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Polyneuropathy Associated with IgA Paraproteinemia and Amyloidosis: A Case Report and Literature Review

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Abstract

Paraproteinemia potentially causes peripheral neuropathy via an unknown underlying pathogenetic mechanism. We report a case of pathologically proven amyloid neuropathy with AL amyloidosis with an IgA kappa light chain, which was initially diagnosed as neuropathy associated with monoclonal gammopathy of undetermined significance. This case indicates that in cases of neuropathy with paraproteinemia, the other potential causes should be excluded by appropriate means, especially pathological evaluations.

참고문헌 (9)

  1. Kyle RA, "Monoclonal gammopathy of undetermined significance and smoldering multiple myeloma", 2, pp.2565~2581 (2004), Philadelphia: Lippincott Williams & Wilkins
  2. Kelly JJ, "Prevalence of monoclonal protein in peripheral neuropathy", pp.1480~1483
  3. Braun PE, "Myelin-associated glycoprotein is the antigen for a monoclonal IgM in polyneuropathy", pp.1261~1265
  4. Barbieri S, "Peripheral neuropathy in monoclonal gammopathy of undetermined significance", (bile-orazio e), pp.383~390
  5. Magy L, "Polyneuropathy associated with IgG", IgA monoclonal gammopathy: a clinical and electrophysiological study of 15 cases, 2003, pp.10(be t), 677~685
  6. Pletz MW, "Immune- mediated neuropathies: etiology and pathogenic relationship to aging processes", 137, pp.1~11 (2003)
  7. Sewell HF, "Autoantibody to nerve tissue in a patient with a peripheral neuropathy and an IgG paraprotein", pp.1163~1166
  8. "Binding of serum IgA of multiple myeloma to normal peripheral nerve", pp.381~387
  9. Mehndiratta MM, "IgA monoclonal gammopathy of undetermined significance with peripheral neuropathy", 221, pp.99~104 (2004)

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