Associations among the Degree of Nonalcoholic Fatty Liver Disease, Metabolic Syndrome, Degree of Obesity in Children, and Parental Obesity
2
조회
0
다운로드
10
인용
0
참고문헌
키워드
초록
Purpose: To analyze the associations among the degrees of nonalcoholic fatty liver disease (NAFLD) by ultra-sonography and metabolic syndrome, degrees of obesity in children, and degrees of parental obesity. Methods: A total of 198 children with obesity who visited a pediatric obesity clinic were prospectively enrolled in this study. The severity of NAFLD based on ultrasonography was classified into no, mild, moderate, or severe NAFLD group. The degree of obesity based on the percentage over standard weight for height per sex was classified into mild, moderate, or severe. Results: Of 132 patients evaluated for the degree of NAFLD and metabolic syndrome, the p-value of correlation between the two factors was 0.009. Therefore, metabolic syndrome might significantly affect the degree of NAFLD. Of 158 patients evaluated for the degree of NAFLD and the degree of obesity, the p-value of correlation between the two factors was 0.122. Of 154 patients evaluated for the degree of obesity and father’s obesity, the p-value was 0.076. Of 159 patients evaluated for the degree of obesity and mother’s obesity, the p-value was 0.000, indicating that mother’s obesity could significantly affect the degree of obesity in children. Of 142 patients evaluated for the degree of obesity and metabolic syndrome, the p-value was 0.288. Conclusion: Metabolic syndrome might significantly affect the degree of nonalcoholic fatty liver in children. In addition, mother’s obesity might be a significant factor that affects the degree of obesity in children.
Abstract
Purpose: To analyze the associations among the degrees of nonalcoholic fatty liver disease (NAFLD) by ultra-sonography and metabolic syndrome, degrees of obesity in children, and degrees of parental obesity. Methods: A total of 198 children with obesity who visited a pediatric obesity clinic were prospectively enrolled in this study. The severity of NAFLD based on ultrasonography was classified into no, mild, moderate, or severe NAFLD group. The degree of obesity based on the percentage over standard weight for height per sex was classified into mild, moderate, or severe. Results: Of 132 patients evaluated for the degree of NAFLD and metabolic syndrome, the p-value of correlation between the two factors was 0.009. Therefore, metabolic syndrome might significantly affect the degree of NAFLD. Of 158 patients evaluated for the degree of NAFLD and the degree of obesity, the p-value of correlation between the two factors was 0.122. Of 154 patients evaluated for the degree of obesity and father’s obesity, the p-value was 0.076. Of 159 patients evaluated for the degree of obesity and mother’s obesity, the p-value was 0.000, indicating that mother’s obesity could significantly affect the degree of obesity in children. Of 142 patients evaluated for the degree of obesity and metabolic syndrome, the p-value was 0.288. Conclusion: Metabolic syndrome might significantly affect the degree of nonalcoholic fatty liver in children. In addition, mother’s obesity might be a significant factor that affects the degree of obesity in children.
참고문헌 (25)
- "The results for school health examination survey 2014" (2015)[URL]
- Keane VA, "Nelson textbook of pediatrics" (2015), Elsevier
- Wieckowska A, "Nonalcoholic fatty liver disease in the pediatric population: a review", Curr Opin Pediatr, 17, pp.636~641 (2005)
- Feldstein AE, "The natural history of non-alcoholic fatty liver disease in children: a follow- up study for up to 20 years", Gut, 58, pp.1538~1544 (2009)
- Patton HM, "Pediatric nonalcoholic fatty liver disease: a critical appraisal of current data and implications for future research", J Pediatr Gastroenterol Nutr, 43, pp.413~427 (2006)
- Patton HM, "Association between metabolic syndrome and liver histology among children with nonalcoholic Fatty liver disease", Am J Gastroenterol, 105, pp.2093~2102 (2010)
- Whitaker RC, "Predicting obesity in young adulthood from childhood and parental obesity", N Engl J Med, 337, pp.869~873 (1997)
- Saadeh S, "The utility of radiological imaging in nonalcoholic fatty liver disease", Gastroenterology, 123, pp.745~750 (2002)
- Lambert M, "Insulin resistance syndrome in a representative sample of children and adolescents from Quebec, Canada", Int J Obes Relat Metab Disord, 28, pp.833~841 (2004)
- Yoo S, "Obesity in Korean pre-adolescent school children: comparison of various anthropometric measurements based on bioelectrical impedance analysis", Int J Obes, 30, pp.1086~1090 (2006)
- 안영미, "학령기아동의 체형분류법에 따른 체중, 키, 비만도 및 체질량지수 비교", Journal of Korean Academy of Nursing, 40(6), pp.775~784 (2010), 한국간호과학회
- Vajro P, "Diagnosis of nonalcoholic fatty liver disease in children and adolescents: position paper of the ESPGHAN Hepatology Committee", J Pediatr Gastroenterol Nutr, 54, pp.700~713 (2012)
- Roldan-Valadez E, "Imaging techniques for assessing hepatic fat content in nonalcoholic fatty liver disease", Ann Hepatol, 7, pp.212~220 (2008)
- Nobili V, "Accuracy and reproducibility of transient elastography for the diagnosis of fibrosis in pediatric nonalcoholic steatohepatitis", Hepatology, 48, pp.442~448 (2008)
- Joseph AE, "Comparison of liver histology with ultrasonography in assessing diffuse parenchymal liver disease", Clin Radiol, 43, pp.26~31 (1991)
- Park SH, "acrovesicular hepatic steatosis in living liver donors: use of CT for quantitative and qualitative assessment", Radiology, 239, pp.105~112 (2006)
- Radetti G, "Non-alcoholic fatty liver disease in obese children evaluated by magnetic resonance imaging", Acta Paediatr, 95, pp.833~837 (2006)
- Pacifico L, "MRI and ultrasound for hepatic fat quantification: relationships to clinical and metabolic characteristics of pediatric nonalcoholic fatty liver disease", Acta Paediatr, 96, pp.542~547 (2007)
- Mencin AA, "Nonalcoholic fatty liver disease in children", Curr Opin Clin Nutr Metab Care, 14, pp.151~157 (2011)
- Loomba R, "Advances in pediatric nonalcoholic fatty liver disease", Hepatology, 50, pp.1282~1293 (2009)
- Sundaram SS, "The metabolic syndrome and nonalcoholic fatty liver disease in children", Curr Opin Pediatr, 21, pp.529~535 (2009)
- 박성근, "The Risk of Abdominal Obesity according to the Degree of Non- Alcoholic Fatty Liver Disease in Korean Men", Journal of Korean Medical Science, 31(3), pp.410~416 (2016), 대한의학회
- Etelson D, "Childhood obesity: do parents recognize this health risk", Obes Res, 11, pp.1362~1368 (2003)
- Golan M, "Parents as the exclusive agents of change in the treatment of childhood obesity", Am J Clin Nutr, 67, pp.1130~1135 (1998)
- 장진하, "소아비만증에서 대사 증후군의 유병률", Korean Journal of Pediatrics, 47(11), pp.1149~1156 (2004), 대한소아과학회