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The Relationship between Depression Severity and Prefrontal Hemodynamic Changes in Adolescents with Major Depression Disorder: A Functional Near-infrared Spectroscopy Study

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Objective: Numerous studies have identified hemodynamic changes in adults with major depressive disorder (MDD) by using functional near-infrared spectroscopy (fNIRS). However, studies on adolescents with MDD are limited. As adolescence is a stage of rapid brain development, differences may occur depending on age. This study used fNIRS as an objective tool to investigate hemodynamic changes in the frontal lobe according to depression severity and age in adolescents with MDD. Methods: Thirty adolescents (12 aged 12−15 years and 18 aged 16−18 years) were retrospectively investigated. The Children’s Depression Inventory was used as a psychiatric evaluation scale, fNIRS was used as an objective brain function evaluation tool, and the Verbal Fluency Test was performed. Results: During the Verbal Fluency Test, in the younger MDD group, oxygenated-hemoglobin concentration increased in the right dorsolateral prefrontal cortex region as the severity of depression increased. In the older MDD group, the oxygenated-hemoglobin concentration decreased in the right dorsolateral prefrontal cortex region as the severity of depression increased. Conclusion: These results suggest that fNIRS may be an objective tool for identifying age differences among adolescents with MDD. To generalize the results and verify fNIRS as a potential biomarker tool, follow-up studies with a larger sample group should be conducted.

Abstract

Objective: Numerous studies have identified hemodynamic changes in adults with major depressive disorder (MDD) by using functional near-infrared spectroscopy (fNIRS). However, studies on adolescents with MDD are limited. As adolescence is a stage of rapid brain development, differences may occur depending on age. This study used fNIRS as an objective tool to investigate hemodynamic changes in the frontal lobe according to depression severity and age in adolescents with MDD. Methods: Thirty adolescents (12 aged 12−15 years and 18 aged 16−18 years) were retrospectively investigated. The Children’s Depression Inventory was used as a psychiatric evaluation scale, fNIRS was used as an objective brain function evaluation tool, and the Verbal Fluency Test was performed. Results: During the Verbal Fluency Test, in the younger MDD group, oxygenated-hemoglobin concentration increased in the right dorsolateral prefrontal cortex region as the severity of depression increased. In the older MDD group, the oxygenated-hemoglobin concentration decreased in the right dorsolateral prefrontal cortex region as the severity of depression increased. Conclusion: These results suggest that fNIRS may be an objective tool for identifying age differences among adolescents with MDD. To generalize the results and verify fNIRS as a potential biomarker tool, follow-up studies with a larger sample group should be conducted.

참고문헌 (58)

  1. "World health statistics 2008"[URL]
  2. Ahn DH, "Mental disorders in adolescents", J Korean Med Assoc, 52, pp.745~757 (2009)
  3. Cho SC, "The reliability and validity of diagnostic interview schedule for children version IV-Korean version(DISC-IV)", J Korean Acad Child Adolesc Psychiatry, 18, pp.138~144 (2007)
  4. Lewinsohn PM, "Handbook of depression", pp.541~559 (2002), The Guilford Press
  5. Stolberg RA, "Handbook of depression", pp.581~601 (2002), The Guilford Press
  6. Pfeffer CR, "Suicide in mood disordered children and adolescents", Child Adolesc Psychiatr Clin N Am, 11, pp.639~647 (2002)
  7. Kovacs M, "Suicidal behaviors and childhood-onset depressive disorders : A longitudinal investigation", J Am Acad Child Adolesc Psychiatry, 32, pp.8~20 (1993)
  8. Giedd JN, "The teen brain : Insights from neuroimaging", J Adolesc Health, 42, pp.335~343 (2008)
  9. Martha PM Jr, "Alterations in the pulsatile properties of circulating growth hormone concentrations during puberty in boys", J Clin Endocrinol Metab, 69, pp.563~570 (1989)
  10. Arnold AP, "Organizational and activational effects of sex steroids on brain and behavior : A reanalysis", Horm Behav, 19, pp.469~498 (1985)
  11. Buchanan CM, "Are adolescents the victims of raging hormones : Evidence for activational effects of hormones on moods and behavior at adolescence", Psychol Bull, 111, pp.62~107 (1992)
  12. Charmandari E, "Pediatric stress : hormonal mediators and human development", Horm Res, 59, pp.161~179 (2003)
  13. Dumontheil I, "Adolescent brain development", Curr Opin Behav Sci, 10, pp.39~44 (2016)
  14. Schulz KM, "Back to the future : The organizational-activational hypothesis adapted to puberty and adolescence", Horm Behav, 55, pp.597~604 (2009)
  15. "13-year-old child development milestones: Your child’s growth and development at age 13" (2019)[URL]
  16. Lakhan SE, "Biomarkers in psychiatry : Drawbacks and potential for misuse", Int Arch Med, 3, pp.1~ (2010)
  17. Ghio L, "Duration of untreated illness and outcomes in unipolar depression : A systematic review and meta-analysis", J Affect Disord, 152-154, pp.45~51 (2014)
  18. Baik SY, "Prefrontal asymmetry during cognitive tasks and its relationship with suicide ideation in major depressive disorder : An fNIRS study", Diagnostics(Basel), 9, pp.193~ (2019)
  19. Ho CSH, "Diagnostic and predictive applications of functional near-infrared spectroscopy for major depressive disorder : A systematic review", Front Psychiatry, 11, pp.378~ (2020)
  20. Kim EJ, "The relationship between response-inhibitory event-related potentials and symptoms of attention-deficit", hyperactivity disorder in adult patients with major depressive disorder, 2020, pp.17, 996~1005
  21. Lee YJ, "Associations between the mismatch-negativity potential and symptom severity in medication-naïve children and adolescents with symptoms of attention deficit", hyperactivity disorder, 2020, pp.18, 249~260
  22. Okada G, "Attenuated left prefrontal activation during a verbal fluency task in patients with depression", Neuropsychobiology, 47, pp.21~26 (2003)
  23. Okada G, "Attenuated prefrontal activation during a verbal fluency task in remitted major depression", Psychiatry Clin Neurosci, 63, pp.423~425 (2009)
  24. Suto T, "Multichannel near-infrared spectroscopy in depression and schizophrenia : Cognitive brain activation study", Biol Psychiatry, 55, pp.501~511 (2004)
  25. Drevets WC, "Neuroimaging studies of mood disorders", Biol Psychiatry, 48, pp.813~829 (2000)
  26. Tomioka H, "A longitudinal functional neuroimaging study in medication-naïve depression after antidepressant treatment", PLoS One, 10, pp.e0120828~ (2015)
  27. Uemura K, "Depressive symptoms in older adults are associated with decreased cerebral oxygenation of the prefrontal cortex during a trail-making test", Arch Gerontol Geriatr, 59, pp.422~428 (2014)
  28. Scholkmann F, "A review on continuous wave functional near-infrared spectroscopy and imaging instrumentation and methodology", Neuroimage, 85, pp.6~27 (2014)
  29. Lee SM, "Increased right dorsolateral prefrontal cortex connectivity during emotion recognition task in adolescents with self-injurious behavior : A functional near-infrared spectroscopy study", Psychiatry Investig, 20, pp.137~143 (2023)
  30. Usami M, "Near infrared spectroscopy study of the frontopolar hemodynamic response and depressive mood in children with major depressive disorder : A pilot study", PLoS One, 9, pp.e86290~ (2014)
  31. Miller EK, "An integrative theory of prefrontal cortex function", Annu Rev Neurosci, 24, pp.167~202 (2001)
  32. Asahi S, "Negative correlation between right prefrontal activity during response inhibition and impulsiveness : A fMRI study", Eur Arch Psychiatry Clin Neurosci, 254, pp.245~251 (2004)
  33. Best M, "Evidence for a dysfunctional prefrontal circuit in patients with an impulsive aggressive disorder", Proc Natl Acad Sci U S A, 99, pp.8448~8453 (2002)
  34. Mann JJ, "Toward a clinical model of suicidal behavior in psychiatric patients", Am J Psychiatry, 156, pp.181~189 (1999)
  35. Yamagata B, "Brain functional alterations observed 4-weekly in major depressive disorder following antidepressant treatment", J Affect Disord, 252, pp.25~31 (2019)
  36. Kovacs M, "The children’s depression inventory: A self-rated depression scale for school-aged youngsters", pp.1983
  37. Cho SC, "Development of the Korean form of the Kovacs’Children’s depression inventory", J Korean Neuropsychiatr Assoc, 29, pp.943~956 (1990)
  38. Kim EK, "Factor structure of the Children’s depression inventory(CDI)in children and adolescents", Korean J Clin Psychol, 24, pp.693~707 (2005)
  39. Shuvra LT, "Analysis of hemodynamic response function using fNIRS", 2018 International Conference on Innovation in Engineering and Technology (ICIET), pp.1~6 (2018)
  40. Hong S, "The estimation of activated prefrontal brain area due to the execution of mental tasks using fNIRS", J Biomed Engineer Res, 36, pp.177~182 (2015)
  41. Bunce SC, "Functional near-infrared spectroscopy", IEEE Eng Med Biol Mag, 25, pp.54~62 (2006)
  42. Choi JK, "Time-divided spread-spectrum code-based 400 fW-detectable multichannel fNIRS IC for portable functional brain imaging", IEEE J Solid-State Circuits, 51, pp.484~495 (2016)
  43. Zeger SL, "Longitudinal data analysis for discrete and continuous outcomes", Biometrics, 42, pp.121~130 (1986)
  44. Ganella DE, "Extinction of conditioned fear in adolescents and adults : A human fMRI study", Front Hum Neurosci, 11, pp.647~ (2018)
  45. Noda T, "Frontal and right temporal activations correlate negatively with depression severity during verbal fluency task : A multi-channel near-infrared spectroscopy study", J Psychiatr Res, 46, pp.905~912 (2012)
  46. Pu S, "Suicidal ideation is associated with reduced prefrontal activation during a verbal fluency task in patients with major depressive disorder", J Affect Disord, 181, pp.9~17 (2015)
  47. Papasideris M, "Medial prefrontal brain activity correlates with emerging symptoms of anxiety and depression in late adolescence : A fNIRS study", Dev Psychobiol, 63, pp.e22199~ (2021)
  48. Zhang H, "Near-infrared spectroscopy for examination of prefrontal activation during cognitive tasks in patients with major depressive disorder : A meta-analysis of observational studies", Psychiatry Clin Neurosci, 69, pp.22~33 (2015)
  49. Lee YJ, "Reduced left ventrolateral prefrontal cortex activation during verbal fluency tasks is associated with suicidal ideation severity in medication-naïve young adults with major depressive disorder : A functional near-infrared spectroscopy study", Psychiatry Res Neuroimaging, 312, pp.111288~ (2021)
  50. Steinschneider M, "Handbook of Neuropsychology", pp.239~299 (1992), Elsevier
  51. Campbell IG, "Sex, puberty, and the timing of sleep EEG measured adolescent brain maturation", Proc Natl Acad Sci U S A, 109, pp.5740~5743 (2012)
  52. Enoki H, "P300 of auditory event-related potentials : The effects of development and aging in humans", Jpn J Electroencephalogr Electromyogr, 18, pp.60~67 (1990)
  53. Hirayasu Y, "Sex effects on rate of change of P300 latency with age", Clin Neurophysiol, 111, pp.187~194 (2000)
  54. Polich J, "Meta-analysis of P300 normative aging studies", Psychophysiology, 33, pp.334~353 (1996)
  55. Polich J, "P300 in the evaluation of aging and dementia", Electroencephalogr Clin Neurophysiol Suppl, 42, pp.304~323 (1991)
  56. Patel SH, "Characterization of N200 and P300 : Selected studies of the event-related potential", Int J Med Sci, 2, pp.147~154 (2005)
  57. Pu S, "The relationship between the prefrontal activation during a verbal fluency task and stress-coping style in major depressive disorder : A near-infrared spectroscopy study", J Psychiatr Res, 46, pp.1427~1434 (2012)
  58. Roh SC, "Frontal alpha asymmetry moderated by suicidal ideation in patients with major depressive disorder : A comparison with healthy individuals", Clin Psychopharmacol Neurosci, 18, pp.58~66 (2020)

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