Determinant of parasite clearance and density on uncomplicated falciparum malaria infections in malaria-endemic area of Lampung Province, Indonesia
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Lampung is a malaria-endemic region in Indonesia with an annual parasite incidence of 0.06 per 1,000 population. The socio-demographic factors, clinical conditions, and artemisinin combination therapy (ACT) types might affect parasite clearance and parasite density. This study aims to investigate factors that influence parasite clearance and parasite density in malaria patients. A retrospective analytic observational and a cross-sectional approach was used to conduct this study. A total of 66 malaria patients were examined to investigate parasite density and clearance, socio-demographic profiles, clinical conditions, and ACT types. To analyze data, univariate, bivariate, and multivariate tests were used. Age (P=0.045; r=0.238) and ACT type (P=0.021; r=0.273) were the only variables that had a significant correlation with parasite clearance. Age (P=0.003; r=0.345) had a significant correlation with parasite density. The most influential factors related to parasite clearance were the ACT type (dihydroartemisinin piperaquine) (P=0.017; odds ratio (OR) 0.109; 95.0% confidence interval (CI), 0.018–0.675) and age (P=0.030; OR 0.132; 95.0% CI, 0.021–0.823). Age (P=0.046; OR 0.320; 0.105–0.978, 95.0% CI) was the most significant variable associated with parasite density.
Abstract
Lampung is a malaria-endemic region in Indonesia with an annual parasite incidence of 0.06 per 1,000 population. The socio-demographic factors, clinical conditions, and artemisinin combination therapy (ACT) types might affect parasite clearance and parasite density. This study aims to investigate factors that influence parasite clearance and parasite density in malaria patients. A retrospective analytic observational and a cross-sectional approach was used to conduct this study. A total of 66 malaria patients were examined to investigate parasite density and clearance, socio-demographic profiles, clinical conditions, and ACT types. To analyze data, univariate, bivariate, and multivariate tests were used. Age (P=0.045; r=0.238) and ACT type (P=0.021; r=0.273) were the only variables that had a significant correlation with parasite clearance. Age (P=0.003; r=0.345) had a significant correlation with parasite density. The most influential factors related to parasite clearance were the ACT type (dihydroartemisinin piperaquine) (P=0.017; odds ratio (OR) 0.109; 95.0% confidence interval (CI), 0.018–0.675) and age (P=0.030; OR 0.132; 95.0% CI, 0.021–0.823). Age (P=0.046; OR 0.320; 0.105–0.978, 95.0% CI) was the most significant variable associated with parasite density.
참고문헌 (26)
- Ministry of Health of Indonesia, "Indonesian Health Profile 2019", Ministry of Health of Indonesia, ~ (2020)
- World Malaria Report 2022, "World Health Organization", World Health Organization, ~ (2022)
- Ministry of Health of Indonesia, "Indonesian Health Profile 2021", Ministry of Health of Indonesia, ~ (2022)
- Lampung Provincial Health Office of Indonesia, "Lampung Province Health Profile 2021", Lampung Provincial Health Office of Indonesia, ~ (2022)
- Lampung Provincial Health Office of Indonesia, "Lampung Province Health Profile 2019", Lampung Provincial Health Office of Indonesia, ~ (2020)
- World Malaria Report, "World Health Organization", World Health Organization, ~ (2020)
- Dahal P, "Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria : a literature review and meta-analysis of individual patient data", BMC Med, 13, pp.212~ (2015)[DOI]
- Arévalo-Herrera M, "Clinical profile of Plasmodium falciparum and Plasmodium vivax infections in low and unstable malaria transmission settings of Colombia", Malar J, 14(1), pp.1~11 (2015)[DOI]
- Chaparro-Narváez PE, "Clinical and epidemiological aspects of complicated malaria in Colombia, 2007-2013", Malar J, 15(1), pp.269~ (2016)[DOI]
- Milner DA Jr, "Malaria pathogenesis", Cold Spring Harb Perspect Med, 8(1), pp.a025569~ (2018)[DOI]
- Phillips A, "Risk factors for severe disease in adults with falciparum malaria", Clin Infect Dis, 48(7), pp.871~878 (2009)[DOI]
- Oakley MS, "Clinical and molecular aspects of malaria fever", Trends Parasitol, 27(10), pp.442~449 (2011)[DOI]
- Ministry of Health of Indonesia, "Guidelines for the Management of Malaria Cases in Indonesia", Ministry of Health of Indonesia, ~ (2008)
- Suwandi JF, "Polymorphism of PfMDR1 and PfATP6 genes in Plasmodium isolates from Falciparum malaria patients in Pesawaran District", Ph.D., pp.2014
- Suwandi JF, "Efficacy of artemisinin base combination therapy and genetic diversity of Plasmodium falciparum from uncomplicated malaria Falciparum patient in district of Pesawaran, Province of Lampung, Indonesia", Iran J Parasitol, 14(1), pp.143~150 (2019)
- Sastroasmoro S, "Basic of Clinical Research Methodology" (2011), Sagung Seto
- Assessment and Monitoring of Antimalarial Drug Efficacy for the Treatment of Uncomplicated Falciparum Malaria, "World Health Organization", World Health Organization, ~ (2003)
- Wijayanti MA, "Microscopic diagnosis of malaria module", Department of Parasitology, pp.2011
- White NJ, "Malaria parasite clearance", Malar J, 16(1), pp.88~ (2017)[DOI]
- Angel Miraclin T, "Slow parasite clearance, absent k13-propeller gene polymorphisms and adequate artesunate levels among patients with malaria : A pilot study from Southern India", Natl Med J India, 32(4), pp.200~206 (2019)[DOI]
- Irawati N, "Determination of the falciparum malaria resistance to artemisinin-based combination therapies in Pesawaran, Lampung, Indonesia", Asian J Epidemiol, 10(1), pp.19~25 (2017)[DOI]
- Kurniawan B, "Study of the K13 gene polymorphisms in Plasmodium falciparum in Pesawaran, Lampung, Indonesia", Pakistan J Biotechnol, 15(4), pp.871~874 (2018)[DOI]
- Ariati Y, "Malaria Vector Bioecology of Anopheles sundaicus in Nongsa Subdistrict, Batam City 2008", J Ekol Kesehat, 10(1), pp.29~37 (2008)
- Suwito, "Anopheles mosquito behavior in South Lampung Regency, Lampung Province", J Pengendali Penyakit dan Penyehatan Lingkung, 2, pp.21~26 (2012)
- Avrina R, "The relationship between parasites density with the clinical manifestation on malaria Plasmodium falciparum and Plasmodium vivax", Media Litbang Kesehat, 21(3), pp.119~126 (2011)
- Krzych U, "Memory T cells maintain protracted protection against malaria", Immunol Lett, 161(2), pp.189~195 (2014)[DOI]