Hiccup Due to Aripiprazole Plus Methylphenidate Treatment in an Adolescent with Attention Deficit and Hyperactivity Disorder and Conduct Disorder: A Case Report
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Our case had hiccups arising in an adolescent with the attention deficit and hyperactivity disorder (ADHD) and conduct disorder (CD) after adding aripiprazole treatment to extended-release methylphenidate. Actually, antipsychotics are also used in the treatment of hiccups, but studies suggest that they can cause hiccups as well. Within 12 hours of taking 2.5 mg aripiprazole added to extended-release methylphenidate at a dose of 54 mg/day, 16-year-old boy began having hiccups in the morning, which lasted after 3-4 hours. As a result, aripiprazole was discontinued and methylphenidate was continued alone because we could not convince the patient to use another additional drug due to this side effect. Subsequently, when his behavior got worsened day by day, his mother administered aripiprazole alone again at the dose of 2.5 mg/day at the weekend and continued treatment because hiccup did not occur again. But when it was administered with methylphenidate on Monday, hiccup started again next morning and lasted one hour at this time. In conclusion, we concluded that concurrent use of methylphenidate and aripiprazole in this adolescent led to hiccups.
Abstract
Our case had hiccups arising in an adolescent with the attention deficit and hyperactivity disorder (ADHD) and conduct disorder (CD) after adding aripiprazole treatment to extended-release methylphenidate. Actually, antipsychotics are also used in the treatment of hiccups, but studies suggest that they can cause hiccups as well. Within 12 hours of taking 2.5 mg aripiprazole added to extended-release methylphenidate at a dose of 54 mg/day, 16-year-old boy began having hiccups in the morning, which lasted after 3-4 hours. As a result, aripiprazole was discontinued and methylphenidate was continued alone because we could not convince the patient to use another additional drug due to this side effect. Subsequently, when his behavior got worsened day by day, his mother administered aripiprazole alone again at the dose of 2.5 mg/day at the weekend and continued treatment because hiccup did not occur again. But when it was administered with methylphenidate on Monday, hiccup started again next morning and lasted one hour at this time. In conclusion, we concluded that concurrent use of methylphenidate and aripiprazole in this adolescent led to hiccups.
참고문헌 (13)
- Full-Young Chang, "Hiccup: Mystery, Nature and Treatment", Journal of Neurogastroenterology and Motility (JNM), 18(2), pp.123~130 (2012), 대한소화기 기능성질환∙운동학회
- Hori H, "Hiccups associated with switching from olanzapine to aripiprazole in a patient with paranoid schizophrenia", Clin Neuropharmacol, 37, pp.88~89 (2014)
- Kutuk MO, "Persistent hiccups due to aripiprazole in an adolescent with obsessive compulsive disorder responding to dose reduction and rechallenge", Oxf Med Case Reports, 2016, pp.66~67 (2016)
- American Psychiatric Association, "Diagnostic and Statistical Manual of Mental Disorders" (2013), American Psychiatric Publishing
- Naranjo CA, "A method for estimating the probability of adverse drug reactions", Clin Pharmacol Ther, 30, pp.239~245 (1981)
- Nevels RM, "Psychopharmacology of aggression in children and adolescents with primary neuropsychiatric disorders : a review of current and potentially promising treatment options", Exp Clin Psychopharmacol, 18, pp.184~201 (2010)
- Nevels RM, "Methylphenidate and its under-recognized, under-explained, and serious drug interactions: a review of the literature with heightened concerns", German J Psychiatry, 16, pp.29~42 (2013)
- GBR-12935 : a specific high affinity ligand for labeling the dopamine transport complex, "Eur J Pharmacol", 1985, 289~290
- Wall SC, "Biogenic amine flux mediated by cloned transporters stably expressed in cultured cell lines : amphetamine specificity for inhibition and efflux", Mol Pharmacol, 47, pp.544~550 (1995)
- Maréchal R, "Successful treatment of intractable hiccup with methylphenidate in a lung cancer patient", Support Care Cancer, 11, pp.126~128 (2003)
- Gregory GA, "Methylphenidate for the treatment of hiccups during anesthesia", Anesthesiology, 31, pp.89~90 (1969)
- Tiwari AK, "Pharmacogenetics of anxiolytic drugs", J Neural Transm(Vienna), 116, pp.667~677 (2009)
- Müller DJ, "Towards the implementation of CYP2D6 and CYP2C19 genotypes in clinical practice : update and report from a pharmacogenetic service clinic", Int Rev Psychiatry, 25, pp.554~571 (2013)