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Signaling Role of NADPH Oxidases in ROS-Dependent Host Cell Death Induced by Pathogenic Entamoeba histolytica

김경아|이영아|신명헌|심서보
대한기생충학ㆍ열대의학회 (The Korean Society For Parasitology and Tropical Medicine)|2022.06|Parasites, Hosts and Diseases|제60권 제3호|pp. 155-161|DOI 10.3347/kjp.2022.60.3.155

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참고문헌

키워드

ROSEntamoeba histolyticahost cell deathNADPH oxidases
주제분류예방의학/직업환경의학

초록

All living organisms are destined to die. Cells, the core of those living creatures, move toward the irresistible direction of death. The question of how to die is critical and is very interesting. There are various types of death in life, including natural death, accidental death, questionable death, suicide, and homicide. The mechanisms and molecules involved in cell death also differ depending on the type of death. The dysenteric amoeba, E. histolytica, designated by the German zoologist Fritz Schaudinn in 1903, has the meaning of tissue lysis; i.e., tissue destroying, in its name. It was initially thought that the amoebae lyse tissue very quickly leading to cell death called necrosis. However, advances in measuring cell death have allowed us to more clearly investigate the various forms of cell death induced by amoeba. Increasing evidence has shown that E. histolytica can cause host cell death through induction of various intracellular signaling pathways. Understanding of the mechanisms and signaling molecules involved in host cell death induced by amoeba can provide new insights on the tissue pathology and parasitism in human amoebiasis. In this review, we emphasized on the signaling role of NADPH oxidases in reactive oxygen species (ROS)-dependent cell death by pathogenic E. histolytica.

Abstract

All living organisms are destined to die. Cells, the core of those living creatures, move toward the irresistible direction of death. The question of how to die is critical and is very interesting. There are various types of death in life, including natural death, accidental death, questionable death, suicide, and homicide. The mechanisms and molecules involved in cell death also differ depending on the type of death. The dysenteric amoeba, E. histolytica, designated by the German zoologist Fritz Schaudinn in 1903, has the meaning of tissue lysis; i.e., tissue destroying, in its name. It was initially thought that the amoebae lyse tissue very quickly leading to cell death called necrosis. However, advances in measuring cell death have allowed us to more clearly investigate the various forms of cell death induced by amoeba. Increasing evidence has shown that E. histolytica can cause host cell death through induction of various intracellular signaling pathways. Understanding of the mechanisms and signaling molecules involved in host cell death induced by amoeba can provide new insights on the tissue pathology and parasitism in human amoebiasis. In this review, we emphasized on the signaling role of NADPH oxidases in reactive oxygen species (ROS)-dependent cell death by pathogenic E. histolytica.

참고문헌 (43)

  1. Samuel L Stanley, "Amoebiasis", The Lancet, 361(9362), pp.1025~1034 (2003), Elsevier BV[DOI]
  2. William A. Petri, "The Bittersweet Interface of Parasite and Host: Lectin-Carbohydrate Interactions During Human Invasion by the Parasite<i>Entamoeba histolytica<", i>, 2002, pp.56(1), 39~64[DOI]
  3. Darcym Moncada, "Antisense Inhibition of Entamoeba histolytica Cysteine Proteases Inhibits Colonic Mucus Degradation", Gastroenterology, 130(3), pp.721~730 (2006), Elsevier BV[DOI]
  4. Zhi Zhang, "Entamoeba histolytica cysteine proteinases with interleukin-1 beta converting enzyme (ICE) activity cause intestinal inflammation and tissue damage in amoebiasis", Molecular Microbiology, 37(3), pp.542~548 (2002), Wiley[DOI]
  5. Jeanie Quach, "Entamoeba histolytica-induced IL-1β secretion is dependent on caspase-4 and gasdermin D", Mucosal Immunology, 12(2), pp.323~339 (2019), Elsevier BV[DOI]
  6. Shanshan Wang, "The colonic pathogen Entamoeba histolytica activates caspase-4", 1 that cleaves the pore-forming protein gasdermin D to regulate IL-1β secretion, 2022, pp.18(3), e1010415~[DOI]
  7. Kim JM, "Interleukin-8 gene expression in the human colon epithelial cell line, HT-29, exposed to Entamoeba histolytica", Korean J Parasitol, 33, pp.357~364 (1995)
  8. Y Yu, "Entamoeba histolytica stimulates interleukin 8 from human colonic epithelial cells without parasite-enterocyte contact", Gastroenterology, 112(5), pp.1536~1547 (1997), Elsevier BV[DOI]
  9. Young Ah Lee, "<i>Entamoeba histolytica<", i>-secreted cysteine proteases induce IL-8 production in human mast cells via a PAR2-independent mechanism, 2014, pp.21, 1~9[DOI]
  10. O Berninghausen, "Necrosis versus apoptosis as the mechanism of target cell death induced by Entamoeba histolytica", Infection and Immunity, 65(9), pp.3615~3621 (1997), American Society for Microbiology[DOI]
  11. J. Grace Nirmala, "Cell death mechanisms in eukaryotes", Cell Biology and Toxicology, 36(2), pp.145~164 (2019), Springer Science and Business Media LLC[DOI]
  12. Maryse Dagenais, "Role of programmed necrosis and cell death in intestinal inflammation", Current Opinion in Gastroenterology, 30(6), pp.566~575 (2014), Ovid Technologies (Wolters Kluwer Health)[DOI]
  13. Ge Yan, "Multiple cell death modalities and their key features (Review)", World Academy of Sciences Journal, 2, pp.39~48 (2020), Spandidos Publications[DOI]
  14. Christopher D. Huston, "Caspase 3-dependent killing of host cells by the parasite Entamoeba histolytica", Cellular Microbiology, 2(6), pp.617~625 (2000), Hindawi Limited[DOI]
  15. Karl B. Seydel, "Entamoeba histolytica induces host cell death in amebic liver abscess by a non-Fas-dependent, non-tumor necrosis factor α-dependent pathway of apoptosis", Infection and Immunity, 66(6), pp.2980~2983 (1998), American Society for Microbiology[DOI]
  16. B.D. Ragland, "Entamoeba histolytica: Target Cells Killed by Trophozoites Undergo DNA Fragmentation Which Is Not Blocked by Bcl-2", Experimental Parasitology, 79(3), pp.460~467 (1994), Elsevier BV[DOI]
  17. Kyeong Ah Kim, "Calpain-dependent calpastatin cleavage regulates caspase-3 activation during apoptosis of Jurkat T cells induced by Entamoeba histolytica", International Journal for Parasitology, 37(11), pp.1209~1219 (2007), Elsevier BV[DOI]
  18. 심서보, "Ultrastructural observation of human neutrophils during apoptotic cell death triggered by Entamoeba histolytica (Brief Communication)", Parasites, Hosts and Diseases, 42(4), pp.205~208 (2004), 대한기생충학ㆍ열대의학회
  19. Katherine S. Ralston, "Trogocytosis by Entamoeba histolytica contributes to cell killing and tissue invasion", Nature, 508(7497), pp.526~530 (2014), Springer Science and Business Media LLC[DOI]
  20. Katherine S. Ralston, "Chew on this: amoebic trogocytosis and host cell killing by Entamoeba histolytica", Trends in Parasitology, 31(9), pp.442~452 (2015), Elsevier BV[DOI]
  21. Hannah W. Miller, "Trogocytosis by Entamoeba histolytica Mediates Acquisition and Display of Human Cell Membrane Proteins and Evasion of Lysis by Human Serum", mBio, 10(2), pp.e00068~ (2019), American Society for Microbiology[DOI]
  22. Hannah W. Miller, "Entamoeba histolytica Develops Resistance to Complement Deposition and Lysis after Acquisition of Human Complement-Regulatory Proteins through Trogocytosis", mBio, 13(2), pp.e0316321~ (2022), American Society for Microbiology[DOI]
  23. J I Ravdin, "Relationship of free intracellular calcium to the cytolytic activity of Entamoeba histolytica", Infection and Immunity, 56(6), pp.1505~1512 (1988), American Society for Microbiology[DOI]
  24. Kyeong Ah Kim, "NOX1 participates in ROS-dependent cell death of colon epithelial Caco2 cells induced by Entamoeba histolytica", Microbes and Infection, 13(12-13), pp.1052~1061 (2011), Elsevier BV[DOI]
  25. K.-J. SONG, "Reactive oxygen species-dependent necroptosis in Jurkat T cells induced by pathogenic free-living Naegleria fowleri", Parasite Immunology, 33(7), pp.390~400 (2011), Wiley[DOI]
  26. José E. Teixeira, "Entamoeba histolytica-induced dephosphorylation in host cells", Infection and Immunity, 70(4), pp.1816~1823 (2002), American Society for Microbiology[DOI]
  27. K. A. KIM, "Calpain-dependent cleavage of SHP-1 and SHP-2 is involved in the dephosphorylation of Jurkat T cells induced by<i>Entamoeba histolytica<", i>, 2010, pp.32(3), 176~183[DOI]
  28. Young Ah Lee, "O-deGlcNAcylation is required for Entamoeba histolytica-induced HepG2 cell death", Microbial Pathogenesis, 123, pp.285~295 (2018), Elsevier BV[DOI]
  29. Henry Jay Forman, "Reactive Oxygen Species and Cell Signaling", American Journal of Respiratory and Critical Care Medicine, 166(supplement_1), pp.S4~S8 (2002), American Thoracic Society[DOI]
  30. J. David Lambeth, "NOX enzymes and the biology of reactive oxygen", Nature Reviews Immunology, 4(3), pp.181~189 (2004), Springer Science and Business Media LLC[DOI]
  31. Karen Bedard, "The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology", Physiological Reviews, 87(1), pp.245~313 (2007), American Physiological Society[DOI]
  32. Miklós Geiszt, "The Nox Family of NAD(P)H Oxidases: Host Defense and Beyond", Journal of Biological Chemistry, 279(50), pp.51715~51718 (2004), Elsevier BV[DOI]
  33. Seobo Sim, "NADPH Oxidase-Derived Reactive Oxygen Species-Mediated Activation of ERK1", 2 Is Required for Apoptosis of Human Neutrophils Induced by <i>Entamoeba histolytica<, The Journal of Immunology, pp.2005, 174(7)[DOI]
  34. Fiorella Biasi, "Evidence of cell damage induced by major components of a diet-compatible mixture of oxysterols in human colon cancer CaCo-2 cell line", Biochimie, 95(3), pp.632~640 (2013), Elsevier BV[DOI]
  35. Jimmy Stalin, "Inhibition of host NOX1 blocks tumor growth and enhances checkpoint inhibitor–based immunotherapy", Life Science Alliance, 2(4), pp.e201800265~ (2019), Life Science Alliance, LLC[DOI]
  36. Kyeong Ah Kim, "NOX1 participates in ROS-dependent cell death of colon epithelial Caco2 cells induced by Entamoeba histolytica", Microbes and Infection, 13(12-13), pp.1052~1061 (2011), Elsevier BV[DOI]
  37. 김경아, "Entamoeba histolytica Induces Cell Death of HT29 Colonic Epithelial Cells via NOX1-Derived ROS", Parasites, Hosts and Diseases, 51(1), pp.61~68 (2013), 대한기생충학ㆍ열대의학회
  38. 장윤수, "Calpains are Involved in Entamoeba histolytica-Induced Death of HT-29 Colonic Epithelial Cells", Parasites, Hosts and Diseases, 49(2), pp.177~180 (2011), 대한기생충학ㆍ열대의학회
  39. 이지은, "Nox4-Mediated Cell Signaling Regulates Differentiation and Survival of Neural Crest Stem Cells", Molecules and Cells, 37(12), pp.907~911 (2014), 한국분자세포생물학회[DOI]
  40. Andris Elksnis, "Pharmacological Inhibition of NOX4 Improves Mitochondrial Function and Survival in Human Beta-Cells", Biomedicines, 9(12), pp.1865~1875 (2021), MDPI AG[DOI]
  41. Young Ah Lee, "NOX4 activation is involved in ROS-dependent Jurkat T-cell death induced by Entamoeba histolytica", Parasite Immunology, 41(11), pp.e12670~ (2019), Wiley[DOI]
  42. Andreas Petry, "NOX2 and NOX4 Mediate Proliferative Response in Endothelial Cells", Antioxidants &amp; Redox Signaling, 8(9-10), pp.1473~1484 (2006), Mary Ann Liebert Inc[DOI]
  43. Jessica A. Sipkens, "Homocysteine-Induced Apoptosis in Endothelial Cells Coincides With Nuclear NOX2 and Peri-nuclear NOX4 Activity", Cell Biochemistry and Biophysics, 67(2), pp.341~352 (2011), Springer Science and Business Media LLC[DOI]

관련 논문AI추천

Involvement of NOX2-derived ROS in human hepatoma HepG2 cell death induced by Entamoeba histolytica신명헌, 이영아대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2023 · 제61권 제4호Entamoeba histolytica Induces Cell Death of HT29 Colonic Epithelial Cells via NOX1-Derived ROS김경아, 김주영, 민아림, 박영일, 신명헌, 이영아대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2013 · 제51권 제1호Involvement of Src Family Tyrosine Kinase in Apoptosis of Human Neutrophils Induced by Protozoan Parasite Entamoeba histolytica신명헌, 심서보, 유재란, 이영아대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2010 · 제48권 제4호Calpains are Involved in Entamoeba histolytica-Induced Death of HT-29 Colonic Epithelial Cells송경주, 신명헌, 장윤수, Ju Young Kim, Kyeong Ah Kim, Sang Kyou Lee, Young Ah Lee대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2011 · 제49권 제2호Amoebic PI3K and PKC is required for Jurkat T cell death induced by Entamoeba histolytica김경아, 신명헌, Arim Min, Young Ah Lee대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2014 · 제52권 제4호Degradation of the transcription factors NF-kappaB, STAT3, and STAT5 is involved in Entamoeba histolytica-induced cell death in Caco-2 colonic epithelial cells신명헌, Arim Min, Kyeong Ah Kim, Young Ah Lee대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2014 · 제52권 제5호

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