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Cerebral Amyloid Angiopathy: A Systematic Review

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Cerebral amyloid angiopathy (CAA) is a disorder characterized by amyloid deposition in the walls of leptomeningeal and cortical arteries, arterioles, and less often capillaries and veins of the central nervous system. CAA occurs mostly as a sporadic condition in the elderly, its incidence associating with advancing age. All sporadic CAA cases are due to deposition of amyloid-β, originating from proteolytic cleavage of the Amyloid Precursor Protein. Hereditary forms of CAA are generally familial (and therefore rare in the general population), more severe and earlier in onset. CAA-related lobar intracerebral hemorrhage is the most well-studied clinical condition associated with brain amyloid deposition. Despite ever increasing understanding of CAA pathogenesis and availability of reliable clinical and diagnostic tools, preventive and therapeutic options remain very limited. Further research efforts are required in order to identify biological targets for novel CAA treatment strategies. We present a systematic review of existing evidence regarding the epidemiology, genetics, pathogenesis, diagnosis and clinical management of CAA.

Abstract

Cerebral amyloid angiopathy (CAA) is a disorder characterized by amyloid deposition in the walls of leptomeningeal and cortical arteries, arterioles, and less often capillaries and veins of the central nervous system. CAA occurs mostly as a sporadic condition in the elderly, its incidence associating with advancing age. All sporadic CAA cases are due to deposition of amyloid-β, originating from proteolytic cleavage of the Amyloid Precursor Protein. Hereditary forms of CAA are generally familial (and therefore rare in the general population), more severe and earlier in onset. CAA-related lobar intracerebral hemorrhage is the most well-studied clinical condition associated with brain amyloid deposition. Despite ever increasing understanding of CAA pathogenesis and availability of reliable clinical and diagnostic tools, preventive and therapeutic options remain very limited. Further research efforts are required in order to identify biological targets for novel CAA treatment strategies. We present a systematic review of existing evidence regarding the epidemiology, genetics, pathogenesis, diagnosis and clinical management of CAA.

참고문헌 (89)

  1. Revesz T, "Cerebral amyloid angiopathies: a pathologic, biochemical, and genetic view", J Neuropathol Exp Neurol, 62, pp.885~898 (2003)
  2. Frangione B, "Familial cerebral amyloid angiopathy related to stroke and dementia", Amyloid, 8(Suppl 1), pp.36~42 (2001)
  3. Selkoe DJ, "Alzheimer’s disease: genes, proteins, and therapy", Physiol Rev, 81, pp.741~766 (2001)
  4. Oppenheim G, "Über “drusige Nekrosen” in der Grosshirnrinde", Neurol Centralbl, 28, pp.410~413 (1909)
  5. Scholz WZ, "StudienzurpathologiederhirngefabeII: die drusige entartung der hirnarterien und capillaren", Gesamte Neurol Psychiatr, 162, pp.694~715 (1938)
  6. Pantelakis S, "A particular type of senile angiopathy of the central nervous system: congophilic angiopathy, topography and frequency", Monatsschr Psychiatr Neurol, 128, pp.219~256 (1954)
  7. Okazaki H, "Clinicopathologic studies of primary cerebral amyloid angiopathy", Mayo Clin Proc, 54, pp.22~31 (1979)
  8. Goldgaber D, "Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer’s disease", Science, 235, pp.877~880 (1987)
  9. Haass C, "Amyloid beta-peptide is produced by cultured cells during normal metabolism", Nature, 359, pp.322~325 (1992)
  10. Robakis NK, "Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides", Proc Natl Acad Sci U S A, 84, pp.4190~4194 (1987)
  11. Busciglio J, "Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells", Proc Natl Acad Sci U S A, 90, pp.2082~2096 (1993)
  12. Jellinger KA, "Alzheimer disease and cerebrovascular pathology: an update", J Neural Transm, 109, pp.813~836 (2002)
  13. Greenberg SM, "Diagnosis of cerebral amyloid angiopathy. Sensitivity and specificity of cortical biopsy", Stroke, 28, pp.1418~1422 (1997)
  14. Neuropathology Group, "Medical Research Council Cognitive Function and Aging Study. Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS)", Lancet, 357, pp.169~175 (2001)
  15. Greenberg SM, "Stroke: Pathophysiology, Diagnosis and Management", pp.693~697 (2004), Harcourt Inc
  16. Ishii K, "Abeta1-40 but not Abeta1-42 levels in cortex correlate with apolipoprotein E epsilon4 allele dosage in sporadic Alzheimer’s disease", Brain Res, 748, pp.250~252 (1997)
  17. Harper JD, "Atomic force microscopic imaging of seeded fibril formation and fibril branching by the Alzheimer’s disease amyloid-beta protein", Chem Biol, 4, pp.951~959 (1997)
  18. Ghiso J, "Genetic alterations of the BRI2 gene: familial British and Danish dementias", Brain Pathol, 16, pp.71~79 (2006)
  19. 김윤석, "Protein Misfolding, Aggregation, and Conformational Diseases PartB: Molecular mechanisms of conformatinal diseases", pp.133~160 (2007), Springer US
  20. Zlokovic BV, "Vascular disorder in Alzheimer’s disease: role in pathogenesis of dementia and therapeutic targets", Adv Drug Deliv Rev, 54, pp.1553~1559 (2002)
  21. Kawarabayashi T, "Accumulation of beta-amyloid fibrils in pancreas of transgenic mice", Neurobiol Aging, 17, pp.215~222 (1996)
  22. Burgermeister P, "Mechanisms of cerebrovascular amyloid deposition. Lessons from mouse models", Ann N Y Acad Sci, 903, pp.307~316 (2000)
  23. Kalaria RN, "Production and increased detection of amyloid beta protein and amyloidogenic fragments in brain microvessels, meningeal vessels and choroid plexus in Alzheimer’s disease", Brain Res Mol Brain Res, 35, pp.58~68 (1996)
  24. Chesebro B, "Anchorless prion protein results in infectious amyloid disease without clinical scrapie", Science, 308, pp.1435~1439 (2005)
  25. Herzig MC, "Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis", Nat Neurosci, 7, pp.954~960 (2004)
  26. Van Dorpe J, "Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the london mutant of human APP in neurons", Am J Pathol, 157, pp.1283~1298 (2000)
  27. Vidal R, "Cerebral amyloid angiopathy and parenchymal amyloid deposition in transgenic mice expressing the Danish mutant form of human BRI2", Brain Pathol, 19, pp.58~68 (2009)
  28. Weller RO, "Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer’s disease", Am J Pathol, 153, pp.725~733 (1998)
  29. Weller RO, "Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer’s disease", Brain Pathol, 18, pp.253~266 (2008)
  30. Deane R, "RAGE mediates amyloid-beta peptide transport across the bloodbrain barrier and accumulation in brain", Nat Med, 9, pp.907~913 (2003)
  31. A beta 1-40 labels amyloid deposits in the aged primate brain in vivo, "Neuroreport", 1996, 2607~2611
  32. Mackic JB, "Cerebrovascular accumulation and increased blood-brain barrier permeability to circulating Alzheimer’s amyloid beta peptide in aged squirrel monkey with cerebral amyloid angiopathy", J Neurochem, 70, pp.210~215 (1998)
  33. Maness LM, "Passage of human amyloid beta-protein 1-40 across the murine bloodbrain barrier", Life Sci, 55, pp.1643~1650 (1994)
  34. Martel CL, "Isoform-specific effects of apolipoproteins E2, E3, and E4 on cerebral capillary sequestration and blood-brain barrier transport of circulating Alzheimer’s amyloid beta", J Neurochem, 69, pp.1995~2004 (1997)
  35. Poduslo JF, "Receptor-mediated transport of human amyloid beta-protein 1-40 and 1-42 at the blood-brain barrier", Neurobiol Dis, 6, pp.190~199 (1999)
  36. Zlokovic BV, "Glycoprotein 330", megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers, 1996, pp.93, 4299~4234
  37. Bading JR, "Brain clearance of Alzheimer’s amyloid-beta40 in the squirrel monkey: a SPECT study in a primate model of cerebral amyloid angiopathy", J Drug Target, 10, pp.359~368 (2002)
  38. DeMattos RB, "Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer’s disease", Science, 295, pp.2264~2267 (2002)
  39. Ghersi-Egea JF, "Fate of cerebrospinal fluid-borne amyloid beta-peptide: rapid clearance into blood and appreciable accumulation by cerebral arteries", J Neurochem, 67, pp.880~883 (1996)
  40. Monro OR, "Substitution at codon 22 reduces clearance of Alzheimer’s amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood", Neurobiol Aging, 23, pp.405~412 (2002)
  41. Shibata M, "Clearance of Alzheimer’s amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier", J Clin Invest, 106, pp.1489~1499 (2000)
  42. Zlokovic BV, "Clearance of amyloid beta-peptide from brain: transport or metabolism", Nat Med, 6, pp.718~719 (2000)
  43. Cirrito JR, "P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model", J Clin Invest, 115, pp.3285~3290 (2005)
  44. Miners JS, "Abeta-degrading enzymes in Alzheimer’s disease", Brain Pathol, 18, pp.240~252 (2008)
  45. Selkoe DJ, "Clearing the brain’s amyloid cobwebs", Neuron, 32, pp.177~180 (2001)
  46. Wang YJ, "Clearance of amyloid-beta in Alzheimer’s disease: progress, problems and perspectives", Drug Discov Today, 11, pp.931~938 (2006)
  47. Sudlow C, "Does apolipoprotein E genotype influence the risk of ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage? Systematic review and metaanalyses of 31 studies among 5961 cases and 17,965 controls", Stroke, 37, pp.364~370 (2006)
  48. Nicoll JA, "High frequency of apolipoprotein E epsilon 2 allele in hemorrhage due to cerebral amyloid angiopathy", Ann Neurol, 41, pp.716~721 (1997)
  49. Farrer LA, "Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium", JAMA, 278, pp.1349~1356 (1997)
  50. Wisniewski T, "Apolipoprotein E: binding to soluble Alzheimer’s beta-amyloid", Biochem Biophys Res Commun, 192, pp.359~365 (1993)
  51. Strittmatter WJ, "Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease", Proc Natl Acad Sci U S A, 90, pp.1977~1981 (1993)
  52. Russo C, "Opposite roles of apolipoprotein E in normal brains and in Alzheimer’s disease", Proc Natl Acad Sci U S A, 95, pp.15598~15602 (1998)
  53. Wisniewski T, "Is Alzheimer’s disease an apolipoprotein E amyloidosis", Lancet, 345, pp.956~958 (1995)
  54. Holtzman DM, "Role of apoe", Abeta interactions in the pathogenesis of Alzheimer’s disease and cerebral amyloid angiopathy, 2001, pp.17, 147~155
  55. Graham DI, "Greenfield’s Neuropathology", pp.293~296 (2002), Arnold
  56. Frackowiak J, "Non-fibrillar beta-amyloid protein is associated with smooth muscle cells of vessel walls in Alzheimer disease", J Neuropathol Exp Neurol, 53, pp.637~645 (1994)
  57. Wisniewski HM, "Role of perivascular cells and myocytes in vascular amyloidosis", Ann N Y Acad Sci, 903, pp.6~18 (2000)
  58. Revesz T, "Sporadic and familial cerebral amyloid angiopathies", Brain Pathol, 12, pp.343~357 (2002)
  59. Eng JA, "Clinical manifestations of cerebral amyloid angiopathy-related inflammation", Ann Neurol, 55, pp.250~256 (2004)
  60. Scolding NJ, "Abeta-related angiitis: primary angiitis of the central nervous system associated with cerebral amyloid angiopathy", Brain, 128, pp.500~515 (2005)
  61. Attems J, "Alzheimer’s disease pathology influences severity and topographical distribution of cerebral amyloid angiopathy", Acta Neuropathol, 110, pp.222~231 (2005)
  62. Pfeifer LA, "Cerebral amyloid angiopathy and cognitive function: the HAAS autopsy study", Neurology, 58, pp.1629~1634 (2002)
  63. Ellis RJ, "Cerebral amyloid angiopathy in the brains of patients with Alzheimer’s disease: the CERAD experience, Part XV", Neurology, 46, pp.1592~1596 (1996)
  64. Puchtler H, "A review of light, polarization and fluorescence microscopic methods for amyloid", Appl Pathol, 3, pp.5~17 (1985)
  65. Stiller D, "Staining mechanism of thioflavin T with special reference to the localization of amyloid", Acta Histochem, 42, pp.234~245 (1972)
  66. Olichney JM, "Cerebral infarction in Alzheimer’s disease is associated with severe amyloid angiopathy and hypertension", Arch Neurol, 52, pp.702~708 (1995)
  67. Vonsattel JP, "Cerebral amyloid angiopathy without and with cerebral hemorrhages: a comparative histological study", Ann Neurol, 30, pp.637~649 (1991)
  68. McCarron MO, "Cerebral amyloid angiopathy and thrombolysis-related intracerebral haemorrhage", Lancet Neurol, 3, pp.484~492 (2004)
  69. Greenberg SM, "Cerebral microbleeds: a guide to detection and interpretation", Lancet Neurol, 8, pp.165~174 (2009)
  70. Greenberg SM, "Microbleeds versus macrobleeds: evidence for distinct entities", Stroke, 40, pp.2382~2386 (2009)
  71. Greenberg SM, "Hemorrhage burden predicts recurrent intracerebral hemorrhage after lobar hemorrhage", Stroke, 35, pp.1415~1420 (2004)
  72. Smith EE, "MRI markers of small vessel disease in lobar and deep hemispheric intracerebral hemorrhage", Stroke, 41, pp.1933~1938 (2010)
  73. Knudsen KA, "Clinical diagnosis of cerebral amyloid angiopathy: validation of the Boston criteria", Neurology, 56, pp.537~539 (2001)
  74. Linn J, "Prevalence of superficial siderosis in patients with cerebral amyloid angiopathy", Neurology, 74, pp.1346~1350 (2010)
  75. Johnson KA, "Imaging of amyloid burden and distribution in cerebral amyloid angiopathy", Ann Neurol, 62, pp.229~234 (2007)
  76. Ly JV, "Cerebral β-amyloid detected by Pittsburgh compound B positron emission topography predisposes to recombinant tissue plasminogen activator-related hemorrhage", Ann Neurol, 68, pp.959~962 (2010)
  77. Kloppenborg RP, "Steroid responsive encephalopathy in cerebral amyloid angiopathy: a case report and review of evidence for immunosuppressive treatment", J Neuroinflammation, 7, pp.18~ (2010)
  78. Luppe S, "Cerebral amyloid angiopathy related vasculitis: successful treatment with azathioprine", J Neurol, 257, pp.2103~2105 (2010)
  79. Arima H, "Effects of perindopril-based lowering of blood pressure on intracerebral hemorrhage related to amyloid angiopathy: the PROGRESS trial", Stroke, 41, pp.394~396 (2010)
  80. Pantoni L, "Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges", Lancet Neurol, 9, pp.689~701 (2010)
  81. Biffi A, "Aspirin and recurrent intracerebral hemorrhage in cerebral amyloid angiopathy", Neurology, 75, pp.693~698 (2010)
  82. Athyros VG, "Aggressive statin treatment, very low serum cholesterol levels and haemorrhagic stroke: is there an association", Curr Opin Cardiol, 25, pp.406~410 (2010)
  83. Palsdottir A, "Hereditary cystatin C amyloid angiopathy: genetic, clinical, and pathological aspects", Brain Pathol, 16, pp.55~59 (2006)
  84. Bornebroek M, "Hereditary cerebral hemorrhage with amyloidosis Dutch type (AbetaPP 693): decreased plasma amyloid-beta 42 concentration", Neurobiol Dis, 14, pp.619~623 (2003)
  85. De Jonghe C, "Flemish and Dutch mutations in amyloid beta precursor protein have different effects on amyloid beta secretion", Neurobiol Dis, 5, pp.281~286 (1998)
  86. Farzan M, "BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloidbeta region of the amyloid-beta precursor protein", Proc Natl Acad Sci USA, 97, pp.9712~9717 (2000)
  87. Haass C, "Mutations associated with a locus for familial Alzheimer’s disease result in alternative processing of amyloid beta-protein precursor", J Biol Chem, 269, pp.17741~17748 (1994)
  88. Stenh C, "The Arctic mutation interferes with processing of the amyloid precursor protein", Neuroreport, 13, pp.1857~1860 (2002)
  89. Van Nostrand WE, "Pathogenic effects of D23N Iowa mutant amyloid beta -protein", J Biol Chem, 276, pp.32860~32866 (2001)

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