Development and Validation of the Korean Version of the Edinburgh Cognitive and Behavioral Amyotrophic Lateral Sclerosis Screen (ECAS-K)
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Background and Purpose Cognitive and behavioral changes are common in amyotrophic lateral sclerosis (ALS), with about 15% of patients presenting with overt frontotemporal dementia and 30%–50% with varying degrees of impairments. We aimed to develop and validate the Korean version of the Edinburgh Cognitive and Behavioral ALS Screen (ECAS-K), a brief multidomain assessment tool developed for ALS patients with physical disability. Methods We developed the ECAS-K according to the translation guidelines, and administered it to 38 patients with ALS and 26 age- and education-level-matched controls. We also administered the Montreal Cognitive Assessment (MoCA) and Frontal Assessment Battery (FAB) to investigate convergent validity, and the Center for Neurologic Study-Liability Scale to assess the association between pseudobulbar affect and cognitive/behavioral changes. Results Internal consistency among the ECAS-K test items was found to be high, with a Cronbach’s alpha of 0.87. Significant differences were found between patients with ALS and the controls in language, fluency, and memory functions (p<0.05). Abnormal performance based on the ECAS total score was noted in 39.4% of patients, and 66.6% presented behavioral changes in at least one domain. Significant correlations were observed between the scores of the ECAS-K and those of other cognitive screening tools (MoCA and FAB, with correlation coefficients of 0.69 and 0.55, respectively; p<0.01). Conclusions We developed and validated the ECAS-K which could be used as an effective tool to screen the cognitive and behavioral impairments in Korean patients with ALS.
Abstract
Background and Purpose Cognitive and behavioral changes are common in amyotrophic lateral sclerosis (ALS), with about 15% of patients presenting with overt frontotemporal dementia and 30%–50% with varying degrees of impairments. We aimed to develop and validate the Korean version of the Edinburgh Cognitive and Behavioral ALS Screen (ECAS-K), a brief multidomain assessment tool developed for ALS patients with physical disability. Methods We developed the ECAS-K according to the translation guidelines, and administered it to 38 patients with ALS and 26 age- and education-level-matched controls. We also administered the Montreal Cognitive Assessment (MoCA) and Frontal Assessment Battery (FAB) to investigate convergent validity, and the Center for Neurologic Study-Liability Scale to assess the association between pseudobulbar affect and cognitive/behavioral changes. Results Internal consistency among the ECAS-K test items was found to be high, with a Cronbach’s alpha of 0.87. Significant differences were found between patients with ALS and the controls in language, fluency, and memory functions (p<0.05). Abnormal performance based on the ECAS total score was noted in 39.4% of patients, and 66.6% presented behavioral changes in at least one domain. Significant correlations were observed between the scores of the ECAS-K and those of other cognitive screening tools (MoCA and FAB, with correlation coefficients of 0.69 and 0.55, respectively; p<0.01). Conclusions We developed and validated the ECAS-K which could be used as an effective tool to screen the cognitive and behavioral impairments in Korean patients with ALS.
참고문헌 (26)
- Xu L, "Global variation in prevalence and incidence of amyotrophic lateral sclerosis : a systematic review and meta-analysis", J Neurol, 267, pp.944~953 (2020)
- Hardiman O, "Amyotrophic lateral sclerosis", Nat Rev Dis Primers, 3, pp.17085~ (2017)
- Jun KY, "Epidemiology of ALS in Korea using nationwide big data", J Neurol Neurosurg Psychiatry, 90, pp.395~403 (2019)
- Huynh W, "The impact of cognitive and behavioral impairment in amyotrophic lateral sclerosis", Expert Rev Neurother, 20, pp.281~293 (2020)
- Phukan J, "The syndrome of cognitive impairment in amyotrophic lateral sclerosis : a population-based study", J Neurol Neurosurg Psychiatry, 83, pp.102~108 (2012)
- Beeldman E, "The cognitive profile of ALS : a systematic review and meta-analysis update", J Neurol Neurosurg Psychiatry, 87, pp.611~619 (2016)
- Olney RK, "The effects of executive and behavioral dysfunction on the course of ALS", Neurology, 65, pp.1774~1777 (2005)
- Burke T, "Caregiver burden in amyotrophic lateral sclerosis : a cross-sectional investigation of predictors", J Neurol, 262, pp.1526~1532 (2015)
- Bock M, "Cognitive-behavioral changes in amyotrophic lateral sclerosis : screening prevalence and impact on patients and caregivers", Amyotroph Lateral Scler Frontotemporal Degener, 17, pp.366~373 (2016)
- Abrahams S, "Screening for cognition and behaviour changes in ALS", Amyotroph Lateral Scler Frontotemporal Degener, 15, pp.9~14 (2014)
- Niven E, "Validation of the Edinburgh cognitive and behavioural amyotrophic lateral sclerosis screen(ECAS) : a cognitive tool for motor disorders", Amyotroph Lateral Scler Frontotemporal Degener, 16, pp.172~179 (2015)
- Lulé D, "The Edinburgh cognitive and behavioural amyotrophic lateral sclerosis screen : a cross-sectional comparison of established screening tools in a German-Swiss population", Amyotroph Lateral Scler Frontotemporal Degener, 16, pp.16~23 (2015)
- Poletti B, "The validation of the Italian Edinburgh cognitive and behavioural ALS screen(ECAS)", Amyotroph Lateral Scler Frontotemporal Degener, 17, pp.489~498 (2016)
- Ye S, "The Edinburgh cognitive and behavioural ALS screen in a Chinese amyotrophic lateral sclerosis population", PLoS One, 11, pp.e0155496~ (2016)
- Brooks BR, "El Escorial revisited : revised criteria for the diagnosis of amyotrophic lateral sclerosis", Amyotroph Lateral Scler Other Motor Neuron Disord, 1, pp.293~299 (2000)
- Cedarbaum JM, "The ALSFRS-R : a revised ALS functional rating scale that incorporates assessments of respiratory function", J Neurol Sci, 169, pp.13~21 (1999)
- Osborne RA, "Screening for frontal lobe and general cognitive impairment in patients with amyotrophic lateral sclerosis", J Neurol Sci, 336, pp.191~196 (2014)
- Nagashima K, "Clinical usefulness of scales for evaluating cognitive impairment in patients with amyotrophic lateral sclerosis", J Neurol Sci, 405, pp.116414~ (2019)
- Ohta Y, "Behavioral and affective features of amyotrophic lateral sclerosis patients", J Neurol Sci, 381, pp.119~125 (2017)
- Crockford C, "ALS-specific cognitive and behavior changes associated with advancing disease stage in ALS", Neurology, 91, pp.e1370~e1380 (2018)
- Crockford CJ, "ECAS A-B-C : alternate forms of the Edinburgh cognitive and behavioural ALS screen", Amyotroph Lateral Scler Frontotemporal Degener, 19, pp.57~64 (2018)
- Strong MJ, "Consensus criteria for the diagnosis of frontotemporal cognitive and behavioural syndromes in amyotrophic lateral sclerosis", Amyotroph Lateral Scler, 10, pp.131~146 (2009)
- Zou ZY, "Genetic epidemiology of amyotrophic lateral sclerosis : a systematic review and meta-analysis", J Neurol Neurosurg Psychiatry, 88, pp.540~549 (2017)
- Wicks P, "SOD1 and cognitive dysfunction in familial amyotrophic lateral sclerosis", J Neurol, 256, pp.234~241 (2009)
- Bella ED, "Behavioral and cognitive phenotypes of patients with amyotrophic lateral sclerosis carrying SOD1 variants", Neurology, 99, pp.e2052~e2062 (2022)
- Chiò A, "Cognitive impairment across ALS clinical stages in a populationbased cohort", Neurology, 93, pp.e984~e994 (2019)