Neurocognitive Functions in Infants with Malnutrition; Relation with Long-chain Polyunsaturated Fatty Acids, Micronutrients Levels and Magnetic Resonance Spectroscopy
0
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Purpose: Malnutrition may influence neurocognitive development in children by directly affecting the brain structural development, or indirectly by affecting the children's cognition experience. Malnutrition alters the cell numbers, cell migration, synaptogenesis, and neurotransmission due to inadequate availability of necessary micronutrients to support cell growth. We aimed to analyze neurocognitive development in infants with malnutrition and its association with long chain polyunsaturated fatty acids (LC-PUFA), micronutrients levels and magnetic resonance spectroscopy (MRS) findings. Methods: The study included two groups; group 1, infants with malnutrition (n=24), group 2; healthy infants (n=21). Peripheral blood was obtained from the participants for studying micronutrients and LC-PUFA levels. The neurocognitive development was analyzed by the use of an Ankara Developmental Screening Inventory test. MRS were performed on all infants. Results: All parameters of neurocognitive development and serum calcium (9.6±0.9 mg/dL vs. 10.4±0.3 mg/dL, p <0.05) and magnesium (2.02±0.27 mg/dL vs. 2.2±0.14 mg/dL, p <0.05) levels were noted as being low in infants with marked malnutrition. No difference was found in LC-PUFA levels between healthy and malnourished infants. Thalamic choline/creatine levels were significantly high in infants with malnutrition (1.33±0.22 vs. 1.18±0.22, p <0.05). Total neurocognitive development in infants was positively correlated with serum calcium levels ( p <0.05, r=0.381). Conclusion: Calcium supplementation may improve neurocognitive development in malnourished infants.
Abstract
Purpose: Malnutrition may influence neurocognitive development in children by directly affecting the brain structural development, or indirectly by affecting the children's cognition experience. Malnutrition alters the cell numbers, cell migration, synaptogenesis, and neurotransmission due to inadequate availability of necessary micronutrients to support cell growth. We aimed to analyze neurocognitive development in infants with malnutrition and its association with long chain polyunsaturated fatty acids (LC-PUFA), micronutrients levels and magnetic resonance spectroscopy (MRS) findings. Methods: The study included two groups; group 1, infants with malnutrition (n=24), group 2; healthy infants (n=21). Peripheral blood was obtained from the participants for studying micronutrients and LC-PUFA levels. The neurocognitive development was analyzed by the use of an Ankara Developmental Screening Inventory test. MRS were performed on all infants. Results: All parameters of neurocognitive development and serum calcium (9.6±0.9 mg/dL vs. 10.4±0.3 mg/dL, p <0.05) and magnesium (2.02±0.27 mg/dL vs. 2.2±0.14 mg/dL, p <0.05) levels were noted as being low in infants with marked malnutrition. No difference was found in LC-PUFA levels between healthy and malnourished infants. Thalamic choline/creatine levels were significantly high in infants with malnutrition (1.33±0.22 vs. 1.18±0.22, p <0.05). Total neurocognitive development in infants was positively correlated with serum calcium levels ( p <0.05, r=0.381). Conclusion: Calcium supplementation may improve neurocognitive development in malnourished infants.
참고문헌 (35)
- Agostoni C, "Nutrition and neurocognitive development", Early Hum Dev, 89(Suppl 1), pp.S1~3 (2013)
- Prado EL, "Nutrition and brain development in early life", Nutr Rev, 72, pp.267~284 (2014)
- Grantham-McGregor S, "Developmental potential in the first 5 years for children in developing countries", Lancet, 369, pp.60~70 (2007)
- Black MM, "Micronutrient deficiencies and cognitive functioning", J Nutr, 133, pp.3927S~3931S (2003)
- Uauy R, "Nutrition in brain development and aging : role of essential fatty acids", Nutr Rev, 64, pp.S24~33 (2006)
- Ulmer S, "Basic principles and clinical applications of magnetic resonance spectroscopy in neuroradiology", J Comput Assist Tomogr, 40, pp.1~13 (2016)
- "Severe acute malnutrition" (2009)[URL]
- Erol N, "Validity studies for development-screening inventory", Turk J Psychol, 8, pp.16~22 (1993)
- Savasir I, "Handbook of Ankara development-screening inventory" (1998), Rekmay
- Hamaguchi H, "Solubilization of human erythrocyte membrane glycoproteins and separation of the MN glycoprotein from a glycoprotein with I, S, and A activity", Biochim Biophys Acta, 278, pp.271~280 (1972)
- Sattler W, "Determination of fatty acids in the main lipoprotein classes by capillary gas chromatography : BF3", methanol transesterification of lyophilized samples instead of Folch extraction gives higher yields, 1991, pp.198, 184~190
- Granados-Rojas L, "Prenatal protein malnutrition differentially affects the volume of the granule layer and mossy fibers in young male and female rats", Proc West Pharmacol Soc, 45, pp.53~54 (2002)
- Mathangi DC, "Effect of chronic protein restriction on motor co-ordination and brain neurotransmitters in albino rats", Food Chem Toxicol, 39, pp.1039~1043 (2001)
- Alamy M, "Malnutrition and brain development : an analysis of the effects of inadequate diet during different stages of life in rat", Neurosci Biobehav Rev, 36, pp.1463~1480 (2012)
- Benítez-Bribiesca L, "Dendritic spine pathology in infants with severe protein-calorie malnutrition", Pediatrics, 104, pp.e21~ (1999)
- Nyaradi A, "The role of nutrition in children's neurocognitive development, from pregnancy through childhood", Front Hum Neurosci, 7, pp.97~ (2013)
- Engle PL, "INCAP studies of malnutrition and cognitive behavior", Food Nutr Bull, 31, pp.83~94 (2010)
- Isik Y, "Serum leptin levels in marasmic children and the relationship between leptin and lipid profile", Ann Nutr Metab, 48, pp.259~262 (2004)
- Akuyam A, "Serum lipid profile in malnourished Nigerian children in Zaria", Niger Postgrad Med J, 15, pp.192~196 (2008)
- Fageer SA, "Assessment of plasma levels of proteins, total cholesterol and high density", J Sci Technol, 14, pp.35~43 (2013)
- Veiga GR, "Dyslipidaemia and undernutrition in children from impoverished areas of Maceió, state of Alagoas, Brazil", Int J Environ Res Public Health, 7, pp.4139~4151 (2010)
- Chisti MJ, "Prevalence, clinical predictors, and outcome of hypocalcaemia in severely-malnourished under-five children admitted to an urban hospital in Bangladesh : a case-control study", J Health Popul Nutr, 32, pp.270~275 (2014)
- Singla PN, "Serum magnesium levels in protein-energy malnutrition", J Trop Pediatr, 44, pp.117~119 (1998)
- El-khayat H, "Cognitive functions in protein-energy malnutrition : in relation to long chain-polyunsaturated fatty acids", Pak J Biol Sci, 10, pp.1773~1781 (2007)
- Gil A, "Role of long-chain polyunsaturated fatty acids in infant nutrition", Eur J Clin Nutr, 57(Suppl 1), pp.S31~34 (2003)
- Schulzke SM, "Long-chain polyunsaturated fatty acid supplementation in preterm infants", Cochrane Database Syst Rev, pp.CD000375~ (2011)
- Smithers LG, "Maternal supplementation with docosahexaenoic acid during pregnancy does not affect early visual development in the infant : a randomized controlled trial", Am J Clin Nutr, 93, pp.1293~1299 (2011)
- McCann JC, "Is docosahexaenoic acid, an n-3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals", Am J Clin Nutr, 82, pp.281~295 (2005)
- Simmer K, "Long-chain polyunsaturated fatty acid supplementation in infants born at term", Cochrane Database Syst Rev, pp.CD000376~ (2008)
- Kendall GS, "White matter NAA", Cho and Cho, Radiology, pp.2014, 271[DOI]
- Guo L, "Early identification of hypoxic-ischemic encephalopathy by combination of magnetic resonance(MR)imaging and proton MR spectroscopy", Exp Ther Med, 12, pp.2835~2842 (2016)
- Nassar M, "Proton Magnetic Resonance Spectroscopy in protein energy malnutrition patients", J Pediatr Gastroenterol Nutr, 52(Suppl 1), pp.e63~ (2011)
- Filippi CG, "Developmental delay in children : assessment with proton MR spectroscopy", AJNR Am J Neuroradiol, 23, pp.882~888 (2002)
- Hart PH, "Vitamin D in fetal development : findings from a birth cohort study", Pediatrics, 135, pp.e167~73 (2015)
- Schlögl M, "Vitamin D and neurocognitive function", Clin Interv Aging, 9, pp.559~568 (2014)