Successful Treatment of Brugia pahangi in Naturally Infected Cats with Ivermectin
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Lymphatic filariasis is a common parasitic disease of cats in tropical regions including Thailand. The objective of this study was to determine the efficacy of ivermectin against microfilariae of Brugia pahangi in naturally infected cats. Eight cats naturally infected with B. pahangi were divided into control (untreated) and treated groups. Cats in the latter group were given ivermectin injection at 400 µg/kg weekly for 2 months. Microfilariae were counted every week until 48 weeks. Microfilaremia was significantly decreased in the treated group 4 weeks after starting the treatment and become zero at week 9 and afterwards. On the other hand, cats in the control group had high microfilaremia throughout the study. It was successful to treat and control B. pahangi infection in naturally infected cats using ivermectin.
Abstract
Lymphatic filariasis is a common parasitic disease of cats in tropical regions including Thailand. The objective of this study was to determine the efficacy of ivermectin against microfilariae of Brugia pahangi in naturally infected cats. Eight cats naturally infected with B. pahangi were divided into control (untreated) and treated groups. Cats in the latter group were given ivermectin injection at 400 µg/kg weekly for 2 months. Microfilariae were counted every week until 48 weeks. Microfilaremia was significantly decreased in the treated group 4 weeks after starting the treatment and become zero at week 9 and afterwards. On the other hand, cats in the control group had high microfilaremia throughout the study. It was successful to treat and control B. pahangi infection in naturally infected cats using ivermectin.
참고문헌 (16)
- Phantana S, "Microfilaricidal efficacy of ivermectin on zoonotic Brugia malayi in naturally infected cats", J Trop Med Parasitol, 25, pp.11~16 (2002)
- Junhom W, "The observation of microfilaria rate and density in cats inoculated with increasing numbers of Brugia pahangi infective larvae", Southeast Asian J Trop Med Public Health, 37(suppl 3):), pp.40~42 (2006)
- Chungpivat S, "Microfilariae in cats in Bangkok", Thai J Vet Med, 23, pp.75~87 (1993)
- Tompkins JB, "Brugia malayi : in vitro effects of ivermectin and moxidectin on adults and microfilariae", Exp Parasitol, 124, pp.394~402 (2010)
- Speare R, "Mass treatment with ivermectin : an underutilized public health strategy", Bulletin of WHO, 82, pp.562~ (2004)
- Bottomley C, "Rates of microfilarial production by Onchocerca volvulus are not cumulatively reduced by multiple ivermectin treatments", Parasitology, 135, pp.1571~1581 (2008)
- McCall JW, "Heartworm and Wolbachia : therapeutic implications", Vet Parasitol, 158, pp.204~214 (2008)
- Stolk WA, "Effects of ivermectin and diethylcabamazine on microfilariae and overall microfilaria production in bancroftian filariasis", Am J Trop Med Hyg, 73, pp.881~887 (2005)
- Tagboto SK, "Onchocerca volvulus and O. lienalis: the microfilaricidal activity of moxidectin compared with that of ivermectin in vitro and in vivo", Ann Trop Med Parasitol, 90, pp.497~505 (1996)
- Chansiri G, "The efficacy of a single-oral-dose administration of ivermectin and diethylcarbamazine on the treatment of feline Brugia malayi", Southeast Asian J Trop Med Public Health, 36, pp.1105~1109 (2005)
- Chungpivat S, "The differentiation of microfilariae in dogs and cats using Giemsa’s staining and the detection of acid phosphatase activity", J Thai Vet Prac, 20, pp.47~55 (2008)
- Lachin JM, "Some large-sample distribution-free estimators and tests for multivariate partially incomplete data from two populations", Stat Med, 11, pp.1151~1170 (1992)
- Thall PF, "Analysis of recurrent events : nonparametric methods for random interval count data", J Am Stat Assoc, 83, pp.339~347 (1988)
- Baird JK, "Ivermectin inhibits molting of Wuchereria bancrofti third stage larvae in vitro", J Parasitol, 77, pp.162~163 (1991)
- Campbell WC, "Efficacy of the avermectins against filarial parasites : a short review", Vet Res Commun, 5, pp.252~262 (1982)
- Mancebo OA, "Comparative efficacy of moxidectin 2% equine oral gel and ivermectin 2% equine oral paste against Onchocerca cervicalis (Railiet and Henry. 1910) microfilariae in horses with naturally acquired infections in Formosa (Argentina)", Vet Parasitol, 73, pp.243~248 (1997)
