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Two Cases of Antibody-Mediated Rejection Following Kidney Transplantation due to HLA-DQB1 Allele-Specific and DQ Alpha Protein-Specific HLA Antibodies

김현숙|김범석|김유선|박금보래|송승환
대한진단검사의학회 (Korean Society For Laboratory Medicine)|2017.05|Annals of Laboratory Medicine|제37권 제3호|pp. 290-292

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주제분류병리학

초록

Dear Editor, The HLA-A, HLA-B, and HLA-DR loci have been used for transplant candidate matching. Recent studies using single antigen bead-based assays (SABAs) have revealed that HLA-DQ donor-specific HLA antibodies (DSHAs) are associated with inferior allograft outcomes [1, 2]. Therefore, donor HLA-DQ typing prior to transplantation is now thought to be highly important.

Abstract

Dear Editor, The HLA-A, HLA-B, and HLA-DR loci have been used for transplant candidate matching. Recent studies using single antigen bead-based assays (SABAs) have revealed that HLA-DQ donor-specific HLA antibodies (DSHAs) are associated with inferior allograft outcomes [1, 2]. Therefore, donor HLA-DQ typing prior to transplantation is now thought to be highly important.

참고문헌 (6)

  1. Willicombe M, "De novo DQ donor-specific antibodies are associated with a significant risk of antibody-mediated rejection and transplant glomerulopathy", Transplantation, 94, pp.172~177 (2012)
  2. Carta P, "Anti-human leukocyte antigen DQ antibodies in renal transplantation: Are we underestimating the most frequent donor specific alloantibodies?", Transplant Rev (Orlando), 29, pp.135~138 (2015)
  3. Tambur AR, "The DQ barrier: improving organ allocation equity using HLA-DQ information", Transplantation, 95, pp.635~640 (2013)
  4. Lomago J, "How did a patient who types for HLA-B*4403 develop antibodies that react with HLA-B*4402?", Hum Immunol, 71, pp.176~178 (2010)
  5. Cecka JM, "HLA high-resolution typing for sensitized patients: a solution in search of a problem?", Am J Transplant, 15, pp.855~856 (2015)
  6. Baxter-Lowe LA, "Center-defined unacceptable HLA antigens facilitate transplants for sensitized patients in a multi-center kidney exchange program", Am J Transplant, 14, pp.1592~1598 (2014)

관련 논문AI추천

Clinical Relevance of Pretransplant HLA Class II Donor-specific Antibodies in Renal Transplantation Patients with Negative T-cell Cytotoxicity Crossmatches김상준, 김연수, 박명희, 송은영, 안규리, 이유주, 하종원, 현정원대한진단검사의학회 · Annals of Laboratory Medicine2012 · 제32권 제2호False-Positive Reactions Against HLA Class II Molecules Detected in Luminex Single-Antigen Bead Assays신수, 노은연, 박경운, 송은영, 인지원대한진단검사의학회 · Annals of Laboratory Medicine2014 · 제34권 제5호Clinical significance of the presence of antihuman leukocyte antigen-donor specific antibody in kidney transplant recipients with allograft dysfunctionBum Soon Choi, Byung Ha Chung, Cheol Whee Park, Chul Woo Yang, Eun-Jee Oh, In Sung Moon, Jeong Ho Kim, Ji-Il Kim, Yeong Jin Choi, Yong-Soo Kim대한내과학회 · The Korean Journal of Internal Medicine2018 · 제33권 제1호Prediction of HLA-DQ in Deceased Donors and its Clinical Significance in Kidney TransplantationHwang Sang-Hyun, Kim Soo-Kyung, Ko Sun-Young, Oh Heung-Bum, Shin Sung, Sung Heungsup, Yang John Jeongseok대한진단검사의학회 · Annals of Laboratory Medicine2021 · 제41권 제2호Impact of Low-Level Donor-Specific Anti-HLA Antibody on Posttransplant Clinical Outcomes in Kidney Transplant Recipients정병하, Eum Sang Hun, Ko Eun Jeong, Lee Haeun, Lee Hanbi, Min Ji-Won, Oh Eun-Jee, Yang Chul Woo대한진단검사의학회 · Annals of Laboratory Medicine2023 · 제43권 제4호Causes of Positive Pretransplant Crossmatches in the Absence of Donor-Specific Anti-Human Leukocyte Antigen Antibodies: A Single-Center ExperienceKang Hyunhye, Lee Sang-Yoon, Oh Eun-Jee, Yoo Jaeeun대한진단검사의학회 · Annals of Laboratory Medicine2021 · 제41권 제4호

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