본문 바로가기
KERD
논문KCI 등재

Serotonin Modulates the Correlations between Obsessive-compulsive Trait and Heart Rate Variability in Normal Healthy Subjects: A SPECT Study with [123I]ADAM and Heart Rate Variability Measurement

0

조회

0

다운로드

1

인용

0

참고문헌

키워드

초록

Objective: The impact of serotonergic system on obsessive-compulsive disorder (OCD) is well studied. However, the correlation between OC presentations and autonomic nervous system (ANS) is still unclear. Furthermore, whether the correlation might be modulated by serotonin is also uncertain. Methods: We recruited eighty-nine healthy subjects. Serotonin transporter (SERT) availability by [123I]ADAM and heart rate variability (HRV) tests were measured. Symptoms checklist-90 was measured for the OC presentations. The interaction between HRV and SERT availability were calculated and the correlation between HRV and OC symptoms were analyzed after stratified SERT level into two groups, split at medium. Results: The interactions were significant in the factors of low frequency (LF), high frequency (HF), and root mean square of successive differences (RMSSD). Furthermore, the significantly negative correlations between OC symptoms and the above HRV indexes existed only in subjects with higher SERT availability. Conclusion: OC symptoms might be correlated with ANS regulations in subjects with higher SERT availability.

Abstract

Objective: The impact of serotonergic system on obsessive-compulsive disorder (OCD) is well studied. However, the correlation between OC presentations and autonomic nervous system (ANS) is still unclear. Furthermore, whether the correlation might be modulated by serotonin is also uncertain. Methods: We recruited eighty-nine healthy subjects. Serotonin transporter (SERT) availability by [123I]ADAM and heart rate variability (HRV) tests were measured. Symptoms checklist-90 was measured for the OC presentations. The interaction between HRV and SERT availability were calculated and the correlation between HRV and OC symptoms were analyzed after stratified SERT level into two groups, split at medium. Results: The interactions were significant in the factors of low frequency (LF), high frequency (HF), and root mean square of successive differences (RMSSD). Furthermore, the significantly negative correlations between OC symptoms and the above HRV indexes existed only in subjects with higher SERT availability. Conclusion: OC symptoms might be correlated with ANS regulations in subjects with higher SERT availability.

참고문헌 (56)

  1. Stein DJ, "Obsessive-compulsive disorder", Nat Rev Dis Primers, 5, pp.52~ (2019)
  2. Fullana MA, "Obsessions and compulsions in the community : prevalence, interference, help-seeking, developmental stability, and co-occurring psychiatric conditions", Am J Psychiatry, 166, pp.329~336 (2009)
  3. Blom RM, "Obsessions in normality and psychopathology", Depress Anxiety, 28, pp.870~875 (2011)
  4. de Bruijn C, "Subthreshold symptoms and obsessive-compulsive disorder : evaluating the diagnostic threshold", Psychol Med, 40, pp.989~997 (2010)
  5. Fullana MA, "Obsessive-compulsive symptom dimensions in the general population : results from an epidemiological study in six European countries", J Affect Disord, 124, pp.291~299 (2010)
  6. Baumgarten HG, "Role of serotonin in obsessive-compulsive disorder", Br J Psychiatry Suppl, (35), pp.13~20 (1998)
  7. Stengler-Wenzke K, "Reduced serotonin transporter-availability in obsessive-compulsive disorder(OCD)", Eur Arch Psychiatry Clin Neurosci, 254, pp.252~255 (2004)
  8. -beta-CIT SPECT imaging shows reduced thalamus-hypothalamus serotonin transporter availability in 24 drug-free obsessive-compulsive checkers, "Neuropsychopharmacology", 2007, 1661~1668
  9. Pogarell O, "Elevated brain serotonin transporter availability in patients with obsessive-compulsive disorder", Biol Psychiatry, 54, pp.1406~1413 (2003)
  10. DASB PET study, "Psychol Med", 2016, 357~366
  11. Zitterl W, "Diencephalic serotonin transporter availability predicts both transporter occupancy and treatment response to sertraline in obsessive-compulsive checkers", Biol Psychiatry, 66, pp.1115~1122 (2009)
  12. Hesse S, "Serotonin and dopamine transporter imaging in patients with obsessive-compulsive disorder", Psychiatry Res, 140, pp.63~72 (2005)
  13. Kubota Y, "Corticostriatal-limbic correlates of sub-clinical obsessive-compulsive traits", Psychiatry Res Neuroimaging, 285, pp.40~46 (2019)
  14. Berntson GG, "Heart rate variability : origins, methods, and interpretive caveats", Psychophysiology, 34, pp.623~648 (1997)
  15. Dishman RK, "Heart rate variability, trait anxiety, and perceived stress among physically fit men and women", Int J Psychophysiol, 37, pp.121~133 (2000)
  16. Beauchaine TP, "Heart rate variability as a transdiagnostic biomarker of psychopathology", Int J Psychophysiol, 98(2 Pt 2), pp.338~350 (2015)
  17. Chalmers JA, "Anxiety disorders are associated with reduced heart rate variability : a meta-analysis", Front Psychiatry, 5, pp.80~ (2014)
  18. Pittig A, "Heart rate and heart rate variability in panic, social anxiety, obsessive-compulsive, and generalized anxiety disorders at baseline and in response to relaxation and hyperventilation", Int J Psychophysiol, 87, pp.19~27 (2013)
  19. Slaap BR, "Five-minute recordings of heart rate variability in obsessive-compulsive disorder, panic disorder and healthy volunteers", J Affect Disord, 78, pp.141~148 (2004)
  20. Booij L, "Tryptophan depletion affects heart rate variability and impulsivity in remitted depressed patients with a history of suicidal ideation", Biol Psychiatry, 60, pp.507~514 (2006)
  21. Kemp AH, "Effects of depression, anxiety, comorbidity, and antidepressants on resting-state heart rate and its variability : an ELSA-Brasil cohort baseline study", Am J Psychiatry, 171, pp.1328~1334 (2014)
  22. Schaffar N, "Central serotonergic projections to the nucleus tractus solitarii : evidence from a double labeling study in the rat", Neuroscience, 26, pp.951~958 (1988)
  23. Sévoz-Couche C, "Key role of 5-HT3 receptors in the nucleus tractus solitarii in cardiovagal stress reactivity", Neurosci Biobehav Rev, 74(Pt B), pp.423~432 (2017)
  24. Chang CC, "Serotonin 2A receptor(5-HT2A)gene promoter variant interacts with chronic perceived stress to modulate resting parasympathetic activity in humans", Psychoneuroendocrinology, 76, pp.119~126 (2017)
  25. Chang WH, "Prefrontal cortex modulates the correlations between brainderived neurotrophic factor level, serotonin, and the autonomic nervous system", Sci Rep, 8, pp.2558~ (2018)
  26. Tsai HC, "Association between serotonin transporter availability and overall rating scores of quality of life in healthy volunteers", Prog Neuropsychopharmacol Biol Psychiatry, 33, pp.711~714 (2009)
  27. ADAM, "Psychiatry Res", 2007, 281~284
  28. Yeh TL, "Availability of dopamine and serotonin transporters in opioiddependent users--a two-isotope SPECT study", Psychopharmacology(Berl), 220, pp.55~64 (2012)
  29. Yeh TL, "The relationships between daily life events and the availabilities of serotonin transporters and dopamine transporters in healthy volunteers--a dual-isotope SPECT study", Neuroimage, 45, pp.275~279 (2009)
  30. Hsieh PC, "Distribution volume ratio of serotonin and dopamine transporters in euthymic patients with a history of major depression-a dual-isotope SPECT study", Psychiatry Res, 184, pp.157~161 (2010)
  31. Sheehan DV, "The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10", J Clin Psychiatry, 59(Suppl 20), pp.22~33 (1998)
  32. Derogatis LR, "Factorial invariance across gender for the primary symptom dimensions of the SCL-90", Br J Soc Clin Psychol, 16, pp.347~356 (1977)
  33. Derogatis LR, "Confirmation of the dimensional structure of the SCL-90 : a study in construct validation", J Clin Psychol, 33, pp.981~989 (1977)
  34. Tsai SY, "Normative study of symptom checklist 90-revised (SCL-90-R) in Taiwan", pp.2017
  35. Chang LT, "A method for attenuation correction in radionuclide computed tomography", IEEE Trans Nucl Sci, 25, pp.638~643 (1978)
  36. Catafau AM, "SPECT of serotonin transporters using 123I-ADAM : optimal imaging time after bolus injection and long-term test-retest in healthy volunteers", J Nucl Med, 46, pp.1301~1309 (2005)
  37. Chou YH, "Imaging the serotonin transporter using 123I-ADAM in the human brain", Psychiatry Res, 172, pp.38~43 (2009)
  38. "Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology", Eur Heart J, 17, pp.354~381 (1996)
  39. ADAM, "Psychiatry Res", 2015, 320~324
  40. Hsiao CY, "The association between baseline subjective anxiety rating and changes in cardiac autonomic nervous activity in response to tryptophan depletion in healthy volunteers", Medicine(Baltimore), 95, pp.e3498~ (2016)
  41. Citkowska-Kisielewska A, "Obsessive-compulsive symptoms in obsessive-compulsive disorder and in generalized anxiety disorder : occurrence and correlations", J Psychiatr Pract, 26, pp.101~119 (2020)
  42. Gentes EL, "A meta-analysis of the relation of intolerance of uncertainty to symptoms of generalized anxiety disorder, major depressive disorder, and obsessive-compulsive disorder", Clin Psychol Rev, 31, pp.923~933 (2011)
  43. Lissemore JI, "Brain serotonin synthesis capacity in obsessive-compulsive disorder : effects of cognitive behavioral therapy and sertraline", Transl Psychiatry, 8, pp.82~ (2018)
  44. Hesse S, "The serotonin transporter availability in untreated early-onset and late-onset patients with obsessive-compulsive disorder", Int J Neuropsychopharmacol, 14, pp.606~617 (2011)
  45. Lomax CL, "Clinical and treatment comparisons between adults with early-and late-onset obsessive-compulsive disorder", Behav Res Ther, 47, pp.99~104 (2009)
  46. Rosario-Campos MC, "Adults with early-onset obsessive-compulsive disorder", Am J Psychiatry, 158, pp.1899~1903 (2001)
  47. Su CF, "Sympathetic and parasympathetic activities evaluated by heart-rate variability in head injury of various severities", Clin Neurophysiol, 116, pp.1273~1279 (2005)
  48. Reyes del Paso GA, "The utility of low frequency heart rate variability as an index of sympathetic cardiac tone : a review with emphasis on a reanalysis of previous studies", Psychophysiology, 50, pp.477~487 (2013)
  49. Jordan D, "Hypothalamic inhibition of neurones in the nucleus tractus solitarius of the cat is GABA mediated", J Physiol, 399, pp.389~404 (1988)
  50. Nikolaus S, "Cortical GABA, striatal dopamine and midbrain serotonin as the key players in compulsive and anxiety disorders--results from in vivo imaging studies", Rev Neurosci, 21, pp.119~139 (2010)
  51. Olver JS, "Dopamine D1 receptor binding in the anterior cingulate cortex of patients with obsessive-compulsive disorder", Psychiatry Res, 183, pp.85~88 (2010)
  52. Yeh TL, "Correlation between striatal dopamine D2", D3 receptor binding and cardiovascular activity in healthy subjects, 2006, pp.19, 964~969
  53. Karthik S, "Investigating the role of glutamate in obsessive-compulsive disorder : current perspectives", Neuropsychiatr Dis Treat, 16, pp.1003~1013 (2020)
  54. Martin DS, "Sympathetic nervous system activation by glutamate injections into the paraventricular nucleus", Brain Res, 577, pp.261~267 (1992)
  55. DASB positron emission tomography study, "Neuropharmacology", 2016, 530~536
  56. Bandelow B, "Biological markers for anxiety disorders, OCD and PTSD: a consensus statement. Part II: neurochemistry, neurophysiology and neurocognition", World J Biol Psychiatry, 18, pp.162~214 (2017)

관련 논문AI추천

Autonomic Readiness for Social Threats in Patients with Social Anxiety DisorderDasom Lee, Deung Hyun Kang, Jae Hyun Kim, Joongsuk Lee, Si Woo Kim, Soo-Hee Choi, So-Yeon Kim대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2025 · 제23권 제2호Serotonin and Mental Disorders: A Concise Review on Molecular Neuroimaging EvidenceLan-Ting Lee, Shih-Hsien Lin, Yen Kuang Yang대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2014 · 제12권 제3호Linking an Anxiety-Related Personality Trait to Cardiac Autonomic Regulation in Well-Defined Healthy Adults: Harm Avoidance and Resting Heart Rate VariabilityChuan-Chia Chang, Hsin-An Chang, Lien-Cheng Kao, Nian-Sheng Tzeng, San-Yuan Huang, Terry B. J. Kuo, Yu-Wen Liu대한신경정신의학회 · PSYCHIATRY INVESTIGATION2016 · 제13권 제4호Interactions Between Depression, Autonomic Dysfunction, Inhibitory Control and Reaction Time: Insights From Heart Rate Variability During Continuous Performance TestCheryl C.H. Yang, Chung-Chih Hsu, Hsun Ou, Terry B.J. Kuo, Tien-Yu Chen대한신경정신의학회 · PSYCHIATRY INVESTIGATION2025 · 제22권 제8호Altered Low Frequency Heart Rate Variability Associated with Agoraphobia in Panic Disorder: A Retrospective Study김민정, 김지혜, 박진영, 박해인, 이덕종연세대학교의과대학 · Yonsei Medical Journal2023 · 제64권 제11호Comparative Study of Heart Rate Variability in Patients with Schizophrenia,Bipolar Disorder, Post-traumatic Stress Disorder, or Major Depressive Disorder김도형, 문은옥, 이승환, 황보람대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2013 · 제11권 제3호

이 간행물의 다른 논문 (20건)