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A Case of Isolated Lymphoblastic Relapse of the Central Nervous System in a Patient with Chronic Myelogenous Leukemia Treated with Imatinib

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참고문헌

주제분류병리학

초록

Isolated central nervous system (CNS) relapse is a rare, unpre- dictable event in patients with CML. Some studies have reported cases of isolated CNS relapse in CML [1-13]. However, very few studies have reported on isolated CNS relapse in the blast phase (BP) of CML in Korea [14, 15]. We report a case of BP CML with extramedullary lymphoblast proliferation in the CNS without evidence of disease in the peripheral blood (PB) and bone marrow (BM).

Abstract

Isolated central nervous system (CNS) relapse is a rare, unpre- dictable event in patients with CML. Some studies have reported cases of isolated CNS relapse in CML [1-13]. However, very few studies have reported on isolated CNS relapse in the blast phase (BP) of CML in Korea [14, 15]. We report a case of BP CML with extramedullary lymphoblast proliferation in the CNS without evidence of disease in the peripheral blood (PB) and bone marrow (BM).

참고문헌 (20)

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  3. Bornhauser M, "CNS blast crisis of chronic myelogenous leukemia in a patient with a major cytogenetic response in bone marrow associated with low levels of imatinib mesylate and its N-desmethylated metabolite in cerebral spinal fluid", Ann Hematol, 83, pp.401~402 (2004)
  4. Bujassoum S, "Isolated central nervous system relapse in lymphoid blast crisis chronic myeloid leukemia and acute lymphoblastic leukemia in patients on imatinib therapy", Leuk Lymphoma, 45, pp.401~403 (2004)
  5. Johnson NA, "Isolated central nervous system relapse in patients with chronic myeloid leukemia on imatinib mesylate", Leuk Lymphoma, 46, pp.629~630 (2005)
  6. Matsuda M, "Extramedullary blast crisis derived from 2 different clones in the central nervous system and neck during complete cytogenetic remission of chronic myelogenous leukemia treated with imatinib mesylate", Int J Hematol, 81, pp.307~309 (2005)
  7. Aichberger KJ, "Liposomal cytarabine for treatment of myeloid central nervous system relapse in chronic myeloid leukaemia occurring during imatinib therapy", Eur J Clin Invest, 37, pp.808~813 (2007)
  8. Barlow A, "Isolated central nervous system lymphoid blast crisis in chronic myeloid leukaemia in major molecular remission", Br J Haematol, 142, pp.327~ (2008)
  9. Altintas A, "Central nervous system blastic crisis in chronic myeloid leukemia on imatinib mesylate therapy: a case report", J Neurooncol, 84, pp.103~105 (2007)
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  12. Fuchs M, "Isolated central nervous system relapse of chronic myeloid leukemia after allogenic hematopoietic stem cell transplantation", BMC Blood Disord, 12, pp.9~ (2012)
  13. Nishimoto M, "Dasatinib maintenance therapy after allogeneic hematopoietic stem cell transplantation for an isolated central nervous system blast crisis in chronic myelogenous leukemia", Acta Haematologica, 130, pp.111~114 (2013)
  14. Kim HJ, "Isolated blast crisis in CNS in a patient with chronic myelogenous leukemia maintaining major cytogenetic response after imatinib", J Clin Oncol, 24, pp.4028~4029 (2006)
  15. Lee KW, "Isolated central nervous system blast crisis in chronic myeloid leukemia", Korean J Med, 77(2), pp.441~444 (2009)
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  17. Baccarani M, "Chronic myeloid leukemia: an update of concepts and management recommendations of European LeukemiaNet", J Clin Oncol, 27, pp.6041~6051 (2009)
  18. Forrest DL, "Cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia are correlated with Sokal risk scores and duration of therapy but not trough imatinib plasma levels", Leuk Res, 33, pp.271~275 (2009)
  19. Hasford J, "A new prognostic score for survival of patients with chronic myeloid leukemia treated with interferon alfa. Writing Committee for the Collaborative CML Prognostic Factors Project Group", J Natl Cancer Inst, 90, pp.850~859 (1998)
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