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Bone Marrow Involvement of Epstein-Barr Virus-Positive Large B-Cell Lymphoma in a Patient with Angioimmunoblastic T-Cell Lymphoma

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초록

Angioimmunoblastic T-cell lymphoma (AITL) is the second most common subtype of peripheral T-cell lymphoma, accounting for approximately 15–20% of the cases [1]. It is a systemic lymphoproliferative disorder that typically presents with constitutional symptoms, generalized lymphadenopathy, hepatosplenomegaly, skin rash, and immunological disturbances [2]. AITL may be accompanied by either polyclonal or clonal proliferation of B lymphocytes, which seems to be triggered by Epstein-Barr virus (EBV) infection [3].

Abstract

Angioimmunoblastic T-cell lymphoma (AITL) is the second most common subtype of peripheral T-cell lymphoma, accounting for approximately 15–20% of the cases [1]. It is a systemic lymphoproliferative disorder that typically presents with constitutional symptoms, generalized lymphadenopathy, hepatosplenomegaly, skin rash, and immunological disturbances [2]. AITL may be accompanied by either polyclonal or clonal proliferation of B lymphocytes, which seems to be triggered by Epstein-Barr virus (EBV) infection [3].

참고문헌 (10)

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  2. Hawley RC, "Angioimmunoblastic T-cell lymphoma with supervening Epstein-barr virus-associated large B-cell lymphoma", Arch Pathol Lab Med, 130, pp.1707~1711 (2006)
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  4. Foucar K, "Bone marrow pathology", pp.557~577 (2010), American Society for Clinical Pathology
  5. Grogg KL, "Spectrum of bone marrow findings in patients with angioimmunoblastic T-cell lymphoma", Br J Haematol, 137, pp.416~422 (2007)[DOI]
  6. Zettl A, "Epstein-Barr virus-associated B-cell lymphoproliferative disorders in angloimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, unspecified", Am J Clin Pathol, 117, pp.368~379 (2002)[DOI]
  7. 최윤희, "혈관면역 T세포 림프종 치료 후 발생한 엡스타인바 바이러스 양성 미만성 큰 B세포 림프종 1예", Blood Research, 43(3), pp.174~178 (2008), 대한혈액학회
  8. Zhou Y, "Cerebellar EBV-associated diffuse large B cell lymphoma following angioimmunoblastic T cell lymphoma", J Hematop, 8, pp.235~241 (2015)[DOI]
  9. Kasahara H, "Successful treatment with rituximab for angioimmunoblastic T-cell lymphoma", Leuk Res Rep, 2, pp.36~38 (2013)
  10. Delfau-Larue MH, "Targeting intratumoral B cells with rituximab in addition to CHOP in angioimmunoblastic T-cell lymphoma. A clinicobiological study of the GELA", Haematologica, 97, pp.1594~1602 (2012)[DOI]

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