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Language-Related White-Matter-Tract Defcits in Children with Benign Epilepsy with Centrotemporal Spikes: A Retrospective Study

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Background and Purpose Benign epilepsy with centrotemporal spikes (BECTS) is one of the most common pediatric epilepsies, and it generally has a good prognosis. However, recent research has indicated that the epileptic activity of BECTS can cause cognitive defects such as language, visuospatial, and auditory verbal memory defcits. Tis study assessed language-delivery defcits in BECTS patients using difusion-tensor magnetic resonance imaging (DTI). Methods T1-weighted MRI, DTI, and language tests were conducted in 16 BECTS patients and 16 age-matched controls. DTI data were analyzed using the TRActs Constrained by Underlying Anatomy tool in FreeSurfer 5.3, and 18 major white-matter tracts were extracted, which included 4 language-related tracts: the inferior longitudinal fasciculus, superior longitudinal fasciculus–parietal terminations, superior longitudinal fasciculus–temporal terminations, and uncinate fasciculus (UNC). Language tests included the Korean version of the Receptive and Expressive Vocabulary Test, Test of Problem-Solving Abilities (TOPS), and the mean length of utterance in words. Results The BECTS group exhibited decreased mean fractional anisotropy and increased mean radial difusivity, with signifcant diferences in both the superior longitudinal fasciculus and the lef UNC (p<0.05), which are the language-related white-matter tracts in the dual-loop model. Te TOPS language test scores were signifcantly lower in the BECTS group than in the control group (p<0.05). Conclusions It appears that BECTS patients can exhibit language defcits. Seizure activities of BECTS could alter DTI scalar values in the language-related white-matter tracts.

Abstract

Background and Purpose Benign epilepsy with centrotemporal spikes (BECTS) is one of the most common pediatric epilepsies, and it generally has a good prognosis. However, recent research has indicated that the epileptic activity of BECTS can cause cognitive defects such as language, visuospatial, and auditory verbal memory defcits. Tis study assessed language-delivery defcits in BECTS patients using difusion-tensor magnetic resonance imaging (DTI). Methods T1-weighted MRI, DTI, and language tests were conducted in 16 BECTS patients and 16 age-matched controls. DTI data were analyzed using the TRActs Constrained by Underlying Anatomy tool in FreeSurfer 5.3, and 18 major white-matter tracts were extracted, which included 4 language-related tracts: the inferior longitudinal fasciculus, superior longitudinal fasciculus–parietal terminations, superior longitudinal fasciculus–temporal terminations, and uncinate fasciculus (UNC). Language tests included the Korean version of the Receptive and Expressive Vocabulary Test, Test of Problem-Solving Abilities (TOPS), and the mean length of utterance in words. Results The BECTS group exhibited decreased mean fractional anisotropy and increased mean radial difusivity, with signifcant diferences in both the superior longitudinal fasciculus and the lef UNC (p<0.05), which are the language-related white-matter tracts in the dual-loop model. Te TOPS language test scores were signifcantly lower in the BECTS group than in the control group (p<0.05). Conclusions It appears that BECTS patients can exhibit language defcits. Seizure activities of BECTS could alter DTI scalar values in the language-related white-matter tracts.

참고문헌 (39)

  1. Northcott E, "The neuropsychological and language profile of children with benign rolandic epilepsy", Epilepsia, 46, pp.924~930 (2005)
  2. Völkl-Kernstock S, "Speech and school performance in children with benign partial epilepsy with centro-temporal spikes(BCECTS)", Seizure, 18, pp.320~326 (2009)
  3. Filippini M, "Neuropsychological profile in new-onset benign epilepsy with centrotemporal spikes(BECTS) : focusing on executive functions", Epilepsy Behav, 54, pp.71~79 (2016)
  4. Rijntjes M, "The dual loop model : its relation to language and other modalities", Front Evol Neurosci, 4, pp.9~ (2012)
  5. Démonet JF, "Renewal of the neurophysiology of language : functional neuroimaging", Physiol Rev, 85, pp.49~95 (2005)
  6. Conturo TE, "Tracking neuronal fiber pathways in the living human brain", Proc Natl Acad Sci U S A, 96, pp.10422~10427 (1999)
  7. Alexander AL, "Diffusion tensor imaging of the corpus callosum in Autism", Neuroimage, 34, pp.61~73 (2007)
  8. Ameis SH, "A diffusion tensor imaging study in children with ADHD, autism spectrum disorder, OCD, and matched controls : distinct and non-distinct white matter disruption and dimensional brain-behavior relationships", Am J Psychiatry, 173, pp.1213~1222 (2016)
  9. Friederici AD, "Pathways to language : fiber tracts in the human brain", Trends Cogn Sci, 13, pp.175~181 (2009)
  10. Sundgren PC, "Diffusion tensor imaging of the brain : review of clinical applications", Neuroradiology, 46, pp.339~350 (2004)
  11. Ciumas C, "White matter development in children with benign childhood epilepsy with centro-temporal spikes", Brain, 137, pp.1095~1106 (2014)
  12. Good CD, "A voxel-based morphometric study of ageing in 465 normal adult human brains", Neuroimage, 14, pp.21~36 (2001)
  13. Afzali M, "Tract based spatial statistical analysis and voxel based morphometry of diffusion indices in temporal lobe epilepsy", Comput Biol Med, 41, pp.1082~1091 (2011)
  14. Xiao F, "Hemispheric lateralization of microstructural white matter abnormalities in children with active benign childhood epilepsy with centrotemporal spikes(BECTS) : a preliminary DTI study", J Neurol Sci, 336, pp.171~179 (2014)
  15. Cao W, "Abnormal asymmetry in benign epilepsy with unilateral and bilateral centrotemporal spikes : a combined fMRI and DTI study", Epilepsy Res, 135, pp.56~63 (2017)
  16. Liamsuwan S, "The value of partial sleep deprivation as a routine measure in pediatric electroencephalography", J Child Neurol, 15, pp.26~29 (2000)
  17. Oldfield RC, "The assessment and analysis of handedness : the Edinburgh inventory", Neuropsychologia, 9, pp.97~113 (1971)
  18. Reuter M, "Highly accurate inverse consistent registration : a robust approach", Neuroimage, 53, pp.1181~1196 (2010)
  19. Fischl B, "Whole brain segmentation : automated labeling of neuroanatomical structures in the human brain", Neuron, 33, pp.341~355 (2002)
  20. Fischl B, "Measuring the thickness of the human cerebral cortex from magnetic resonance images", Proc Natl Acad Sci U S A, 97, pp.11050~11055 (2000)
  21. Sled JG, "A nonparametric method for automatic correction of intensity nonuniformity in MRI data", IEEE Trans Med Imaging, 17, pp.87~97 (1998)
  22. Yendiki A, "Automated probabilistic reconstruction of white-matter pathways in health and disease using an atlas of the underlying anatomy", Front Neuroinform, 5, pp.23~ (2011)
  23. Andersson JLR, "An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging", Neuroimage, 125, pp.1063~1078 (2016)
  24. Yendiki A, "Spurious group differences due to head motion in a diffusion MRI study", Neuroimage, 88, pp.79~90 (2014)
  25. 홍경훈, "수용ㆍ표현 어휘력 검사(Receptive and Expressive Vocabulary Test: REVT)의 개발연구: 문항개발 및 신뢰도 분석을 중심으로", Communication Sciences and Disorders, 14(1), pp.34~45 (2009), 한국언어청각임상학회
  26. Bae SY, "Test of problem solving" (2000), Seoul Community Rehabilitation Center
  27. Lee HJ, "Measures of utterance length of normal languagedelayed children", Commun Sci Disord, 4, pp.1~14 (1999)
  28. Pfefferbaum A, "Age-related decline in brain white matter anisotropy measured with spatially corrected echo-planar diffusion tensor imaging", Magn Reson Med, 44, pp.259~268 (2000)
  29. Madhavan KM, "Superior longitudinal fasciculus and language functioning in healthy aging", Brain Res, 1562, pp.11~22 (2014)
  30. Schmahmann JD, "Association fibre pathways of the brain : parallel observations from diffusion spectrum imaging and autoradiography", Brain, 130, pp.630~653 (2007)
  31. Yeterian EH, "The cortical connectivity of the prefrontal cortex in the monkey brain", Cortex, 48, pp.58~81 (2012)
  32. Makris N, "Segmentation of subcomponents within the superior longitudinal fascicle in humans : a quantitative, in vivo, DT-MRI study", Cereb Cortex, 15, pp.854~869 (2005)
  33. Catani M, "A diffusion tensor imaging tractography atlas for virtual in vivo dissections", Cortex, 44, pp.1105~1132 (2008)
  34. Dubois J, "Structural asymmetries in the infant language and sensori-motor networks", Cereb Cortex, 19, pp.414~423 (2009)
  35. Pierpaoli C, "Water diffusion changes in Wallerian degeneration and their dependence on white matter architecture", Neuroimage, 13, pp.1174~1185 (2001)
  36. Song SK, "Dysmyelination revealed through MRI as increased radial(but unchanged axial)diffusion of water", Neuroimage, 17, pp.1429~1436 (2002)
  37. Takahashi M, "Magnetic resonance microimaging of intraaxonal water diffusion in live excised lamprey spinal cord", Proc Natl Acad Sci U S A, 99, pp.16192~16196 (2002)
  38. Chahine LM, "Benign pediatric localization-related epilepsies", Epileptic Disord, 8, pp.243~258 (2006)
  39. Brauer J, "Dorsal and ventral pathways in language development", Brain Lang, 127, pp.289~295 (2013)

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