Anaphylactic Transfusion Reaction in a Patient with Anhaptoglobinemia: The First Case in Korea
0
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Anaphylactic transfusion reactions are rare complications of blood transfusions. Anhaptoglobinemia, a condition that has high incidence in Asia, can cause allergic transfusion reactions or anaphylaxis in severe cases. A 50-yr-old Korean woman was diagnosed with relapsed acute promyelocytic leukemia. She developed thrombocytopenia during chemotherapy and an anaphylactic transfusion reaction on the 4th and 5th platelet transfusions immediately after the transfusion of the platelet concentrates was initiated. Blood analysis showed no detectable serum haptoglobin. We examined her genetic phenotype and detected anhaptoglobinemia, which occurs because of an allelic deletion in the Hp gene cluster. The presence of an antibody against haptoglobin was detected by performing ELISA. To prevent anaphylactic reactions, apheresis platelets were transfused after washing. Consequently, anaphylactic transfusion reactions did not develop. Here, we report the first case of anhaptoglobinemia causing anaphylactic transfusion reaction in Korea.
Abstract
Anaphylactic transfusion reactions are rare complications of blood transfusions. Anhaptoglobinemia, a condition that has high incidence in Asia, can cause allergic transfusion reactions or anaphylaxis in severe cases. A 50-yr-old Korean woman was diagnosed with relapsed acute promyelocytic leukemia. She developed thrombocytopenia during chemotherapy and an anaphylactic transfusion reaction on the 4th and 5th platelet transfusions immediately after the transfusion of the platelet concentrates was initiated. Blood analysis showed no detectable serum haptoglobin. We examined her genetic phenotype and detected anhaptoglobinemia, which occurs because of an allelic deletion in the Hp gene cluster. The presence of an antibody against haptoglobin was detected by performing ELISA. To prevent anaphylactic reactions, apheresis platelets were transfused after washing. Consequently, anaphylactic transfusion reactions did not develop. Here, we report the first case of anhaptoglobinemia causing anaphylactic transfusion reaction in Korea.
참고문헌 (11)
- Tobian AA, "Prevention of allergic transfusion reactions to platelets and red blood cells through plasma reduction", Transfusion, 51, pp.1676~1683 (2011)
- Levy AP, "Haptoglobin: basic and clinical aspects", Antioxid Redox Signal, 12, pp.293~304 (2010)
- Koda Y, "Simple PCR detection of haptoglobin gene deletion in anhaptoglobinemic patients with antihaptoglobin antibody that causes anaphylactic transfusion reactions", Blood, 95, pp.1138~1143 (2000)
- Park KU, "Haptoglobin genotypic distribution (including Hp0 allele) and associated serum haptoglobin concentrations in Koreans", J Clin Pathol, 57, pp.1094~1095 (2004)
- Koda Y, "The haptoglobin-gene deletion responsible for anhaptoglobinemia", Am J Hum Genet, 62, pp.245~252 (1998)
- Vo TD, "Platelet washing to prevent recurrent febrile reactions to leucocyte-reduced transfusions", ransfus Med, 11, pp.45~47 (2001)
- Vesilind GW, "Evaluation of a centrifugal blood cell processor for washing platelet concentrates", Transfusion, 28, pp.46~51 (1988)
- Nishiki S, "Effectiveness of washed platelet concentrate and red cell transfusions for a patient with anhaptoglobinemia with antihaptoglobin antibody", Transfus Med, 12, pp.71~73 (2002)
- Mantovani AP, "Prevalence of IgA deficiency in adult systemic lupus erythematosus and the study of the association with its clinical and autoantibody profiles", Rev Bras Reumatol, 50, pp.273~282 (2010)
- Heddle NM, "The role of the plasma from platelet concentrates in transfusion reactions", N Engl J Med, 331, pp.625~628 (1994)
- Jilma-Stohlawetz P, "The effect of plasma removal from apheresis platelet concentrates on platelet function", Vox Sang, 102, pp.258~260 (2012)