Relationships of Low Serum Levels of Interleukin-10 With Poststroke Anxiety and Cognitive Impairment in Patients With Clinical Acute Stroke
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background and Purpose The relationships among interleukin (IL)-10 levels, anxiety, and cognitive status after stroke remain controversial. We aimed to determine the associations of serum IL-10 levels with poststroke anxiety (PSA) and poststroke cognitive impairment (PSCI). Methods We recruited 350 patients with stroke, of whom only 151 completed a 1-month follow- up assessment. The Mini Mental State Examination (MMSE) and Hamilton Anxiety Scale (HAMA) were used to assess the cognitive status and anxiety, respectively. Serum IL-10 levels were measured within 24 hours of admission. Results IL-10 levels were significantly lower in the PSA group than in the non-PSA group, and they were negatively associated with HAMA scores (r=-0.371, p<0.001). After adjusting for all potential confounders, IL-10 levels remained an independent predictor of PSA (odds ratio=0.471, 95% confidence interval=0.237–0.936, p=0.032). IL-10 levels were strongly correlated with behavior during interviews, psychic anxiety, and somatic anxiety. Patients without PSCI had higher IL-10 levels were higher in non-PSCI patients than in PSCI patients, and they were positively associated with MMSE scores in the bivariate correlation analysis (r=0.169, p=0.038), and also with memory capacity, naming ability, and copying capacity. However, IL-10 did not predict PSCI in the univariable or multivariable logistic regression. Conclusions Low IL-10 levels were associated with increased risks of PSA and PSCI at a 1-month follow-up after stroke. Serum IL-10 levels may therefore be helpful in predicting PSA.
Abstract
Background and Purpose The relationships among interleukin (IL)-10 levels, anxiety, and cognitive status after stroke remain controversial. We aimed to determine the associations of serum IL-10 levels with poststroke anxiety (PSA) and poststroke cognitive impairment (PSCI). Methods We recruited 350 patients with stroke, of whom only 151 completed a 1-month follow- up assessment. The Mini Mental State Examination (MMSE) and Hamilton Anxiety Scale (HAMA) were used to assess the cognitive status and anxiety, respectively. Serum IL-10 levels were measured within 24 hours of admission. Results IL-10 levels were significantly lower in the PSA group than in the non-PSA group, and they were negatively associated with HAMA scores (r=-0.371, p<0.001). After adjusting for all potential confounders, IL-10 levels remained an independent predictor of PSA (odds ratio=0.471, 95% confidence interval=0.237–0.936, p=0.032). IL-10 levels were strongly correlated with behavior during interviews, psychic anxiety, and somatic anxiety. Patients without PSCI had higher IL-10 levels were higher in non-PSCI patients than in PSCI patients, and they were positively associated with MMSE scores in the bivariate correlation analysis (r=0.169, p=0.038), and also with memory capacity, naming ability, and copying capacity. However, IL-10 did not predict PSCI in the univariable or multivariable logistic regression. Conclusions Low IL-10 levels were associated with increased risks of PSA and PSCI at a 1-month follow-up after stroke. Serum IL-10 levels may therefore be helpful in predicting PSA.
참고문헌 (43)
- GBD 2016 Disease, "Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016 : a systematic analysis for the global burden of disease study 2016", Lancet, 390, pp.1211~1259 (2017)
- Campbell Burton CA, "Frequency of anxiety after stroke : a systematic review and meta-analysis of observational studies", Int J Stroke, 8, pp.545~559 (2013)
- Menlove L, "Predictors of anxiety after stroke : a systematic review of observational studies", J Stroke Cerebrovasc Dis, 24, pp.1107~1117 (2015)
- Crayton E, "Psychological determinants of medication adherence in stroke survivors : a systematic review of observational studies", Ann Behav Med, 51, pp.833~845 (2017)
- de Haan EH, "Cognitive function following stroke and vascular cognitive impairment", Curr Opin Neurol, 19, pp.559~564 (2006)
- Nys GM, "Early cognitive impairment predicts long-term depressive symptoms and quality of life after stroke", J Neurol Sci, 247, pp.149~156 (2006)
- Lee M, "Cognitive impairment and risk of future stroke : a systematic review and metaanalysis", CMAJ, 186, pp.E536~E546 (2014)
- Labaka A, "Reduced hippocampal IL-10 expression, altered monoaminergic activity and anxiety and depressive-like behavior in female mice subjected to chronic social instability stress", Behav Brain Res, 335, pp.8~18 (2017)
- Xiu MH, "Contribution of IL-10 and its-592 A", C polymorphism to cognitive functions in first-episode drug-naive schizophrenia, 2016, pp.57, 116~124
- Garcia JM, "Role of interleukin-10 in acute brain injuries", Front Neurol, 8, pp.244~ (2017)
- Chen H, "IL-10 promotes neurite outgrowth and synapse formation in cultured cortical neurons after the oxygen-glucose deprivation via JAK1", STAT3 pathway, 2016, pp.6, 30459~
- Saraiva M, "The regulation of IL-10 production by immune cells", Nat Rev Immunol, 10, pp.170~181 (2010)
- Liu X, "Increased Th17", Treg ratio in poststroke fatigue, 2015, pp.2015, 931398~
- Wiener CD, "Interleukin-6 and interleukin-10 in mood disorders : a population-based study", Psychiatry Res, 273, pp.685~689 (2019)
- Al-Fadhel SZ, "IL-10 is associated with increased mu-opioid receptor levels in major depressive disorder", Eur Psychiatry, 57, pp.46~51 (2019)
- Köhler CA, "Mapping risk factors for depression across the lifespan : an umbrella review of evidence from meta-analyses and Mendelian randomization studies", J Psychiatr Res, 103, pp.189~207 (2018)
- Köhler CA, "Peripheral cytokine and chemokine alterations in depression : a meta-analysis of 82 studies", Acta Psychiatr Scand, 135, pp.373~387 (2017)
- Dowlati Y, "A meta-analysis of cytokines in major depression", Biol Psychiatry, 67, pp.446~457 (2010)
- Chi CH, "Interleukin-10 level is associated with post-stroke depression in acute ischaemic stroke patients", J Affect Disord, 293, pp.254~260 (2021)
- Patel RR, "IL-10 normalizes aberrant amygdala GABA transmission and reverses anxiety-like behavior and dependence-induced escalation of alcohol intake", Prog Neurobiol, 199, pp.101952~ (2021)
- Dhabhar FS, "Low serum IL-10 concentrations and loss of regulatory association between IL-6 and IL-10 in adults with major depression", J Psychiatr Res, 43, pp.962~969 (2009)
- Lynch AM, "Lipopolysaccharide-induced increase in signalling in hippocampus is abrogated by IL-10--a role for IL-1 beta?", J Neurochem, 88, pp.635~646 (2004)
- Kelly A, "The anti-inflammatory cytokine, interleukin(IL)-10, blocks the inhibitory effect of IL-1 beta on long term potentiation. A role for JNK", J Biol Chem, 276, pp.45564~45572 (2001)
- Kiyota T, "AAV serotype 2", 1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APP+PS1 mice, 2012, pp.19, 724~733
- Arosio B, "Interleukin-10 and interleukin-6 gene polymorphisms as risk factors for Alzheimer’s disease", Neurobiol Aging, 25, pp.1009~1015 (2004)
- Zhang HY, "A1 astrocytes contribute to murine depression-like behavior and cognitive dysfunction, which can be alleviated by IL-10 or fluorocitrate treatment", J Neuroinflammation, 17, pp.200~ (2020)
- Chakrabarty P, "IL-10 alters immunoproteostasis in APP mice, increasing plaque burden and worsening cognitive behavior", Neuron, 85, pp.519~533 (2015)
- No authors listed, "Stroke--1989. Recommendations on stroke prevention, diagnosis, and therapy. Report of the WHO task force on stroke and other cerebrovascular disorders", Stroke, 20, pp.1407~1431 (1989)
- Sims JR, "ABC", 2 for rapid clinical estimate of infarct, perfusion, and mismatch volumes, 2009, pp.72, 2104~2110
- Li X, "The prognostic value of serum cytokines in patients with acute ischemic stroke", Aging Dis, 10, pp.544~556 (2019)
- Mahoney FI, "Functional evaluation : the barthel index", Md State Med J, 14, pp.61~65 (1965)
- Lobbestael J, "Inter-rater reliability of the structured clinical interview for DSM-IV axis I disorders(SCID I)and axis II disorders(SCID II)", Clin Psychol Psychother, 18, pp.75~79 (2011)
- Du Y, "Effect of acupuncture treatment on post-stroke cognitive impairment: a randomized controlled trial", Medicine(Baltimore), 99, pp.e23803~ (2020)
- Müller N, "Childhood adversity and current stress are related to pro-and anti-inflammatory cytokines in major depression", J Affect Disord, 253, pp.270~276 (2019)
- Gao T, "Interleukin-4 signalling pathway underlies the anxiolytic effect induced by 3-deoxyadenosine", Psychopharmacology(Berl), 236, pp.2959~2973 (2019)
- Kulesh AA, "The relationship between serum and liquor IL-1β, IL-6, TNFα, IL-10 levels and clinical, cognitive and functional characteristics in acute ischemic stroke", Klin Med(Mosk), 94, pp.657~662 (2016)
- Patanella AK, "Correlations between peripheral blood mononuclear cell production of BDNF, TNF-alpha, IL-6, IL-10 and cognitive performances in multiple sclerosis patients", J Neurosci Res, 88, pp.1106~1112 (2010)
- Wennberg AMV, "The cross-sectional and longitudinal associations between IL-6, IL-10, and TNFα and cognitive outcomes in the Mayo clinic study of aging", J Gerontol A Biol Sci Med Sci, 74, pp.1289~1295 (2019)
- Wang J, "The interactive effect of genetic polymorphisms of IL-10 and COMT on cognitive function in schizophrenia", J Psychiatr Res, 136, pp.501~507 (2021)
- Guillot-Sestier MV, "Il10 deficiency rebalances innate immunity to mitigate Alzheimer-like pathology", Neuron, 85, pp.534~548 (2015)
- Munshi S, "Peripheral anti-inflammatory cytokine interleukin-10 treatment mitigates interleukin-1β-induced anxiety and sickness behaviors in adult male rats", Behav Brain Res, 372, pp.112024~ (2019)
- Mesquita AR, "IL-10 modulates depressive-like behavior", J Psychiatr Res, 43, pp.89~97 (2008)
- Roque S, "Interleukin-10 : a key cytokine in depression?", Cardiovasc Psychiatry Neurol, 2009, pp.187894~ (2009)