동물병원성 뇌수막염 유발 곰팡이 Cryptococcus neoformans의 Pathogenomic Signaling Network 연구와 항곰팡이제 개발
Pathogenomic Signaling Networks and Antifungal Drug Development for Human Fungal Pathogen Cryptococcus neoformans.
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Past decade systemic mycoses caused by opportunistic human fungal pathogens, including Candida, Aspergillus, and Cryptococcus, have been a growing problem for both immunocompromised and immunocompetent individuals. Particularly, Cryptococcus neoformans has recently emerged as a major fungal pathogen, which can cause fungal pneumonia and meningitis that are lethal if not timely medicated. However, treatment for cryptococcosis has been difficult due to a lack of proper anti-cryptococcal drugs with fungicidal activity and less toxicity. In this review we introduced novel therapeutic methods for treating cryptococcosis by exploring pathogenomic signaling networks of C. neoformans with genome-wide transcriptome approaches as well as diverse molecular/genetic tools.
Abstract
Past decade systemic mycoses caused by opportunistic human fungal pathogens, including Candida, Aspergillus, and Cryptococcus, have been a growing problem for both immunocompromised and immunocompetent individuals. Particularly, Cryptococcus neoformans has recently emerged as a major fungal pathogen, which can cause fungal pneumonia and meningitis that are lethal if not timely medicated. However, treatment for cryptococcosis has been difficult due to a lack of proper anti-cryptococcal drugs with fungicidal activity and less toxicity. In this review we introduced novel therapeutic methods for treating cryptococcosis by exploring pathogenomic signaling networks of C. neoformans with genome-wide transcriptome approaches as well as diverse molecular/genetic tools.
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