Elevated Serum Uric Acid in Benign Convulsions with Mild Gastroenteritis in Children
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Background and Purpose To identify whether serum uric acid levels are significantly higher in patients with benign convulsion associated with mild gastroenteritis (CwG) than in patients with acute gastroenteritis. Methods This retrospective study compared the serum levels of uric acid between CwG, acute gastroenteritis, and febrile seizure afer correcting for the varying degree of mild dehydration using serum HCO3 – levels. We also compared the serum uric acid levels between patients with CwG and febrile seizures in order to exclude the efect of seizures on uric acid. Results Tis study included 154 CwG patients (age range 0.73–3.19 years), 2,938 patients with acute gastroenteritis, and 154 patients with febrile seizure. Te serum uric acid level was signifcantly higher in CwG patients than in patients with acute gastroenteritis [9.79±2.16 mg/ dL vs. 6.04±2.3 mg/dL (mean±SD), p<0.001]. Tis diference was also signifcant afer correcting for dehydration. Te serum uric acid level was signifcantly higher in CwG patients than in dehydration-corrected acute gastroenteritis patients (9.79±2.16 mg/dL vs. 6.67±2.48 mg/dL, p<0.001). Te serum uric acid level was not elevated in patients with febrile seizure. Conclusions We have confrmed that serum uric acid is elevated in CwG patients even afer correcting for their dehydration status, and that this was not a postictal phenomenon. Highly elevated serum uric acid in CwG could be a useful clinical indicator of CwG in patients with acute gastroenteritis.
Abstract
Background and Purpose To identify whether serum uric acid levels are significantly higher in patients with benign convulsion associated with mild gastroenteritis (CwG) than in patients with acute gastroenteritis. Methods This retrospective study compared the serum levels of uric acid between CwG, acute gastroenteritis, and febrile seizure afer correcting for the varying degree of mild dehydration using serum HCO3 – levels. We also compared the serum uric acid levels between patients with CwG and febrile seizures in order to exclude the efect of seizures on uric acid. Results Tis study included 154 CwG patients (age range 0.73–3.19 years), 2,938 patients with acute gastroenteritis, and 154 patients with febrile seizure. Te serum uric acid level was signifcantly higher in CwG patients than in patients with acute gastroenteritis [9.79±2.16 mg/ dL vs. 6.04±2.3 mg/dL (mean±SD), p<0.001]. Tis diference was also signifcant afer correcting for dehydration. Te serum uric acid level was signifcantly higher in CwG patients than in dehydration-corrected acute gastroenteritis patients (9.79±2.16 mg/dL vs. 6.67±2.48 mg/dL, p<0.001). Te serum uric acid level was not elevated in patients with febrile seizure. Conclusions We have confrmed that serum uric acid is elevated in CwG patients even afer correcting for their dehydration status, and that this was not a postictal phenomenon. Highly elevated serum uric acid in CwG could be a useful clinical indicator of CwG in patients with acute gastroenteritis.
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