Correlation between Vitamin B12 and Mental Health in Children and Adolescents: A Systematic Review and Meta-analysis
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To conduct the association between vitamin B12 and mental health in children and adolescents. Five databases were searched for observational studies in any language reporting on mental health and vitamin B12 levels or intake in children and adolescents from inception to March 18, 2022. Two authors independently extracted data and assessed study quality. Qualitative and quantitative analysis of data were performed. The review was registered in the PROSPERO database (CRD42022345476). Fifty six studies containing 37,932 participants were identified in the review. Vitamin B12 levels were lower in participants with autism spectrum disorders (ASD) (standardized mean difference [SMD], −1.61; 95% confidence interval [95% CI], −2.44 to −0.79; p < 0.001), attention deficit hyperactivity disorders (SMD, −0.39; 95% CI, −0.78 to −0.00; p = 0.049) compared with control group. Vitamin B12 intake were lower in participants with ASDs (SMD, −0.86; 95% CI, −1.48 to −0.24; p = 0.006) compared with control group, but showed no difference between depression group (SMD, −0.06; 95% CI, −0.15 to 0.03; p = 0.17) and the control group. Higher vitamin B12 intake were associated with lower risk of depression (odds ratio [OR], 0.79; 95% CI, 0.63−0.98; p = 0.034) and behavioral problems (OR, 0.83; 95% CI, 0.69−0.99; p = 0.04). The vast majority of included studies supported potential positive influence of vitamin B12 on mental health, and vitamin B12 deficiency may be a reversible cause for some mental health disorders in children and adolescents.
Abstract
To conduct the association between vitamin B12 and mental health in children and adolescents. Five databases were searched for observational studies in any language reporting on mental health and vitamin B12 levels or intake in children and adolescents from inception to March 18, 2022. Two authors independently extracted data and assessed study quality. Qualitative and quantitative analysis of data were performed. The review was registered in the PROSPERO database (CRD42022345476). Fifty six studies containing 37,932 participants were identified in the review. Vitamin B12 levels were lower in participants with autism spectrum disorders (ASD) (standardized mean difference [SMD], −1.61; 95% confidence interval [95% CI], −2.44 to −0.79; p < 0.001), attention deficit hyperactivity disorders (SMD, −0.39; 95% CI, −0.78 to −0.00; p = 0.049) compared with control group. Vitamin B12 intake were lower in participants with ASDs (SMD, −0.86; 95% CI, −1.48 to −0.24; p = 0.006) compared with control group, but showed no difference between depression group (SMD, −0.06; 95% CI, −0.15 to 0.03; p = 0.17) and the control group. Higher vitamin B12 intake were associated with lower risk of depression (odds ratio [OR], 0.79; 95% CI, 0.63−0.98; p = 0.034) and behavioral problems (OR, 0.83; 95% CI, 0.69−0.99; p = 0.04). The vast majority of included studies supported potential positive influence of vitamin B12 on mental health, and vitamin B12 deficiency may be a reversible cause for some mental health disorders in children and adolescents.
참고문헌 (71)
- Kessler RC, "Lifetime prevalence and age-of-onset distributions of mental disorders in the World Health Organization’s World Mental Health Survey Initiative", World Psychiatry, 6, pp.168~176 (2007)
- "Mental health of adolescents" (2021)[URL]
- Adan RAH, "Nutritional psychiatry : Towards improving mental health by what you eat", Eur Neuropsychopharmacol, 29, pp.1321~1332 (2019)
- Parletta N, "A Mediterranean-style dietary intervention supplemented with fish oil improves diet quality and mental health in people with depression : A randomized controlled trial(HELFIMED)", Nutr Neurosci, 22, pp.474~487 (2019)
- Muñoz MA, "Adherence to the Mediterranean diet is associated with better mental and physical health", Br J Nutr, 101, pp.1821~1827 (2009)
- Ventriglio A, "Mediterranean diet and its benefits on health and mental health : A literature review", Clin Pract Epidemiol Ment Health, 16(Suppl-1), pp.156~164 (2020)
- Zeuschner CL, "Vitamin B12 and vegetarian diets", Med J Aust, 199(S4), pp.S27~S32 (2013)
- Takahashi-Iñiguez T, "Role of vitamin B12 on methylmalonyl-CoA mutase activity", J Zhejiang Univ Sci B, 13, pp.423~437 (2012)
- Reynolds E, "Vitamin B12, folic acid, and the nervous system", Lancet Neurol, 5, pp.949~960 (2006)
- Green R, "Vitamin B12 deficiency", Nat Rev Dis Primers, 3, pp.17040~ (2017)
- Khosravi M, "The relationship between dietary patterns and depression mediated by serum levels of Folate and vitamin B12", BMC Psychiatry, 20, pp.63~ (2020)
- Esnafoglu E, "The relationship of severity of depression with homocysteine, folate, vitamin B12, and vitamin D levels in children and adolescents", Child Adolesc Ment Health, 25, pp.249~255 (2020)
- Saraswathy KN, "Association of vitamin B12 mediated hyperhomocysteinemia with depression and anxiety disorder : A cross-sectional study among Bhil indigenous population of India", Clin Nutr ESPEN, 30, pp.199~203 (2019)
- Kazanci SY, "Vitamin B12 < 300pg", mL in children and especially adolescents may predispose forgetfulness, anxiety, and unhappiness, 2017, pp.27, e4663~
- Zhang Y, "Decreased brain levels of vitamin B12 in aging, autism and schizophrenia", PLoS One, 11, pp.e0146797~ (2016)
- Hope S, "Higher vitamin B12 levels in neurodevelopmental disorders than in healthy controls and schizophrenia : A comparison among participants between 2 and 53 years", FASEB J, 34, pp.8114~8124 (2020)
- Türksoy N, "Vitamin B12, folate, and homocysteine levels in patients with obsessive-compulsive disorder", Neuropsychiatr Dis Treat, 10, pp.1671~1675 (2014)
- Esnafoğlu E, "Vitamin B12, folic acid, homocysteine and vitamin D levels in children and adolescents with obsessive compulsive disorder", Psychiatry Res, 254, pp.232~237 (2017)
- Petridou ET, "Folate and B12 serum levels in association with depression in the aged : A systematic review and meta-analysis", Aging Ment Health, 20, pp.965~973 (2016)
- Cao B, "Vitamin B12 and the risk of schizophrenia : A meta-analysis", Schizophr Res, 172, pp.216~217 (2016)
- Borges-Vieira JG, "Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders : A systematic review of randomized controlled trials", Nutr Neurosci, 26, pp.187~207 (2023)
- Moher D, "Preferred reporting items for systematic reviews and meta-analyses : The PRISMA statement", PLoS Med, 6, pp.e1000097~ (2009)
- "Mental health: Strengthening our response" (2018)[URL]
- Lin CD, "Dictionary of psychology" (2003), Shanghai Educational Publishing House
- Song Z, "Association between maternal anxiety and children’s problem behaviors : A systematic review and meta-analysis", Int J Environ Res Public Health, 19, pp.11106~ (2022)
- Wells G, "The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses", Ottawa Hospital Research Institute, ~ (2014)
- Hozo SP, "Estimating the mean and variance from the median, range, and the size of a sample", BMC Med Res Methodol, 5, pp.13~ (2005)
- Higgins JP, "Measuring inconsistency in meta-analyses", BMJ, 327, pp.557~560 (2003)
- Egger M, "Bias in meta-analysis detected by a simple, graphical test", BMJ, 315, pp.629~634 (1997)
- Duval S, "Trim and fill : A simple funnel-plot-based method of testing and adjusting for publication bias in metaanalysis", Biometrics, 56, pp.455~463 (2000)
- Hollowood-Jones K, "Altered metabolism of mothers of young children with Autism Spectrum Disorder : A case control study", BMC Pediatr, 20, pp.557~ (2020)
- Garipardic M, "Association of attention deficit hyperactivity disorder and autism spectrum disorders with mean platelet volume and vitamin D", Med Sci Monit, 23, pp.1378~1384 (2017)
- Barnhill K, "Dietary status and nutrient intake of children with autism spectrum disorder : A case-control study", Res Autism Spectr Disord, 50, pp.51~59 (2018)
- Topal Z, "Evaluation of peripheral inflammatory markers, serum B12, folate, ferritin levels and clinical correlations in children with autism spectrum disorder(ASD)and attention deficit hyperactivity disorder(ADHD)", Nord J Psychiatry, 76, pp.150~157 (2022)
- Zou M, "Fisher discriminant analysis for classification of autism spectrum disorders based on folate-related metabolism markers", J Nutr Biochem, 64, pp.25~31 (2019)
- Bala KA, "Hormone disorder and vitamin deficiency in attention deficit hyperactivity disorder(ADHD)and autism spectrum disorders(ASDs)", J Pediatr Endocrinol Metab, 29, pp.1077~1082 (2016)
- Ali A, "Hyperhomocysteinemia among Omani autistic children : A case-control study", Acta Biochim Pol, 58, pp.547~551 (2011)
- Hatice Altun, "The Levels of Vitamin D, Vitamin D Receptor, Homocysteine and Complex B Vitamin in Children with Autism Spectrum Disorders", Clinical Psychopharmacology and Neuroscience, 16(4), pp.383~390 (2018), 대한정신약물학회[DOI]
- Al-Farsi YM, "Low folate and vitamin B12 nourishment is common in Omani children with newly diagnosed autism", Nutrition, 29, pp.537~541 (2013)
- Marí-Bauset S, "Nutritional status of children with autism spectrum disorders(ASDs) : A case-control study", J Autism Dev Disord, 45, pp.203~212 (2015)
- Paşca SP, "One carbon metabolism disturbances and the C677T MTHFR gene polymorphism in children with autism spectrum disorders", J Cell Mol Med, 13, pp.4229~4238 (2009)
- Bala KA, "Plasma amino acid profile in autism spectrum disorder(ASD)", Eur Rev Med Pharmacol Sci, 20, pp.923~929 (2016)
- Erden S, "Serum B12, homocysteine, and anti-parietal cell antibody levels in children with autism", Int J Psychiatry Clin Pract, 26, pp.8~13 (2022)
- Tu WJ, "Serum homocysteine concentrations in Chinese children with autism", Clin Chem Lab Med, 51, pp.e19~e22 (2013)
- Graf-Myles J, "Dietary adequacy of children with autism compared with controls and the impact of restricted diet", J Dev Behav Pediatr, 34, pp.449~459 (2013)
- Meguid NA, "Dietary adequacy of Egyptian children with autism spectrum disorder compared to healthy developing children", Metab Brain Dis, 32, pp.607~615 (2017)
- Johnson CR, "Eating habits and dietary status in young children with autism", J Dev Phys Disabil, 20, pp.437~448 (2008)
- Malhi P, "Feeding problems and nutrient intake in children with and without autism : A comparative study", Indian J Pediatr, 84, pp.283~288 (2017)
- Emond A, "Feeding symptoms, dietary patterns, and growth in young children with autism spectrum disorders", Pediatrics, 126, pp.e337~e342 (2010)
- Zimmer MH, "Food variety as a predictor of nutritional status among children with autism", J Autism Dev Disord, 42, pp.549~556 (2012)
- Shmaya Y, "Nutritional deficiencies and overweight prevalence among children with autism spectrum disorder", Res Dev Disabil, 38, pp.1~6 (2015)
- Altun H, "Homocysteine, pyridoxine, folate and vitamin B12 levels in children with attention deficit hyperactivity disorder", Psychiatr Danub, 30, pp.310~316 (2018)
- Wang LJ, "Dietary profiles, nutritional biochemistry status, and attention-deficit", hyperactivity disorder : Path analysis for a casecontrol study, 2019, pp.8, 709~
- Üskül H, "Evaluation of blood parameters in attention deficit hyperactivity disorder", Konuralp Tıp Dergisi, 9, pp.207~212 (2017)
- Saha T, "Components of the folate metabolic pathway and ADHD core traits : an exploration in eastern Indian probands", J Hum Genet, 62, pp.687~695 (2017)
- Jamshidnia A, "Food intake and attention-deficit", hyperactivity disorder in children : A case_control study, 2021, pp.44, 342~347
- Sourander A, "Maternal serum vitamin B12 and offspring attention-deficit", hyperactivity disorder(ADHD), 2021, pp.30, 1449~1462
- Mohseni H, "The relationship between history of dietary nutrients intakes and incidence of aggressive behavior in adolescent girls : A case-control study", Clin Nutr ESPEN, 43, pp.200~205 (2021)
- Ars CL, "Prenatal folate, homocysteine and vitamin B12 levels and child brain volumes, cognitive development and psychological functioning : The Generation R Study", Br J Nutr, 122(s1), pp.S1~S9 (2019)
- Duong MC, "Vitamin B-12 deficiency in children is associated with grade repetition and school absenteeism, independent of folate, iron, zinc, or vitamin A status biomarkers", J Nutr, 145, pp.1541~1548 (2015)
- Miyake Y, "Maternal B vitamin intake during pregnancy and childhood behavioral problems in Japan : The Kyushu Okinawa Maternal and Child Health Study", Nutr Neurosci, 23, pp.706~713 (2020)
- Robinson SL, "Iron deficiency, anemia, and low vitamin B-12 serostatus in middle childhood are associated with behavior problems in adolescent boys : Results from the Bogotáschool children cohort", J Nutr, 148, pp.760~770 (2018)
- Rubio-López N, "Nutrient intake and depression symptoms in Spanish children : The ANIVA study", Int J Environ Res Public Health, 13, pp.352~ (2016)
- Murakami K, "Dietary folate, riboflavin, vitamin B-6, and vitamin B-12 and depressive symptoms in early adolescence : The Ryukyus Child Health Study", Psychosom Med, 72, pp.763~768 (2010)
- Kim TH, "Associations between dietary pattern and depression in Korean adolescent girls", J Pediatr Adolesc Gynecol, 28, pp.533~537 (2015)
- Metwally AM, "Early life predictors of socio-emotional development in a sample of Egyptian infants", PLoS One, 11, pp.e0158086~ (2016)
- Raghavan R, "Maternal multivitamin intake, plasma folate and vitamin B12 levels and autism spectrum disorder risk in offspring", Paediatr Perinat Epidemiol, 32, pp.100~111 (2018)
- Prades N, "Water-soluble vitamin insufficiency, deficiency and supplementation in children and adolescents with a psychiatric disorder : A systematic review and meta-analysis", Nutr Neurosci, 26, pp.85~107 (2023)
- Chen L, "Oxidative stress marker aberrations in children with autism spectrum disorder : A systematic review and meta-analysis of 87 studies(N = 9109)", Transl Psychiatry, 11, pp.15~ (2021)
- Esteban-Figuerola P, "Differences in food consumption and nutritional intake between children with autism spectrum disorders and typically developing children : A meta-analysis", Autism, 23, pp.1079~1095 (2019)
- Wu Y, "Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression : A systematic review and meta-analysis", Nutr Rev, 80, pp.351~366 (2022)
