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Genetic characteristics of the Korean isolate KI-1 of Toxoplasma gondii

신은희|김태윤|박재환|채종일|국상미|Aifen Lin
대한기생충학ㆍ열대의학회 (The Korean Society For Parasitology and Tropical Medicine)|2005.03|Parasites, Hosts and Diseases|제43권 제1호|pp. 1-12

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주제분류예방의학/직업환경의학

초록

Abstract

Toxoplasma gondii tachyzoites were isolated from an ocular patient in the Republic of Korea and maintained in the laboratory (designated KI-1). In the present study, its genotype was determined by analyzing dense granule antigen 6 (GRA6) gene and surface antigen 2 (SAG2) gene as typing markers. Digestion of the amplification products of GRA6 and of the 5 and 3 ends of SAG2, respectively, with Mse I, Sau3A I, and Hha I, revealed that KI-1 is included in the genotype I, which includes the worldwide virulent RH strain. In addition, when the whole sequences of the coding regions of SAG1, rhoptry antigen 1 (ROP1), and GRA8 genes of KI-1 were compared with those of RH, minor nucleotide polymorphisms and amino acid substitutions were identified. These results show that KI-1 is a new geographical strain of T. gondii that can be included in the genotype I.

참고문헌 (14)

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관련 논문AI추천

Laboratory passage and characterization of an isolate of Toxoplasma gondii from an ocular patient in Korea남호우, 신은희, 오명돈, 이순형, 채종일, 한은택, AifenLIN대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2003 · 제41권 제3호Genotyping of a Korean isolate of Toxoplasma gondii by multilocus PCR-RFLP and microsatellite analysis김태윤, 이영하, 최인욱, Juan-Hua Quan대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2008 · 제46권 제2호Evaluation of the Korean Isolate-1 Tachyzoite Antigen for Serodiagnosis of Toxoplasmosis김동희, 김효진, 신은희, 안명희, 채종일, 이조운이, Aifen Lin대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2008 · 제46권 제1호Genotype of Toxoplasma gondii from Blood of Stray Cats in Gyeonggi-do, Korea김윤아, 유재란, 이상은, 이호사, 조신형, Ho Gun Rhie, Hye-Youn Kim대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2009 · 제47권 제4호Molecular identification of Korean Trichinella isolatesDong-IlCHUNG, EdoardoPOZIO, SunHUH, Woon-MokSOHN대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2003 · 제41권 제2호Molecular epidemiology of Toxoplasma gondii in cattle in Korea김규태, 서민구대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2023 · 제61권 제2호

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