다발골수종 환자의 염색체 이상과 예후관련 검사항목과의 연관성-단일 기관 연구
Correlation of Chromosomal Aberrations with Prognostic Markers in Multiple Myeloma Patients- A Single Institution Study
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Abstract
Background : Immunoglobulin heavy chain (IGH) gene rearrangement, 13q14 deletion and trisomy 1q are frequently observed in Korean patients with multiple myeloma. The purpose of our study was to analyze the statistical correlation between chromosomal aberrations and routine laboratory test results as prognostic markers and to evaluate the potential of chromosomal aberrations for the indirect assessment of prognosis in multiple myeloma patients. Methods : We investigated the prevalence of cytogenetic aberrations in 41 patients with newly diagnosed multiple myeloma. Cytogenetic analysis was conducted by conventional karyotyping and FISH for the presence of IGH/CCND1 translocation, 13q14 deletion, and trisomy 1q using bone marrow aspirates. The records of routine laboratory tests were reviewed and their correlation with cytogenetic abnormalities was investigated. Results : Sixteen (39.0%) of 41 patients had at least one cytogenetic abnormalities in conventional karyotyping or FISH. In FISH analysis of 37 patients, 8 (21.6%) showed positive result for IGH/CCND1 translocation, 8 (21.6%) for trisomy 1q, and 5 (13.5%) for 13q14 deletion. Cytogenetic abnormalities, especially trisomy 1q, were associated with significantly lower hemoglobin level and significantly higher bone marrow plasma cell percentage and β2-microglobulin level. Conclusions : Statistical correlation between the presence of trisomy 1q and prognostic markers suggests that the evaluation of trisomy 1q in multiple myeloma patients may be used for the indirect assessment of prognosis in these patients. (Korean J Lab Med 2008;28:413-8)
참고문헌 (17)
- Chen L, "Molecular cytogenetic aberrations in patients with multiple myeloma studied by interphase fluorescence in situ hybridization", Exp Oncol, 29, pp.116~120 (2007)
- Christensen JH, "Interphase fluorescence in situ hybridization in multiple myeloma and monoclonal gammopathy of undetermined significance without and with positive plasma cell identification: analysis of 192 cases from the Region of Southern Denmark", Cancer Genet Cytogenet, 174, pp.89~99 (2007)
- Wu KL, "Abnormalities of chromosome 1p", q are highly associated with chromosome 13, Br J Haematol, pp.2007, 136[DOI]
- Takimoto M, "Close relation between 14q32", IGH translocations and chromosome 13 abnormalities in multiple myeloma: a high incidence of 11q13, MAF, pp.Int J Hematol, 2008[DOI]
- Hallek M, "Multiple myeloma: increasing evidence for a multistep transformation process", Blood, 91, pp.3~21 (1998)
- Mohamed AN, "Chromosome aberrations in a series of 120 multiple myeloma cases with abnormal karyotypes", Am J Hematol, 82, pp.1080~1087 (2007)
- Chang H, "Detection of chromosome 13q deletions and IgH translocations in patients with multiple myeloma by FISH: comparison with karyotype analysis", Leuk Lymphoma, 45, pp.965~969 (2004)
- Liebisch P, "Value of comparative genomic hybridization and fluorescence in situ hybridization for molecular diagnostics in multiple myeloma", Br J Haematol, 122, pp.193~201 (2003)
- Liebisch P, "High incidence of trisomies 1q, 9q, and 11q in multiple myeloma: results from a comprehensive molecular cytogenetic analysis", Leukemia, 17, pp.2535~2537 (2003)
- Bang SM, "Identification of 13q deletion, trisomy 1q, and IgH rearrangement as the most frequent chromosomal changes found in Korean patients with multiple myeloma", Cancer Genet Cytogenet, 168, pp.124~132 (2006)
- 김경태, "다발성골수종에서 염색체 이상의 임상적 중요성", 대한내과학회지, 69(3), pp.303~311 (2005), 대한내과학회
- Hwang SH, "Prognostic relevances of bone marrow features in patients with multiple myeloma", Korean J Clin Pathol, 19, pp.8~14 (1999)
- The International Myeloma Working Group, "Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group", Br J Haematol, 121, pp.749~757 (2003)
- Durie BG, "A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival", Cancer, 36, pp.842~854 (1975)
- 허정원, "다발성골수종 환자에서 간기세포 Fluorescence in situ Hybridization을 이용한 IgH과 Cyclin D1 재배열 검색", Annals of Laboratory Medicine, 22(5), pp.367~371 (2002), 대한진단검사의학회
- Fonseca R, "Myeloma and the t(11;14)(q13;q32); evidence for a biologically defined unique subset of patients", Blood, 99, pp.3735~3741 (2002)
- Moreau P, "Recurrent 14q32 translocations determine the prognosis of multiple myeloma, especially in patients receiving intensive chemotherapy", Blood, 100, pp.1579~1583 (2002)