Oxytocin and Vasopressin Levels and Related Factors in Adolescents with Social Phobia and Other Anxiety Disorders
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Objective: This study aimed to determine whether a difference exists in plasma oxytocin and vasopressin levels among social anxiety disorder, other anxiety disorders, and healthy control groups in adolescents. The relationship between several psychiatric variables (i.e., state and trait anxiety, social anxiety, childhood trauma, and behavioral inhibition) and oxytocin or vasopressin levels were also investigated in adolescents with anxiety disorders. Methods: The study included three groups of adolescents: social anxiety disorder (n = 29), those with other anxiety disorders (n = 27), and the control group (n = 28). The participants filled out self-report scales to determine various psychological variables. Oxytocin and vasopressin levels were determined from the blood samples of the participants. Results: The oxytocin levels did not show a significant difference between the social anxiety disorder group and the other anxiety disorders group. However, the oxytocin levels were significantly higher in the social anxiety disorder and other anxiety disorders groups than in the control group. The vasopressin levels did not show a significant difference among the groups. According to the hierarchical regression analysis, the state and trait anxiety levels predicted oxytocin in opposite directions. Oxytocin showed positive and negative relationship with trait and state anxiety respectively. No predictive factors were found for the vasopressin levels. Conclusion: We found that the oxytocin levels of adolescents with social anxiety disorder were not different from those of adolescents with other anxiety disorders. Further studies can improve our knowledge of the relationship among anxiety disorders and oxytocin or vasopressin.
Abstract
Objective: This study aimed to determine whether a difference exists in plasma oxytocin and vasopressin levels among social anxiety disorder, other anxiety disorders, and healthy control groups in adolescents. The relationship between several psychiatric variables (i.e., state and trait anxiety, social anxiety, childhood trauma, and behavioral inhibition) and oxytocin or vasopressin levels were also investigated in adolescents with anxiety disorders. Methods: The study included three groups of adolescents: social anxiety disorder (n = 29), those with other anxiety disorders (n = 27), and the control group (n = 28). The participants filled out self-report scales to determine various psychological variables. Oxytocin and vasopressin levels were determined from the blood samples of the participants. Results: The oxytocin levels did not show a significant difference between the social anxiety disorder group and the other anxiety disorders group. However, the oxytocin levels were significantly higher in the social anxiety disorder and other anxiety disorders groups than in the control group. The vasopressin levels did not show a significant difference among the groups. According to the hierarchical regression analysis, the state and trait anxiety levels predicted oxytocin in opposite directions. Oxytocin showed positive and negative relationship with trait and state anxiety respectively. No predictive factors were found for the vasopressin levels. Conclusion: We found that the oxytocin levels of adolescents with social anxiety disorder were not different from those of adolescents with other anxiety disorders. Further studies can improve our knowledge of the relationship among anxiety disorders and oxytocin or vasopressin.
참고문헌 (67)
- Lipsitz JD, "Social phobia. Epidemiology and cost of illness", Pharmacoeconomics, 18, pp.23~32 (2000)
- Wittchen HU, "Disability and quality of life in pure and comorbid social phobia--findings from a controlled study", Eur Psychiatry, 14, pp.118~131 (1999)
- American Psychiatric Association, "Diagnostic and statistical manual of mental disorders: DSM-5" (2013), American Psychiatric Association Publishing
- Pine DS, "Rutter’s child and adolescent psychiatry", pp.822~840 (2015), Wiley-Blackwell
- Stein DJ, "Social anxiety disorder and generalized anxiety disorder: serotonergic and dopaminergic neurocircuitry", J Clin Psychiatry, 63(Suppl 6), pp.12~19 (2002)
- Rauch SL, "Neuroimaging studies of amygdala function in anxiety disorders", Ann N Y Acad Sci, 985, pp.389~410 (2003)
- Carson DS, "Arginine vasopressin is a blood-based biomarker of social functioning in children with autism", PLoS One, 10, pp.e0132224~ (2015)
- Hoge EA, "Oxytocin levels in social anxiety disorder", CNS Neurosci Ther, 14, pp.165~170 (2008)
- Kang Seob Oh, "The Relationship between Plasma Oxytocin Levels and Social Anxiety Symptoms", PSYCHIATRY INVESTIGATION, 15(11), pp.1079~1086 (2018), 대한신경정신의학회[DOI]
- Guyton AC, "Pocket companion to Guyton and Hall textbook of medical physiology", pp.2006, Saunders
- Ludwig M, "Dendritic peptide release and peptide-dependent behaviours", Nat Rev Neurosci, 7, pp.126~136 (2006)
- Hall JE, "Pocket companion to Guyton and Hall textbook of medical physiology", pp.939~950 (2016), Elsevier
- Suzuki S, "Development of social attention and oxytocin levels in maltreated children", Sci Rep, 10, pp.7407~ (2020)
- Yoon S, "Anxiety disorders: rethinking and understanding recent discoveries", pp.103~120 (2020), Springer
- Neumann ID, "Brain oxytocin inhibits basal and stress-induced activity of the hypothalamo-pituitary-adrenal axis in male and female rats : partial action within the paraventricular nucleus", J Neuroendocrinol, 12, pp.235~243 (2000)
- Kirsch P, "Oxytocin in the socioemotional brain : implications for psychiatric disorders", Dialogues Clin Neurosci, 17, pp.463~476 (2015)
- Hoge EA, "Plasma oxytocin immunoreactive products and response to trust in patients with social anxiety disorder", Depress Anxiety, 29, pp.924~930 (2012)
- Lebowitz ER, "Salivary oxytocin in clinically anxious youth : associations with separation anxiety and family accommodation", Psychoneuroendocrinology, 65, pp.35~43 (2016)
- Beidel DC, "Shy children, phobic adults: nature and treatment of social anxiety disorder" (2007), American Psychiatric Association Publishing
- Bartz JA, "Social effects of oxytocin in humans : context and person matter", Trends Cogn Sci, 15, pp.301~309 (2011)
- Labuschagne I, "Medial frontal hyperactivity to sad faces in generalized social anxiety disorder and modulation by oxytocin", Int J Neuropsychopharmacol, 15, pp.883~896 (2012)
- Eapen V, "Separation anxiety, attachment and inter-personal representations : disentangling the role of oxytocin in the perinatal period", PLoS One, 9, pp.e107745~ (2014)
- Mitre M, "Sex-specific differences in oxytocin receptor expression and function for parental behavior", Gend Genome, 1, pp.142~166 (2017)
- Marazziti D, "Sex-related differences in plasma oxytocin levels in humans", Clin Pract Epidemiol Ment Health, 15, pp.58~63 (2019)
- Caldwell HK, "Oxytocin and sex differences in behavior", Curr Opin Behav Sci, 23, pp.13~20 (2018)
- Feng C, "Neuroticism modulates the effects of intranasal vasopressin treatment on the neural response to positive and negative social interactions", Neuropsychologia, 73, pp.108~115 (2015)
- Lukas M, "Oxytocin and vasopressin in rodent behaviors related to social dysfunctions in autism spectrum disorders", Behav Brain Res, 251, pp.85~94 (2013)
- Neumann ID, "Balance of brain oxytocin and vasopressin : implications for anxiety, depression, and social behaviors", Trends Neurosci, 35, pp.649~659 (2012)
- Landgraf R, "Vasopressin and oxytocin release within the brain : a dynamic concept of multiple and variable modes of neuropeptide communication", Front Neuroendocrinol, 25, pp.150~176 (2004)
- Beiderbeck DI, "Differences in intermale aggression are accompanied by opposite vasopressin release patterns within the septum in rats bred for low and high anxiety", Eur J Neurosci, 26, pp.3597~3605 (2007)
- Blume A, "Oxytocin reduces anxiety via ERK1", 2 activation : local effect within the rat hypothalamic paraventricular nucleus, 2008, pp.27, 1947~1956
- Huber D, "Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala", Science, 308, pp.245~248 (2005)
- Ludwig M, "Intranasal application of vasopressin fails to elicit changes in brain immediate early gene expression, neural activity and behavioural performance of rats", J Neuroendocrinol, 25, pp.655~667 (2013)
- Heim C, "Lower CSF oxytocin concentrations in women with a history of childhood abuse", Mol Psychiatry, 14, pp.954~958 (2009)
- Hersen M, "Comprehensive handbook of psychological assessment: volume 2: personality assessment" (2004), Wiley
- Pacheco-Unguetti AP, "Attention and anxiety : different attentional functioning under state and trait anxiety", Psychol Sci, 21, pp.298~304 (2010)
- Tops M, "Anxiety, cortisol, and attachment predict plasma oxytocin", Psychophysiology, 44, pp.444~449 (2007)
- Gökler B, "Reliability and validity of schedule for affective disorders and schizophrenia for school age children-present and lifetime version-Turkish version (K-SADS-PL-T)", Turk J Child Adolesc Ment Health, 11, pp.109~116 (2004)
- Ünal F, "Reliability and validity of schedule for affective disorders and schizophrenia for school age children-present and lifetime revied version according to DSM-5-Turkish version (K-SADS-PL-DSM-5-T)", Abstracts of the 28th Turkish Child and Adolescent Psychiatry Congress, pp.333~334 (2018)
- Kaufman J, "Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version(K-SADS-PL) : initial reliability and validity data", J Am Acad Child Adolesc Psychiatry, 36, pp.980~988 (1997)
- Öy B, "Çocuklar için depresyon ölçeği : geçerlik ve güvenirlik çalişması", Türk Psikiyatr Derg, 2, pp.132~136 (1991)
- Özusta Ş, "Validity and reliability of Turkish version of state -trait anxiety inventory for children", Turk J Psychol, 10, pp.32~44 (1995)
- Aslan SH, "The reliability, validity and factor structure of the childhood trauma questionnaire among a group of university students", Turk J Psychiatry, 10, pp.275~285 (1999)
- Demir T, "Validity and reliability of social phobia scale for children and adolescents", Dusunen Adam J Psychiatry Neurol Sci, 13, pp.42~48 (2000)
- Şişman S, "Turkish adaptation of behavioral inhibition system", behavioral activation system scales (BIS, Stud Psychol, pp.2012, 32[DOI]
- Kovacs M, "The children’s depression, inventory(CDI)", Psychopharmacol Bull, 21, pp.995~998 (1985)
- Ivarsson T, "The children’s depression inventory (CDI) as measure of depression in Swedish adolescents. A normative study", Nord J Psychiatry, 60, pp.220~226 (2006)
- "State-trait anxiety inventory for children" (1970)[URL]
- Muris P, "Three traditional and three new childhood anxiety questionnaires : their reliability and validity in a normal adolescent sample", Behav Res Ther, 40, pp.753~772 (2002)
- Bernstein DP, "Initial reliability and validity of a new retrospective measure of child abuse and neglect", Am J Psychiatry, 151, pp.1132~1136 (1994)
- Bernstein DP, "Validity of the childhood trauma questionnaire in an adolescent psychiatric population", J Am Acad Child Adolesc Psychiatry, 36, pp.340~348 (1997)
- La Greca A, "Social anxiety scale for children revised : factor structure and concurrent validity", J Clin Child Adolesc Psychol, 22, pp.17~27 (1993)
- Carver CS, "Behavioral inhibition, behavioral activation, and affective responses to impending reward and punishment : the BIS", BAS scales, 1994, pp.67, 319~333
- Meyer-Lindenberg A, "Oxytocin and vasopressin in the human brain : social neuropeptides for translational medicine", Nat Rev Neurosci, 12, pp.524~538 (2011)
- Striepens N, "Prosocial effects of oxytocin and clinical evidence for its therapeutic potential", Front Neuroendocrinol, 32, pp.426~450 (2011)
- Heinrichs M, "Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress", Biol Psychiatry, 54, pp.1389~1398 (2003)
- Neumann ID, "Oxytocin in general anxiety and social fear : a translational approach", Biol Psychiatry, 79, pp.213~221 (2016)
- MacDonald K, "Oxytocin and psychotherapy : a pilot study of its physiological, behavioral and subjective effects in males with depression", Psychoneuroendocrinology, 38, pp.2831~2843 (2013)
- Weisman O, "Oxytocin administration alters HPA reactivity in the context of parent-infant interaction", Eur Neuropsychopharmacol, 23, pp.1724~1731 (2013)
- OlffM, "The role of oxytocin in social bonding, stress regulation and mental health : an update on the moderating effects of context and interindividual differences", Psychoneuroendocrinology, 38, pp.1883~1894 (2013)
- Ein-Dor T, "Epigenetic modification of the oxytocin and glucocorticoid receptor genes is linked to attachment avoidance in young adults", Attach Hum Dev, 20, pp.439~454 (2018)
- Baker M, "Early rearing history influences oxytocin receptor epigenetic regulation in rhesus macaques", Proc Natl Acad Sci U S A, 114, pp.11769~11774 (2017)
- Clark DM, "Information processing in social phobia", Biol Psychiatry, 51, pp.92~100 (2002)
- Hezel DM, "Theory of mind impairments in social anxiety disorder", Behav Ther, 45, pp.530~540 (2014)
- Lawson EA, "Postprandial oxytocin secretion is associated with severity of anxiety and depressive symptoms in anorexia nervosa", J Clin Psychiatry, 74, pp.e451~e457 (2013)
- Krause S, "Child maltreatment is associated with a reduction of the oxytocin receptor in peripheral blood mononuclear cells", Front Psychol, 9, pp.173~ (2018)
- Kim TK, "G9a-mediated regulation of OXT and AVP expression in the basolateral amygdala mediates stress-induced lasting behavioral depression and its reversal by exercise", Mol Neurobiol, 53, pp.2843~2856 (2016)
