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Clinical Advances in Treatment Strategies for Obsessive-compulsive Disorder in Adults

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In the present article, we provide a comprehensive review of the treatment strategies for obsessive-compulsive disorder (OCD), a common, chronic, and often debilitating disorder, characterized by overwhelming obsessions and compulsions. OCD typically starts in childhood or adolescence and persists throughout life, causing functional impairment across multiple domains. The article begins by describing the historical concepts of OCD from religious and guilt-based explanations to psychoanalytic perspectives, and then explores the changing understanding of OCD as a treatable condition. Recent advances include the development of evidence-based psychological treatments, such as exposure and response prevention, and pharmacological treatments, such as selective serotonin reuptake inhibitors. The latest version of the Diagnostic and Statistical Manual of Mental Disorders, and the International Classification of Diseases, has removed OCD from the anxiety disorder grouping and regrouped it into obsessive-compulsive and related disorders. We conclude by highlighting the current state of knowledge and development in the clinical management of OCD, including recommendations for first- and second-line treatments, alternative, or augmentative strategies for and novel agents under investigation for OCD. In future, the latest advances in neuroimaging, electrophysiology, digital technology, and data-driven analysis will help elucidate the pathophysiology of OCD and develop personalized intervention strategies.

Abstract

In the present article, we provide a comprehensive review of the treatment strategies for obsessive-compulsive disorder (OCD), a common, chronic, and often debilitating disorder, characterized by overwhelming obsessions and compulsions. OCD typically starts in childhood or adolescence and persists throughout life, causing functional impairment across multiple domains. The article begins by describing the historical concepts of OCD from religious and guilt-based explanations to psychoanalytic perspectives, and then explores the changing understanding of OCD as a treatable condition. Recent advances include the development of evidence-based psychological treatments, such as exposure and response prevention, and pharmacological treatments, such as selective serotonin reuptake inhibitors. The latest version of the Diagnostic and Statistical Manual of Mental Disorders, and the International Classification of Diseases, has removed OCD from the anxiety disorder grouping and regrouped it into obsessive-compulsive and related disorders. We conclude by highlighting the current state of knowledge and development in the clinical management of OCD, including recommendations for first- and second-line treatments, alternative, or augmentative strategies for and novel agents under investigation for OCD. In future, the latest advances in neuroimaging, electrophysiology, digital technology, and data-driven analysis will help elucidate the pathophysiology of OCD and develop personalized intervention strategies.

참고문헌 (60)

  1. Osland S, "The prevalence of diagnosed obsessive compulsive disorder and associated comorbidities : A population-based Canadian study", Psychiatry Res, 268, pp.137~142 (2018)
  2. Kessler RC, "Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication", Arch Gen Psychiatry, 62, pp.617~627 (2005)
  3. Bobes J, "Quality of life and disability in patients with obsessive-compulsive disorder", Eur Psychiatry, 16, pp.239~245 (2001)
  4. Berrios GE, "A history of clinical psychiatry: The origin and history of psychiatric disorders", pp.573~592 (1995), Athlone
  5. Raymond F, "Les obsessions et la psychasthénie", pp.543~ (1903), Felix Alcan
  6. Castel PH, "A new history of ourselves, in the shadow of our obsessions and compulsions", Philos Psychiatr Psychol, 21, pp.299~309 (2014)
  7. Solomon RL, "Traumatic avoidance learning : The outcomes of several extinction procedures with dogs", J Abnorm Psychol, 48, pp.291~302 (1953)
  8. Meyer V, "Modification of expectations in cases with obsessional rituals", Behav Res Ther, 4, pp.273~280 (1966)
  9. Goodman WK, "Obsessivecompulsive disorder", Psychiatr Clin North Am, 37, pp.257~267 (2014)
  10. Fernández Córdoba E, "Use of monochlorimipramine in psychiatric patients who are resistant to other therapy", Actas Luso Esp Neurol Psiquiatr, 26, pp.119~147 (1967)
  11. Vahabzadeh A, "Neurobiology of Brain Disorders", pp.612~620 (2015), Academic
  12. American Psychiatric Association, "Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5)" (2013), American Psychiatric Association
  13. Mataix-Cols D, "Population-based, multigenerational family clustering study of obsessive-compulsive disorder", JAMA Psychiatry, 70, pp.709~717 (2013)
  14. Mahjani B, "Maternal effects as causes of risk for obsessivecompulsive disorder", Biol Psychiatry, 87, pp.1045~1051 (2020)
  15. Bandelow B, "World Federation of Societies of Biological Psychiatry(WFSBP)guidelines for treatment of anxiety, obsessive-compulsive and posttraumatic stress disorders-Version 3. Part II : OCD and PTSD", World J Biol Psychiatry, 24, pp.118~134 (2023)
  16. Nezgovorova V, "Optimizing first line treatments for adults with OCD", Compr Psychiatry, 115, pp.152305~ (2022)
  17. Hirschtritt ME, "Obsessive-compulsive disorder : Advances in diagnosis and treatment", JAMA, 317, pp.1358~1367 (2017)
  18. Stein DJ, "Obsessive-compulsive disorder", Nat Rev Dis Primers, 5, pp.52~ (2019)
  19. Del Casale A, "Psychopharmacological treatment of obsessive-compulsive disorder(OCD)", Curr Neuropharmacol, 17, pp.710~736 (2019)
  20. 김원, "한국형 강박장애 치료 알고리듬 2007(Ⅰ): 개발과정과 개요", 대한정신약물학회지, 18(5), pp.338~346 (2007), 대한정신약물학회
  21. Pallanti S, "Treatment-refractory obsessive-compulsive disorder : Methodological issues, operational definitions and therapeutic lines", Prog Neuropsychopharmacol Biol Psychiatry, 30, pp.400~412 (2006)
  22. Skapinakis P, "Pharmacological and psychotherapeutic interventions for management of obsessivecompulsive disorder in adults : A systematic review and network meta-analysis", Lancet Psychiatry, 3, pp.730~739 (2016)
  23. Fineberg NA, "Pharmacotherapy of obsessive-compulsive disorder : Evidencebased treatment and beyond", Aust N Z J Psychiatry, 47, pp.121~141 (2013)
  24. Erzegovesi S, "Clinical predictors of drug response in obsessive-compulsive disorder", J Clin Psychopharmacol, 21, pp.488~492 (2001)
  25. Van Ameringen M, "Pharmacological treatment strategies in obsessive compulsive disorder : A cross-sectional view in nine international OCD centers", J Psychopharmacol, 28, pp.596~602 (2014)
  26. Dold M, "Antipsychotic augmentation of serotonin reuptake inhibitors in treatmentresistant obsessive-compulsive disorder : A meta-analysis of double-blind, randomized, placebo-controlled trials", Int J Neuropsychopharmacol, 16, pp.557~574 (2013)
  27. Li X, "Risperidone and haloperidol augmentation of serotonin reuptake inhibitors in refractory obsessive-compulsive disorder : A crossover study", J Clin Psychiatry, 66, pp.736~743 (2005)
  28. Veale D, "Atypical antipsychotic augmentation in SSRI treatment refractory obsessive-compulsive disorder : A systematic review and meta-analysis", BMC Psychiatry, 14, pp.317~ (2014)
  29. Muscatello MR, "Effect of aripiprazole augmentation of serotonin reuptake inhibitors or clomipramine in treatment-resistant obsessive-compulsive disorder : A double-blind, placebo-controlled study", J Clin Psychopharmacol, 31, pp.174~179 (2011)
  30. Sayyah M, "Effects of aripiprazole augmentation in treatment-resistant obsessive-compulsive disorder(a double blind clinical trial)", Depress Anxiety, 29, pp.850~854 (2012)
  31. Leucht S, "Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia : A multiple-treatments meta-analysis", Lancet, 382, pp.951~962 (2013)
  32. Albert U, "Role and clinical implications of atypical antipsychotics in anxiety disorders, obsessive-compulsive disorder, traumarelated, and somatic symptom disorders : A systematized review", Int Clin Psychopharmacol, 31, pp.249~258 (2016)
  33. Matsunaga H, "A long-term trial of the effectiveness and safety of atypical antipsychotic agents in augmenting SSRI-refractory obsessive-compulsive disorder", J Clin Psychiatry, 70, pp.863~868 (2009)
  34. Hadi F, "Glutamatergic medications as adjunctive therapy for moderate to severe obsessive-compulsive disorder in adults : A systematic review and meta-analysis", BMC Pharmacol Toxicol, 22, pp.69~ (2021)
  35. Lee DK, "The potential of N-acetylcysteine for treatment of trichotillomania, excoriation disorder, onychophagia, and onychotillomania : An updated literature review", Int J Environ Res Public Health, 19, pp.6370~ (2022)
  36. Sarris J, "N-acetyl cysteine(NAC)augmentation in the treatment of obsessive-compulsive disorder : A phase III, 20-week, doubleblind, randomized, placebo-controlled trial", Prog Neuropsychopharmacol Biol Psychiatry, 117, pp.110550~ (2022)
  37. Bandeira ID, "Ketamine in the treatment of obsessive-compulsive disorder : A systematic review", Harv Rev Psychiatry, 30, pp.135~145 (2022)
  38. Grassi G, "Investigational and experimental drugs to treat obsessive-compulsive disorder", J Exp Pharmacol, 12, pp.695~706 (2021)
  39. Andrade C, "Ondansetron augmentation of serotonin reuptake inhibitors as a treatment strategy in obsessive-compulsive disorder", J Clin Psychiatry, 76, pp.e72~e75 (2015)
  40. Hewlett WA, "Clomipramine, clonazepam, and clonidine treatment of obsessive-compulsive disorder", J Clin Psychopharmacol, 12, pp.420~430 (1992)
  41. Denys D, "A double blind comparison of venlafaxine and paroxetine in obsessive-compulsive disorder", J Clin Psychopharmacol, 23, pp.568~575 (2003)
  42. Grant JE, "Tolcapone in obsessive-compulsive disorder : A randomized double-blind placebo-controlled crossover trial", Int Clin Psychopharmacol, 36, pp.225~229 (2021)
  43. Öst LG, "Cognitive behavioral treatments of obsessive-compulsive disorder. A systematic review and meta-analysis of studies published 1993-2014", Clin Psychol Rev, 40, pp.156~169 (2015)
  44. Reid JE, "Cognitive behavioural therapy with exposure and response prevention in the treatment of obsessive-compulsive disorder : A systematic review and metaanalysis of randomised controlled trials", Compr Psychiatry, 106, pp.152223~ (2021)
  45. Marzano L, "The application of mHealth to mental health : Opportunities and challenges", Lancet Psychiatry, 2, pp.942~948 (2015)
  46. Hoppen LM, "Low intensity technology-delivered cognitive behavioral therapy for obsessive-compulsive disorder : A meta-analysis", BMC Psychiatry, 21, pp.322~ (2021)
  47. Soondrum T, "The applicability of acceptance and commitment therapy for obsessivecompulsive disorder : A systematic review and meta-analysis", Brain Sci, 12, pp.656~ (2022)
  48. Abramowitz JS, "New directions in the cognitive-behavioral treatment of OCD : Theory, research, and practice", Behav Ther, 49, pp.311~322 (2018)
  49. Samantaray NN, "Efficacy of inhibitory learning theory-based exposure and response prevention and selective serotonin reuptake inhibitor in obsessive-compulsive disorder management : A treatment comparison", Ind Psychiatry J, 27, pp.53~60 (2018)
  50. O’Connor K, "Beyond reasonable doubt: Reasoning processes in obsessive-compulsive disorder and related disorders" (2005), John Wiley & Sons
  51. O’Connor K, "Clinician’s handbook for obsessive compulsive disorder: Inference-based therapy" (2012), Wiley-Blackwell
  52. Julien D, "The inference-based approach to obsessive-compulsive disorder : A comprehensive review of its etiological model, treatment efficacy, and model of change", J Affect Disord, 202, pp.187~196 (2016)
  53. Aardema F, "Evaluation of inference-based cognitive-behavioral therapy for obsessive-compulsive disorder : A multicenter randomized controlled trial with three treatment modalities", Psychother Psychosom, 91, pp.348~359 (2022)
  54. Perera MPN, "Repetitive transcranial magnetic stimulation for obsessive-compulsive disorder : A meta-analysis of randomized, sham-controlled trials", Biol Psychiatry Cogn Neurosci Neuroimaging, 6, pp.947~960 (2021)
  55. Harmelech T, "Long-term outcomes of a course of deep TMS for treatment-resistant OCD", Brain Stimul, 15, pp.226~228 (2022)
  56. Alonso P, "Deep brain stimulation for obsessivecompulsive disorder : A meta-analysis of treatment outcome and predictors of response", PLoS One, 10, pp.e0133591~ (2015)
  57. Martinho FP, "Efficacy, effect on mood symptoms, and safety of deep brain stimulation in refractory obsessive-compulsive disorder : A systematic review and metaanalysis", J Clin Psychiatry, 81, pp.19~ (2020)
  58. Hageman SB, "Deep brain stimulation versus ablative surgery for treatment-refractory obsessive-compulsive disorder : A meta-analysis", Acta Psychiatr Scand, 143, pp.307~318 (2021)
  59. Jung HH, "Bilateral thermal capsulotomy with MR-guided focused ultrasound for patients with treatment-refractory obsessivecompulsive disorder : A proof-of-concept study", Mol Psychiatry, 20, pp.1205~1211 (2015)
  60. Zohar J, "Pharmacological treatment of obsessive compulsive disorder : A review", Obsessive Compuls Disord, 4, pp.43~92 (2000)

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