The Loudness Dependence of Auditory Evoked Potentials is associated with the Symptom Severity and Treatment in Boys with Attention Deficit Hyperactivity Disorder
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Objective: The loudness dependence of the auditory evoked potential (LDAEP) is associated with central serotonergic neurotransmission. Recent studies have proposed that LDAEP is also influenced by dopaminergic activity. Evidence shows attention deficit hyperactivity disorder (ADHD) symptoms are associated with dopamine dysfunction. This study aimed to evaluate the relation between ADHD symptoms and LDAEP, as well as medication-mediated changes of LDAEP. Methods: A total of 38 male children (6−12 years old) with ADHD were analyzed in this study. Symptom severity was assessed using the ADHD rating scale (ARS) and the continuous performance test. To determine LDAEP, the auditory event-related potential was evaluated before medication. Changes in LDAEP were measured after 12 weeks of treatment with methylphenidate. Results: The subjects had a mean age of 9.24 ± 1.74 years with an average IQ of 109.4 ± 13.8. Before pharmacological treatment with methylphenidate, LDAEP was positively associated with the ARS score after adjusting for age and IQ (r = 0.592, p = 0.005). LDAEP was correlated with inattention (r = 0.522, p = 0.015) and hyperactivity-impulsivity (r = 0.6, p = 0.004). However, the LDAEP of 15 subjects decreased following methylphenidate treatment (Z = −1.988, p = 0.047). Conclusion: In boys with ADHD, LDAEP appears to be associated with symptom severity. LDAEP showed a significant association with impulsivity and inattention. Importantly, LDAEP was shown to decrease after drug treatment. Our findings support the utility of LDAEP as a noninvasive and clinically useful method to assess symptom severity in children with ADHD.
Abstract
Objective: The loudness dependence of the auditory evoked potential (LDAEP) is associated with central serotonergic neurotransmission. Recent studies have proposed that LDAEP is also influenced by dopaminergic activity. Evidence shows attention deficit hyperactivity disorder (ADHD) symptoms are associated with dopamine dysfunction. This study aimed to evaluate the relation between ADHD symptoms and LDAEP, as well as medication-mediated changes of LDAEP. Methods: A total of 38 male children (6−12 years old) with ADHD were analyzed in this study. Symptom severity was assessed using the ADHD rating scale (ARS) and the continuous performance test. To determine LDAEP, the auditory event-related potential was evaluated before medication. Changes in LDAEP were measured after 12 weeks of treatment with methylphenidate. Results: The subjects had a mean age of 9.24 ± 1.74 years with an average IQ of 109.4 ± 13.8. Before pharmacological treatment with methylphenidate, LDAEP was positively associated with the ARS score after adjusting for age and IQ (r = 0.592, p = 0.005). LDAEP was correlated with inattention (r = 0.522, p = 0.015) and hyperactivity-impulsivity (r = 0.6, p = 0.004). However, the LDAEP of 15 subjects decreased following methylphenidate treatment (Z = −1.988, p = 0.047). Conclusion: In boys with ADHD, LDAEP appears to be associated with symptom severity. LDAEP showed a significant association with impulsivity and inattention. Importantly, LDAEP was shown to decrease after drug treatment. Our findings support the utility of LDAEP as a noninvasive and clinically useful method to assess symptom severity in children with ADHD.
참고문헌 (95)
- Biederman J, "Diagnostic continuity between child and adolescent ADHD : findings from a longitudinal clinical sample", J Am Acad Child Adolesc Psychiatry, 37, pp.305~313 (1998)
- Biederman J, "Attention-deficit", hyperactivity disorder : a life-span perspective, 1998, pp.59(Suppl 7), 4~16
- American Psychiatric Association, "Diagnostic and statistical manual of mental disorders: DSM-IV-TRⓇ" (2000), American Psychiatric Association
- Kooij SJ, "European consensus statement on diagnosis and treatment of adult ADHD : The European Network Adult ADHD", BMC Psychiatry, 10, pp.67~ (2010)
- Matte B, "ADHD in DSM-5 : a field trial in a large, representative sample of 18-to 19-year-old adults", Psychol Med, 45, pp.361~373 (2015)
- Park MH, "Regional brain perfusion before and after treatment with methylphenidate may be associated with the G1287A polymorphism of the norepinephrine transporter gene in children with attention-deficit", hyperactivity disorder, 2012, pp.514, 159~163
- 이일주, "Comparison of Quantitative Electroencephalography between Tic Disorder and Attention-Deficit", Hyperactivity Disorder in Children, 2021, pp.19(4), 739~750[DOI]
- Lee TH, "Effects of ADHD therapeutic agents, methylphenidate and atomoxetine, on hippocampal neurogenesis in the adolescent mouse dentate gyrus", Neurosci Lett, 524, pp.84~88 (2012)
- Durell T, "Atomoxetine treatment for ADHD : younger adults compared with older adults", J Atten Disord, 13, pp.401~406 (2010)
- Mereu M, "Dopamine transporter(DAT)genetic hypofunction in mice produces alterations consistent with ADHD but not schizophrenia or bipolar disorder", Neuropharmacology, 121, pp.179~194 (2017)
- Pribilova N, "Long term pharmacotherapy by methylfenidate or atomoxetine DAT 1 10", 10 ADHD children in correlation with results of the imaging methods, 2016, pp.37, 289~294
- Todd RD, "Collaborative analysis of DRD4 and DAT genotypes in population-defined ADHD subtypes", J Child Psychol Psychiatry, 46, pp.1067~1073 (2005)
- KangSeobOh, "Dopamine Transporter Genotype Influences the Attention Deficit in Korean Boys with ADHD", Yonsei Medical Journal, 44(5), pp.787~792 (2003), 연세대학교의과대학
- Cheon KA, "Association of 4-repeat allele of the dopamine D4 receptor gene exon III polymorphism and response to methylphenidate treatment in Korean ADHD children", Neuropsychopharmacology, 32, pp.1377~1383 (2007)
- Sun Mi Kim, "Effects of Methylphenidate on Somatic Symptoms and Brain Functional Connectivity in Adolescents with Attention Deficit Hyperactivity Disorder: A Pilot Study", Clinical Psychopharmacology and Neuroscience, 20(2), pp.259~270 (2022), 대한정신약물학회[DOI]
- da Silva N Jr, "Attention deficit", hyperactivity disorder : is there a correlation between dopamine transporter density and cerebral blood flow?, 2011, pp.36, 656~660
- Hong SB, "Dopaminergic and noradrenergic gene polymorphisms and response to methylphenidate in Korean children with attention-deficit", hyperactivity disorder : is there an interaction?, 2012, pp.22, 343~352
- Silberstein RB, "First-dose methylphenidate-induced changes in brain functional connectivity are correlated with 3-month attention-deficit", hyperactivity disorder symptom response, 2017, pp.82, 679~686
- Childress AC, "An update on the pharmacokinetic considerations in the treatment of ADHD with long-acting methylphenidate and amphetamine formulations", Expert Opin Drug Metab Toxicol, 15, pp.937~974 (2019)
- Hasler R, "Attention-related EEG markers in adult ADHD", Neuropsychologia, 87, pp.120~133 (2016)
- Chmielewski WX, "Effects of multisensory stimuli on inhibitory control in adolescent ADHD : it is the content of information that matters", Neuroimage Clin, 19, pp.527~537 (2018)
- Gu C, "Neural processing of working memory in adults with ADHD in a visuospatial change detection task with distractors", PeerJ, 6, pp.e5601~ (2018)
- Janssen TWP, "An ERP source imaging study of the oddball task in children with Attention Deficit", Hyperactivity Disorder, 2016, pp.127, 1351~1357
- Raz S, "Behavioral and neural correlates of facial versus nonfacial stimuli processing in adults with ADHD : an ERP study", Neuropsychology, 29, pp.726~738 (2015)
- Grane VA, "Correction: ERP correlates of proactive and reactive cognitive control in treatment-naïve adult ADHD", PLoS One, 11, pp.e0163404~ (2016)
- Chronaki G, "Event-related potentials and emotion processing in child psychopathology", Front Psychol, 7, pp.564~ (2016)
- Cheng CH, "A meta-analysis of mismatch negativity in children with attention deficit-hyperactivity disorders", Neurosci Lett, 612, pp.132~137 (2016)
- Polich J, "Updating P300 : an integrative theory of P3a and P3b", Clin Neurophysiol, 118, pp.2128~2148 (2007)
- Heinrich H, "Attention, cognitive control and motivation in ADHD : linking event-related brain potentials and DNA methylation patterns in boys at early school age", Sci Rep, 7, pp.3823~ (2017)
- Paul-Jordanov I, "Methylphenidate and if-then plans are comparable in modulating the P300 and increasing response inhibition in children with ADHD", Atten Defic Hyperact Disord, 2, pp.115~126 (2010)
- Lugo-Candelas C, "Neural correlates of emotion reactivity and regulation in young children with ADHD symptoms", J Abnorm Child Psychol, 45, pp.1311~1324 (2017)
- Gomarus HK, "ERP correlates of selective attention and working memory capacities in children with ADHD and", or PDD-NOS, 2009, pp.120, 60~72
- Wiersema JR, "ERP correlates of effortful control in children with varying levels of ADHD symptoms", J Abnorm Child Psychol, 37, pp.327~336 (2009)
- Liotti M, "Evidence for specificity of ERP abnormalities during response inhibition in ADHD children : a comparison with reading disorder children without ADHD", Brain Cogn, 72, pp.228~237 (2010)
- Yamamuro K, "Event-related potentials correlate with the severity of child and adolescent patients with attention deficit", hyperactivity disorder, 2016, pp.73, 131~138
- O’Neill BV, "The loudness dependence of the auditory evoked potential(LDAEP)as an in vivo biomarker of central serotonergic function in humans : rationale, evaluation and review of findings", Hum Psychopharmacol, 23, pp.355~370 (2008)
- Lee BH, "Prediction of long-term treatment response to selective serotonin reuptake inhibitors(SSRIs)using scalp and source loudness dependence of auditory evoked potentials(LDAEP)analysis in patients with major depressive disorder", Int J Mol Sci, 16, pp.6251~6265 (2015)
- Bun-Hee Lee, "How Childhood Maltreatment Is Related to Suicidality, Bipolarity and Central Serotonergic Activity in Patients with Major Depressive Disorder: A Cross-Sectional Pilot Study", PSYCHIATRY INVESTIGATION, 13(2), pp.190~195 (2016), 대한신경정신의학회[DOI]
- 박영민, "Can the Loudness Dependence of Auditory Evoked Potentials and Suicidality Be Used to Differentiate between Depressive Patients with and without Bipolarity", PSYCHIATRY INVESTIGATION, 10(2), pp.143~147 (2013), 대한신경정신의학회
- 박영민, "Relationship between Serotonergic Dysfunction Based on Loudness Dependence of Auditory-Evoked Potentials and Suicide in Patients with Major Depressive Disorder", PSYCHIATRY INVESTIGATION, 12(4), pp.421~424 (2015), 대한신경정신의학회[DOI]
- 박영민, "Clinical Usefulness of Loudness Dependence of Auditory Evoked Potentials (LDAEP) in Patients with Bipolar Disorder", PSYCHIATRY INVESTIGATION, 10(3), pp.233~237 (2013), 대한신경정신의학회[DOI]
- Young-Min Park, "The Hypothesis on the Prediction of Treatment Response with Buspirone Augmentation along with Serotonergic Antidepressant in Patients with Major Depressive Disorder Using Loudness Dependence of Auditory Evoked Potentials: Two Cases and Review of the Literature for Evidence", PSYCHIATRY INVESTIGATION, 17(3), pp.222~224 (2020), 대한신경정신의학회[DOI]
- Park YM, "The loudness dependence of the auditory evoked potential(LDAEP)as a predictor of the response to escitalopram in patients with generalized anxiety disorder", Psychopharmacology(Berl), 213, pp.625~632 (2011)
- Mingyu Hwang, "Relationship Between the Loudness Dependence of the Auditory Evoked Potential and the Severity of Suicidal Ideation in Patients with Major Depressive Disorder", Clinical Psychopharmacology and Neuroscience, 19(2), pp.323~333 (2021), 대한정신약물학회[DOI]
- Kim JS, "The relationship between auditory evoked potentials and symptoms of attention-deficit", hyperactivity disorder in adult patients with major depressive disorder, 2019, pp.142, 50~56
- Kim JS, "Auditory evoked potential could reflect emotional sensitivity and impulsivity", Sci Rep, 6, pp.37683~ (2016)
- Juckel G, "Association of catechol-O-methyltransferase variants with loudness dependence of auditory evoked potentials", Hum Psychopharmacol, 23, pp.115~120 (2008)
- Lee IH, "Loudness dependence of auditory evoked potentials(LDAEP)correlates with the availability of dopamine transporters and serotonin transporters in healthy volunteers-a two isotopes SPECT study", Psychopharmacology(Berl), 214, pp.617~624 (2011)
- Development of KEDI-WISC, individual intelligence test for Korean children, "Park KS", Seoul Korean Educational Development Institute, ~ (1996)
- Kim MK, "A study on the abbreviated form of the K-WISC", Seoul J Psychiatry, 11, pp.194~201 (1986)
- Kaufman AS, "A four-test short form of the WISC-R", Contemp Educ Psychol, 1, pp.180~196 (1976)
- 소유경, "한국어판 부모, 교사 ADHD 평가 척도의 신뢰도와 타당도 연구", 신경정신의학, 41(2), pp.283~289 (2002), 대한신경정신의학회
- Greenberg LM, "Developmental normative data on the test of variables of attention (T.O.V.A.)", J Child Psychol Psychiatry, 34, pp.1019~1030 (1993)
- Shin MS, "A study of the development and standardization of ADHD Diagnostic System", J Korean Acad Child Adolesc Psychiatry, 11, pp.91~99 (2000)
- Min JA, "Clinical characteristics associated with different strengths of loudness dependence of auditory evoked potentials(LDAEP)in major depressive disorder", Psychiatry Res, 200, pp.374~381 (2012)
- Gow RV, "Abnormal centroparietal ERP response in predominantly medication-naive adolescent boys with ADHD during both response inhibition and execution", J Clin Neurophysiol, 29, pp.181~189 (2012)
- Mavrogiorgou P, "Serotonergic modulation of orbitofrontal activity and its relevance for decision making and impulsivity", Hum Brain Mapp, 38, pp.1507~1517 (2017)
- Beucke JC, "Serotonergic neurotransmission in early Parkinson’s disease : a pilot study to assess implications for depression in this disorder", World J Biol Psychiatry, 11, pp.781~787 (2010)
- Park HK, "Preserved serotonergic activity in early-onset Parkinson’s disease", Can J Neurol Sci, 47, pp.344~349 (2020)
- Juckel G, "Auditoryevoked potentials as indicator of brain serotonergic activity--first evidence in behaving cats", Biol Psychiatry, 41, pp.1181~1195 (1997)
- Plotkin M, "Serotonin transporters, dopamine transporters and LDAEP in early Parkinson`s disease", J Nucl Med, 48(Suppl 2), pp.8~ (2007)
- Doly S, "Serotonin 2B receptors in mesoaccumbens dopamine pathway regulate cocaine responses", J Neurosci, 37, pp.10372~10388 (2017)
- Fischer AG, "An update on the role of serotonin and its interplay with dopamine for reward", Front Hum Neurosci, 11, pp.484~ (2017)
- Ishii T, "Anatomical relationships between serotonin 5-HT2A and dopamine D2 receptors in living human brain", PLoS One, 12, pp.e0189318~ (2017)
- Wood AC, "Twin studies and their implications for molecular genetic studies : endophenotypes integrate quantitative and molecular genetics in ADHD research", J Am Acad Child Adolesc Psychiatry, 49, pp.874~883 (2010)
- O’Neill BV, "Effects of selective and combined serotonin and dopamine depletion on the loudness dependence of the auditory evoked potential(LDAEP)in humans", Hum Psychopharmacol, 23, pp.301~312 (2008)
- Pogarell O, "Serotonin and dopamine transporter availabilities correlate with the loudness dependence of auditory evoked potentials in patients with obsessive-compulsive disorder", Neuropsychopharmacology, 29, pp.1910~1917 (2004)
- Mavrogiorgou P, "Relationship between neuroanatomical and serotonergic hypotheses of obsessive-compulsive disorder : a combined functional magnetic resonance imaging-evoked potential study", J Clin Psychiatry, 79, pp.17~ (2018)
- Pauletti C, "Serotonergic central tone in Parkinson's disease with fatigue : evidence from the loudness dependence of auditory evoked potentials(LDAEP)", Neurosci Lett, 764, pp.136242~ (2021)
- Park YM, "The loudness dependence of the auditory evoked potential(LDAEP)in schizophrenia, bipolar disorder, major depressive disorder, anxiety disorder, and healthy controls", Prog Neuropsychopharmacol Biol Psychiatry, 34, pp.313~316 (2010)
- Uhl I, "Loudness dependence of auditory evoked potentials(LDAEP)in clinical monitoring of suicidal patients with major depression : a pilot study", Eur Arch Psychiatry Clin Neurosci, 262, pp.487~492 (2012)
- Kim JS, "Auditory evoked potentials and suicidal behaviors in patients with major depressive disorders", Sci Rep, 11, pp.7255~ (2021)
- Hagenmuller F, "The Loudness Dependence of Auditory Evoked Potentials(LDAEP)in individuals at risk for developing bipolar disorders and schizophrenia", Clin Neurophysiol, 127, pp.1342~1350 (2016)
- Reimherr FW, "ADHD and anxiety : clinical significance and treatment implications", Curr Psychiatry Rep, 19, pp.109~ (2017)
- Mitchison GM, "Prevalence and gender differences of ODD, anxiety, and depression in a sample of children with ADHD", J Atten Disord, 23, pp.1339~1345 (2019)
- Jeong-Cheol Seo, "Prevalence and Comorbidities of Attention Deficit Hyperactivity Disorder Among Adults and Children", Adolescents in Korea, 2022, pp.20(1), 126~134[DOI]
- Yunhye Oh, "Association between Attention Deficit Hyperactivity Disorder Medication and Depression: A 10-year Follow-up Self-controlled Case Study", Clinical Psychopharmacology and Neuroscience, 20(2), pp.320~329 (2022), 대한정신약물학회[DOI]
- Graßnickel V, "Loudness dependence of auditory evoked potentials(LDAEP)in clinical monitoring of suicidal patients with major depression in comparison with non-suicidal depressed patients and healthy volunteers : a follow-up-study", J Affect Disord, 184, pp.299~304 (2015)
- Baptista J, "Serotonin transporter polymorphism moderates the effects of caregiver intrusiveness on ADHD symptoms among institutionalized preschoolers", Eur Child Adolesc Psychiatry, 26, pp.303~313 (2017)
- van Rooij D, "Variation in serotonin neurotransmission genes affects neural activation during response inhibition in adolescents and young adults with ADHD and healthy controls", World J Biol Psychiatry, 16, pp.625~634 (2015)
- Park S, "Associations between serotonin transporter gene(SLC6A4)methylation and clinical characteristics and cortical thickness in children with ADHD", Psychol Med, 45, pp.3009~3017 (2015)
- Banerjee E, "Does serotonin deficit mediate susceptibility to ADHD?", Neurochem Int, 82, pp.52~68 (2015)
- Brammer WA, "Prosociality and negative emotionality mediate the association of serotonin transporter genotype with childhood ADHD and ODD", J Clin Child Adolesc Psychol, 42, pp.809~819 (2013)
- Landaas ET, "An international multicenter association study of the serotonin transporter gene in persistent ADHD", Genes Brain Behav, 9, pp.449~458 (2010)
- Retz W, "Association of serotonin transporter promoter gene polymorphism with violence : relation with personality disorders, impulsivity, and childhood ADHD psychopathology", Behav Sci Law, 22, pp.415~425 (2004)
- Oades RD, "Role of the serotonin system in ADHD : treatment implications", Expert Rev Neurother, 7, pp.1357~1374 (2007)
- Molina-Carballo A, "Methylphenidate effects on blood serotonin and melatonin levels may help to synchronise biological rhythms in children with ADHD", J Psychiatr Res, 47, pp.377~383 (2013)
- Thakur GA, "The 5-HTTLPR polymorphism of the serotonin transporter gene and short term behavioral response to methylphenidate in children with ADHD", BMC Psychiatry, 10, pp.50~ (2010)
- Cheung CH, "Cognitive and neurophysiological markers of ADHD persistence and remission", Br J Psychiatry, 208, pp.548~555 (2016)
- Pasini A, "Neurocognitive effects of methylphenidate on ADHD children with different DAT genotypes : a longitudinal open label trial", Eur J Paediatr Neurol, 17, pp.407~414 (2013)
- Monden Y, "Right prefrontal activation as a neuro-functional biomarker for monitoring acute effects of methylphenidate in ADHD children : an fNIRS study", Neuroimage Clin, 1, pp.131~140 (2012)
- Snyder SM, "Integration of an EEG biomarker with a clinician’s ADHD evaluation", Brain Behav, 5, pp.e00330~ (2015)
- Nagy E, "Sex-related ERP differences in deviance detection", Int J Psychophysiol, 48, pp.285~292 (2003)
- Guillem F, "Sex differences in memory processing in schizophrenia : an eventrelated potential(ERP)study", Prog Neuropsychopharmacol Biol Psychiatry, 33, pp.1~10 (2009)
- Buchmann J, "Intelligence moderates impulsivity and attention in ADHD children: an ERP study using a go", nogo paradigm, 2011, pp.12(Suppl 1), 35~39
