Evaluation of the anti-Toxoplasma gondii Activity of Hederagenin in vitro and in vivo
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Toxoplasma gondii infection is widespread worldwide, not only posing a serious threat to human food safety and animal husbandry, but also endangering human health. The selectivity index was employed to measure anti-T. gondii activity. Hederagenin (HE) exhibited potent anti-T. gondii activity and low cytotoxicity. For this reason, HE was selected for in vivo experiments. HE showed 64.8%±13.1% inhibition for peritoneal tachyzoites in mice, higher than spiramycin 56.8%±6.0%. Biochemical parameters such as alanine aminotransferase, aspartate aminotransferase, glutathione, and malondialdehyde, illustrated that HE was a good inhibitor of T. gondii in vivo. This compound was also effective in reliev- ing T. gondii-induced liver damage. Collectively, it was demonstrated that HE had potential as an anti-T. gondii agent.
Abstract
Toxoplasma gondii infection is widespread worldwide, not only posing a serious threat to human food safety and animal husbandry, but also endangering human health. The selectivity index was employed to measure anti-T. gondii activity. Hederagenin (HE) exhibited potent anti-T. gondii activity and low cytotoxicity. For this reason, HE was selected for in vivo experiments. HE showed 64.8%±13.1% inhibition for peritoneal tachyzoites in mice, higher than spiramycin 56.8%±6.0%. Biochemical parameters such as alanine aminotransferase, aspartate aminotransferase, glutathione, and malondialdehyde, illustrated that HE was a good inhibitor of T. gondii in vivo. This compound was also effective in reliev- ing T. gondii-induced liver damage. Collectively, it was demonstrated that HE had potential as an anti-T. gondii agent.
참고문헌 (22)
- Tenter AM, "Toxoplasma gondii: From animals to humans", Int J Parasitol, 30, pp.1217~1258 (2000)[DOI]
- Osunkalu VO, "Seroprevalence of Toxoplasma gondii igg antibody in hiv-infected patients at the lagos university teaching hospital", HIV, 2011, pp.3, 101~105
- Martins-Duarte ÉS, "Toxoplasma gondii: The effect of fluconazole combined with sulfadiazine and pyrimethamine against acute toxoplasmosis in murine model", Exp Parasitol, 133, pp.294~299 (2013)[DOI]
- Mui EJ, "Triazine inhibits Toxoplasma gondii tachyzoites in vitro and in vivo", Antimicrob Agents Chemother, 49, pp.3463~3467 (2005)[DOI]
- Deng H, "Synthesis, in vitro and in vivo biological evaluation of dihydroartemisinin derivatives with potential anti-Toxoplasma gondii agents", Bioorg Chem, 94, pp.103467~ (2020)[DOI]
- Luan T, "Synthesis and biological evaluation of ursolic acid derivatives bearing triazole moieties as potential anti-Toxoplasma gondii agents", J Enzyme Inhib Med Chem, 34, pp.761~772 (2019)[DOI]
- Shang FF, "Synthesis and antitoxoplasma activity in vitro of chrysin derivatives", Chin J Org Chem, 39, pp.2574~2580 (2019)[DOI]
- Rodríguez-Hernández D, "Hederagenin as a triterpene template for the development of new antitumor compounds", Eur J Med Chem, 105, pp.57~62 (2015)[DOI]
- Saha S, "Structure-biological activity relationships in triterpenic saponins: the relative activity of protobassic acid and its derivatives against plant pathogenic fungi", Pest Manage Sci, 66, pp.825~831 (2010)[DOI]
- Rodríguez-Hernández D, "Highly potent anti-leishmanial derivatives of hederagenin, a triperpenoid from Sapindus saponaria L", Eur J Med Chem, 24, pp.153~159 (2016)[DOI]
- Jin CM, "Toxoplasma gondii: a simple high-throughput assay for drug screening in vitro", Exp parasitol, 121, pp.132~136 (2009)[DOI]
- Giusti G, "A comparative study of some spectrophotometric and colorimetric procedures for the determination of serum glutamic-oxaloacetic and glutamic-pyruvic transaminase in hepatic diseases", Enzymol Biol Clin, 10, pp.17~38 (1969)[DOI]
- Guo HY, "Synthesis and biological evaluation of (+)-usnic acid derivatives as potential anti-Toxoplasma gondii agents", J Agric Food Chem, 67, pp.9630~9642 (2019)[DOI]
- Dubey JP, "History of the discovery of the life cycle of Toxoplasma gondii", Int J Parasitol, 39, pp.877~882 (2009)[DOI]
- Hai-bin Zhang, "Synthesis and evaluation of novel arctigenin derivatives as potential anti-Toxoplasma gondii agents", European Journal of Medicinal Chemistry, 158, pp.414~427 (2018), Elsevier BV[DOI]
- RB Gurung, "The Ratio of Aspartate Aminotransferase to Alanine Aminotransferase (AST", ALT): the Correlation of Value with Underlying Severity of Alcoholic Liver Disease, 2013, pp.11(3), 233~236[DOI]
- Autier B, "The liver as an organ at risk for Toxoplasma transmission during transplantation: myth or reality?", J Clin Pathol, 71, pp.763~766 (2018)[DOI]
- Dillioglugil MO, "Effect of pentylenetetrazole and sound stimulation induced single and repeated convulsive seizures on the mda, gsh and no levels, and sod activities in rat liver and kidney tissues", Brain Res Bull, 83, pp.356~359 (2010)[DOI]
- Kučera O, "Acetaminophen toxicity in rat and mouse hepatocytes in vitro", Drug Chem Toxicol, 40, pp.448~456 (2017)[DOI]
- Macias-Barragan J, "Effects of alpha lipoic acid and pirfenidone on liver cells antioxidant modulation against oxidative damage", Rev Med Chil, 142, pp.1553~1564 (2014)[DOI]
- Ulku Karaman, "Malondialdehyde, Glutathione, and Nitric Oxide Levels in Toxoplasma gondii Seropositive Patients", The Korean Journal of Parasitology, 46(4), pp.293~295 (2008), 대한기생충학ㆍ열대의학회
- Xu X, "Reactive oxygen species-triggered trophoblast apoptosis is initiated by endoplasmic reticulum stress via activation of caspase-12, chop, and the JNK pathway in Toxoplasma gondii infection in mice", Infect immun, 80, pp.2121~2132 (2012)[DOI]