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Recent Advances in the Pharmacology of Tardive Dyskinesia

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Tardive dyskinesia (TD) is a syndrome of abnormal involuntary movements that follows treatment with dopamine D2-receptor antagonists. Recent approval of vesicular monoamine transporter-2 (VMAT2) inhibitors offers hope for reducing the impact of TD. Although these drugs represent a significant advance in patient care and a practical step forward in providing relief for patients with TD, understanding of the pharmacology of TD that could inform future research to prevent and reverse TD remains incomplete. This review surveys evidence for the effectiveness of VMAT2 inhibitors and other agents in the context of theories of pathogenesis of TD. In patients for whom VMAT2 inhibitors are ineffective or intolerable, as well as for extending therapeutic options and insights regarding underlying mechanisms, a review of clinical trial results examined as experimental tests of etiologic hypotheses is worthwhile. There are still compelling reasons for further investigations of the pharmacology of TD, which could generate alternative preventive and potentially curative treatments. Finally, benefits from novel drugs are best realized within an overall treatment strategy addressing the condition and needs of individual patients.

Abstract

Tardive dyskinesia (TD) is a syndrome of abnormal involuntary movements that follows treatment with dopamine D2-receptor antagonists. Recent approval of vesicular monoamine transporter-2 (VMAT2) inhibitors offers hope for reducing the impact of TD. Although these drugs represent a significant advance in patient care and a practical step forward in providing relief for patients with TD, understanding of the pharmacology of TD that could inform future research to prevent and reverse TD remains incomplete. This review surveys evidence for the effectiveness of VMAT2 inhibitors and other agents in the context of theories of pathogenesis of TD. In patients for whom VMAT2 inhibitors are ineffective or intolerable, as well as for extending therapeutic options and insights regarding underlying mechanisms, a review of clinical trial results examined as experimental tests of etiologic hypotheses is worthwhile. There are still compelling reasons for further investigations of the pharmacology of TD, which could generate alternative preventive and potentially curative treatments. Finally, benefits from novel drugs are best realized within an overall treatment strategy addressing the condition and needs of individual patients.

참고문헌 (126)

  1. Cunningham Owens DG, "A guide to the extrapyramidal side-effects of antipsychotic drugs" (2014), Cambridge University Press
  2. Factor SA, "Drug induced movement disorders" (2005), USA Blackwell Publishing
  3. Waln O, "An update on tardive dyskinesia: from phenomenology to treatment", Tremor Other Hyperkinet Mov (N Y), 3 (2013)
  4. Caroff SN, "Drug-induced extrapyramidal syndromes : implications for contemporary practice", Psychiatr Clin North Am, 39, pp.391~411 (2016)
  5. Carbon M, "Tardive dyskinesia prevalence in the period of second-generation antipsychotic use : a meta-analysis", J Clin Psychiatry, 78, pp.e264~e278 (2017)
  6. Carbon M, "Tardive dyskinesia risk with first-and second-generation antipsychotics in comparative randomized controlled trials : a meta-analysis", World Psychiatry, 17, pp.330~340 (2018)
  7. Woods SW, "Incidence of tardive dyskinesia with atypical versus conventional antipsychotic medications: a prospective cohort study", J Clin Psychiatry, 71, pp.463~474 (2010)
  8. Factor SA, "Recent developments in drug-induced movement disorders : a mixed picture", Lancet Neurol, 18, pp.880~890 (2019)
  9. Stegmayer K, "Tardive dyskinesia associated with atypical antipsychotics : prevalence, mechanisms and management strategies", CNS Drugs, 32, pp.135~147 (2018)
  10. Achalia RM, "Prevalence and risk factors associated with tardive dyskinesia among Indian patients with schizophrenia", Asian J Psychiatr, 9, pp.31~35 (2014)
  11. Ryu S, "Tardive dyskinesia and tardive dystonia with second-generation antipsychotics in non-elderly schizophrenic patients unexposed to first-generation antipsychotics : a cross-sectional and retrospective study", J Clin Psychopharmacol, 35, pp.13~21 (2015)
  12. Caroff SN, "Cumulative burden of illness in veterans with tardive dyskinesia and serious mental disorders", J Clin Psychopharmacol, 40, pp.38~45 (2020)
  13. Caroff SN, "RE-KINECT : a prospective study of the presence and healthcare burden of tardive dyskinesia in clinical practice settings", J Clin Psychopharmacol, 40, pp.259~268 (2020)
  14. Caroff SN, "Historical perspectives on tardive dyskinesia", J Neurol Sci, 389, pp.4~9 (2018)
  15. Caroff SN, "Awareness and impact of possible tar-dive dyskinesia by primary psychiatric diagnosis in patients prescribed antipsychotics: results from the RE-KINECT study", Academy of Managed Care Pharmacy (AMCP)Nexus 2018 (2018)
  16. Caroff SN, "A modified Delphi consensus study of the screening, diagnosis, and treatment of tardive dyskinesia", J Clin Psychiatry, 81, pp.19cs12983~ (2020)
  17. Caroff SN, "Overcoming barriers to effective management of tardive dyskinesia", Neuropsychiatr Dis Treat, 15, pp.785~794 (2019)
  18. Caroff SN, "Pharmacological treatment of tardive dyskinesia : recent developments", Expert Rev Neurother, 17, pp.871~881 (2017)
  19. Caroff SN, "Correlates of the abnormal involuntary movement scale in veterans with tardive dyskinesia", J Clin Psychopharmacol, 40, pp.373~380 (2020)
  20. Kane JM, "Revisiting the abnormal involuntary movement scale: proceedings from the tardive dyskinesia assessment workshop", J Clin Psychiatry, 79, pp.17cs11959~ (2018)
  21. Jeste DV, "Tardive dyskinesia and neuroleptics: from dogma to reason", pp.15~32 (1986), American Psychiatric Press
  22. Margolese HC, "Tardive dyskinesia in the era of typical and atypical antipsychotics. Part 1: pathophysiology and mechanisms of induction", Can J Psychiatry, 50, pp.541~547 (2005)
  23. Teo JT, "Tardive dyskinesia is caused by maladaptive synaptic plasticity : a hypothesis", Mov Disord, 27, pp.1205~1215 (2012)
  24. Loonen AJ, "New insights into the mechanism of drug-induced dyskinesia", CNS Spectr, 18, pp.15~20 (2013)
  25. Hyde TM, "Drug induced movement disorders", pp.213~256 (2005), Blackwell Publishing
  26. Witter DP, "Pharmacotherapy for the treatment of tardive dyskinesia in schizophrenia patients", Expert Opin Pharmacother, 18, pp.965~972 (2017)
  27. Bhidayasiri R, "Evidence-based guideline : treatment of tardive syndromes : report of the guideline development subcommittee of the American Academy of Neurology", Neurology, 81, pp.463~469 (2013)
  28. Bhidayasiri R, "Updating the recommendations for treatment of tardive syndromes : a systematic review of new evidence and practical treatment algorithm", J Neurol Sci, 389, pp.67~75 (2018)
  29. Soares-Weiser K, "Tardive dyskinesia", Semin Neurol, 27, pp.159~169 (2007)
  30. Soares-Weiser K, "Miscellaneous treatments for antipsychotic-induced tardive dyskinesia", Cochrane Database Syst Rev, 3, pp.CD000208~ (2018)
  31. Margolius A, "Current treatment of tardive dyskinesia", Parkinsonism Relat Disord, 59, pp.155~160 (2019)
  32. Lehman AF, "Practice guideline for the treatment of patients with schizophrenia, second edition", Am J Psychiatry, 161(2 Suppl), pp.1~56 (2004)
  33. Meyer JM, "Future directions in tardive dyskinesia research", J Neurol Sci, 389, pp.76~80 (2018)
  34. Seeman P, "Psychosis pathways converge via D2high dopamine receptors", Synapse, 60, pp.319~346 (2006)
  35. Kostrzewa RM, "Lifelong rodent model of tardive dyskinesia-persistence after antipsychotic drug withdrawal", Curr Top Behav Neurosci, 29, pp.353~362 (2016)
  36. Moore KE, "Dyskinesia : animal experimental correlates", Acta Psychiatr Scand, 63(291 Suppl), pp.88~102 (1981)
  37. Klawans HL Jr, "The pharmacology of tardive dyskinesias", Am J Psychiatry, 130, pp.82~86 (1973)
  38. D’Abreu A, "Tardive dyskinesia-like syndrome due to drugs that do not block dopamine receptors: rare or non-existent: literature review", Tremor Other Hyperkinet Mov(N Y), 8, pp.570~ (2018)
  39. Hernandez G, "Tardive dyskinesia is associated with altered putamen Akt", GSK-3β signaling in nonhuman primates, 2019, pp.34, 717~726
  40. Mahmoudi S, "Upregulation of dopamine D3, not D2, receptors correlates with tardive dyskinesia in a primate model", Mov Disord, 29, pp.1125~1133 (2014)
  41. Jiang LH, "One year of continuous treatment with haloperidol or clozapine fails to induce a hypersensitive response of caudate putamen neurons to dopamine D1 and D2 receptor agonists", J Pharmacol Exp Ther, 253, pp.1198~1205 (1990)
  42. Soares KV, "The treatment of tardive dyskinesia--a systematic review and meta-analysis", Schizophr Res, 39, pp.1~16 (1999)
  43. El-Sayeh HG, "Non-antipsychotic catecholaminergic drugs for antipsychotic-induced tardive dyskinesia", Cochrane Database Syst Rev, 1, pp.CD000458~ (2018)
  44. Chan CH, "Switching antipsychotic treatment to aripiprazole in psychotic patients with neuroleptic-induced tardive dyskinesia : a 24-week follow-up study", Int Clin Psychopharmacol, 33, pp.155~162 (2018)
  45. Mentzel CL, "Effect of antipsychotic type and dose changes on tardive dyskinesia and parkinsonism severity in patients with a serious mental illness : the Curaçao extrapyramidal syndromes study XII", J Clin Psychiatry, 78, pp.e279~e285 (2017)
  46. Lin CC, "Non-VMAT2 inhibitor treatments for the treatment of tardive dyskinesia", J Neurol Sci, 389, pp.48~54 (2018)
  47. Caroff SN, "Treatment outcomes of patients with tardive dyskinesia and chronic schizophrenia", J Clin Psychiatry, 72, pp.295~303 (2011)
  48. Fernandez HH, "The course of tardive dyskinesia and parkinsonism in psychiatric inpatients : 14-year follow-up", Neurology, 56, pp.805~807 (2001)
  49. Turek I, "Tardive dyskinesia : its relation to neuroleptic and antiparkinson drugs", Br J Psychiatry, 121, pp.605~612 (1972)
  50. Kane JM, "Tardive dyskinesia : prevalence, incidence, and risk factors", J Clin Psychopharmacol, 8(4 Suppl), pp.52S~56S (1988)
  51. Gilbert PL, "Neuroleptic withdrawal in schizophrenic patients. A review of the literature", Arch Gen Psychiatry, 52, pp.173~188 (1995)
  52. Bergman H, "Systematic review of interventions for treating or preventing antipsychotic-induced tardive dyskinesia", Health Technol Assess, 21, pp.1~218 (2017)
  53. Casey DE, "Tardive dyskinesia and neuroleptics: from dogma to reason", pp.76~97 (1986), American Psychiatric Press
  54. Glazer WM, "A discontinuation study", Arch Gen Psychiatry, 41, pp.623~627 (1984)
  55. Zutshi D, "Tardive syndromes are rarely reversible after discontinuing dopamine receptor blocking agents: experience from a university-based movement disorder clinic", Tremor Other Hyperkinet Mov (N Y), 4, pp.266~ (2014)
  56. Bergman H, "Antipsychotic reduction and", or cessation and antipsychotics as specific treatments for tardive dyskinesia, 2018, pp.2, CD000459~
  57. Quitkin F, "Tardive dyskinesia:are first signs reversible?", Am J Psychiatry, 134, pp.84~87 (1977)
  58. Jeste DV, "Tardive dyskinesia--reversible and persistent", Arch Gen Psychiatry, 36, pp.585~590 (1979)
  59. Kane JM, "Tardive dyskinesia : a task force report of the American Psychiatric Association" (1992), American Psychiatric Association
  60. Kane JM, "Tardive dyskinesia and neuroleptics: from dogma to reason", pp.100~107 (1986), American Psychiatric Press
  61. Caroff SN, "Hospital utilization rates following antipsychotic dose reductions : implications for tardive dyskinesia", BMC Psychiatry, 18, pp.306~ (2018)
  62. Caroff SN, "Hospital utilization rates following antipsychotic dose reduction in mood disorders : implications for treatment of tardive dyskinesia", BMC Psychiatry, 20, pp.365~ (2020)
  63. Egan MF, "Treatment of tardive dyskinesia", Schizophr Bull, 23, pp.583~609 (1997)
  64. Kazamatsuri H, "Long-term treatment of tardive dyskinesia with haloperidol and tetrabenazine", Am J Psychiatry, 130, pp.479~483 (1973)
  65. Mentzel TQ, "Clozapine monotherapy as a treatment for antipsychotic-induced tardive dyskinesia : a meta-analysis", J Clin Psychiatry, 79, pp.17r11852~ (2018)
  66. Tarsy D, "Effects of newer antipsychotics on extrapyramidal function", CNS Drugs, 16, pp.23~45 (2002)
  67. Tenback DE, "Effects of antipsychotic treatment on tardive dyskinesia : a 6-month evaluation of patients from the European Schizophrenia Outpatient Health Outcomes(SOHO)study", J Clin Psychiatry, 66, pp.1130~1133 (2005)
  68. Jankovic J, "Dopamine depleters in the treatment of hyperkinetic movement disorders", Expert Opin Pharmacother, 17, pp.2461~2470 (2016)
  69. Citrome L, "Tardive dyskinesia : placing vesicular monoamine transporter type 2(VMAT2)inhibitors into clinical perspective", Expert Rev Neurother, 18, pp.323~332 (2018)
  70. Meyer JM, "Forgotten but not gone : new developments in the understanding and treatment of tardive dyskinesia", CNS Spectr, 21(1 Suppl), pp.13~24 (2016)
  71. Scorr LM, "VMAT2 inhibitors for the treatment of tardive dyskinesia", J Neurol Sci, 389, pp.43~47 (2018)
  72. Solmi M, "Treatment of tardive dyskinesia with VMAT-2 inhibitors : a systematic review and meta-analysis of randomized controlled trials", Drug Des Devel Ther, 12, pp.1215~1238 (2018)
  73. Caroff SN, "Treatment of tardive dyskinesia with tetrabenazine or valbenazine : a systematic review", J Comp Eff Res, 7, pp.135~148 (2018)
  74. Leung JG, "Tetrabenazine for the treatment of tardive dyskinesia", Ann Pharmacother, 45, pp.525~531 (2011)
  75. Citrome L, "Valbenazine for tardive dyskinesia: a systematic review of the efficacy and safety profile for this newly approved novel medication-what is the number needed to treat, number needed to harm and likelihood to be helped or harmed?", Int J Clin Pract, 71, pp.e12964~ (2017)
  76. O’Brien CF, "NBI-98854, a selective monoamine transport inhibitor for the treatment of tardive dyskinesia : a randomized, double-blind, placebo-controlled study", Mov Disord, 30, pp.1681~1687 (2015)
  77. Hauser RA, "KINECT 3 : a phase 3 randomized, double-blind, placebo-controlled trial of valbenazine for tardive dyskinesia", Am J Psychiatry, 174, pp.476~484 (2017)
  78. Factor SA, "The effects of valbenazine in participants with tardive dyskinesia : results of the 1-year KINECT 3 extension study", J Clin Psychiatry, 78, pp.1344~1350 (2017)
  79. Caroff S, "Characteristics of patients with tardive dyskinesia who maintain treatment response after discontinuing long-term valbenazine: pooled analysis of two trials", ACNP 57th Annual Meeting (2018)
  80. Citrome L, "Deutetrabenazine for tardive dyskinesia: a systematic review of the efficacy and safety profile for this newly approved novel medication-what is the number needed to treat, number needed to harm and likelihood to be helped or harmed?", Int J Clin Pract, 71, pp.e13030~ (2017)
  81. Fernandez HH, "Randomized controlled trial of deutetrabenazine for tardive dyskinesia : the ARM-TD study", Neurology, 88, pp.2003~2010 (2017)
  82. Anderson KE, "Deutetrabenazine for treatment of involuntary movements in patients with tardive dyskinesia(AIM-TD) : a double-blind, randomised, placebo-controlled, phase 3 trial", Lancet Psychiatry, 4, pp.595~604 (2017)
  83. Anderson KE, "Deutetrabenazine for the treatment of tardive dyskinesia: results from an open-label, long-term study", American Psychiatric Association (APA) 2017 Annual Meeting (2017)
  84. Mandel RJ, "A quantitative estimate of the role of striatal D-2 receptor proliferation in dopaminergic behavioral supersensitivity : the contribution of mesolimbic dopamine to the magnitude of 6-OHDA lesion-induced agonist sensitivity in the rat", Behav Brain Res, 59, pp.53~64 (1993)
  85. Moy SS, "Differential effects of bilateral dopamine depletion in neonatal and adult rats", Neurosci Biobehav Rev, 21, pp.425~435 (1997)
  86. Borgkvist A, "Synaptic plasticity may underlie l-DOPA induced dyskinesia", Curr Opin Neurobiol, 48, pp.71~78 (2018)
  87. Stanley N. Caroff, "Risk of Neuroleptic Malignant Syndrome with Vesicular Monoamine Transporter Inhibitors", Clinical Psychopharmacology and Neuroscience, 18(2), pp.322~326 (2020), 대한정신약물학회[DOI]
  88. Gunne LM, "An animal model for coexisting tardive dyskinesia and tardive parkinsonism : a glutamate hypothesis for tardive dyskinesia", Clin Neuropharmacol, 16, pp.90~95 (1993)
  89. Andreassen OA, "Inhibition by memantine of the development of persistent oral dyskinesias induced by long-term haloperidol treatment of rats", Br J Pharmacol, 119, pp.751~757 (1996)
  90. Oertel W, "Randomized, placebo-controlled trial of ADS-5102(amantadine)extended-release capsules for levodopa-induced dyskinesia in Parkinson’s disease(EASE LID 3)", Mov Disord, 32, pp.1701~1709 (2017)
  91. Paik J, "Amantadine extended-release(GOCOVRITM) : a review in levodopa-induced dyskinesia in Parkinson’s disease", CNS Drugs, 32, pp.797~806 (2018)
  92. Caroff SN, "Revisiting amantadine as a treatment for drug-induced movement disorders", Ann Clin Psychiatry, 32, pp.198~208 (2020)
  93. Kornhuber J, "Amantadine and memantine are NMDA receptor antagonists with neuroprotective properties", J Neural Transm, 43(Suppl), pp.91~104 (1994)
  94. Greenamyre JT, "N-methyl-D-aspartate antagonists in the treatment of Parkinson’s disease", Arch Neurol, 48, pp.977~981 (1991)
  95. Stoof JC, "The anti-parkinsonian drug amantadine inhibits the N-methyl-D-aspartic acidevoked release of acetylcholine from rat neostriatum in a non-competitive way", Eur J Pharmacol, 213, pp.439~443 (1992)
  96. Perez-Lloret S, "Efficacy and safety of amantadine for the treatment of L-DOPA-induced dyskinesia", J Neural Transm(Vienna), 125, pp.1237~1250 (2018)
  97. Vale S, "Amantadine for dyskinesia tarda", N Engl J Med, 284, pp.673~ (1971)
  98. Allen RM, "Palliative treatment of tardive dyskinesia with combination of amantadine-neuroleptic administration", Biol Psychiatry, 17, pp.719~727 (1982)
  99. Crane GE, "More on amantadine in tardive dyskinesia", N Engl J Med, 285, pp.1150~1151 (1971)
  100. Angus S, "A controlled trial of amantadine hydrochloride and neuroleptics in the treatment of tardive dyskinesia", J Clin Psychopharmacol, 17, pp.88~91 (1997)
  101. Pappa S, "Effects of amantadine on tardive dyskinesia : a randomized, double-blind, placebo-controlled study", Clin Neuropharmacol, 33, pp.271~275 (2010)
  102. van Harten PN, "The inter-relationships of tardive dyskinesia, parkinsonism, akathisia and tardive dystonia : the Curaçao extrapyramidal syndromes study II", Schizophr Res, 26, pp.235~242 (1997)
  103. Ward KM, "Antipsychotic-related movement disorders:drug-induced parkinsonism vs. tardive dyskinesiakey differences in pathophysiology and clinical management", Neurol Ther, 7, pp.233~248 (2018)
  104. Miller R, "Loss of striatal cholinergic neurons as a basis for tardive and L-dopa-induced dyskinesias, neuroleptic-induced supersensitivity psychosis and refractory schizophrenia", Biol Psychiatry, 34, pp.713~738 (1993)
  105. Conti MM, "A new outlook on cholinergic interneurons in Parkinson’s disease and L-DOPA-induced dyskinesia", Neurosci Biobehav Rev, 92, pp.67~82 (2018)
  106. Bergman H, "Anticholinergic medication for antipsychotic-induced tardive dyskinesia", Cochrane Database Syst Rev, 1, pp.CD000204~ (2018)
  107. Caroff SN, "Treatment of tardive dyskinesia with donepezil : a pilot study", J Clin Psychiatry, 62, pp.772~775 (2001)
  108. Caroff SN, "Treatment of tardive dyskinesia with galantamine : a randomized controlled crossover trial", J Clin Psychiatry, 68, pp.410~415 (2007)
  109. Tammenmaa-Aho I, "Cholinergic medication for antipsychotic-induced tardive dyskinesia", Cochrane Database Syst Rev, 3, pp.CD000207~ (2018)
  110. Shen W, "M4 muscarinic receptor signaling ameliorates striatal plasticity deficits in models of L-DOPA-induced dyskinesia", Neuron, 88, pp.762~773 (2015)
  111. Quik M, "Potential therapeutic application for nicotinic receptor drugs in movement disorders", Nicotine Tob Res, 21, pp.357~369 (2019)
  112. Bonsi P, "Centrality of striatal cholinergic transmission in Basal Ganglia function", Front Neuroanat, 5, pp.6~ (2011)
  113. Chambers NE, "Effects of muscarinic acetylcholine m1 and m4 receptor blockade on dyskinesia in the hemi-parkinsonian rat", Neuroscience, 409, pp.180~194 (2019)
  114. Bordia T, "Varenicline is a potent partial agonist at α6β2* nicotinic acetylcholine receptors in rat and monkey striatum", J Pharmacol Exp Ther, 342, pp.327~334 (2012)
  115. Quik M, "Nicotine and nicotinic receptor drugs : potential for Parkinson’s disease and drug-induced movement disorders", Int Rev Neurobiol, 124, pp.247~271 (2015)
  116. Bordia T, "Nicotine reduces antipsychotic-induced orofacial dyskinesia in rats", J Pharmacol Exp Ther, 340, pp.612~619 (2012)
  117. Stanley N. Caroff, "Effect of Varenicline on Tardive Dyskinesia: A Pilot Study", Clinical Psychopharmacology and Neuroscience, 19(2), pp.355~360 (2021), 대한정신약물학회[DOI]
  118. Alabed S, "Gammaaminobutyric acid agonists for antipsychotic-induced tardive dyskinesia", Cochrane Database Syst Rev, 4, pp.CD000203~ (2018)
  119. Bergman H, "Benzodiazepines for antipsychotic-induced tardive dyskinesia", Cochrane Database Syst Rev, 1, pp.CD000205~ (2018)
  120. Woods SW, "Effects of levetiracetam on tardive dyskinesia : a randomized, double-blind, placebo-controlled study", J Clin Psychiatry, 69, pp.546~554 (2008)
  121. Lister J, "Lipoic acid and haloperidol-induced vacuous chewing movements : Implications for prophylactic antioxidant use in tardive dyskinesia", Prog Neuropsychopharmacol Biol Psychiatry, 72, pp.23~29 (2017)
  122. Adelufosi AO, "Pyridoxal 5 phosphate for neuroleptic-induced tardive dyskinesia", Cochrane Database Syst Rev, (4), pp.CD010501~ (2015)
  123. Zheng W, "Extract of Ginkgo biloba for tardive dyskinesia : metaanalysis of randomized controlled trials", Pharmacopsychiatry, 49, pp.107~111 (2016)
  124. Soares-Weiser K, "Vitamin E for antipsychotic-induced tardive dyskinesia", Cochrane Database Syst Rev, 1, pp.CD000209~ (2018)
  125. Hatcher-Martin JM, "Propranolol therapy for tardive dyskinesia : a retrospective examination", Parkinsonism Relat Disord, 32, pp.124~126 (2016)
  126. Salem H, "Revisiting antipsychotic-induced akathisia : current issues and prospective challenges", Curr Neuropharmacol, 15, pp.789~798 (2017)

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