A Practical Utility and Benefit of Pharmacogenetic-based Antidepressant Treatment Strategy for Major Depressive Disorder Patients with Difficult-to-treat
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Objective: We report the results of pharmacogenomics-based antidepressant treatment (PGXt) results in treating treatment- resistant major depressive disorder (TRD) patients in real practice. Methods: Nine patients were prescribed NeuropharmagenⓇ for selection of antidepressants for individual patient and their clinical outcomes were followed. Results: After treatment by PGXt results from current antidepressants, substantial reduction of depressive symptoms was observed at some point and maintained during observation period in six patients. Conclusion: Our case series potentially shows the clinical utility and benefit of PGXt for treatment of TRD patients.
Abstract
Objective: We report the results of pharmacogenomics-based antidepressant treatment (PGXt) results in treating treatment- resistant major depressive disorder (TRD) patients in real practice. Methods: Nine patients were prescribed NeuropharmagenⓇ for selection of antidepressants for individual patient and their clinical outcomes were followed. Results: After treatment by PGXt results from current antidepressants, substantial reduction of depressive symptoms was observed at some point and maintained during observation period in six patients. Conclusion: Our case series potentially shows the clinical utility and benefit of PGXt for treatment of TRD patients.
참고문헌 (25)
- Changsu Han, "A Pharmacogenomic-based Antidepressant Treatment for Patients with Major Depressive Disorder: Results from an 8-week, Randomized, Single-blinded Clinical Trial", Clinical Psychopharmacology and Neuroscience, 16(4), pp.469~480 (2018), 대한정신약물학회[DOI]
- Peterson JF, "Attitudes of clinicians following large-scale pharmacogenomics implementation", Pharmacogenomics J, 16, pp.393~398 (2016)
- Salm M, "Use of genetic tests among neurologists and psychiatrists : knowledge, attitudes, behaviors, and needs for training", J Genet Couns, 23, pp.156~163 (2014)
- Pérez V, "Efficacy of prospective pharmacogenetic testing in the treatment of major depressive disorder : results of a randomized, double-blind clinical trial", BMC Psychiatry, 17, pp.250~ (2017)
- Espadaler J, "Pharmacogenetic testing for the guidance of psychiatric treatment : a multicenter retrospective analysis", CNS Spectr, 22, pp.315~324 (2017)
- Bradley P, "Improved efficacy with targeted pharmacogenetic-guided treatment of patients with depression and anxiety : a randomized clinical trial demonstrating clinical utility", J Psychiatr Res, 96, pp.100~107 (2018)
- Hall-Flavin DK, "Using a pharmacogenomic algorithm to guide the treatment of depression", Transl Psychiatry, 2, pp.e172~ (2012)
- Winner JG, "A prospective, randomized, double-blind study assessing the clinical impact of integrated pharmacogenomic testing for major depressive disorder", Discov Med, 16, pp.219~227 (2013)
- Bousman CA, "Concordance between actual and pharmacogenetic predicted desvenlafaxine dose needed to achieve remission in major depressive disorder : a 10-week open-label study", Pharmacogenet Genomics, 27, pp.1~6 (2017)
- Ajeet B. Singh, "Improved Antidepressant Remission in Major Depression via a Pharmacokinetic Pathway Polygene Pharmacogenetic Report", Clinical Psychopharmacology and Neuroscience, 13(2), pp.150~156 (2015), 대한정신약물학회
- Hall-Flavin DK, "Utility of integrated pharmacogenomic testing to support the treatment of major depressive disorder in a psychiatric outpatient setting", Pharmacogenet Genomics, 23, pp.535~548 (2013)
- Brennan FX, "A naturalistic study of the effectiveness of pharmacogenetic testing to guide treatment in psychiatric patients with mood and anxiety disorders", Prim Care Companion CNS Disord, 17, pp.e1~ (2015)
- Rosenblat JD, "The effect of pharmacogenomic testing on response and remission rates in the acute treatment of major depressive disorder : a meta-analysis", J Affect Disord, 241, pp.484~491 (2018)
- Fabbri C, "Pharmacogenetic tests to guide drug treatment in depression : comparison of the available testing kits and clinical trials", Prog Neuropsychopharmacol Biol Psychiatry, 86, pp.36~44 (2018)
- Fabbri C, "Progress and prospects in pharmacogenetics of antidepressant drugs", Expert Opin Drug Metab Toxicol, 12, pp.1157~1168 (2016)
- Nassan M, "Pharmacokinetic pharmacogenetic prescribing guidelines for antidepressants : a template for psychiatric precision medicine", Mayo Clin Proc, 91, pp.897~907 (2016)
- de Leon J, "Clinical guidelines for psychiatrists for the use of pharmacogenetic testing for CYP450 2D6 and CYP450 2C19", Psychosomatics, 47, pp.75~85 (2006)
- Kennedy SH, "Clinical guidelines for the treatment of depressive disorders. IV. medications and other biological treatments", Can J Psychiatry, 46(Suppl 1), pp.38S~58S (2001)
- Anderson IM, "Evidence-based guidelines for treating depressive disorders with antidepressants : a revision of the 2000British Association for Psychopharmacology guidelines", J Psychopharmacol, 22, pp.343~396 (2008)
- Bauer M, "World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Unipolar Depressive Disorders, part 1: update 2013 on the acute and continuation treatment of unipolar depressive disorders", World J Biol Psychiatry, 14, pp.334~385 (2013)
- Patkar AA, "Atypical antipsychotic augmentation strategies in the context of guideline-based care for the treatment of major depressive disorder", CNS Drugs, 27(Suppl 1), pp.S29~S37 (2013)
- Wang SM, "Criticisms of drugs in early development for the treatment of depression: what can be improved?", Expert Opin Investig Drugs, 24, pp.445~453 (2015)
- Hee Ryung Wang, "Korean Medication Algorithm for Depressive Disorder: Comparisons with Other Treatment Guidelines", Clinical Psychopharmacology and Neuroscience, 15(3), pp.199~209 (2017), 대한정신약물학회[DOI]
- Alessandro Serretti, "The Present and Future of Precision Medicine in Psychiatry: Focus on Clinical Psychopharmacology of Antidepressants", Clinical Psychopharmacology and Neuroscience, 16(1), pp.1~6 (2018), 대한정신약물학회[DOI]
- Changsu Han, "The Potential Utility of Aripiprazole Augmentation for Major Depressive Disorder with Mixed Features Specifier: A Retrospective Study", Clinical Psychopharmacology and Neuroscience, 17(4), pp.495~502 (2019), 대한정신약물학회[DOI]
