Failure of Repeated MDA with Albendazole for Trichuriasis Control in Schoolchildren of the Yangon Region, Myanmar
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Soil-transmitted helminth (STH) infections are still a considerable challenge in Myanmar. We undertook a control program for STH infections (especially Trichuris trichiura) among schoolchildren in Myanmar using mass drug administration (MDA) and health education. Around 1,700 schoolchildren from 15 primary schools in 3 suburban districts (Shwe Pyi Thar, Twantay, and Kyauktan) of the Yangon Region were subjected in this study during 2017-2019. All of the schoolchildren in each school were orally administered albendazole (400 mg in a single dose) 2, 3, and 4 times a year in 2017, 2018, and 2019, respectively. The results revealed that the egg positive rate of any intestinal helminths (including STH) was reduced from 37.6% (649/1,724) in 2017 to 22.8% (352/1,542) in 2019. The egg positive rate of Ascaris lumbricoides was decreased remarkably from 23.3% (402/1,724) in 2017 to 3.6% (56/1,542) in 2019. However, that of T. trichiura was only slightly reduced from 26.9% (464/1,724) in 2017 to 20.2% (312/1,542) in 2019. The intensity of infection with A. lumbricoides and T. trichiura was both more or less reduced, and the proportion of light infection cases with A. lumbricoides and T. trichiura increased from 35.6% in 2017 to 64.3% in 2019 and from 70.3% in 2017 to 81.7% in 2019, respectively. The results indicated that repeated MDAs (2-4 times a year for 3 years) using albendazole on schoolchildren in Myanmar failed to control T. trichiura infection. For a successful control of trichuriasis in Myanmar, new MDA strategies, using a modified albendazole regimen (multiple daily doses for 2 or 3 days) or an alternative anthelmintic drug, such as oxantel pamoate, is strongly recommended.
Abstract
Soil-transmitted helminth (STH) infections are still a considerable challenge in Myanmar. We undertook a control program for STH infections (especially Trichuris trichiura) among schoolchildren in Myanmar using mass drug administration (MDA) and health education. Around 1,700 schoolchildren from 15 primary schools in 3 suburban districts (Shwe Pyi Thar, Twantay, and Kyauktan) of the Yangon Region were subjected in this study during 2017-2019. All of the schoolchildren in each school were orally administered albendazole (400 mg in a single dose) 2, 3, and 4 times a year in 2017, 2018, and 2019, respectively. The results revealed that the egg positive rate of any intestinal helminths (including STH) was reduced from 37.6% (649/1,724) in 2017 to 22.8% (352/1,542) in 2019. The egg positive rate of Ascaris lumbricoides was decreased remarkably from 23.3% (402/1,724) in 2017 to 3.6% (56/1,542) in 2019. However, that of T. trichiura was only slightly reduced from 26.9% (464/1,724) in 2017 to 20.2% (312/1,542) in 2019. The intensity of infection with A. lumbricoides and T. trichiura was both more or less reduced, and the proportion of light infection cases with A. lumbricoides and T. trichiura increased from 35.6% in 2017 to 64.3% in 2019 and from 70.3% in 2017 to 81.7% in 2019, respectively. The results indicated that repeated MDAs (2-4 times a year for 3 years) using albendazole on schoolchildren in Myanmar failed to control T. trichiura infection. For a successful control of trichuriasis in Myanmar, new MDA strategies, using a modified albendazole regimen (multiple daily doses for 2 or 3 days) or an alternative anthelmintic drug, such as oxantel pamoate, is strongly recommended.
참고문헌 (13)
- World Health Organization, "Bench Aids for the Diagnosis of In-testinal Parasites" (2019), World Health Organization
- Gabrielli AF, "Preventive chemotherapy in human helminthiasis: theoretical and operational aspects", Trans R Soc Trop Med Hyg, 105, pp.683~693 (2011)[DOI]
- Zeng XJ, "Effect of integrated control intervention on soiltransmitted helminth infections in Jiangxi province in southeast China", Acta Trop, 194, pp.148~154 (2019)[DOI]
- Tun A, "Control of soil-transmitted helminthiasis in Myanmar: results of 7 years of deworming", Trop Med Int Health, 18, pp.1017~1020 (2013)[DOI]
- Htoon TT, "Status of infection with soil-transmitted helminths among primary school children in three selected townships of Yangon Region", Myanmar Heal Sci Res J, 27, pp.221~226 (2015)
- 채종일, "Effect of Mass Drug Administration with a Single Dose of Albendazole on Ascaris lumbricoides and Trichuris trichiura Infection among Schoolchildren in Yangon Region, Myanmar", The Korean Journal of Parasitology, 58(2), pp.195~200 (2020), 대한기생충학ㆍ열대의학회[DOI]
- The 2014Myanmar Population and Housing Census: Highlights of the Main Results, "Ministry of Immigration and Population, Myanmar", Ministry of Immigration and Population, Myanmar, 1~47, pp.Census Report Vol 2 (2015)
- World Health Organization, "Guideline: Preventive Chemotherapy to Control Soil-Transmitted Helminth Infections in at-Risk Population Groups" (2017), World Health Organization
- Julia C. Dunn, "Soil-transmitted helminth reinfection four and six months after mass drug administration: results from the delta region of Myanmar", PLOS Neglected Tropical Diseases, 13(2), pp.e0006591~ (2019), Public Library of Science (PLoS)[DOI]
- Wendelin Moser, "Efficacy of recommended drugs against soil transmitted helminths: systematic review and network meta-analysis", BMJ, pp.j4307~ (2017), BMJ[DOI]
- Rong Xiang, "Research Advances of Leptotrombidium scutellare in China", The Korean Journal of Parasitology, 59(1), pp.1~8 (2021), 대한기생충학ㆍ열대의학회
- Moser W, "Drug combinations against soiltransmitted helminth infections", Adv Parasitol, 103, pp.91~115 (2019)[DOI]
- Diawara A, "Association between response to albendazole treatment and β-tubulin frequencies in soil-transmitted helminths", PLoS Negl Trop Dis, 7, pp.e2247~ (2013)[DOI]