Association Between Parkinsonism and Participation in Agriculture in Korea
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Background and Purpose: Environmental factors might influence the pathogenesis of Parkinson’s disease (PD) or multiple-system atrophy (MSA), and previous examinations of pesticide exposure, well-water drinking, and farming have produced inconclusive results. Because agriculture has been of considerable importance to Korean society, and hence the risk of exposure to pesticides was high in Korea, this study investigated whether such exposure is associated with elevated risks of developing PD and MSA. Methods: Two hundred and thirty-five PD patients, 133 MSA patients, and 77 normal control subjects were examined. Data concerning environmental factors were collected by face-to-face interviews using a structured questionnaire. Odds ratios (ORs) were calculated by binary logistic regression. Results: ORs for environmental risk factors for developing PD were 1.06 [95% confidence interval (CI) = 1.02- 1.10] for age and 2.37 (95% CI = 1.32-4.27) for rural well-water drinking for >10 years. Smoking >10 pack-years (OR = 0.31; 95% CI = 0.11-0.64) was a preventable factor for developing PD in this study. However, no significant risk factors were identified for MSA. Conclusions: These results suggest that exposure to certain environmental risk factors plays a role in the development of PD. However, the development of MSA appears to be independent of environmental risk factors in Korean patients.
Abstract
Background and Purpose: Environmental factors might influence the pathogenesis of Parkinson’s disease (PD) or multiple-system atrophy (MSA), and previous examinations of pesticide exposure, well-water drinking, and farming have produced inconclusive results. Because agriculture has been of considerable importance to Korean society, and hence the risk of exposure to pesticides was high in Korea, this study investigated whether such exposure is associated with elevated risks of developing PD and MSA. Methods: Two hundred and thirty-five PD patients, 133 MSA patients, and 77 normal control subjects were examined. Data concerning environmental factors were collected by face-to-face interviews using a structured questionnaire. Odds ratios (ORs) were calculated by binary logistic regression. Results: ORs for environmental risk factors for developing PD were 1.06 [95% confidence interval (CI) = 1.02- 1.10] for age and 2.37 (95% CI = 1.32-4.27) for rural well-water drinking for >10 years. Smoking >10 pack-years (OR = 0.31; 95% CI = 0.11-0.64) was a preventable factor for developing PD in this study. However, no significant risk factors were identified for MSA. Conclusions: These results suggest that exposure to certain environmental risk factors plays a role in the development of PD. However, the development of MSA appears to be independent of environmental risk factors in Korean patients.
참고문헌 (31)
- Marder K, "Risk of Parkinson’s disease among firstdegree relatives: A community-based study", Neurology, 47, pp.155~160 (1996)
- Langston JW, "Parkinson’s disease in a chemist working with 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine", N Engl J Med, 309, pp.310~ (1983)
- Rajput AH, "Early onset Parkinson’s disease in Saskatchewanenvironmental considerations for etiology", Can J Neurol Sci, 13, pp.312~316 (1986)
- Koller W, "Environmental risk factors in Parkinson’s disease", Neurology, 40, pp.1218~1221 (1990)
- Wong GF, "Environmental risk factors in siblings with Parkinson’s disease", Arch Neurol, 48, pp.287~289 (1991)
- De Michele G, "Environmental and genetic risk factors in Parkinson’s disease: a case-control study in southern Italy", Mov Disord, 11, pp.17~23 (1996)
- Zorzon M, "Familial and environmental risk factors in Parkinson’s disease: a case-control study in north-east Italy", Acta Neurol Scand, 105, pp.77~82 (2002)
- Priyadarshi A, "Environmental risk factors and Parkinson’s disease: a metaanalysis", Environ Res, 86, pp.122~127 (2001)
- Firestone JA, "Checkoway H. Pesticides and risk of Parkinson disease: a population-based case-control study", Arch Neurol, 62, pp.91~95 (2005)
- Liou HH, "Environmental risk factors and Parkinson’s disease: a case-control study in Taiwan", Neurology, 48, pp.1583~1588 (1997)
- Chan DK, "Genetic and environmental risk factors for Parkinson’s disease in a Chinese population", J Neurol Neurosurg Psychiatry, 65, pp.781~784 (1998)
- Priyadarshi A, "A meta-analysis of Parkinson’s disease and exposure to pesticides", Neurotoxicology, 21, pp.435~440 (2000)
- Seidler A, "Possible environmental, occupational, and other etiologic factors for Parkinson’s disease: a case-control study in Germany", Neurology, 46, pp.1275~1284 (1996)
- Semchuk KM, "Parkinson’s disease: a test of the multifactorial etiologic hypothesis", Neurology, 43, pp.1173~1180 (1993)
- Hanna PA, "Multiple system atrophy: the putative causative role of environmental toxins", Arch Neurol, 56, pp.90~94 (1999)
- Nee LE, "Environmental-occupational risk factors and familial associations in multiple system atrophy: a preliminary investigation", Clin Auton Res, 1, pp.9~13 (1991)
- Vanacore N, "European Study Group on Atypical Parkinsonism (ESGAP). Epidemiology of multiple system atrophy. ESGAP Consortium. European Study Group on Atypical Parkinsonisms", Neurol Sci, 22, pp.97~99 (2001)
- Hughes AJ, "Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinico-pathological study of 100 cases", J Neurol Neurosurg Psychiatry, 55, pp.181~184 (1992)
- Gilman S, "Ben-Shlomo Y, Fowler CJ, et al. Consensus statement on the diagnosis of multiple system atrophy", J Neurol Sci, 163, pp.94~98 (1999)
- McNaught KS, "Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson’s disease", Ann Neurol, 56, pp.149~162 (2004)
- Gorell JM, "Occupational exposures to metals as risk factors for Parkinson’s disease", Neurology, 48, pp.650~658 (1997)
- Seidler A, "Possible environmental, occupational, and other etiologic factors for Parkinson’s disease: a case-control study in Germany", Neurology, 46, pp.1275~1284 (1996)
- Kuopio AM, "Environmental risk factors in Parkinson’s disease", Mov Disord, 14, pp.928~939 (1999)
- Brown TP, "Pesticides and Parkinson’s diseaseis there a link", Environ Health Perspect, 114, pp.156~164 (2006)
- Galanaud JP, "Cigarette smoking and Parkinson’s disease: a case-control study in a population characterized by a high prevalence of pesticide exposure", Mov Disord, 20, pp.181~189 (2005)
- Hernán MA, "A meta-analysis of coffee drinking, cigarettesmoking, and the risk of Parkinson’s disease", Ann Neurol, 52, pp.276~284 (2002)
- Choi IS, "Parkinsonism after carbon monoxide poisoning", Eur Neurol, 48, pp.30~33 (2002)
- Blin O, "Mitochondrial respiratory failure in skeletal muscle from patients with Parkinson’s disease and multiple system atrophy", J Neurol Sci, 125, pp.95~101 (1994)
- Nee LE, "HLA in autonomic failure", Arch Neurol, 46, pp.758~759 (1989)
- Dexter DT, "Alterations in levels of iron, ferritin, and other trace metals in neurodegenerative diseases affecting the basal ganglia", Ann Neurol, 32, pp.S94~S100 (1992), The Royal Kings and Queens Parkinson’s Disease Research Group
- Chrysostome V, "Epidemiology of multiple system atrophy: a prevalence and pilot risk factor study in Aquitaine", France. Neuroepidemiology, 23, pp.201~208 (2004)