Clinical Significance of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Acute Unilateral Vestibulopathy
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Background and Purpose The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been identified as useful biomarkers for assessing the inflammatory response and for predicting the prognosis of various diseases. This study aimed to determine the clinical significance and effects on prognostic prediction of NLR and PLR in acute unilateral vestibulopathy (AUV). Methods We retrospectively recruited 128 patients who were diagnosed with AUV from July 2016 to April 2021, and compared NLR and PLR values between these patients with AUV and age- and sex-matched healthy subjects. We also analyzed the correlations of various clinical parameters with NLR and PLR. Results NLR and PLR in the AUV group were 3.41±2.80 (mean±standard deviation) and 128.86±67.06, respectively, with only NLR being significantly higher than that in the control group (1.55±0.60, p<0.001). The gain asymmetry of the horizontal vestibulo-ocular reflex (VOR) was slightly larger in patients with high NLR (n=52) than in those with normal NLR (n=76) (41.9%±20.2% vs. 33.6%±17.4%, p=0.048). However, the hospitalization period, preceding infection, canal paresis, and absolute horizontal VOR gain did not differ between patients with high and normal NLR and PLR values. The correlation analyses also revealed that none of the clinical parameters were significantly correlated with NLR or PLR. At 3-month follow- up examinations, NLR and PLR did not differ significantly between patients with and without function recovery of the horizontal VOR. Conclusions This study found a high NLR in AUV, suggesting an acute inflammatory status in the vestibular organ. However, the usefulness of NLR and PLR as prognostic markers remains unclear.
Abstract
Background and Purpose The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been identified as useful biomarkers for assessing the inflammatory response and for predicting the prognosis of various diseases. This study aimed to determine the clinical significance and effects on prognostic prediction of NLR and PLR in acute unilateral vestibulopathy (AUV). Methods We retrospectively recruited 128 patients who were diagnosed with AUV from July 2016 to April 2021, and compared NLR and PLR values between these patients with AUV and age- and sex-matched healthy subjects. We also analyzed the correlations of various clinical parameters with NLR and PLR. Results NLR and PLR in the AUV group were 3.41±2.80 (mean±standard deviation) and 128.86±67.06, respectively, with only NLR being significantly higher than that in the control group (1.55±0.60, p<0.001). The gain asymmetry of the horizontal vestibulo-ocular reflex (VOR) was slightly larger in patients with high NLR (n=52) than in those with normal NLR (n=76) (41.9%±20.2% vs. 33.6%±17.4%, p=0.048). However, the hospitalization period, preceding infection, canal paresis, and absolute horizontal VOR gain did not differ between patients with high and normal NLR and PLR values. The correlation analyses also revealed that none of the clinical parameters were significantly correlated with NLR or PLR. At 3-month follow- up examinations, NLR and PLR did not differ significantly between patients with and without function recovery of the horizontal VOR. Conclusions This study found a high NLR in AUV, suggesting an acute inflammatory status in the vestibular organ. However, the usefulness of NLR and PLR as prognostic markers remains unclear.
참고문헌 (30)
- Strupp M, "Acute unilateral vestibulopathy", Neurol Clin, 33, pp.669~685 (2015)
- Strupp M, "Acute unilateral vestibulopathy", vestibular neuritis : diagnostic criteria, 2022, pp.32, 389~406
- Arbusow V, "Detection of herpes simplex virus type 1 in human vestibular nuclei", Neurology, 55, pp.880~882 (2000)
- Hirata Y, "Herpetic vestibular neuritis : an experimental study", Acta Otolaryngol Suppl, 519, pp.93~96 (1995)
- Greco A, "Is vestibular neuritis an immune related vestibular neuropathy inducing vertigo?", J Immunol Res, 2014, pp.459048~ (2014)
- Zhang S, "Prognostic value of neutrophil to lymphocyte ratio in gastric cancer patients receiving immune checkpoint inhibitors : a systematic review and meta-analysis", Front Oncol, 13, pp.1070019~ (2023)
- Liu YL, "High neutrophil-to-lymphocyte ratio is a predictor of poor short-term outcome in patients with mild acute ischemic stroke receiving intravenous thrombolysis", Brain Behav, 10, pp.e01857~ (2020)
- Chen C, "Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as potential predictors of prognosis in acute ischemic stroke", Front Neurol, 25, pp.525621~ (2021)
- Ozbay I, "Neutrophil-to-lymphocyte ratio in patients with peripheral vertigo : a prospective controlled clinical study", Am J Otolaryngol, 35, pp.699~702 (2014)
- Tekeşin A, "Inflammatory biomarkers in benign paroxysmal positional vertigo : a Turkey case-control study", Ideggyogy Sz, 71, pp.411~416 (2018)
- Diao TX, "The peripheral blood inflammatory markers in Ménière’s disease patients with and without migraine", Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 57, pp.1426~1432 (2022)
- Chung JH, "The significance of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in vestibular neuritis", Laryngoscope, 125, pp.E257~E261 (2015)
- Shushan S, "Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio among patients with vestibular neuritis", ORL J Otorhinolaryngol Relat Spec, 81, pp.304~308 (2019)
- Şahin Mİ, "Mean platelet volume, neutrophiland platelet to lymphocyte ratios are elevated in vestibular neuritis", J Clin Neurosci, 67, pp.134~138 (2019)
- Oh EH, "Neutrophil-mediated immune response as a possible mechanism of acute unilateral vestibulopathy", J Vestib Res, 30, pp.363~374 (2020)
- Jeong JU, "Predictive values of neutrophil-to-lymphocyte ratio(NLR), platelet-to-lymphocyte ratio(PLR), and other prognostic factors in pediatric vestibular neuritis patients", Int J Pediatr Otorhinolaryngol, 164, pp.111383~ (2023)
- Kim HS, "Discordant vestibulo-ocular reflex function according to the frequency and mode of stimulation", J Neurol, 269, pp.4742~4752 (2022)
- Rujescu D, "Genome-wide association study in vestibular neuritis : involvement of the host factor for HSV-1 replication", Front Neurol, 9, pp.59~ (2018)
- Rujescu D, "High-risk allele for herpes labialis severity at the IFNL3", 4 locus is associated with vestibular neuritis, 2020, pp.11, 570638~
- Bumm P, "T-lymphocyte subpopulations and HLA-DR antigens in patients with Bell’s palsy, hearing loss, neuronitis vestibularis, and Meniere’s disease", Eur Arch Otorhinolaryngol, pp.S447~S448 (1994)
- Kassner SS, "Proinflammatory activation of peripheral blood mononuclear cells in patients with vestibular neuritis", Audiol Neurootol, 16, pp.242~247 (2011)
- Bardoel BW, "The balancing act of neutrophils", Cell Host Microbe, 15, pp.526~536 (2014)
- Kınar A, "Can Systemic Immune-Inflammation Index(SII)be a prognostic factor of Bell’s palsy patients?", Neurol Sci, 42, pp.3197~3201 (2021)
- Xie W, "Etiological analysis of patients with sudden sensorineural hearing loss : a prospective case-control study", Sci Rep, 13, pp.5221~ (2023)
- Chen L, "The value of inflammatory biomarkers in the occurrence and prognosis of sudden sensorineural hearing loss : a meta-analysis", Eur Arch Otorhinolaryngol, 280, pp.3119~3129 (2022)
- Yan T, "Vestibular neuritis in patients among different age groups : clinical features and outcomes", J Am Acad Audiol, 31, pp.629~635 (2020)
- Bronstein AM, "Long-term clinical outcome in vestibular neuritis", Curr Opin Neurol, 32, pp.174~180 (2019)
- Arshad Q, "Factors influencing clinical outcome in vestibular neuritis-a focussed review and reanalysis of prospective data", J Neurol Sci, 446, pp.120579~ (2023)
- Oron Y, "Cardiovascular risk factors among patients with vestibular neuritis", Ann Otol Rhinol Laryngol, 126, pp.597~601 (2017)
- Beyan C, "Mean platelet volume values may not be elevated in patients with vestibular neuritis", J Clin Neurosci, 70, pp.269~ (2019)