Resting Heart Rate and Cognitive Decline: A Meta-Analysis of Prospective Cohort Studies
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background and Purpose Several previous meta-analyses have identified an association between cognitive decline and heart rate variability, which reflects autonomic nerve activity. This systematic review and meta-analysis investigated the impact of increased resting heart rate (RHR) on the incidence of cognitive decline, including dementia. Methods The PubMed, Embase, and PsycInfo databases were searched for relevant prospective cohort studies published before April 18, 2022. A methodological quality assessment of the included studies was conducted using the Newcastle–Ottawa Scale. Summary estimates of the incidence of cognitive decline, including dementia, were generated using a random-effects model. Potential publication bias was evaluated using Begg’s funnel plots and Egger’s regression tests. Results The meta-analysis included 7 prospective cohort studies comprising 53,621 participants. A weak significant association was observed between RHR and the risk of cognitive decline, although the analysis indicated high heterogeneity among the studies (relative risk=1.18, 95% confidence interval=1.04–1.33, I2=82.5%). Significant associations were determined between RHR and all combined types of dementia except for Alzheimer’s disease and mild cognitive impairment. There was also a dose–response association between increased RHR and cognitive decline. The meta-estimate of the cognitive decline risk associated with a 10 beatper- minute increase in RHR was 1.06, and it was 1.10 for dementia. Conclusions This study found that a higher RHR was associated with an increased cognitive decline risk. Due to study limitations such as publication bias and high heterogeneity, additional studies are required to validate this finding.
Abstract
Background and Purpose Several previous meta-analyses have identified an association between cognitive decline and heart rate variability, which reflects autonomic nerve activity. This systematic review and meta-analysis investigated the impact of increased resting heart rate (RHR) on the incidence of cognitive decline, including dementia. Methods The PubMed, Embase, and PsycInfo databases were searched for relevant prospective cohort studies published before April 18, 2022. A methodological quality assessment of the included studies was conducted using the Newcastle–Ottawa Scale. Summary estimates of the incidence of cognitive decline, including dementia, were generated using a random-effects model. Potential publication bias was evaluated using Begg’s funnel plots and Egger’s regression tests. Results The meta-analysis included 7 prospective cohort studies comprising 53,621 participants. A weak significant association was observed between RHR and the risk of cognitive decline, although the analysis indicated high heterogeneity among the studies (relative risk=1.18, 95% confidence interval=1.04–1.33, I2=82.5%). Significant associations were determined between RHR and all combined types of dementia except for Alzheimer’s disease and mild cognitive impairment. There was also a dose–response association between increased RHR and cognitive decline. The meta-estimate of the cognitive decline risk associated with a 10 beatper- minute increase in RHR was 1.06, and it was 1.10 for dementia. Conclusions This study found that a higher RHR was associated with an increased cognitive decline risk. Due to study limitations such as publication bias and high heterogeneity, additional studies are required to validate this finding.
참고문헌 (37)
- 정영희, "Effect of Integrated Cognitive Intervention Therapy in Patients with Mild to Moderate Alzheimer's Disease", Dementia and Neurocognitive Disorders(대한치매학회지), 19(3), pp.86~95 (2020), 대한치매학회[DOI]
- "World Alzheimer report 2018" (2018)[URL]
- Lincoln P, "The Blackfriars Consensus on brain health and dementia", Lancet, 383, pp.1805~1806 (2014)
- "World Alzheimer report 2014. Dementia and risk reduction: an analysis of protective and modifiable risk factors" (2014)[URL]
- Peters R, "Combining modifiable risk factors and risk of dementia : a systematic review and meta-analysis", BMJ Open, 9, pp.e022846~ (2019)
- Wulsin LR, "The contribution of autonomic imbalance to the development of metabolic syndrome", Psychosom Med, 78, pp.474~480 (2016)
- Licht CM, "Dysregulation of the autonomic nervous system predicts the development of the metabolic syndrome", J Clin Endocrinol Metab, 98, pp.2484~2493 (2013)
- Licht CM, "Increased sympathetic and decreased parasympathetic activity rather than changes in hypothalamic-pituitaryadrenal axis activity is associated with metabolic abnormalities", J Clin Endocrinol Metab, 95, pp.2458~2466 (2010)
- Iturria-Medina Y, "Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis", Nat Commun, 7, pp.11934~ (2016)
- Hajjar I, "Assessment of cerebrovascular reactivity during resting state breathing and its correlation with cognitive function in hypertension", Cerebrovasc Dis, 38, pp.10~16 (2014)
- Cheng YC, "Heart rate variability in patients with dementia or neurocognitive disorders : a systematic review and meta-analysis", Aust N Z J Psychiatry, 56, pp.16~27 (2022)
- da Silva VP, "Heart rate variability indexes in dementia : a systematic review with a quantitative analysis", Curr Alzheimer Res, 15, pp.80~88 (2018)
- Page MJ, "The PRISMA 2020 statement : an updated guideline for reporting systematic reviews", BMJ, 372, pp.n71~ (2021)
- "The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses" (2011)[URL]
- Higgins JP, "Quantifying heterogeneity in a metaanalysis", Stat Med, 21, pp.1539~1558 (2002)
- Borenstein M, "A basic introduction to fixed-effect and random-effects models for meta-analysis", Res Synth Methods, 1, pp.97~111 (2010)
- Young K, "Resting heart rate and cognitive function : the Honolulu-Asia Aging Study", Proceedings of the American Geriatrics Society (AGS) 2010 Annual Scientific Meeting, pp.S65~ (2010)
- Leong DP, "Resting heart rate and decline in cognitive function : observations from the ONTARGET", TRANSCEND studies, 2013, pp.34(suppl_1), 2737~
- Besser LM, "Late-life vascular risk factors and Alzheimer disease neuropathology in individuals with normal cognition", J Neuropathol Exp Neurol, 75, pp.955~962 (2016)
- study), "Am J Cardiol", 2019, 334~340
- Haring B, "Heart rate, brain imaging biomarkers and cognitive impairment in older(≥63years)women", Am J Cardiol, 129, pp.102~108 (2020)
- Singleton MJ, "Association of resting heart rate with incident dementia and mild cognitive impairment : SPRINT", J Am Coll Cardiol, 77(18_Supplement_1), pp.1657~ (2021)
- Imahori Y, "Association of resting heart rate with cognitive decline and dementia in older adults : a population-based cohort study", Alzheimers Dement (2021)[DOI]
- Collins O, "Parasympathetic autonomic dysfunction is common in mild cognitive impairment", Neurobiol Aging, 33, pp.2324~2333 (2012)
- Kim DH, "Association between reduced heart rate variability and cognitive impairment in older disabled women in the community : Women’s Health and Aging Study I", J Am Geriatr Soc, 54, pp.1751~1757 (2006)
- Aharon-Peretz J, "Increased sympathetic and decreased parasympathetic cardiac innervation in patients with Alzheimer’s disease", Arch Neurol, 49, pp.919~922 (1992)
- Whelton SP, "Association between resting heart rate and inflammatory biomarkers(high-sensitivity C-reactive protein, interleukin-6, and fibrinogen)(from the Multi-Ethnic Study of Atherosclerosis)", Am J Cardiol, 113, pp.644~649 (2014)
- Thayer JF, "Heart rate variability, prefrontal neural function, and cognitive performance : the neurovisceral integration perspective on self-regulation, adaptation, and health", Ann Behav Med, 37, pp.141~153 (2009)
- Tahsili-Fahadan P, "Heart–brain axis : effects of neurologic injury on cardiovascular function", Circ Res, 120, pp.559~572 (2017)
- Ruggiero DA, "A role of insular cortex in cardiovascular function", J Comp Neurol, 257, pp.189~207 (1987)
- Wei L, "Heart rate variability associated with grey matter volumes in striatal and limbic structures of the central autonomic network", Brain Res, 1681, pp.14~20 (2018)
- Westerhaus MJ, "Central representation of the sympathetic nervous system in the cerebral cortex", Brain Res, 903, pp.117~127 (2001)
- Aitake M, "Sensory mismatch induces autonomic responses associated with hippocampal theta waves in rats", Behav Brain Res, 220, pp.244~253 (2011)
- Nicolini P, "Autonomic function in amnestic and non-amnestic mild cognitive impairment : spectral heart rate variability analysis provides evidence for a brain-heart axis", Sci Rep, 10, pp.11661~ (2020)
- Latvala A, "Association of resting heart rate and blood pressure in late adolescence with subsequent mental disorders : a longitudinal population study of more than 1 million men in Sweden", JAMA Psychiatry, 73, pp.1268~1275 (2016)
- Eriksson P, "Job strain and resting heart rate : a cross-sectional study in a Swedish random working sample", BMC Public Health, 16, pp.228~ (2016)
- Yayla Ç, "Drugs that affect the resting heart rate", Angiology, 68, pp.174~ (2017)