Potential of Transcranial Direct Current Stimulation in Alzheimer’s Disease: Optimizing Trials Toward Clinical Use
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초록
Transcranial direct current stimulation (tDCS) is a safe and well-tolerated noninvasive method for stimulating the brain that is rapidly developing into a treatment method for various neurological and psychiatric conditions. In particular, there is growing evidence of a therapeutic role for tDCS in ameliorating or delaying the cognitive decline in Alzheimer’s disease (AD). We provide a brief overview of the current development and application status of tDCS as a nonpharmacological therapeutic method for AD and mild cognitive impairment (MCI), summarize the levels of evidence, and identify the improvements needed for clinical applications. We also suggest future directions for large-scale controlled clinical trials of tDCS in AD and MCI, and emphasize the necessity of identifying the mechanistic targets to facilitate clinical applications.
Abstract
Transcranial direct current stimulation (tDCS) is a safe and well-tolerated noninvasive method for stimulating the brain that is rapidly developing into a treatment method for various neurological and psychiatric conditions. In particular, there is growing evidence of a therapeutic role for tDCS in ameliorating or delaying the cognitive decline in Alzheimer’s disease (AD). We provide a brief overview of the current development and application status of tDCS as a nonpharmacological therapeutic method for AD and mild cognitive impairment (MCI), summarize the levels of evidence, and identify the improvements needed for clinical applications. We also suggest future directions for large-scale controlled clinical trials of tDCS in AD and MCI, and emphasize the necessity of identifying the mechanistic targets to facilitate clinical applications.
참고문헌 (110)
- Mayeux R, "Epidemiology of Alzheimer disease", Cold Spring Harb Perspect Med, 2, pp.a006239~ (2012)
- Fregni F, "Evidence-based guidelines and secondary meta-analysis for the use of transcranial direct current stimulation in neurological and psychiatric disorders", Int J Neuropsychopharmacol, 24, pp.256~313 (2021)
- Stagg CJ, "Physiological basis of transcranial direct current stimulation", Neuroscientist, 17, pp.37~53 (2011)
- Pelletier SJ, "Cellular and molecular mechanisms of action of transcranial direct current stimulation : evidence from in vitro and in vivo models", Int J Neuropsychopharmacol, 8, pp.pyu047~ (2014)
- Mohammadi A, "Induction of neuroplasticity by transcranial direct current stimulation", J Biomed Phys Eng, 6, pp.205~208 (2016)
- Indahlastari A, "A systematic review and metaanalysis of transcranial direct current stimulation to remediate agerelated cognitive decline in healthy older adults", Neuropsychiatr Dis Treat, 17, pp.971~990 (2021)
- Bikson M, "Safety of transcranial direct current stimulation : evidence based update 2016", Brain Stimul, 9, pp.641~661 (2016)
- Woods AJ, "A technical guide to tDCS, and related non-invasive brain stimulation tools", Clin Neurophysiol, 127, pp.1031~1048 (2016)
- Kronberg G, "Direct current stimulation boosts hebbian plasticity in vitro", Brain Stimul, 13, pp.287~301 (2020)
- Charvet L, "Remotely supervised transcranial direct current stimulation increases the benefit of at-home cognitive training in multiple sclerosis", Neuromodulation, 21, pp.383~389 (2018)
- Nissim NR, "Effects of transcranial direct current stimulation paired with cognitive training on functional connectivity of the working memory network in older adults", Front Aging Neurosci, 11, pp.340~ (2019)
- Elmasry J, "A systematic review of transcranial electrical stimulation combined with cognitive training", Restor Neurol Neurosci, 33, pp.263~278 (2015)
- Charvet LE, "Supervised transcranial direct current stimulation(tDCS)at home : a guide for clinical research and practice", Brain Stimul, 13, pp.686~693 (2020)
- Shaw M, "Delivering transcranial direct current stimulation away from clinic : remotely supervised tDCS", Mil Med, 185(Suppl 1), pp.319~325 (2020)
- Siegert A, "New methods, old brains-a systematic review on the effects of tDCS on the cognition of elderly people", Front Hum Neurosci, 15, pp.730134~ (2021)
- Radman T, "Role of cortical cell type and morphology in subthreshold and suprathreshold uniform electric field stimulation in vitro", Brain Stimul, 2, pp.215~228 (2009)
- Rahman A, "Cellular effects of acute direct current stimulation : somatic and synaptic terminal effects", J Physiol, 591, pp.2563~2578 (2013)
- Reato D, "Effects of weak transcranial alternating current stimulation on brain activity-a review of known mechanisms from animal studies", Front Hum Neurosci, 7, pp.687~ (2013)
- Fritsch B, "Direct current stimulation promotes BDNF-dependent synaptic plasticity : potential implications for motor learning", Neuron, 66, pp.198~204 (2010)
- Kronberg G, "Direct current stimulation modulates LTP and LTD : activity dependence and dendritic effects", Brain Stimul, 10, pp.51~58 (2017)
- Jackson MP, "Animal models of transcranial direct current stimulation : methods and mechanisms", Clin Neurophysiol, 127, pp.3425~3454 (2016)
- Nitsche MA, "Transcranial direct current stimulation : state of the art 2008", Brain Stimul, 1, pp.206~223 (2008)
- Brunoni AR, "Clinical research with transcranial direct current stimulation(tDCS) : challenges and future directions", Brain Stimul, 5, pp.175~195 (2012)
- Nikolin S, "Safety of repeated sessions of transcranial direct current stimulation : a systematic review", Brain Stimul, 11, pp.278~288 (2018)
- Vanneste S, "Bilateral dorsolateral prefrontal cortex modulation for tinnitus by transcranial direct current stimulation : a preliminary clinical study", Exp Brain Res, 202, pp.779~785 (2010)
- Priori A, "Repetitive transcranial magnetic stimulation or transcranial direct current stimulation?", Brain Stimul, 2, pp.241~245 (2009)
- Thomas C, "Effect of aging on cortical current flow due to transcranial direct current stimulation : considerations for safety", Annu Int Conf IEEE Eng Med Biol Soc, 2018, pp.3084~3087 (2018)
- Pilloni G, "Long term at-home treatment with transcranial direct current stimulation(tDCS)improves symptoms of cerebellar ataxia : a case report", J Neuroeng Rehabil, 16, pp.41~ (2019)
- Charvet LE, "Remotely supervised transcranial direct current stimulation for the treatment of fatigue in multiple sclerosis : results from a randomized, sham-controlled trial", Mult Scler, 24, pp.1760~1769 (2018)
- Dobbs B, "Generalizing remotely supervised transcranial direct current stimulation(tDCS) : feasibility and benefit in Parkinson’s disease", J Neuroeng Rehabil, 15, pp.114~ (2018)
- Korai SA, "Neurobiological after-effects of low intensity transcranial electric stimulation of the human nervous system : from basic mechanisms to metaplasticity", Front Neurol, 12, pp.587771~ (2021)
- Cavaleiro C, "Memory and cognition-related neuroplasticity enhancement by transcranial direct current stimulation in rodents : a systematic review", Neural Plast, 2020, pp.4795267~ (2020)
- Sharma M, "Weak DCS causes a relatively strong cumulative boost of synaptic plasticity with spaced learning", Brain Stimul, 15, pp.57~62 (2022)
- 김상준, "Functional and Histologic Changes After Repeated Transcranial Direct Current Stimulation in Rat Stroke Model", Journal of Korean Medical Science, 25(10), pp.1499~1505 (2010), 대한의학회
- Monte-Silva K, "Induction of late LTP-like plasticity in the human motor cortex by repeated non-invasive brain stimulation", Brain Stimul, 6, pp.424~432 (2013)
- Meesen RL, "A single session of 1mA anodal tDCS-supported motor training does not improve motor performance in patients with multiple sclerosis", Restor Neurol Neurosci, 32, pp.293~300 (2014)
- Zanão TA, "Impact of two or less missing treatment sessions on tDCS clinical efficacy : results from a factorial, randomized, controlled trial in major depression", Neuromodulation, 17, pp.737~742 (2014)
- Im JJ, "Effects of 6-month at-home transcranial direct current stimulation on cognition and cerebral glucose metabolism in Alzheimer’s disease", Brain Stimul, 12, pp.1222~1228 (2019)
- Song S, "Effects of single-session versus multi-session non-invasive brain stimulation on craving and consumption in individuals with drug addiction, eating disorders or obesity : a meta-analysis", Brain Stimul, 12, pp.606~618 (2019)
- Lau CI, "Effect of single-session transcranial direct current stimulation on cognition in Parkinson’s disease", CNS Neurosci Ther, 25, pp.1237~1243 (2019)
- Vrinda Saxena, "Role of Transcranial Direct Current Stimulation in the Management of Alzheimer’s Disease: A Meta-analysis of Effects, Adherence and Adverse Effects", Clinical Psychopharmacology and Neuroscience, 19(4), pp.589~599 (2021), 대한정신약물학회[DOI]
- Horvath JC, "Quantitative review finds no evidence of cognitive effects in healthy populations from single-session transcranial direct current stimulation(tDCS)", Brain Stimul, 8, pp.535~550 (2015)
- Gangemi A, "Effects of short-and long-term neurostimulation(tDCS)on Alzheimer’s disease patients : two randomized studies", Aging Clin Exp Res, 33, pp.383~390 (2021)
- Lu H, "Randomized controlled trial of TDCS on cognition in 201 seniors with mild neurocognitive disorder", Ann Clin Transl Neurol, 6, pp.1938~1948 (2019)
- Bystad M, "Transcranial direct current stimulation as a memory enhancer in patients with Alzheimer’s disease : a randomized, placebo-controlled trial", Alzheimers Res Ther, 8, pp.13~ (2016)
- Cotelli M, "Anodal tDCS during face-name associations memory training in Alzheimer’s patients", Front Aging Neurosci, 6, pp.38~ (2014)
- Suemoto CK, "Effects of a non-focal plasticity protocol on apathy in moderate Alzheimer’s disease : a randomized, double-blind, sham-controlled trial", Brain Stimul, 7, pp.308~313 (2014)
- Talsma LJ, "Boosting cognition : effects of multiple-session transcranial direct current stimulation on working memory", J Cogn Neurosci, 29, pp.755~768 (2017)
- Pilloni G, "Update on the use of transcranial electrical brain stimulation to manage acute and chronic COVID-19 symptoms", Front Hum Neurosci, 14, pp.595567~ (2020)
- Pilloni G, "Gait and functional mobility in multiple sclerosis : immediate effects of transcranial direct current stimulation(tDCS)paired with aerobic exercise", Front Neurol, 11, pp.310~ (2020)
- Alvarez-Alvarado S, "Impact of transcranial direct current stimulation and cognitive training on frontal lobe neurotransmitter concentrations", Front Aging Neurosci, 13, pp.761348~ (2021)
- Farnad L, "Exploring and optimizing the neuroplastic effects of anodal transcranial direct current stimulation over the primary motor cortex of older humans", Brain Stimul, 14, pp.622~634 (2021)
- Burke SN, "Neural plasticity in the ageing brain", Nat Rev Neurosci, 7, pp.30~40 (2006)
- Pascual-Leone A, "A developmental framework of brain and cognition from infancy to old age", Brain Topogr, 24, pp.183~186 (2011)
- Habich A, "Stimulating aged brains with transcranial direct current stimulation : opportunities and challenges", Psychiatry Res Neuroimaging, 306, pp.111179~ (2020)
- Antonenko D, "Age-dependent effects of brain stimulation on network centrality", Neuroimage, 176, pp.71~82 (2018)
- Ghasemian-Shirvan E, "Age-dependent non-linear neuroplastic effects of cathodal tDCS in the elderly population : a titration study", Brain Stimul, 15, pp.296~305 (2022)
- Indahlastari A, "White matter hyperintensities affect transcranial electrical stimulation in the aging brain", Brain Stimul, 14, pp.69~73 (2021)
- Hanley CJ, "Optimising cognitive enhancement : systematic assessment of the effects of tDCS duration in older adults", Brain Sci, 10, pp.304~ (2020)
- Laakso I, "Inter-subject variability in electric fields of motor cortical tDCS", Brain Stimul, 8, pp.906~913 (2015)
- Krause B, "Not all brains are created equal : the relevance of individual differences in responsiveness to transcranial electrical stimulation", Front Syst Neurosci, 8, pp.25~ (2014)
- Choe J, "Transcranial direct current stimulation modulates neuronal activity and learning in pilot training", Front Hum Neurosci, 10, pp.34~ (2016)
- Bikson M, "Origins of specificity during tDCS : anatomical, activity-selective, and input-bias mechanisms", Front Hum Neurosci, 7, pp.688~ (2013)
- Gomez Palacio Schjetnan A, "Transcranial direct current stimulation in stroke rehabilitation : a review of recent advancements", Stroke Res Treat, 2013, pp.170256~ (2013)
- Brasil-Neto JP, "Learning, memory, and transcranial direct current stimulation", Front Psychiatry, 3, pp.80~ (2012)
- Boggio PS, "Effects of transcranial direct current stimulation on working memory in patients with Parkinson’s disease", J Neurol Sci, 249, pp.31~38 (2006)
- Richmond LL, "Transcranial direct current stimulation enhances verbal working memory training performance over time and near transfer outcomes", J Cogn Neurosci, 26, pp.2443~2454 (2014)
- Segrave RA, "Concurrent cognitive control training augments the antidepressant efficacy of tDCS : a pilot study", Brain Stimul, 7, pp.325~331 (2014)
- Andrews SC, "Improving working memory : the effect of combining cognitive activity and anodal transcranial direct current stimulation to the left dorsolateral prefrontal cortex", Brain Stimul, 4, pp.84~89 (2011)
- Waters-Metenier S, "Bihemispheric transcranial direct current stimulation enhances effectorindependent representations of motor synergy and sequence learning", J Neurosci, 34, pp.1037~1050 (2014)
- Saucedo Marquez CM, "Task-specific effect of transcranial direct current stimulation on motor learning", Front Hum Neurosci, 7, pp.333~ (2013)
- Reis J, "Timebut not sleep-dependent consolidation of tDCS-enhanced visuomotor skills", Cereb Cortex, 25, pp.109~117 (2015)
- Reis J, "Noninvasive cortical stimulation enhances motor skill acquisition over multiple days through an effect on consolidation", Proc Natl Acad Sci U S A, 106, pp.1590~1595 (2009)
- Brunoni AR, "Working memory improvement with non-invasive brain stimulation of the dorsolateral prefrontal cortex : a systematic review and meta-analysis", Brain Cogn, 86, pp.1~9 (2014)
- Sarkar A, "Cognitive enhancement or cognitive cost : trait-specific outcomes of brain stimulation in the case of mathematics anxiety", J Neurosci, 34, pp.16605~16610 (2014)
- McIntire LK, "A comparison of the effects of transcranial direct current stimulation and caffeine on vigilance and cognitive performance during extended wakefulness", Brain Stimul, 7, pp.499~507 (2014)
- Nelson JT, "Enhancing vigilance in operators with prefrontal cortex transcranial direct current stimulation (tDCS)", Neuroimage, 85(Pt 3), pp.909~917 (2014)
- Gill J, "It’s the thought that counts : examining the task-dependent effects of transcranial direct current stimulation on executive function", Brain Stimul, 8, pp.253~259 (2015)
- Chu CS, "Cognitive effects and acceptability of non-invasive brain stimulation on Alzheimer’s disease and mild cognitive impairment : a component network meta-analysis", J Neurol Neurosurg Psychiatry, 92, pp.195~203 (2021)
- Khedr EM, "Therapeutic role of transcranial direct current stimulation in Alzheimer disease patients : double-blind, placebo-controlled clinical trial", Neurorehabil Neural Repair, 33, pp.384~394 (2019)
- Yun K, "Changes in cerebral glucose metabolism after 3 weeks of noninvasive electrical stimulation of mild cognitive impairment patients", Alzheimers Res Ther, 8, pp.49~ (2016)
- He F, "Repeated anodal high-definition transcranial direct current stimulation over the left dorsolateral prefrontal cortex in mild cognitive impairment patients increased regional homogeneity in multiple brain regions", PLoS One, 16, pp.e0256100~ (2021)
- Rasmussen ID, "High-definition transcranial direct current stimulation improves delayed memory in Alzheimer’s disease patients : a pilot study using computational modeling to optimize electrode position", J Alzheimers Dis, 83, pp.753~769 (2021)
- Khedr EM, "A double-blind randomized clinical trial on the efficacy of cortical direct current stimulation for the treatment of Alzheimer’s disease", Front Aging Neurosci, 6, pp.275~ (2014)
- Medeiros LF, "Neurobiological effects of transcranial direct current stimulation : a review", Front Psychiatry, 3, pp.110~ (2012)
- Fukai M, "Endogenous dopamine release under transcranial direct-current stimulation governs enhanced attention : a study with positron emission tomography", Transl Psychiatry, 9, pp.115~ (2019)
- Brunoni AR, "Impact of 5-HTTLPR and BDNF polymorphisms on response to sertraline versus transcranial direct current stimulation : implications for the serotonergic system", Eur Neuropsychopharmacol, 23, pp.1530~1540 (2013)
- Cambiaghi M, "Transcranial direct current stimulation of the mouse prefrontal cortex modulates serotonergic neural activity of the dorsal raphe nucleus", Brain Stimul, 13, pp.548~550 (2020)
- Newman EL, "Cholinergic modulation of cognitive processing : insights drawn from computational models", Front Behav Neurosci, 6, pp.24~ (2012)
- Hansen N, "Action mechanisms of transcranial direct current stimulation in Alzheimer’s disease and memory loss", Front Psychiatry, 3, pp.48~ (2012)
- Hasselmo ME, "Cholinergic modulation of activity-dependent synaptic plasticity in the piriform cortex and associative memory function in a network biophysical simulation", J Neurosci, 15, pp.6592~6604 (1995)
- Patil MM, "Cholinergic agonist carbachol enables associative long-term potentiation in piriform cortex slices", J Neurophysiol, 80, pp.2467~2474 (1998)
- Kuo MF, "Focusing effect of acetylcholine on neuroplasticity in the human motor cortex", J Neurosci, 27, pp.14442~14447 (2007)
- Thirugnanasambandam N, "Nicotinergic impact on focal and non-focal neuroplasticity induced by non-invasive brain stimulation in non-smoking humans", Neuropsychopharmacology, 36, pp.879~886 (2011)
- Lengu K, "Effects of high definition-transcranial direct current stimulation on local GABA and glutamate levels among older adults with and without mild cognitive impairment : an exploratory study", J Alzheimers Dis, 84, pp.1091~1102 (2021)
- Cruz Gonzalez P, "Can transcranial direct-current stimulation alone or combined with cognitive training be used as a clinical intervention to improve cognitive functioning in persons with mild cognitive impairment and dementia? A systematic review and meta-analysis", Front Hum Neurosci, 12, pp.416~ (2018)
- Liu CS, "Using transcranial direct current stimulation to treat symptoms in mild cognitive impairment and Alzheimer’s disease", Neurodegener Dis Manag, 7, pp.317~329 (2017)
- Rajji TK, "Transcranial magnetic and electrical stimulation in Alzheimer’s disease and mild cognitive impairment : a review of randomized controlled trials", Clin Pharmacol Ther, 106, pp.776~780 (2019)
- Nardone R, "Effect of transcranial brain stimulation for the treatment of Alzheimer disease : a review", Int J Alzheimers Dis, 2012, pp.687909~ (2012)
- Kasschau M, "A protocol for the use of remotely-supervised transcranial direct current stimulation(tDCS)in multiple sclerosis(MS)", J Vis Exp, 106, pp.e53542~ (2015)
- Shaw MT, "Telerehabilitation benefits patients with multiple sclerosis in an urban setting", J Telemed Telecare, 27, pp.39~45 (2021)
- Agarwal S, "Remotely-supervised transcranial direct current stimulation paired with cognitive training in Parkinson’s disease : an open-label study", J Clin Neurosci, 57, pp.51~57 (2018)
- Clayton AM, "Remotely supervised transcranial direct current stimulation after ECT improves mood and cognition in a patient with multiple sclerosis : a case study", J ECT, 34, pp.e15~ (2018)
- Eilam-Stock T, "Cognitive telerehabilitation with transcranial direct current stimulation improves cognitive and emotional functioning following a traumatic brain injury : a case study", Arch Clin Neuropsychol, 36, pp.442~453 (2021)
- Charvet LE, "Remotely-supervised transcranial direct current stimulation(tDCS)for clinical trials : guidelines for technology and protocols", Front Syst Neurosci, 9, pp.26~ (2015)
- "Assessment of TDCS-induced neuronal responses in multiple sclerosis (MS) with advanced MRI"[URL]
- "A pilot trial of remotely-supervised transcranial direct current stimulation (RS-TDCS) to enhance motor learning in progressive multiple sclerosis (MS)"[URL]
- "tDCS for the management of multiple sclerosis related fatigue"[URL]
- "Remotely supervised transcranial direct current stimulation for persistent post-traumatic headache"[URL]
- Gomes MA, "Transcranial direct current stimulation(tDCS)in elderly with mild cognitive impairment : a pilot study", Dement Neuropsychol, 13, pp.187~195 (2019)
