigate the association between the synaptosomal-associated protein 25 kDa (SNAP-25) genotype and performance on the continuous performance test (CPT) in Korean children with attention-deficit/hyperactivity disorder (ADHD). Methods: Eighty-seven children with ADHD (mean age, 9.23±1.99 years) participated in this study. Omission errors, commission errors, reaction time, and reaction time variability on the CPT were analyzed. The single-nucleotide polymorphism (SNP) rs3746544 (1065 T>G) of SNAP-25 was genotyped to examine the association with CPT performance. Results: We found significantly more omission errors on the CPT among children with the TT genotype of SNAP-25 (t=2.56, p=0.012) after correcting for multiple testing. Conclusion: Our results suggest the possible involvement of the SNAP-25 1065 T>G polymorphism in the inattention phenotype in children with ADHD. Further studies with more refined neuropsychological measures and much larger sample sizes are needed to confirm our findings.
Abstract
Objective: This study aimed to investigate the association between the synaptosomal-associated protein 25 kDa (SNAP-25) genotype and performance on the continuous performance test (CPT) in Korean children with attention-deficit/hyperactivity disorder (ADHD). Methods: Eighty-seven children with ADHD (mean age, 9.23±1.99 years) participated in this study. Omission errors, commission errors, reaction time, and reaction time variability on the CPT were analyzed. The single-nucleotide polymorphism (SNP) rs3746544 (1065 T>G) of SNAP-25 was genotyped to examine the association with CPT performance. Results: We found significantly more omission errors on the CPT among children with the TT genotype of SNAP-25 (t=2.56, p=0.012) after correcting for multiple testing. Conclusion: Our results suggest the possible involvement of the SNAP-25 1065 T>G polymorphism in the inattention phenotype in children with ADHD. Further studies with more refined neuropsychological measures and much larger sample sizes are needed to confirm our findings.
참고문헌 (48)
- Biederman J, "Attention-deficit hyperactivity disorder", Lancet, 366, pp.237~248 (2005)
- Faraone SV, "Molecular genetics of attentiondeficit", hyperactivity disorder, 2005, pp.57, 1313~1323
- Heiser P, "Molecular genetic aspects of attentiondeficit", hyperactivity disorder, 2004, pp.28, 625~641
- Doyle AE, "Are endophenotypes based on measures of executive functions useful for molecular genetic studies of ADHD?", J Child Psychol Psychiatry, 46, pp.774~803 (2005)
- Doyle AE, "Attention-deficit", hyperactivity disorder endophenotypes, 2005, pp.57, 1324~1335
- Castellanos FX, "Neuroscience of attentiondeficit", hyperactivity disorder : the search for endophenotypes, 2002, pp.3, 617~628
- Fan J, "Assessing the heritability of attentional networks", BMC Neurosci, 2, pp.14~ (2001)
- Aron AR, "The cognitive neuroscience of response inhibition : relevance for genetic research in attention-deficit", hyperactivity disorder, 2005, pp.57, 1285~1292
- Jucaite A, "Reduced midbrain dopamine transporter binding in male adolescents with attention-deficit", hyperactivity disorder : association between striatal dopamine markers and motor hyperactivity, 2005, pp.57, 229~238
- Greenberg LM, "Developmental normative data on the test of variables of attention (T.O.V.A.)", J Child Psychol Psychiatry, 34, pp.1019~1030 (1993)
- Huang-Pollock CL, "Evaluating vigilance deficits in ADHD : a meta-analysis of CPT performance", J Abnorm Psychol, 121, pp.360~371 (2012)
- Frazier TW, "Meta-analysis of intellectual and neuropsychological test performance in attention-deficit", hyperactivity disorder, 2004, pp.18, 543~555
- Kollins SH, "SNPs in dopamine D2 receptor gene (DRD2) and norepinephrine transporter gene (NET) are associated with continuous performance task (CPT) phenotypes in ADHD children and their families", Am J Med Genet B Neuropsychiatr Genet, 147B, pp.1580~1588 (2008)
- Hervey AS, "Neuropsychology of adults with attention-deficit", hyperactivity disorder : a meta-analytic review, 2004, pp.18, 485~503
- Bora Kim, "Association between Dopamine D4 Receptor Gene Polymorphism and Scores on a Continuous Performance Test in Korean Children with Attention Deficit Hyperactivity Disorder", PSYCHIATRY INVESTIGATION, 6(3), pp.216~221 (2009), 대한신경정신의학회
- Manor I, "The short DRD4 repeats confer risk to attention deficit hyperactivity disorder in a family-based design and impair performance on a continuous performance test(TOVA)", Mol Psychiatry, 7, pp.790~794 (2002)
- Manor I, "Association of the dopamine D5 receptor with attention deficit hyperactivity disorder (ADHD)and scores on a continuous performance test (TOVA)", Am J Med Genet B Neuropsychiatr Genet, 127B, pp.73~77 (2004)
- Loo SK, "Functional effects of the DAT1 polymorphism on EEG measures in ADHD", J Am Acad Child Adolesc Psychiatry, 42, pp.986~993 (2003)
- Song DH, "The 1287 G", A polymorphism of the norepinephrine transporter gene(NET)is involved in commission errors in Korean children with attention deficit hyperactivity disorder, 2011, pp.7, 12~
- Jones MD, "Abnormal presynaptic catecholamine regulation in a hyperactive SNAP-25-deficient mouse mutant", Pharmacol Biochem Behav, 68, pp.669~676 (2001)
- Osen-Sand A, "Inhibition of axonal growth by SNAP-25antisense oligonucleotides in vitro and in vivo", Nature, 364, pp.445~448 (1993)
- Barr CL, "Identification of DNA variants in the SNAP-25gene and linkage study of these polymorphisms and attention-deficit hyperactivity disorder", Mol Psychiatry, 5, pp.405~409 (2000)
- Brophy K, "Synaptosomal-associated protein 25(SNAP-25)and attention deficit hyperactivity disorder(ADHD) : evidence of linkage and association in the Irish population", Mol Psychiatry, 7, pp.913~917 (2002)
- Mill J, "Association study of a SNAP-25 microsatellite and attention deficit hyperactivity disorder", Am J Med Genet, 114, pp.269~271 (2002)
- Mill J, "Haplotype analysis of SNAP-25 suggests a role in the aetiology of ADHD", Mol Psychiatry, 9, pp.801~810 (2004)
- Feng Y, "The SNAP25 gene as a susceptibility gene contributing to attention-deficit hyperactivity disorder", Mol Psychiatry, 10, pp.998~1005 (2005)
- Kustanovich V, "Biased paternal transmission of SNAP-25 risk alleles in attention-deficit hyperactivity disorder", Mol Psychiatry, 8, pp.309~315 (2003)
- Choi TK, "Support for the MnlI polymorphism of SNAP25; a Korean ADHD case-control study", Mol Psychiatry, 12, pp.224~226 (2007)
- Liu YS, "The association of SNAP25 gene polymorphisms in attention deficit", hyperactivity disorder : a systematic review and meta-analysis, 2017, pp.54, 2189~2200
- Corradini I, "SNAP-25 in neuropsychiatric disorders", Ann N Y Acad Sci, 1152, pp.93~99 (2009)
- Steffensen SC, "Transgenic rescue of SNAP-25 restores dopamine-modulated synaptic transmission in the coloboma mutant", Brain Res, 847, pp.186~195 (1999)
- Raber J, "Coloboma hyperactive mutant mice exhibit regional and transmitter-specific deficits in neurotransmission", J Neurochem, 68, pp.176~186 (1997)
- Gizer IR, "Candidate gene studies of ADHD : a meta-analytic review", Hum Genet, 126, pp.51~90 (2009)
- 김영신, "The Reliability and Validity of Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version-Korean Version (K-SADS-PL-K)", Yonsei Medical Journal, 45(1), pp.81~89 (2004), 연세대학교의과대학
- 소유경, "한국어판 부모, 교사 ADHD 평가 척도의 신뢰도와 타당도 연구", 신경정신의학, 41(2) (2002), 대한신경정신의학회
- Shin MS, "A study of the development and standardization of ADHD diagnostic system", Korean J Child Adolesc Psychiatr, 11, pp.91~99 (2000)
- Song J, "Association of SNAP-25, SLC6A2, and LPHN3 with OROS methylphenidate treatment response in attentiondeficit", hyperactivity disorder, 2014, pp.37, 136~141
- Heyser CJ, "Coloboma hyperactive mutant exhibits delayed neurobehavioral developmental milestones", Brain Res Dev Brain Res, 89, pp.264~269 (1995)
- Spellmann I, "Associations of SNAP-25 polymorphisms with cognitive dysfunctions in Caucasian patients with schizophrenia during a brief trail of treatment with atypical antipsychotics", Eur Arch Psychiatry Clin Neurosci, 258, pp.335~344 (2008)
- Braida D, "Association between SNAP-25 gene polymorphisms and cognition in autism: functional consequences and potential therapeutic strategies", Transl Psychiatry, 5, pp.e500~ (2015)
- Gosso MF, "The SNAP-25 gene is associated with cognitive ability : evidence from a family-based study in two independent Dutch cohorts", Mol Psychiatry, 11, pp.878~886 (2006)
- Cho SC, "No evidence of an association between norepinephrine transporter gene polymorphisms and attention deficit hyperactivity disorder : a family-based and case-control association study in a Korean sample", Neuropsychobiology, 57, pp.131~138 (2008)
- Comings DE, "Molecular heterosis : a review", Mol Genet Metab, 71, pp.19~31 (2000)
- Hughes TA, "Regulation of gene expression by alternative untranslated regions", Trends Genet, 22, pp.119~122 (2006)
- Kim JW, "Investigation of variation in SNAP-25 and ADHD and relationship to co-morbid major depressive disorder", Am J Med Genet B Neuropsychiatr Genet, 144B, pp.781~790 (2007)
- Davids E, "Animal models of attention-deficit hyperactivity disorder", Brain Res Brain Res Rev, 42, pp.1~21 (2003)
- Dulcan M, "Practice parameters for the assessment and treatment of children, adolescents, and adults with attention-deficit", hyperactivity disorder. American Academy of Child and Adolescent Psychiatry, 1997, pp.36(10 Suppl), 85S~121S
- Corkum PV, "Is the Continuous Performance Task a valuable research tool for use with children with attention-deficit-hyperactivity disorder?", J Child Psychol Psychiatry, 34, pp.1217~1239 (1993)
