Decreased 18F-Fluorodeoxyglucose Uptake in Lumbar Vertebrae of Stroke Patients
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Background and Purpose We investigated 18F-fluorodeoxyglucose (FDG) uptake levels in the lumbar vertebrae, liver, and spleen of stroke patients with carotid atherosclerosis. Methods This study analyzed acute ischemic stroke patients with carotid atherosclerosis who underwent whole-body FDG positron-emission tomography between October 2015 and January 2017. FDG uptake in the lumbar vertebrae, liver, and spleen was measured and compared between stroke patients and control subjects without stroke history. Multivariate linear regression analysis was performed to identify independent factors related to FDG uptake in the proximal internal carotid artery (ICA). Results Twenty stroke patients aged 75.1±9.0 years (mean±standard deviation; 10 females) and 20 control subjects aged 62.9±10.7 years (6 females) were included. In comparison with the control group, the stroke group showed significantly higher FDG uptake in the proximal ICA (1.16±0.26 vs. 0.87±0.19, p<0.01), but significantly lower FDG uptake in the lumbar vertebrae (1.09±0.26 vs. 1.38±0.38, p=0.007) and liver (1.71±0.30 vs. 2.01±0.34, p=0.005). Multivariate linear regression analysis showed that the lumbar FDG uptake was negatively correlated with FDG uptake in the proximal ICA (standardized coefficient=-0.367, p=0.013) after adjusting for age and hypertension. Conclusions Stroke patients showed decreased FDG uptake in the lumbar vertebrae. Further studies are warranted to evaluate the pathophysiological link between cerebral atherosclerosis and bone.
Abstract
Background and Purpose We investigated 18F-fluorodeoxyglucose (FDG) uptake levels in the lumbar vertebrae, liver, and spleen of stroke patients with carotid atherosclerosis. Methods This study analyzed acute ischemic stroke patients with carotid atherosclerosis who underwent whole-body FDG positron-emission tomography between October 2015 and January 2017. FDG uptake in the lumbar vertebrae, liver, and spleen was measured and compared between stroke patients and control subjects without stroke history. Multivariate linear regression analysis was performed to identify independent factors related to FDG uptake in the proximal internal carotid artery (ICA). Results Twenty stroke patients aged 75.1±9.0 years (mean±standard deviation; 10 females) and 20 control subjects aged 62.9±10.7 years (6 females) were included. In comparison with the control group, the stroke group showed significantly higher FDG uptake in the proximal ICA (1.16±0.26 vs. 0.87±0.19, p<0.01), but significantly lower FDG uptake in the lumbar vertebrae (1.09±0.26 vs. 1.38±0.38, p=0.007) and liver (1.71±0.30 vs. 2.01±0.34, p=0.005). Multivariate linear regression analysis showed that the lumbar FDG uptake was negatively correlated with FDG uptake in the proximal ICA (standardized coefficient=-0.367, p=0.013) after adjusting for age and hypertension. Conclusions Stroke patients showed decreased FDG uptake in the lumbar vertebrae. Further studies are warranted to evaluate the pathophysiological link between cerebral atherosclerosis and bone.
참고문헌 (14)
- Hansson GK, "Inflammation, atherosclerosis, and coronary artery disease", N Engl J Med, 352, pp.1685~1695 (2005)
- Moore KJ, "Targeting inflammation in CVD : advances and challenges", Nat Rev Cardiol, 16, pp.74~75 (2019)
- Kim EJ, "Metabolic activity of the spleen and bone marrow in patients with acute myocardial infarction evaluated by 18F-fluorodeoxyglucose positron emission tomograpic imaging", Circ Cardiovasc Imaging, 7, pp.454~460 (2014)
- Emami H, "Splenic metabolic activity predicts risk of future cardiovascular events : demonstration of a cardiosplenic axis in humans", JACC Cardiovasc Imaging, 8, pp.121~130 (2015)
- van der Valk FM, "Increased haematopoietic activity in patients with atherosclerosis", Eur Heart J, 38, pp.425~432 (2017)
- -NaF positron emission tomography on culprit carotid atherosclerosis : a prospective study, "JACC Cardiovasc Imaging", 2019, 370~372
- Kim JM, "Decreased bone marrow activity measured by using 18F-fluorodeoxyglucose positron emission tomography among patients with cerebral atherosclerosis", J Neurosonol Neuroimag, 11, pp.78~83 (2019)
- Tawakol A, "In vivo 18F-fluorodeoxyglucose positron emission tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients", J Am Coll Cardiol, 48, pp.1818~1824 (2006)
- Kim JM, "Therapeutic strategy for atherosclerosis based on bone-vascular axis hypothesis", Pharmacol Ther, 206, pp.107436~ (2020)
- Méndez-Ferrer S, "Mesenchymal and haematopoietic stem cells form a unique bone marrow niche", Nature, 466, pp.829~834 (2010)
- Morrison SJ, "The bone marrow niche for haematopoietic stem cells", Nature, 505, pp.327~334 (2014)
- Fadini GP, "Concise review : perspectives and clinical implications of bone marrow and circulating stem cell defects in diabetes", Stem Cells, 35, pp.106~116 (2017)
- Wang D, "Adult stem cells in vascular remodeling", Theranostics, 8, pp.815~829 (2018)
- Jaiswal S, "Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease", N Engl J Med, 377, pp.111~121 (2017)